| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuxin Dai, Mingke Qiu, Shenglai Zhang, Jingyu Peng, Xin Hou, Jie Liu, Feifei Li, Jingmin O. The Mechanism of Oxymatrine Targeting miR-27a-3p/PPAR-γ Signaling Pathway through m6A Modification to Regulate the Influence on Hemangioma Stem Cells on Propranolol Resistance. Cancers. vol 15. issue 21. 2023-11-14. PMID:37958388. |
in tumor-forming experiments, omt exhibited a dose-dependent inhibitory effect on the volume of ih ppnl-resistant tumors, which was partially dependent on the regulation of m6a methylation transfer enzyme mettl3 and the mir-27a-3p/ppar-γ axis, thereby inducing apoptosis. |
2023-11-14 |
2023-11-20 |
Not clear |
| Zifei Liu, Lei Zhou, Dongxu Li, Honghui Lu, Liang Liu, Weijia Mao, Xiaoqing Yu, Yixuan Fan, Qunhao Huang, Feng Wang, Yongjie Wa. N6-methyladenosine methyltransferase METTL3 modulates the cell cycle of granulosa cells via CCND1 and AURKB in Haimen goats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 11. 2023-10-24. PMID:37874265. |
our results showed that knockdown of mettl3 disrupted the cell cycle in goat granulosa cells, leading to aggravated cell apoptosis and inhibition of cell proliferation and hormone secretion. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jianmei Yi, Feng Peng, Jingli Zhao, Xiaosong Gon. METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3. Scientific reports. vol 13. issue 1. 2023-10-12. PMID:37828232. |
knocking down mettl3 resulted in a decrease in both the m6a level and protein expression of stag3, inhibited cell proliferation and migration while promoting apoptosis, which were restored through stag3 overexpression. |
2023-10-12 |
2023-10-15 |
mouse |
| Jingsi Jia, Yu Yuan, Yi He, Binaya Wasti, Wentao Duan, Zhifeng Chen, Danhong Li, Wenjin Sun, Qingping Zeng, Libing Ma, Xiufeng Zhang, Shaokun Liu, Dongshan Zhang, Linxia Liu, Qimi Liu, Hengxing Liang, Guyi Wang, Xudong Xiang, Bing Xia. Inhibition of METTL3 alleviated LPS-induced alveolar epithelial cell apoptosis and acute lung injury via restoring neprilysin expression. Life sciences. 2023-10-07. PMID:37805166. |
inhibition of mettl3 alleviated lps-induced alveolar epithelial cell apoptosis and acute lung injury via restoring neprilysin expression. |
2023-10-07 |
2023-10-15 |
Not clear |
| Gang Huang, Yuda Qiu, Yafei Fan, Jianfeng Li. METTL3-deficiency Suppresses Neural Apoptosis to Induce Protective Effects in Cerebral I/R Injury via Inhibiting RNA m6A Modifications: A Pre-clinical and Pilot Study. Neurochemical research. 2023-08-23. PMID:37610605. |
moreover, silencing of mettl3 rescued mcao/reperfusion and ogd/rx-induced oxidative stress-associated cell apoptosis and cell cycle arrest in both mice brain tissues in vivo and the mouse primary astrocytes in vitro, which were abrogated by overexpressing abhd11-as1 and downregulating mir-1301-3p. |
2023-08-23 |
2023-09-07 |
mouse |
| Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Li. METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury. Neurospine. vol 20. issue 2. 2023-07-04. PMID:37401082. |
mettl3 affects spinal cord neuronal apoptosis by regulating bcl-2 m6a modifications after spinal cord injury. |
2023-07-04 |
2023-08-14 |
Not clear |
| Zhaofei Dong, Fuli Min, Sai Zhang, Huili Zhang, Tao Zen. EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy. Neurochemical research. 2023-06-02. PMID:37268752. |
egr1 activated mettl3 and reduced vim expression, thereby impairing hippocampal neuron injury and apoptosis, preventing epilepsy progression. |
2023-06-02 |
2023-08-14 |
mouse |
| Xiaoqing Huang, Zhiyong Yang, Yanwen Li, Xingxing Lon. m6A methyltransferase METTL3 facilitates multiple myeloma cell growth through the m6A modification of BZW2. Annals of hematology. 2023-05-24. PMID:37222774. |
additionally, mettl3 accelerated mm cell proliferation and restrained apoptosis via increasing bzw2 expression. |
2023-05-24 |
2023-08-14 |
Not clear |
| Xueying An, Wenshu Wu, Lin Yang, Jian Dong, Bin Liu, Junxia Guo, Jianmei Chen, Baosheng Guo, Wangsen Cao, Qing Jian. ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression. Translational research : the journal of laboratory and clinical medicine. 2023-04-30. PMID:37121538. |
conversely, m6a inhibition by 3-deazaadenosine, sirna-mediated mettl3 knockdown or a mettl3-selective inhibitor by stm2457 effectively inhibits os cell growth and induced os cell apoptosis. |
2023-04-30 |
2023-08-14 |
Not clear |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
mettl3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the n6-methyladenosine level of sirt1 mrna. |
2023-04-22 |
2023-08-14 |
mouse |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
we assessed the effects of m6a methyltransferase mettl3 on sirt1 protein expression, reactive oxygen species (ros) levels, and apoptosis in an oxidative stress model of organ of corti 1 (oc1) cells. |
2023-04-22 |
2023-08-14 |
mouse |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
in oc1 cells, mettl3 positively regulated sirt1 protein levels, while reversely regulated the level of ros and apoptosis. |
2023-04-22 |
2023-08-14 |
mouse |
| Song Xiang, Yihua Wang, Dengliang Lei, Yunhai Luo, Dadi Peng, Kezhen Zong, Yanyao Liu, Zuotian Huang, Shaojiang Mo, Xingyu Pu, Jinli Zheng, Zhongjun W. Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m Clinical immunology (Orlando, Fla.). 2023-04-08. PMID:37030526. |
furthermore, mettl3 pretreatment in donor significantly reduced liver grafts necrosis formation, apoptosis, improved liver function and depressed the proinflammatory cytokine/chemokine expression. |
2023-04-08 |
2023-08-14 |
rat |
| Song Xiang, Yihua Wang, Dengliang Lei, Yunhai Luo, Dadi Peng, Kezhen Zong, Yanyao Liu, Zuotian Huang, Shaojiang Mo, Xingyu Pu, Jinli Zheng, Zhongjun W. Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m Clinical immunology (Orlando, Fla.). 2023-04-08. PMID:37030526. |
mechanistically, western blot and immunohistochemical showed that mettl3 inhibited apoptosis via upregulating ho-1. |
2023-04-08 |
2023-08-14 |
rat |
| Song Xiang, Yihua Wang, Dengliang Lei, Yunhai Luo, Dadi Peng, Kezhen Zong, Yanyao Liu, Zuotian Huang, Shaojiang Mo, Xingyu Pu, Jinli Zheng, Zhongjun W. Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m Clinical immunology (Orlando, Fla.). 2023-04-08. PMID:37030526. |
additionally, mettl3 alleviated primary hepatocytes apoptosis by upregulating ho-1 under hypoxia/reoxygenation condition. |
2023-04-08 |
2023-08-14 |
rat |
| Dongdong Li, Ming Guo, Zhimeng Lv, Yina Shao, Weikang Liang, Chenghua L. METTL3 activates PERK-eIF2α dependent coelomocyte apoptosis by targeting the endoplasmic reticulum degradation-related protein SEL1L in echinoderms. Biochimica et biophysica acta. Gene regulatory mechanisms. 2023-03-18. PMID:36933883. |
mettl3 activates perk-eif2α dependent coelomocyte apoptosis by targeting the endoplasmic reticulum degradation-related protein sel1l in echinoderms. |
2023-03-18 |
2023-08-14 |
Not clear |
| Cong-Jie Chen, Jie-Yun Huang, Jian-Qing Huang, Jia-Yi Deng, Xiao-Hui Shangguan, Ai-Zhen Chen, Long-Tian Chen, Wei-Hao W. Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4. Cell cycle (Georgetown, Tex.). 2023-02-10. PMID:36762777. |
then rescue experiments were performed to explore effects of mettl3 and thrap3, rbm25, or usp4 on cell proliferation and apoptosis. |
2023-02-10 |
2023-08-14 |
Not clear |
| Na Li, Jingli Wei, Qian Zhang, Qi Zhang, Bailing Li. Methyltransferase-like 3 enhances cell proliferation and cisplatin resistance in natural killer/T-cell lymphoma through promoting N6-methyladenosine modification and the stability of staphylococcal nuclease and Tudor domain-containing protein 1 mRNA. Anti-cancer drugs. 2023-02-02. PMID:36730541. |
knockdown of mettl3 noticeably repressed proliferation and facilitated apoptosis in snt-8 cells, whereas overexpression of mettl3 showed opposite results in snk-6 cells. |
2023-02-02 |
2023-08-14 |
human |
| Yanfang Chen, Peng Cao, Zijian Xiao, Zhongfan Rua. m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome. International immunopharmacology. vol 113. issue Pt A. 2022-12-03. PMID:36461592. |
here, we aim to explore the role of methyltransferase-like 3 (mettl3) in hua-mediated neuronal apoptosis and microglial inflammation. |
2022-12-03 |
2023-08-14 |
mouse |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis. Psychiatry investigation. vol 19. issue 10. 2022-11-03. PMID:36327957. |
m6a methyltransferase mettl3 reduces hippocampal neuron apoptosis in a mouse model of autism through the malat1/sfrp2/wnt/β-catenin axis. |
2022-11-03 |
2023-08-14 |
mouse |