| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiujing Dou, Ziwen Ma, Di Yan, Nan Gao, Zhongyu Li, Yang Li, Xingjun Feng, Lingxue Meng, Anshan Sha. Sodium butyrate alleviates intestinal injury and microbial flora disturbance induced by lipopolysaccharides in rats. Food & function. 2022-01-19. PMID:35044411. |
the results showed that nab supplementation alleviated lps-induced nuclear atrophy, apoptosis, mitochondrial damage, and rupture. |
2022-01-19 |
2023-08-13 |
rat |
| Ying Xia, Fuli Mi, Guoqiang Du, Shenghui Qi. Analysis of protective immune responses to seasonal influenza vaccination in HIV-infected individuals. Human vaccines & immunotherapeutics. vol 17. issue 1. 2021-06-21. PMID:32412824. |
our study could also demonstrate that apoptosis of cd4+t cells and b cells (d7) were inversely correlated with influenza-specific h1n1 nab. |
2021-06-21 |
2023-08-13 |
human |
| Xinxin Liu, Chang Jiang, Guanghua Liu, Ping Wang, Mingfang Shi, Mingzhen Yang, Zongye Zhong, Shenglong Ding, Yun Li, Bangzhong Liu, Yuanwu Ca. Sodium butyrate protects against oxidative stress in human nucleus pulposus cells via elevating PPARγ-regulated Klotho expression. International immunopharmacology. vol 85. 2021-04-21. PMID:32554208. |
flow cytometry and western blotting showed that tbhp-induced apoptosis of npcs was inhibited by nab. |
2021-04-21 |
2023-08-13 |
human |
| Feifan Wang, Hongshen Wu, Mengjing Fan, Rikao Yu, Yan Zhang, Jiaxin Liu, Xuejian Zhou, Yueshu Cai, Shihan Huang, Zhenghui Hu, Xiaodong Ji. Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-21. PMID:31957111. |
the interplay between autophagy and apoptosis in nab treatment was clarified. |
2021-01-21 |
2023-08-13 |
human |
| Xiaojiao Qin, Yanhong Xu, Shiqiao Peng, Shengnan Qian, Xiaoying Zhang, Shuang Shen, Jiajun Yang, Jianping Y. Sodium butyrate opens mitochondrial permeability transition pore (MPTP) to induce a proton leak in induction of cell apoptosis. Biochemical and biophysical research communications. vol 527. issue 3. 2021-01-19. PMID:32423794. |
sodium butyrate (nab) induces apoptosis in glioma cells at pharmacological dosages (>2.5 mm), but the mechanism remains largely unknown beyond the mitochondrial potential drop. |
2021-01-19 |
2023-08-13 |
Not clear |
| Xiaojiao Qin, Yanhong Xu, Shiqiao Peng, Shengnan Qian, Xiaoying Zhang, Shuang Shen, Jiajun Yang, Jianping Y. Sodium butyrate opens mitochondrial permeability transition pore (MPTP) to induce a proton leak in induction of cell apoptosis. Biochemical and biophysical research communications. vol 527. issue 3. 2021-01-19. PMID:32423794. |
in this study, nab was found to open the mitochondrial permeability transient pore (mptp) to induce a proton leak in the mechanism of apoptosis. |
2021-01-19 |
2023-08-13 |
Not clear |
| Xiaojiao Qin, Yanhong Xu, Shiqiao Peng, Shengnan Qian, Xiaoying Zhang, Shuang Shen, Jiajun Yang, Jianping Y. Sodium butyrate opens mitochondrial permeability transition pore (MPTP) to induce a proton leak in induction of cell apoptosis. Biochemical and biophysical research communications. vol 527. issue 3. 2021-01-19. PMID:32423794. |
these data suggest that the proton leak is induced by nab for the mitochondrial potential drop in the induction of apoptosis. |
2021-01-19 |
2023-08-13 |
Not clear |
| Dan Xian, Yingying Zhan, Zicong Yang, Cao Fan, Ling Liu, Yingzhong Li. Anti-interleukin-5-neutralizing antibody attenuates caradiac injury and cadiac dysfunction by aggravating the inflammatory response in doxorubicin-treated mice. Cell biology international. vol 44. issue 6. 2021-01-12. PMID:32125042. |
furthermore, the effect of mouse il-5 nab on dox-induced mø differentiation and its role on mouse cardiomyocyte (mcm) cells apoptosis were detected in vitro, and the results exhibited that mouse il-5 nab promoted mø1 differentiation but inhibited mø2 differentiation in vitro and alleviated apoptosis in mcm cells. |
2021-01-12 |
2023-08-13 |
mouse |
| T N Zhao, L D Yuan, L X Chen, Y Yuan, D L Ca. PI3K/Akt and ERK1/2 pathways are responsible for sodium butyrateinduced inhibition of neuronal apoptosis in rats with cerebral infarction. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-04. PMID:32752588. |
the aim of this study was to elucidate the neuronal protection effect of sodium butyrate (nab) on neuronal apoptosis in rats with cerebral infarction (ci), and the involvement of the phosphatidilinositol 3-kinase/protein kinase b (pi3k/akt) and extracellular-signal-regulated kinase 1/2 (erk1/2) pathways. |
2020-11-04 |
2023-08-13 |
rat |
| T N Zhao, L D Yuan, L X Chen, Y Yuan, D L Ca. PI3K/Akt and ERK1/2 pathways are responsible for sodium butyrateinduced inhibition of neuronal apoptosis in rats with cerebral infarction. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-04. PMID:32752588. |
nab treatment alleviates neuronal apoptosis via the pi3k/akt and erk1/2 pathways in ci rats, thus protecting the deterioration of ci. |
2020-11-04 |
2023-08-13 |
rat |
| Chen-Meng Qiao, Meng-Fei Sun, Xue-Bing Jia, Yun Shi, Bo-Ping Zhang, Zhi-Lan Zhou, Li-Ping Zhao, Chun Cui, Yan-Qin She. Sodium butyrate causes α-synuclein degradation by an Atg5-dependent and PI3K/Akt/mTOR-related autophagy pathway. Experimental cell research. vol 387. issue 1. 2020-10-26. PMID:31836471. |
moreover, the pi3k/akt/mtor pathway was significantly inhibited and cell apoptosis was activated by nab. |
2020-10-26 |
2023-08-13 |
Not clear |
| Liansheng Gao, Zhongyuan Zhang, Weilin Xu, Tao Li, Guangyu Ying, Bing Qin, Jianru Li, Jingwei Zheng, Tengfei Zhao, Feng Yan, Yongjian Zhu, Gao Che. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853891. |
this study aimed to explore the neuroprotective effects and mechanisms of natrium benzoate (nab) and dj-1 in attenuating reactive oxygen species (ros)-induced neuronal apoptosis in traumatic spinal cord injury (t-sci) in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Liansheng Gao, Zhongyuan Zhang, Weilin Xu, Tao Li, Guangyu Ying, Bing Qin, Jianru Li, Jingwei Zheng, Tengfei Zhao, Feng Yan, Yongjian Zhu, Gao Che. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853891. |
in conclusion, nab increased dj-1, and thus reduced ros and ros-induced neuronal apoptosis by promoting akt phosphorylation in t-sci rats. |
2020-10-01 |
2023-08-13 |
rat |
| Weilin Xu, Tao Li, Liansheng Gao, Cameron Lenahan, Jingwei Zheng, Jun Yan, Anwen Shao, Jianmin Zhan. Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31114478. |
the aim of this study was to explore whether sodium benzoate (nab) could reduce neural cell apoptosis and alleviate neurological deficits after ich. |
2020-10-01 |
2023-08-13 |
rat |
| Weilin Xu, Tao Li, Liansheng Gao, Cameron Lenahan, Jingwei Zheng, Jun Yan, Anwen Shao, Jianmin Zhan. Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31114478. |
therefore, we concluded that nab could attenuate secondary brain injury via inhibiting neuronal apoptosis and reducing mitochondria-mediated oxidative stress via dj-1/akt/ikk/nfκb pathway. |
2020-10-01 |
2023-08-13 |
rat |
| Upashi Goswami, Raghuram Kandimalla, Sanjeeb Kalita, Arun Chattopadhyay, Siddhartha Sankar Ghos. Polyethylene Glycol-Encapsulated Histone Deacetylase Inhibitor Drug-Composite Nanoparticles for Combination Therapy with Artesunate. ACS omega. vol 3. issue 9. 2020-09-30. PMID:30320264. |
thus, induction of apoptosis with the synergistic effect of both nab and art with its meticulous mechanism makes it a promising tool for combinational cancer therapy. |
2020-09-30 |
2023-08-13 |
mouse |
| Lin Li, Huan-Huan Wang, Xin-Tian Nie, Wan-Ru Jiang, Yuan-Shu Zhan. Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. Journal of cellular biochemistry. 2019-11-20. PMID:30259565. |
nab attenuated protein damage and reduced apoptosis in lps-induced mac-t cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Lin Li, Huan-Huan Wang, Xin-Tian Nie, Wan-Ru Jiang, Yuan-Shu Zhan. Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. Journal of cellular biochemistry. 2019-11-20. PMID:30259565. |
in addition, nab decreased apoptosis by inhibiting caspase-3, caspase-9, and bax protein levels, and this action was mainly achieved via activation of the pi3k/akt signaling pathways in lps-induced mac-t cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Matthew A Taylor, Firas Khathayer, Swapan K Ra. Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:31011879. |
this study investigated the efficacy of quercetin (qct) in combination with sodium butyrate (nab) in enhancing apoptosis in rat c6 and human t98g glioblastoma cells though blockage of autophagy under nutrient-starvation. |
2019-08-12 |
2023-08-13 |
human |
| Matthew A Taylor, Firas Khathayer, Swapan K Ra. Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:31011879. |
western blotting results showed that combination of qct and nab increased apoptosis by decreasing anti-apoptotic bcl-2 and increasing pro-apoptotic bax, decreasing survivin, activating caspase-3, and degrading poly (adp-ribose) polymerase (parp). |
2019-08-12 |
2023-08-13 |
human |