| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis. Psychiatry investigation. vol 19. issue 10. 2022-11-03. PMID:36327957. |
hippocampal neuron apoptosis contributes to autism, while mettl3 has been documented to possess great potentials in neuron apoptosis. |
2022-11-03 |
2023-08-14 |
mouse |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis. Psychiatry investigation. vol 19. issue 10. 2022-11-03. PMID:36327957. |
our study probed into the role of mettl3 in neuron apoptosis in autism and to determine the underlying mechanism. |
2022-11-03 |
2023-08-14 |
mouse |
| Yuchan Li, Xiaoxue Li, Muwen Deng, Changda Ye, Yuanhong Peng, Yan L. Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m Oxidative medicine and cellular longevity. vol 2022. 2022-10-17. PMID:36246404. |
cancer-associated fibroblasts hinder lung squamous cell carcinoma oxidative stress-induced apoptosis via mettl3 mediated m cancer-associated fibroblasts (cafs) within the tumor microenvironment are key players in tumorigenesis and tumor development. |
2022-10-17 |
2023-08-14 |
Not clear |
| Hongyu Zhou, Nana Zhan. miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-07-27. PMID:35892080. |
mechanistically, mir-212-5p inhibited the proliferation and promoted apoptosis of npc cells via suppressing mettl3 expression. |
2022-07-27 |
2023-08-14 |
Not clear |
| Min Li, Mingyue Xia, Ziyu Zhang, Yanyin Tan, Enjie Li, Zhigang Guo, Mingzhi Fang, Yong Zhu, Zhigang H. METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma. International journal of oncology. vol 61. issue 3. 2022-07-20. PMID:35856434. |
using cell survival assays, flow cytometric and colony formation analyses, it was revealed that inhibition of mettl3 sensitized hct‑8 cells to 5‑fu by enhancing dna damage and inducing apoptosis in hct‑8 cells under 5‑fu treatment. |
2022-07-20 |
2023-08-14 |
Not clear |
| Yiping Kong, Yiwen Zhang, Yongjie Cai, Di Li, Baicheng Yi, Qiong X. METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation. Cellular signalling. 2022-04-24. PMID:35461899. |
mettl3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during lps-induced inflammation. |
2022-04-24 |
2023-08-13 |
Not clear |
| Li Yang, Xin Chen, Xiang Qian, Jiejie Zhang, Meijuan Wu, Aijun Y. Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Endometrioid Ovarian Cancer. Frontiers in oncology. vol 12. 2022-03-14. PMID:35280730. |
mettl3 knockdown in the cov362 cells significantly decreased cell proliferation, promoted cell apoptosis, and induced cell cycle arrest at the g0/g1 phase. |
2022-03-14 |
2023-08-13 |
Not clear |
| Rucheng Yan, Weiwei Dai, Ruixin Wu, Houbao Huang, Minfeng Sh. Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer. Cancer letters. 2022-03-12. PMID:35278613. |
ectopic expression of mettl3 significantly blocked melittin-induced apoptosis in vitro and in vivo. |
2022-03-12 |
2023-08-13 |
Not clear |
| Lichao Yang, Guotao Wu, Qiang Wu, Liangxin Peng, Lianwen Yua. METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice. Cell death discovery. vol 8. issue 1. 2022-02-15. PMID:35165276. |
within lps-treated mode-k cells, mettl3 knockdown promoted cell viability, inhibited cell apoptosis, decreased apoptotic caspase3/9 cleavage, and decreased the levels of proinflammatory cytokines (il-1β, tnf-α, il-6, and il-18) and inflammatory enzymes (cox-2 and inos). |
2022-02-15 |
2023-08-13 |
mouse |
| Ying He, Wei Wang, Xiaoxiao Xu, Beining Yang, Xijie Yu, Yanru Wu, Jiawei Wan. Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m Bone. vol 154. 2021-12-11. PMID:34530171. |
mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating bcl2 stability via ythdf1-mediated m n |
2021-12-11 |
2023-08-13 |
Not clear |
| Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu, Jun Xi. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics & chromatin. vol 14. issue 1. 2021-12-11. PMID:34863249. |
additionally, these data implicate that mettl3 is enriched in ht-22 cells, and mettl3 knockdown reduces cell proliferation and increases apoptosis through suppressing wnt/β-catenin signaling pathway. |
2021-12-11 |
2023-08-13 |
mouse |
| Guoping Wang, Zhongchen Zhang, Chenmei Xi. Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis. Bioengineered. vol 12. issue 2. 2021-11-29. PMID:34842045. |
importantly, mir-338-5p inhibitor or mettl3 overexpression could rescue the inhibitory effect of linc00240 knockdown on cell proliferation and migration, and inhibit the apoptosis induction in gc cells. |
2021-11-29 |
2023-08-13 |
Not clear |
| Xiaoping Pan, Xiaolv Hong, Sumei Li, Ping Meng, Feng Xia. METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Experimental & molecular medicine. vol 53. issue 1. 2021-11-08. PMID:33420414. |
mettl3 knockdown was shown to reduce the expression of mir-221-3p by reducing pri-mir-221-3p m6a mrna methylation, thereby reducing the ic50 value of adr-resistant mcf-7 cells, reducing the expression of mdr1 and bcrp, and inducing apoptosis. |
2021-11-08 |
2023-08-13 |
mouse |
| Kun Zhao, Chuanxi Yang, Jing Zhang, Wei Sun, Bin Zhou, Xiangqing Kong, Jing Sh. METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner. Cell death discovery. vol 7. issue 1. 2021-10-30. PMID:34645805. |
the effects of mettl3 on cardiomyocyte proliferation and apoptosis were investigated in an in vivo rat model of mi and in an in vitro model of neonatal rat cardiomyocytes (nrcms) exposed to hypoxia. |
2021-10-30 |
2023-08-13 |
rat |
| Kun Zhao, Chuanxi Yang, Jing Zhang, Wei Sun, Bin Zhou, Xiangqing Kong, Jing Sh. METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner. Cell death discovery. vol 7. issue 1. 2021-10-30. PMID:34645805. |
furthermore, mettl3 pretreatment enhanced cardiomyocyte proliferation and inhibited cardiomyocyte apoptosis under hypoxic or mi conditions, and silencing mettl3 had the opposite effects. |
2021-10-30 |
2023-08-13 |
rat |
| Yulian Xiao, Yanping Yang, Dandan H. Knockdown of METTL3 inhibits enterovirus 71-induced apoptosis of mouse Schwann cell through regulation of autophagy. Pathogens and disease. vol 79. issue 6. 2021-10-18. PMID:34279591. |
knockdown of mettl3 inhibits enterovirus 71-induced apoptosis of mouse schwann cell through regulation of autophagy. |
2021-10-18 |
2023-08-13 |
mouse |
| Yulian Xiao, Yanping Yang, Dandan H. Knockdown of METTL3 inhibits enterovirus 71-induced apoptosis of mouse Schwann cell through regulation of autophagy. Pathogens and disease. vol 79. issue 6. 2021-10-18. PMID:34279591. |
knocking down mettl3 inhibited ev-71-induced apoptosis and autophagy. |
2021-10-18 |
2023-08-13 |
mouse |
| Jie Wang, Jingyun Zha, Xiaolin Wan. Knockdown of lncRNA NUTM2A-AS1 inhibits lung adenocarcinoma cell viability by regulating the miR-590-5p/METTL3 axis. Oncology letters. vol 22. issue 5. 2021-10-12. PMID:34630705. |
the present study aimed to identify the underlying molecular mechanism of the effect of lncrna nutm2a-as1 in luad by exploring whether lncrna nutm2a-as1 could affect luad cell proliferation and apoptosis through the microrna (mir)-590-5p/methyltransferase 3, n6-adenosine-methyltransferase complex catalytic subunit (mettl3) axis. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jie Wang, Jingyun Zha, Xiaolin Wan. Knockdown of lncRNA NUTM2A-AS1 inhibits lung adenocarcinoma cell viability by regulating the miR-590-5p/METTL3 axis. Oncology letters. vol 22. issue 5. 2021-10-12. PMID:34630705. |
in addition, mir-590-5p inhibited nci-h23 cell viability and induced apoptosis by downregulating mettl3 expression. |
2021-10-12 |
2023-08-13 |
Not clear |
| Xiangmei Zhao, Lei Yang, Lijie Qi. Methyltransferase-like 3 (METTL3) attenuates cardiomyocyte apoptosis with myocardial ischemia-reperfusion (I/R) injury through miR-25-3p and miR-873-5p. Cell biology international. 2021-10-04. PMID:34553450. |
methyltransferase-like 3 (mettl3) attenuates cardiomyocyte apoptosis with myocardial ischemia-reperfusion (i/r) injury through mir-25-3p and mir-873-5p. |
2021-10-04 |
2023-08-13 |
Not clear |