| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yangbo Li, Pengzhan He, Ying Chen, Jiaming Hu, Beiying Deng, Chuan Liu, Baoping Yu, Weiguo Don. Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844824. |
the findings of our study demonstrate that sodium butyrate (nab) exerts inhibitory effects on tumor cell proliferation and promotes tumor cell apoptosis in vitro, while also impeding tumor progression in vivo through the enhancement of the mitophagy pathway. |
2024-06-06 |
2024-06-10 |
Not clear |
| Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Tatsushi Yoshid. Venetoclax efficacy on acute myeloid leukemia is enhanced by the combination with butyrate. Scientific reports. vol 14. issue 1. 2024-02-29. PMID:38424468. |
the combined treatment with nab and venetoclax strongly cleaved a caspase substrate poly (adp-ribose) polymerase (parp) and a potent pan-caspase inhibitor q-vd-oph almost completely blocked the cell death induced by the combination, meaning that the combination mainly induced apoptosis. |
2024-02-29 |
2024-03-03 |
Not clear |
| Ji Hyeon Cho, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Su Jong Han, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Ha. Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex. Autophagy. 2024-02-27. PMID:38409852. |
here, we examined the regulatory effects of sodium butyrate (nab) on high glucose-induced mitophagy dysregulation, neuronal apoptosis, and cognitive impairment and its underlying mechanisms in human-induced pluripotent stem cell-derived neurons, sh-sy5ys, and streptozotocin (stz)-induced diabetic mice. |
2024-02-27 |
2024-03-02 |
mouse |
| Nayeon Kim, Changwon Yan. Sodium Butyrate Inhibits the Expression of Thymidylate Synthase and Induces Cell Death in Colorectal Cancer Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338851. |
therefore, we investigated the enhancing effects on inhibition of cell viability and induction of apoptosis after co-treatment of nab with 5-fu in two crc cell lines, hct116 and lovo. |
2024-02-10 |
2024-02-12 |
human |
| Dongze Li, Li Zhang, Ping Yang, Yanqiu He, Tingting Zhou, Xi Cheng, Zongzhe Jiang, Yang Long, Qin Wan, Pijun Yan, Chenlin Gao, Wei Huang, Yong X. Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation. Ecotoxicology and environmental safety. vol 270. 2023-12-27. PMID:38150747. |
our study found that, although the experimental concentration of nab is below the maximum allowable concentration in food, it still damaged the insulin secretion function of c57bl/6j mice and induced inflammation and apoptosis of islet β cells. |
2023-12-27 |
2023-12-30 |
mouse |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
recent evidence suggests that nab induces cell proliferation and apoptosis. |
2023-09-09 |
2023-10-07 |
cattle |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
the present study aimed to investigate the role of nab treatment on the proliferation, apoptosis, and mitophagy of bovine skeletal muscle satellite cells (bscs). |
2023-09-09 |
2023-10-07 |
cattle |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
the results showed that nab inhibited proliferation, promoted apoptosis of bscs, and promoted mitophagy in a time- and dose-dependent manner in bscs. |
2023-09-09 |
2023-10-07 |
cattle |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
in contrast, the addition of pp242, an inhibitor of the mtor signaling pathway also inhibited mrna and protein expression levels of mtor, akt1, foxo1, and eif4ebp1 and promoted mitophagy and apoptosis, which were consistent with the effect of nab treatment. |
2023-09-09 |
2023-10-07 |
cattle |
| Yanling Ding, Pengfei Wang, Chenglong Li, Yanfeng Zhang, Chaoyun Yang, Xiaonan Zhou, Xiaowei Wang, Zonghua Su, Wenxuan Ming, Ling Zeng, Yuangang Shi, Cong-Jun Li, Xiaolong Kan. Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686278. |
nab might promote mitophagy and apoptosis in bscs by inhibiting the mtor signaling pathway. |
2023-09-09 |
2023-10-07 |
cattle |
| Zehra Omeroglu Ulu, Nurdan Sena Degirmenci, Zeynep Busra Bolat, Fikrettin Sahi. Synergistic anti-cancer effect of sodium pentaborate pentahydrate, curcumin and piperine on hepatocellular carcinoma cells. Scientific reports. vol 13. issue 1. 2023-09-01. PMID:37658091. |
synergistic effect of combined treatment with nab, cur and pip on hcc cells was observed on cytotoxicity, apoptosis and cell cycle assay. |
2023-09-01 |
2023-09-07 |
human |
| Zijian Zhou, Xuan Zhou, Yu Zhang, Yuanyuan Yang, Lujia Wang, Zhong W. Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-06. PMID:37414240. |
treatment with sodium butyrate (nab) was found to partially reverse the oxidative stress, inflammation, and apoptosis associated with caox crystallization in the kidney. |
2023-07-06 |
2023-08-14 |
rat |
| Zijian Zhou, Xuan Zhou, Yu Zhang, Yuanyuan Yang, Lujia Wang, Zhong W. Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-06. PMID:37414240. |
in addition, in hk-2 cells, nab reversed the decreased cell viability, increased ros levels and apoptosis damage caused by oxalate exposure. |
2023-07-06 |
2023-08-14 |
rat |
| Zijian Zhou, Xuan Zhou, Yu Zhang, Yuanyuan Yang, Lujia Wang, Zhong W. Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-06. PMID:37414240. |
subsequently, nab was found to significantly reduce cyp2c9 levels in vivo and in vitro, and inhibition of cyp2c9 by sulfaphenazole (a specific cyp2c9 inhibitor), was able to reduce ros levels, inflammation injury, and apoptosis in oxalate-induced hk-2 cells. |
2023-07-06 |
2023-08-14 |
rat |
| Qiong Wang, Xiaoying M. Gut microbial sodium butyrate alleviates renal ischemia-reperfusion injury by regulating HES1/PPARα. Molecular immunology. vol 150. 2022-08-05. PMID:35930845. |
nab pretreatment inhibited oxidative stress, inflammation, and apoptosis following renal iri in vivo and in vitro. |
2022-08-05 |
2023-08-14 |
rat |
| Xueyan Wang, Chengwei Duan, Yu Li, Hongjian Lu, Kongwei Guo, Xin Ge, Tianpeng Chen, Yanxing Shang, Hongbin Liu, Dongmei Zhan. Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation. International immunopharmacology. vol 111. 2022-08-02. PMID:35917736. |
oral supplementation with sodium butyrate (nab) significantly reduced hfd-induced microgliosis, inflammatory cytokine expression, endoplasmic reticulum (er) stress, neuronal apoptosis, and neuropeptide y (npy) expression in the mouse hypothalamus. |
2022-08-02 |
2023-08-14 |
mouse |
| Fengjiao Li, Yun Wu, Yujie Yan, Saizhi Wu, Jingyu Zhu, Gaihua Zhang, Peng Zhang, Lianwen Yuan, Yong Zeng, Zhonghua Li. Transcriptomic landscape of sodium butyrate-induced growth inhibition of human colorectal cancer organoids. Molecular omics. 2022-07-15. PMID:35837877. |
recent studies have shown that sodium butyrate (nab) can inhibit cell proliferation and stimulate cell apoptosis in colorectal cancer (crc) cells. |
2022-07-15 |
2023-08-14 |
human |
| Xiujing Dou, Ziwen Ma, Di Yan, Nan Gao, Zhongyu Li, Yang Li, Xingjun Feng, Lingxue Meng, Anshan Sha. Sodium butyrate alleviates intestinal injury and microbial flora disturbance induced by lipopolysaccharides in rats. Food & function. 2022-01-19. PMID:35044411. |
the results showed that nab supplementation alleviated lps-induced nuclear atrophy, apoptosis, mitochondrial damage, and rupture. |
2022-01-19 |
2023-08-13 |
rat |
| Ying Xia, Fuli Mi, Guoqiang Du, Shenghui Qi. Analysis of protective immune responses to seasonal influenza vaccination in HIV-infected individuals. Human vaccines & immunotherapeutics. vol 17. issue 1. 2021-06-21. PMID:32412824. |
our study could also demonstrate that apoptosis of cd4+t cells and b cells (d7) were inversely correlated with influenza-specific h1n1 nab. |
2021-06-21 |
2023-08-13 |
human |
| Xinxin Liu, Chang Jiang, Guanghua Liu, Ping Wang, Mingfang Shi, Mingzhen Yang, Zongye Zhong, Shenglong Ding, Yun Li, Bangzhong Liu, Yuanwu Ca. Sodium butyrate protects against oxidative stress in human nucleus pulposus cells via elevating PPARγ-regulated Klotho expression. International immunopharmacology. vol 85. 2021-04-21. PMID:32554208. |
flow cytometry and western blotting showed that tbhp-induced apoptosis of npcs was inhibited by nab. |
2021-04-21 |
2023-08-13 |
human |