| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilin Guo, Yangyang Bai, Lu Wang, Zhen Xu, Nan Zhang, Wuliang Wang, Hu Zha. METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2. Scientific reports. vol 14. issue 1. 2024-10-18. PMID:39424828. |
knockdown of mettl3 resulted in reduced growth, migration, and invasion of cc cells, as well as affected apoptosis, while overexpression of mettl3 reversed these effects. |
2024-10-18 |
2024-10-21 |
Not clear |
| Xiaofeng Du, Yanting Wang, Fan Ga. PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress. Diagnostic pathology. vol 19. issue 1. 2024-10-16. PMID:39407268. |
psat1 is upregulated by mettl3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress. |
2024-10-16 |
2024-10-18 |
Not clear |
| Qingjie Kang, Xiaoyu Hu, Zhenzhou Chen, Xiaolong Liang, Song Xiang, Ziwei Wan. The METTL3/TRAP1 axis as a key regulator of 5-fluorouracil chemosensitivity in colorectal cancer. Molecular and cellular biochemistry. 2024-09-17. PMID:39287889. |
initially, we observed that 5-fu treatment inhibited cell viability and induced apoptosis, accompanied by a reduction in mettl3 expression in hct-116 and hct-8 cells. |
2024-09-17 |
2024-09-20 |
Not clear |
| Qingjie Kang, Xiaoyu Hu, Zhenzhou Chen, Xiaolong Liang, Song Xiang, Ziwei Wan. The METTL3/TRAP1 axis as a key regulator of 5-fluorouracil chemosensitivity in colorectal cancer. Molecular and cellular biochemistry. 2024-09-17. PMID:39287889. |
subsequent assays including drug sensitivity, edu, colony formation, tunel staining, and flow cytometry revealed that mettl3 depletion enhanced 5-fu sensitivity and increased apoptosis induction both in vitro and in vivo. |
2024-09-17 |
2024-09-20 |
Not clear |
| Qingjie Kang, Xiaoyu Hu, Zhenzhou Chen, Xiaolong Liang, Song Xiang, Ziwei Wan. The METTL3/TRAP1 axis as a key regulator of 5-fluorouracil chemosensitivity in colorectal cancer. Molecular and cellular biochemistry. 2024-09-17. PMID:39287889. |
moreover, knockdown of mettl3 in 5-fu-resistant crc cell lines hct-116/fu and hct-15/fu significantly decreased 5-fu tolerance and induced apoptosis upon 5-fu treatment. |
2024-09-17 |
2024-09-20 |
Not clear |
| Qingjie Kang, Xiaoyu Hu, Zhenzhou Chen, Xiaolong Liang, Song Xiang, Ziwei Wan. The METTL3/TRAP1 axis as a key regulator of 5-fluorouracil chemosensitivity in colorectal cancer. Molecular and cellular biochemistry. 2024-09-17. PMID:39287889. |
mechanistically, we found that mettl3 regulated 5-fu sensitivity and apoptosis induction by modulating trap1 expression. |
2024-09-17 |
2024-09-20 |
Not clear |
| Weili Shi, Rui Chen, Mingjie Zhou, Yunian Li, Yuwei Zhang, Jikui Wang, Bingtao Hao, Shixiu Lia. Methyltransferase METTL3 governs the modulation of SH3BGR expression through m6A methylation modification, imparting influence on apoptosis in the context of Down syndrome-associated cardiac development. Cell death discovery. vol 10. issue 1. 2024-09-05. PMID:39237501. |
methyltransferase mettl3 governs the modulation of sh3bgr expression through m6a methylation modification, imparting influence on apoptosis in the context of down syndrome-associated cardiac development. |
2024-09-05 |
2024-09-08 |
mouse |
| Weili Shi, Rui Chen, Mingjie Zhou, Yunian Li, Yuwei Zhang, Jikui Wang, Bingtao Hao, Shixiu Lia. Methyltransferase METTL3 governs the modulation of SH3BGR expression through m6A methylation modification, imparting influence on apoptosis in the context of Down syndrome-associated cardiac development. Cell death discovery. vol 10. issue 1. 2024-09-05. PMID:39237501. |
in ds hearts, mettl3 downregulation and sh3bgr upregulation, potentially orchestrated by abnormal m6a modification, contribute to gene dysregulation and apoptosis. |
2024-09-05 |
2024-09-08 |
mouse |
| Xiangmei Li, Yinlu Wang, Jiuling Cheng, Liliang Qiu, Ruiyang Wang, Yuping Zhang, Huaqi Wan. METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis. Cellular signalling. 2024-08-17. PMID:39153585. |
mettl3 -mediated m6a modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the mir-216b-5p/kras axis. |
2024-08-17 |
2024-08-20 |
mouse |
| Xiangmei Li, Yinlu Wang, Jiuling Cheng, Liliang Qiu, Ruiyang Wang, Yuping Zhang, Huaqi Wan. METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis. Cellular signalling. 2024-08-17. PMID:39153585. |
in summary, mettl3 plays a role in regulating the stability of circ_0000620 expression, and circ_0000620 exerts its effects on luad apoptosis and cisplatin sensitivity through the mir-216b-5p/kras signaling pathway. |
2024-08-17 |
2024-08-20 |
mouse |
| Zhihong Xie, Hong Luo, Tao Wang, Lei Wang, Jian Zhang, Wentao Dong, Gang Liu, Fanchao Li, Qinglin Kang, Xuesong Zhu, Fei Zhang, Wuxun Pen. METTL3 inhibits BMSC apoptosis and facilitates osteonecrosis repair via an m6A-IGF2BP2-dependent mechanism. Heliyon. vol 10. issue 10. 2024-05-24. PMID:38784565. |
mettl3 inhibits bmsc apoptosis and facilitates osteonecrosis repair via an m6a-igf2bp2-dependent mechanism. |
2024-05-24 |
2024-05-27 |
Not clear |
| Zhihong Xie, Hong Luo, Tao Wang, Lei Wang, Jian Zhang, Wentao Dong, Gang Liu, Fanchao Li, Qinglin Kang, Xuesong Zhu, Fei Zhang, Wuxun Pen. METTL3 inhibits BMSC apoptosis and facilitates osteonecrosis repair via an m6A-IGF2BP2-dependent mechanism. Heliyon. vol 10. issue 10. 2024-05-24. PMID:38784565. |
we performed methylated rna immunoprecipitation sequencing (merip-seq) combined with rna-seq on a hypoxia-induced apoptosis bmsc model and found that the rna methyltransferase-like 3 (mettl3) is involved in hypoxia-induced bmsc apoptosis. |
2024-05-24 |
2024-05-27 |
Not clear |
| Zhihong Xie, Hong Luo, Tao Wang, Lei Wang, Jian Zhang, Wentao Dong, Gang Liu, Fanchao Li, Qinglin Kang, Xuesong Zhu, Fei Zhang, Wuxun Pen. METTL3 inhibits BMSC apoptosis and facilitates osteonecrosis repair via an m6A-IGF2BP2-dependent mechanism. Heliyon. vol 10. issue 10. 2024-05-24. PMID:38784565. |
in conclusion, overexpression of mettl3 promoted m6a modification of mrnas of bcl-2, mcl-1, and birc5, promoted the binding of igf2bp2 to the above-mentioned mrnas, enhanced mrna stability, inhibited hypoxia-induced bmsc apoptosis, and promoted repair of sonfh, thereby providing novel targets for transplantation of bmscs for sonfh. |
2024-05-24 |
2024-05-27 |
Not clear |
| Dong-Bo Ma, Hui Zhang, Xi-Ling Wang, Qiu-Ge W. METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis. The Kaohsiung journal of medical sciences. 2024-05-17. PMID:38757482. |
this study elucidated the association of methyltransferase-like 3 (mettl3) with streptococcus pneumoniae (sp)-induced apoptosis and inflammatory injury of alveolar epithelial cells (aecs). |
2024-05-17 |
2024-05-27 |
Not clear |
| Dong-Bo Ma, Hui Zhang, Xi-Ling Wang, Qiu-Ge W. METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis. The Kaohsiung journal of medical sciences. 2024-05-17. PMID:38757482. |
the results of this investigation revealed that sp-induced apoptosis and inflammatory injury in aecs and upregulated mettl3 expression. |
2024-05-17 |
2024-05-27 |
Not clear |
| Dong-Bo Ma, Hui Zhang, Xi-Ling Wang, Qiu-Ge W. METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis. The Kaohsiung journal of medical sciences. 2024-05-17. PMID:38757482. |
in addition, the downregulation of mettl3 alleviated apoptosis and inflammatory injury in aecs. |
2024-05-17 |
2024-05-27 |
Not clear |
| Dong-Bo Ma, Hui Zhang, Xi-Ling Wang, Qiu-Ge W. METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis. The Kaohsiung journal of medical sciences. 2024-05-17. PMID:38757482. |
neat1 or muc19 overexpression disrupted their protective role of silencing mettl3 in aecs, thereby increasing apoptosis and inflammatory injury. |
2024-05-17 |
2024-05-27 |
Not clear |
| Zenghui Li, Yuqing Feng, Hong Han, Xingyue Jiang, Weiyu Chen, Xuezhen Ma, Yang Mei, Dan Yuan, Dingxiao Zhang, Junfeng Sh. A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy. Angewandte Chemie (International ed. in English). 2024-04-12. PMID:38607929. |
furthermore, tumor growth was significantly suppressed while apoptosis was enhanced upon rsm3 treatment, accompanied by in-creased mettl3 degradation, and reduced global rna methylation levels in two in vivo tumor models. |
2024-04-12 |
2024-04-15 |
Not clear |
| Xidong Zhang, Yanhua Nie, Rui Zhang, Jiquan Yu, Jianjun G. Reduced DNMT1 levels induce cell apoptosis via upregulation of METTL3 in cardiac hypertrophy. Heliyon. vol 10. issue 3. 2024-02-05. PMID:38314261. |
reduced dnmt1 levels induce cell apoptosis via upregulation of mettl3 in cardiac hypertrophy. |
2024-02-05 |
2024-02-07 |
mouse |
| Xidong Zhang, Yanhua Nie, Rui Zhang, Jiquan Yu, Jianjun G. Reduced DNMT1 levels induce cell apoptosis via upregulation of METTL3 in cardiac hypertrophy. Heliyon. vol 10. issue 3. 2024-02-05. PMID:38314261. |
furthermore, mettl3 expression was elevated in nrcms treated with ang ii, and suppression of mettl3 inhibited cell apoptosis induced by ang ii in nrcms.in addition, this study revealed that the dnmt1/mettl3 pathway affected ang ii-induced apoptosis in nrcms. |
2024-02-05 |
2024-02-07 |
mouse |