| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
the present study was aimed to investigate the protective role of nab treatment on the beta-cell proliferation, function and glucose homeostasis as well as apoptosis in juvenile diabetic rat. |
2014-05-27 |
2023-08-12 |
rat |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
nab treatment decreased plasma glucose, hba1c, beta-cell apoptosis and improved plasma insulin level and glucose homeostasis through hdac inhibition and histone acetylation in diabetic animal as compared to control. |
2014-05-27 |
2023-08-12 |
rat |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
nab treatment improved the beta-cell proliferation, function and glucose homeostasis as well as reduced beta-cell apoptosis in juvenile diabetic rat by the modulation of p38/erk mapk and apoptotic pathway. |
2014-05-27 |
2023-08-12 |
rat |
| Suxia Sun, Wenjun Li, Siqiang Chen, He Zhang, Shaozhen Yu, Minhong Zhang, Fei Zo. [Effect of sodium butyrate on apoptosis and stromal interaction molecule and Orai1 activity in human colon cancer HCT-116 cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 32. issue 2. 2013-09-26. PMID:22381755. |
to investigate the mechanism underlying sodium butyrate (nab)-induced apoptosis of a human colon cancer cell line hct-116. |
2013-09-26 |
2023-08-12 |
human |
| Humaira Adnan, Holly Quach, Kimberley MacIntosh, Monica Antenos, Gordon M Kirb. Low levels of GSTA1 expression are required for Caco-2 cell proliferation. PloS one. vol 7. issue 12. 2013-06-03. PMID:23251616. |
in contrast, 10 mm nab causes significant toxicity in preconfluent cells via apoptosis through caspase-3 activation with reduced gsta1 activity. |
2013-06-03 |
2023-08-12 |
human |
| Chunrui Li, Jianfeng Zhou, Xueqiong Wu, Ye Tian, Jingniu Deng, Wenli Li. Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 5. 2013-01-18. PMID:19821084. |
the effects of two different histone deacetylase (hdac) inhibitors, sodium butyrate (nab) and trichostatin a (tsa),on apoptosis of human leukemic cells in vitro and the molecular mechanisms were investigated. |
2013-01-18 |
2023-08-12 |
human |
| Chunrui Li, Jianfeng Zhou, Xueqiong Wu, Ye Tian, Jingniu Deng, Wenli Li. Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 5. 2013-01-18. PMID:19821084. |
nab and tsa could induce the apoptosis of hl-60 and k562 cells, and z-vad-fmk caused a marked decrease in apoptosis induced by hdac inhibitors. |
2013-01-18 |
2023-08-12 |
human |
| Chunrui Li, Jianfeng Zhou, Xueqiong Wu, Ye Tian, Jingniu Deng, Wenli Li. Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 5. 2013-01-18. PMID:19821084. |
the results suggested that nab and tsa induce distinct caspase-dependent apoptosis of human leukemic cells through down-regulating the expression of daxx protein in vitro. |
2013-01-18 |
2023-08-12 |
human |
| Marie-Paule Mingeot-Leclercq, Paul M Tulkens, Sophie Denamur, Timo Vaara, Martti Vaar. Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells. Peptides. vol 35. issue 2. 2012-11-19. PMID:22504013. |
neither polymyxin b nor the nab compounds induced apoptosis. |
2012-11-19 |
2023-08-12 |
Not clear |
| G Krupitz. The Effects of Butyrate and the Role of c-myc in N.1 Ovarian Carcinoma Cells Determined by Northern Blotting. Methods in molecular medicine. vol 39. 2012-10-02. PMID:21340801. |
however, application of nab to colon carcinoma cells (but not to normal colon cells) induces apoptosis (5). |
2012-10-02 |
2023-08-12 |
Not clear |
| Suxia Sun, Wenjun Li, He Zhang, Longying Zha, Yong Xue, Xianbo Wu, Fei Zo. Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells. Bioscience reports. vol 32. issue 1. 2012-02-29. PMID:21699495. |
thus we conclude that nab triggers colon cancer cell apoptosis in an soce-dependent manner. |
2012-02-29 |
2023-08-12 |
human |
| Yaron Suissa, Oren Ziv, Tama Dinur, Eli Arama, Offer Gerlit. The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation. The Journal of biological chemistry. vol 286. issue 17. 2011-07-14. PMID:21385866. |
we have previously shown that elimination of misspecified cells due to reduced dpp signaling is achieved by the interaction of the co-repressor nab with the transcriptional repressor brk, which in turn induces jun n-terminal kinase-dependent apoptosis. |
2011-07-14 |
2023-08-12 |
drosophila_melanogaster |
| S Orzechowska, B Pajak, B Gajkowska, A Orzechowsk. Cholesterol level determines viability and mitogenicity, but it does not affect sodium butyrate-dependent sensitization of Colo 205 cells to TNF-α-induced apoptosis. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152874. |
colo 205 cells remained immune to tnf-α-induced apoptosis unless nab was added, in which case nab-induced cell death was further potentiated by tnf-α. |
2011-05-09 |
2023-08-12 |
human |
| Maria C Daroqui, Leonard H Augenlich. Transcriptional attenuation in colon carcinoma cells in response to butyrate. Cancer prevention research (Philadelphia, Pa.). vol 3. issue 10. 2011-01-25. PMID:20841488. |
the short-chain fatty acid sodium butyrate (nab), produced in the colonic lumen, induces cell cycle arrest, differentiation, and/or apoptosis in colorectal carcinoma cells in vitro, establishing a potential role for nab in colon cancer prevention. |
2011-01-25 |
2023-08-12 |
human |
| Roxana Magaly Flores-Ancona, Fanny Yocelin García-Gómez, Ana María Jiménez-Betanzos, Mario Solis-Paredes, Violeta Castro-Leyva, Alfredo Cruz-Orea, Francisco Arenas-Huertero, Eva Ramón-Gallego. Effects of sodium butyrate on cell death induced by photodynamic therapy in U373-MG and D54-MG astrocytoma cell lines. Photochemistry and photobiology. vol 85. issue 5. 2009-12-03. PMID:19453389. |
chromatin modifiers such as sodium butyrate (nab) induce several genes involved in apoptosis, among others. |
2009-12-03 |
2023-08-12 |
Not clear |
| Takafumi Inoue, Kiyoko Kato, Hidenori Kato, Kazuo Asanoma, Ayumi Kuboyama, Yousuke Ueoka, Shin-ichiro Yamaguchi, Tatsuhiro Ohgami, Norio Wak. Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate. Cancer science. vol 100. issue 7. 2009-09-09. PMID:19432898. |
treatment with 1 mm nab or 2 to 5 mm nab induced senescence or apoptosis, respectively. |
2009-09-09 |
2023-08-12 |
Not clear |
| M P dos Santos, G Schwartsmann, R Roesler, A L Brunetto, A L Abujamr. Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells. Leukemia research. vol 33. issue 2. 2009-02-27. PMID:18692895. |
sodium butyrate (nab), a potent histone deacetylase inhibitor, induces cell cycle arrest and apoptosis in malignant cells. |
2009-02-27 |
2023-08-12 |
human |
| Basavarajappa Mohana Kumar, Hye-Jin Song, Seong-Keun Cho, Sivasankaran Balasubramanian, Sang-Yong Choe, Gyu-Jin Rh. Effect of histone acetylation modification with sodium butyrate, a histone deacetylase inhibitor, on cell cycle, apoptosis, ploidy and gene expression in porcine fetal fibroblasts. The Journal of reproduction and development. vol 53. issue 4. 2007-11-01. PMID:17558190. |
the present study evaluated the effective dose of sodium butyrate (nab), a histone deacetylase (hdac) inhibitor, for determination of the level of enhancement of histone acetylation in porcine fetal fibroblasts (pffs) based on their morphology, growth, apoptosis and cell cycle status. |
2007-11-01 |
2023-08-12 |
Not clear |
| Basavarajappa Mohana Kumar, Hye-Jin Song, Seong-Keun Cho, Sivasankaran Balasubramanian, Sang-Yong Choe, Gyu-Jin Rh. Effect of histone acetylation modification with sodium butyrate, a histone deacetylase inhibitor, on cell cycle, apoptosis, ploidy and gene expression in porcine fetal fibroblasts. The Journal of reproduction and development. vol 53. issue 4. 2007-11-01. PMID:17558190. |
nab induced apoptosis in a dose-dependent manner; the rates of apoptosis were 2.5 +/- 0.4% for 1.0 mm nab, 7.6 +/- 1.1% for 2.0 mm nab and 11.2 +/- 1.4% for 3.0 mm nab. |
2007-11-01 |
2023-08-12 |
Not clear |
| Michael Bordonaro, Darina L Lazarova, Alan C Sartorell. The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors. Experimental cell research. vol 313. issue 8. 2007-06-11. PMID:17359971. |
we have reported that (a) the histone deacetylase inhibitor (hdaci)(2) sodium butyrate (nab) modulates the canonical wnt transcriptional activity of crc cells in vitro and (b) a linear relationship exists between the increase in wnt transcriptional activity and the levels of apoptosis in ten crc cell lines treated with nab. |
2007-06-11 |
2023-08-12 |
Not clear |