| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jui-Hsin Su, Yu-Cheng Chen, Mohamed El-Shazly, Ying-Chi Du, Chiang-Wen Su, Chia-Wei Tsao, Li-Lian Liu, Yalan Chou, Wen-Been Chang, Yin-Di Su, Michael Y Chiang, Yao-Tsung Yeh, Mei-Chin L. Towards the small and the beautiful: a small dibromotyrosine derivative from Pseudoceratina sp. sponge exhibits potent apoptotic effect through targeting IKK/NFκB signaling pathway. Marine drugs. vol 11. issue 9. 2014-05-06. PMID:24065159. |
first, the results of mtt cytotoxic and the annexin v-fitc/pi apoptotic assays, indicated that the dt cytotoxic activity is mediated through induction of apoptosis. |
2014-05-06 |
2023-08-12 |
Not clear |
| Wenlong Lv, Mei Zhang, Zhenhuan Zhang, Luqiang Huang, Shanmin Yang, Liangjie Yin, Jinsheng Hong, Deping Han, Chun Chen, Sadasivan Vidyasagar, Paul Okunieff, Lurong Zhan. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines. Advances in experimental medicine and biology. vol 789. 2014-05-05. PMID:23852495. |
in vitro results showed that bone marrow cells treated with amifostine 0.5 h before irradiation (0.5 gy) experienced several benefits, as compared to vehicle controls, including (1) reduced reactive oxygen species levels, which reduced the production of free radicals; (2) better preservation of mitochondria, as indicated by mitotracker-positive staining and the increased intensity of staining; (3) reduced apoptosis, as demonstrated by annexin v staining; and (4) a better proliferation rate, as illustrated by mtt assay. |
2014-05-05 |
2023-08-12 |
mouse |
| Si-Qun Wen, Liang-Ming Ma, Yu-Jin Lu, Bo Ba. [Triptolide inhibits proliferation and induces apoptosis of imatinib resistant K562/G01 cells]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 5. 2014-05-05. PMID:24156423. |
mtt assay was used to detect the effect of imatinib or triptolide alone and their combination on k562/g01 proliferation; the cell cycle, apoptosis rate, p-gp protein expression were detected by flow cytometry (fcm); the expression of p-gp was assessed by western blot; the bcr/abl gene expression was assayed by real time quantitative pcr. |
2014-05-05 |
2023-08-12 |
Not clear |
| Hong-Pu Chen, Yi-Qun Huang, Xu-Dong M. [Antiproliferative effects of LY294002 on MCL Jeko-1 cell line and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 5. 2014-05-05. PMID:24156430. |
the proliferation inhibitory rate of jeko-1 cells treated by different doses of ly294002 was assayed by mtt method; the level of apoptosis of jeko-1 cells was detected by flow cytometry; the expression level of apoptosis-related protein cyclin d1, bcl-2, procaspase-3 and pi3k/akt signaling pathway protein phosphorylated-akt (p-akt), phosphorylated-tor (p-mtor), phosphorylated-p70s6k (p-p70s6k) phosphorylated-akt (p-akt) in jeko-1 cells were determined by western blot. |
2014-05-05 |
2023-08-12 |
Not clear |
| Jie Zhao, Liang-Ming M. [Effect of bortezomib on reverse multidrug resistance and XIAP expression in imatinib-resistant primary cells of chronic myeloid leukemia in blastic crisis]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 4. 2014-05-01. PMID:23998582. |
mtt method was used to detect the inhibitory effect on cell growth, flow cytometry was used to assay the apoptosis and p170 expression, and rt-pcr was used to monitor the expression of xiap mrna. |
2014-05-01 |
2023-08-12 |
Not clear |
| Zhi-Qiang Jia, Yu-Tao Wei, Ai-Ming Li, Zhi-Yong Chen. [Effect of proteasome inhibitor bortezomib on proliferation, apoptosis and SHIP gene expression in K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 4. 2014-05-01. PMID:23998585. |
cell proliferation was analyzed by mtt assay, cell apoptosis was detected by flow cytometry and ship mrna expression was assayed by rt-pcr.the results showed that after being treated with 10, 20, 50 and 100 nmol/l bortezomib for 24 h, the inhibitory rates of k562 cells were (5.76 ± 1.47)%, (10.55 ± 1.59)%, (17.14 ± 2.05)% and (27.69 ± 3.57)% respectively, and were higher than that in control (1.30 ± 0.10); when k562 cells were treated with 20 nmol/l bortezomib for 24, 48 and 72 h, the inhibitory rates of cell proliferation were (10.55 ± 1.59)%, (16.33 ± 2.53)% and (19.78 ± 1.56)% respectively, there was statistic difference of cell proliferation rate between 24 h group and 48 h group (p < 0.05). |
2014-05-01 |
2023-08-12 |
Not clear |
| Ya-Juan Chen, Hui-Min Li, Wei Lu, Chen Qin. [Blocking effect of arsenic trioxide on the proliferation and cell cycle of human Burkitt lymphoma cells and its related mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 6. 2014-05-01. PMID:24370028. |
human burkitt lymphoma cell line namalwa was used as the model, the effect of as2o3 on cell proliferation, cell cycle and apoptosis, as well as the expression of cell cycle modulation related genes, including mrna and protein level, were detected by mtt method, flow cytometry, real-time quantitative pcr (rq-pcr) and western blot, respectively. |
2014-05-01 |
2023-08-12 |
human |
| Yu-Ping Wei, Hai Bai, Yan-Qing Sun, Shen Bao, Rui Xi, Lin Li. [Effect of salidroside on apoptosis of bone marrow mesenchymal stem cells induced by ara-C]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 6. 2014-05-01. PMID:24370051. |
the proliferation and apoptosis of cells exposed to ara- c were detected by mtt and flow cytometry respectively. |
2014-05-01 |
2023-08-12 |
human |
| Jing Zuo, Da-Hu Wang, Yu-Jun Zhang, Liang Liu, Feng-Ling Liu, Wei Li. Expression and mechanism of PinX1 and telomerase activity in the carcinogenesis of esophageal epithelial cells. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23912465. |
the cell proliferation and apoptosis of eca109 cells were analyzed by fcm and mtt assay. |
2014-04-29 |
2023-08-12 |
human |
| Weiguo Cao, Weiping Yang, Rong Fan, Hao Li, Jinsong Jiang, Mei Geng, Yening Jin, Yunlin W. miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 2. 2014-04-28. PMID:24068565. |
the viability of cisplatin-induce gastric cancer cells increased significantly (p < 0.05) with significant decrease of apoptosis after mir-34a expression inhibition, as demonstrated by mtt and flow cytometry with mir-34a over-expression, the viability of cisplatin-induce gastric cancer cells decreased significantly (p < 0.05), with significant apoptosis increase (p < 0.05). |
2014-04-28 |
2023-08-12 |
human |
| Olga Kim, Jung Hwan Yoon, Won Suk Choi, Hassan Ashktorab, Duane T Smoot, Suk Woo Nam, Jung Young Lee, Won Sang Par. GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity. Journal of cellular physiology. vol 229. issue 6. 2014-04-28. PMID:24151046. |
we analyzed cell viability, proliferation, and death in ags cells transfected with gkn1, gkn2, gkn1 plus gkn2 using mtt, brdu incorporation, and apoptosis assays, respectively. |
2014-04-28 |
2023-08-12 |
Not clear |
| Xingfu Bao, Yuyan Liu, Guanghong Han, Zhigang Zuo, Min H. The effect on proliferation and differentiation of cementoblast by using sclerostin as inhibitor. International journal of molecular sciences. vol 14. issue 10. 2014-04-24. PMID:24152444. |
in the current study, we investigated the effects of sclerostin on the processes of proliferation and differentiation; a series of experiments including mtt, apoptosis examination, alkaline phosphatase (alp) activity, gene analysis, and alizarin red staining were carried out to evaluate the proliferation and differentiation of cementoblasts. |
2014-04-24 |
2023-08-12 |
Not clear |
| Liping Han, Xiaoxue Zhang, Lina Geng, Mengmeng Li, Yi Zhang, Mei X W. The expression of immediate early response gene X-1 in preeclampsia placenta and its pro-apoptotic role in preeclampsia. Hypertension in pregnancy. vol 32. issue 2. 2014-04-22. PMID:23725081. |
flow cytometry and mtt revealed that the serum isolated from preeclampsia patients appeared to promote iex-1 expression in cytoplasm of huvecs, inhibited the proliferation and promoted the apoptosis of huvecs when compared to the serum of normal pregnant women. |
2014-04-22 |
2023-08-12 |
human |
| Lekha Nair K, Sankar Jagadeeshan, Asha Nair S, G S Vinod Kuma. Folic acid conjugated δ-valerolactone-poly(ethylene glycol) based triblock copolymer as a promising carrier for targeted doxorubicin delivery. PloS one. vol 8. issue 8. 2014-04-22. PMID:23990912. |
mtt assay followed by apoptosis assays clearly indicated that folate decorated micelles showed significantly better cytotoxicity (ic50 = 0.014 µm) and efficiency to induce apoptosis than other treated groups. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jianmin Liang, Ying Yu, Boyu Wang, Bin Lu, Jizhou Zhang, Hongbo Zhang, Pengfei G. Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondria and inhibition of AIF and cytochrome c release. Molecules (Basel, Switzerland). vol 18. issue 10. 2014-04-22. PMID:24135936. |
to investigate the role of mitochondria in the protective effects of ginsenoside rb1 on cellular apoptosis caused by oxygen-glucose deprivation, in this study, mtt assay, tunel staining, flow cytometry, immunocytochemistry and western blotting were used to examine the cellular viability, apoptosis, ros level, mitochondrial membrane potential, and the distribution of apoptosis inducing factor, cytochrome c, bax and bcl-2 in nucleus, mitochondria and cytoplasm. |
2014-04-22 |
2023-08-12 |
Not clear |
| Mirella Vazzana, Monica Celi, Cecilia Tramati, Vincenzo Ferrantelli, Vincenzo Arizza, Nicolò Parrinell. In vitro effect of cadmium and copper on separated blood leukocytes of Dicentrarchus labrax. Ecotoxicology and environmental safety. vol 102. 2014-04-22. PMID:24530726. |
a significant reduction in the cells׳ ability to uptake neutral red and viability by mtt assay was recorded, indicating that both cadmium and copper could change the membrane permeability, inducing cellular apoptosis when the concentration of metals reached 10(-3)m. the apoptotic effect may also explain the high level of cytotoxicity found when the leukocytes were exposed to higher concentration of metals. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jun Shao, Ming-Qing Li, Yu-Han Meng, Kai-Kai Chang, Ying Wang, Li Zhang, Da-Jin L. Estrogen promotes the growth of decidual stromal cells in human early pregnancy. Molecular human reproduction. vol 19. issue 10. 2014-04-18. PMID:23649593. |
the dscs behaviors in vitro were verified by viability (mtt, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and apoptosis assay, respectively. |
2014-04-18 |
2023-08-12 |
human |
| Wenjuan Luo, Cuicui Liu, Ruijuan Zhang, Jianwei He, Bei Ha. Anticancer activity of binary toxins from Lysinibacillus sphaericus IAB872 against human lung cancer cell line A549. Natural product communications. vol 9. issue 1. 2014-04-18. PMID:24660476. |
the effect of bin protein on a549 cell proliferation, apoptosis, cell cycle, migration and invasion were examined by mtt assay, western blotting, immunocytochemical staining, flow cytometry assay and wound-healing assay. |
2014-04-18 |
2023-08-12 |
human |
| Ying Niu, Jian-Sheng Li, Xian-Run Lu. Enhancement of expression of survivin promoter-driven CD/TK double suicide genes by the nuclear matrix attachment region in transgenic gastric cancer cells. Gene. vol 534. issue 2. 2014-04-17. PMID:24220851. |
cell viability and apoptosis were measured using the methyl thiazolyl tetrazolium (mtt) assay and flow cytometry. |
2014-04-17 |
2023-08-12 |
human |
| Ying Niu, Jian-Sheng Li, Xian-Run Lu. Enhancement of expression of survivin promoter-driven CD/TK double suicide genes by the nuclear matrix attachment region in transgenic gastric cancer cells. Gene. vol 534. issue 2. 2014-04-17. PMID:24220851. |
mtt and flow cytometry analyses indicated that treatment with the prodrugs (5-fc+gcv) significantly decreased the cellular survival rate and enhanced the cellular apoptosis in the sgc-7901 cells. |
2014-04-17 |
2023-08-12 |
human |