| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangyan Gao, Qianqian Wang, Chang Zhang, Chen Zhang, Tianyu Qu, Jingya Zhang, Jifu Wei, Renhua Gu. RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma. Journal of cellular and molecular medicine. vol 25. issue 5. 2021-09-21. PMID:33491264. |
cell function experiments have proved that under the treatment of gefitinib, mettl3 knockdown promotes apoptosis and inhibits proliferation of lung cancer cells. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yan. METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246. Cell death discovery. vol 7. issue 1. 2021-09-15. PMID:34497267. |
decreased mettl3 inhibited the proliferation and migration of ovarian cancer cells and promoted apoptosis, while mettl3 overexpression exerted opposite effects. |
2021-09-15 |
2023-08-13 |
mouse |
| Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yan. METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246. Cell death discovery. vol 7. issue 1. 2021-09-15. PMID:34497267. |
high expression of mettl3 downregulated ccng2, promoted the metabolism and growth of transplanted tumors in nude mice, and inhibited apoptosis. |
2021-09-15 |
2023-08-13 |
mouse |
| Ying Yang, Xiaoqing Yang, Yi Wu, Meijiao F. METTL3 promotes inflammation and cell apoptosis in a pediatric pneumonia model by regulating EZH2. Allergologia et immunopathologia. vol 49. issue 5. 2021-09-03. PMID:34476922. |
mettl3 promotes inflammation and cell apoptosis in a pediatric pneumonia model by regulating ezh2. |
2021-09-03 |
2023-08-13 |
Not clear |
| Xiao Chang, Yu-Ying Lin, Li-Na Bai, Wei Zh. miR-302a-3p suppresses melanoma cell progression via targeting METTL3. Journal of chemotherapy (Florence, Italy). 2021-07-21. PMID:34286671. |
herein, we investigated the functions of mir-302a-3p and its target rna mettl3 on proliferation, apoptosis, and invasion of melanoma. |
2021-07-21 |
2023-08-13 |
Not clear |
| Zhao Ma, Qin Li, Peng Liu, Wei Dong, Ying Zu. METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32869897. |
moreover, mettl3 knockdown in tov-112d and crl-11731d cells weakened the capability of cell proliferation and migration, and promoted cell apoptosis compared to negative control and cells with wtap or mettl14 knockdown using cck-8 assay, transwell assay, wound healing assay, and tunel assay. furthermore, mettl3 knockdown also reduced m6a enrichment of the genes associated with ovarian cancer including eif3c, axl, csf-1, fzd10 in tov-112d, and crl-11731d cells by rip-qpcr assay. |
2021-07-09 |
2023-08-13 |
Not clear |
| Yongxi Zhang, Shuyuan Liu, Tiesuo Zhao, Chengxue Dan. METTL3‑mediated m6A modification of Bcl‑2 mRNA promotes non‑small cell lung cancer progression. Oncology reports. vol 46. issue 2. 2021-07-05. PMID:34132367. |
here, knockdown and overexpression of mettl3 notably decreased nsclc cell viability, apoptosis and migration |
2021-07-05 |
2023-08-13 |
Not clear |
| Zhi Yang, Xiaodi Jiang, Deming Li, Xiaofeng Jian. HBXIP promotes gastric cancer Aging. vol 12. issue 24. 2021-05-19. PMID:33048840. |
silencing hbxip led to a decreased expression of mettl3, which inhibited gc cell proliferation, migration and invasion while promoting their apoptosis. |
2021-05-19 |
2023-08-13 |
Not clear |
| Hao Hu, Qi Kong, Xiao-Xu Huang, Hao-Ran Zhang, Kai-Feng Hu, Yan Jing, Yang-Fan Jiang, Yue Peng, Long-Chao Wu, Qi-Sheng Fu, Li Xu, Ya-Bin Xi. Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway. Journal of Cancer. vol 12. issue 11. 2021-05-14. PMID:33976730. |
subsequently, restoration of mettl3 eliminated the suppressive effect of proliferation or the promotive effect of apoptosis caused by blacat2 knockdown. |
2021-05-14 |
2023-08-13 |
Not clear |
| Shaohong Huang, Shaoning Luo, Chulian Gong, Limin Liang, Yi Xiao, Mingan Li, Jinyuan H. MTTL3 upregulates microRNA-1246 to promote occurrence and progression of NSCLC via targeting paternally expressed gene 3. Molecular therapy. Nucleic acids. vol 24. 2021-04-28. PMID:33898106. |
nsclc cells were relatively treated with altered expression of mettl3, mir-1246, or peg3 to measure their roles in the proliferation, migration, invasion, apoptosis, and |
2021-04-28 |
2023-08-13 |
Not clear |
| Shumei Liang, Hongwei Guan, Xiaoyan Lin, Na Li, Feng Geng, Juan L. METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32256816. |
apoptotic rates were increased in mettl3-silenced ovarian cancer cells, which may have been mediated by the activation of the mitochondrial apoptosis pathway, and mettl3 knockdown reduced cell invasion. |
2020-09-28 |
2023-08-13 |
human |
| Qingbai Liu, Meng Li, Lei Jiang, Rui Jiang, Bin F. METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. Biochemical and biophysical research communications. vol 516. issue 1. 2020-07-13. PMID:31186141. |
mettl3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. |
2020-07-13 |
2023-08-13 |
Not clear |
| Hong Wang, Bei Xu, Jun Sh. N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2. Gene. vol 722. 2019-11-08. PMID:31454538. |
in vivo and vitro, mettl3 knockdown could decrease the methylation level, reduce the proliferation, accelerate the apoptosis and inhibited the tumor growth. |
2019-11-08 |
2023-08-13 |
Not clear |
| Hong Wang, Bei Xu, Jun Sh. N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2. Gene. vol 722. 2019-11-08. PMID:31454538. |
moreover, we found that bcl-2 acted as the target of mettl3, thereby regulating the proliferation and apoptosis of breast cancer. |
2019-11-08 |
2023-08-13 |
Not clear |
| Chen-Xin Wang, Guan-Shen Cui, Xiuying Liu, Kai Xu, Meng Wang, Xin-Xin Zhang, Li-Yuan Jiang, Ang Li, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Gui-Bin Jiang, Hai-Lin Wang, Wei-Min Tong, Wei Li, Xiu-Jie Wang, Yun-Gui Yang, Qi Zho. METTL3-mediated m6A modification is required for cerebellar development. PLoS biology. vol 16. issue 6. 2019-04-22. PMID:29879109. |
mettl3 conditional knockout (cko) mice manifest cerebellar hypoplasia caused by drastically enhanced apoptosis of newborn cerebellar granule cells (cgcs) in the external granular layer (egl). |
2019-04-22 |
2023-08-13 |
mouse |
| Xiao-Li Ping, Bao-Fa Sun, Lu Wang, Wen Xiao, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu, Yun-Gui Yan. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell research. vol 24. issue 2. 2014-09-24. PMID:24407421. |
morpholino-mediated knockdown targeting wtap and/or mettl3 in zebrafish embryos caused tissue differentiation defects and increased apoptosis. |
2014-09-24 |
2023-08-12 |
human |