| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yimeng Hu, Jie Liu, Yin Yuan, Jing Chen, Siyuan Cheng, Huawei Wang, Yancheng X. Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress. Environmental toxicology and pharmacology. vol 64. 2019-01-28. PMID:30342372. |
our objective was to explore the effect and underlying mechanism of nab on islet β-cell dysfunction and apoptosis in type 2 diabetic (t2dm) rats. |
2019-01-28 |
2023-08-13 |
rat |
| Yimeng Hu, Jie Liu, Yin Yuan, Jing Chen, Siyuan Cheng, Huawei Wang, Yancheng X. Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress. Environmental toxicology and pharmacology. vol 64. 2019-01-28. PMID:30342372. |
nab also improved diabetes-induced histological alteration of islet and functional damage; moreover, results of tunel and western blotting indicated nab alleviated β-cell apoptosis. |
2019-01-28 |
2023-08-13 |
rat |
| Betul Yilmaz, Arzu Zeynep Karaba. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-04. PMID:29565269. |
food additive sodium benzoate (nab) activates nfκb and induces apoptosis in hct116 cells. |
2018-09-04 |
2023-08-13 |
Not clear |
| Betul Yilmaz, Arzu Zeynep Karaba. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-04. PMID:29565269. |
in this study, the effects of nab on viability parameters and nfκb, one of the most important regulators in apoptosis, were examined in hct116 colon cancer cells. |
2018-09-04 |
2023-08-13 |
Not clear |
| Betul Yilmaz, Arzu Zeynep Karaba. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-04. PMID:29565269. |
nab (6.25 mm-50 mm) treatment inhibited cell viability by inducing apoptosis, which was evident with increased annexin v-pe staining and caspase-3 activity. |
2018-09-04 |
2023-08-13 |
Not clear |
| Betul Yilmaz, Arzu Zeynep Karaba. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-04. PMID:29565269. |
nfκb activation accompanied the induction of apoptosis in nab treated cells. |
2018-09-04 |
2023-08-13 |
Not clear |
| Betul Yilmaz, Arzu Zeynep Karaba. Food Additive Sodium Benzoate (NaB) Activates NFκB and Induces Apoptosis in HCT116 Cells. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-04. PMID:29565269. |
overall, these results suggest that nab induces apoptosis and activates nfκb in hct116 colon cancer cells. |
2018-09-04 |
2023-08-13 |
Not clear |
| Andrew J Tsung, Maheedhara R Guda, Swapna Asuthkar, Collin M Labak, Ian J Purvis, Yining Lu, Neha Jain, Sarah E Bach, Durbaka V R Prasad, Kiran K Velpul. Methylation regulates HEY1 expression in glioblastoma. Oncotarget. vol 8. issue 27. 2018-04-06. PMID:28574840. |
nab treatment also induced apoptosis of gbm cells as measured by flow cytometric analysis. |
2018-04-06 |
2023-08-13 |
Not clear |
| Ying Wang, Peng-Chao Hu, Yan-Bin Ma, Rong Fan, Fang-Fang Gao, Jing-Wei Zhang, Lei We. Sodium butyrate-induced apoptosis and ultrastructural changes in MCF-7 breast cancer cells. Ultrastructural pathology. vol 40. issue 4. 2017-03-27. PMID:27158913. |
here, we demonstrated that a certain concentration of nab effectively induced mcf-7 cell apoptosis. |
2017-03-27 |
2023-08-13 |
Not clear |
| Zhao-Tong Wang, Zhuo-Jia Chen, Guan-Min Jiang, Ying-Min Wu, Tao Liu, Yan-Mei Yi, Jun Zeng, Jun Du, Hong-Sheng Wan. Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells. Cellular signalling. vol 28. issue 5. 2016-12-13. PMID:26876786. |
our present study reveals that histone deacetylase inhibitors (hdacis) suberoyl anilide hydroxamic acid (saha) and sodium butyrate (nab) significantly inhibit cell proliferation, arrest cell cycle at g0/g1 phase, and induce mitochondrial related apoptosis of tnbc cells. |
2016-12-13 |
2023-08-13 |
human |
| Peng Zhang, James C Weaver, Gang Chen, Julia Beretov, Tatsuya Atsumi, Miao Qi, Ravinay Bhindi, Jian C Qi, Michele C Madigan, Bill Giannakopoulos, Steven A Krili. The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. PloS one. vol 11. issue 3. 2016-08-05. PMID:27031114. |
domain v treatment in wt mice also resulted in less neutrophil infiltration, less apoptosis and improved ejection fraction at 24 h. rag-1 -/- antibody deficient mice reconstituted with igm nabs confirmed that domain v prevented igm nab induced cardiac iri. |
2016-08-05 |
2023-08-13 |
mouse |
| Ebrahim Eftekhar, Hajar Jaberie, Fakhraddin Naghibalhossain. Carcinoembryonic Antigen Expression and Resistance to Radiation and 5-Fluorouracil-Induced Apoptosis and Autophagy. International journal of molecular and cellular medicine. vol 5. issue 2. 2016-08-01. PMID:27478804. |
mtt assay was used to measure ic50 value of the cells exposed to graded concentrations of 5- fu with either 0.1 mm nab or 1 μm 5-aza for 72 h . using cho- and sw742-cea transfectants, we also investigated the effect of cea expression on uv- and 5-fu-induced apoptosis and autophagy. |
2016-08-01 |
2023-08-13 |
Not clear |
| Jing Sun, Fangyan Wang, Haixiao Li, Huiqing Zhang, Jiangtao Jin, Wenqian Chen, Mengqi Pang, Junjie Yu, Yiwen He, Jiaming Liu, Chunfeng Li. Neuroprotective Effect of Sodium Butyrate against Cerebral Ischemia/Reperfusion Injury in Mice. BioMed research international. vol 2015. 2016-03-10. PMID:26064905. |
10 mg/kg nab treatment also remarkably inhibited the apoptosis, decreasing the levels of caspase-3 and bax and increasing the levels of bcl-2, p-akt, and bdnf. |
2016-03-10 |
2023-08-13 |
mouse |
| Sabbir Khan, Gopabandhu Jen. Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 73. 2015-08-03. PMID:25158305. |
the present study was aimed to investigate the renoprotective effects of sodium butyrate (nab) in diabetes-induced renal damages, apoptosis and fibrosis in juvenile rats. |
2015-08-03 |
2023-08-13 |
rat |
| Sabbir Khan, Gopabandhu Jen. Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 73. 2015-08-03. PMID:25158305. |
post-treatment with nab significantly decreased plasma glucose, creatinine, urea, histological alterations including the fibrosis and collagen deposition as well as decreased the hdacs activity, expression of enos, inos, α-sma, collagen i, fibronectin, tgfβ-1, nfκb, apoptosis and dna damage in the diabetic kidney. |
2015-08-03 |
2023-08-13 |
rat |
| Sabbir Khan, Gopabandhu Jen. Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 73. 2015-08-03. PMID:25158305. |
these results showed that nab treatment improved the renal function and ameliorated the histological alterations, fibrosis, apoptosis and dna damage in the kidney of juvenile rats. |
2015-08-03 |
2023-08-13 |
rat |
| Sabita N Saldanha, Rishabh Kala, Trygve O Tollefsbo. Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate. Experimental cell research. vol 324. issue 1. 2014-07-01. PMID:24518414. |
taken together, these findings suggest that at low and physiologically achievable concentrations, combinatorial egcg and nab are effective in promoting apoptosis, inducing cell cycle arrest and dna-damage in crc cells. |
2014-07-01 |
2023-08-12 |
Not clear |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
the present study was aimed to investigate the protective role of nab treatment on the beta-cell proliferation, function and glucose homeostasis as well as apoptosis in juvenile diabetic rat. |
2014-05-27 |
2023-08-12 |
rat |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
nab treatment decreased plasma glucose, hba1c, beta-cell apoptosis and improved plasma insulin level and glucose homeostasis through hdac inhibition and histone acetylation in diabetic animal as compared to control. |
2014-05-27 |
2023-08-12 |
rat |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
nab treatment improved the beta-cell proliferation, function and glucose homeostasis as well as reduced beta-cell apoptosis in juvenile diabetic rat by the modulation of p38/erk mapk and apoptotic pathway. |
2014-05-27 |
2023-08-12 |
rat |