| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Morimoto, Tadaaki Yamada, Soichi Hirai, Yuki Katayama, Sarina Fukui, Ryo Sawada, Yusuke Tachibana, Yohei Matsui, Ryota Nakamura, Masaki Ishida, Hayato Kawachi, Kei Kunimasa, Takaaki Sasaki, Makoto Nishida, Naoki Furuya, Satoshi Watanabe, Shinsuke Shiotsu, Naoya Nishioka, Mano Horinaka, Toshiyuki Sakai, Hisanori Uehara, Seiji Yano, Bo-Kyung Son, Shinsaku Tokuda, Koichi Takayam. AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells. Cancer letters. 2024-02-11. PMID:38342232. |
axl inhibition reduced the viability of axl-overexpressing kras g12c-mutated lung cancer cells by enhancing kras g12c inhibition-induced apoptosis. |
2024-02-11 |
2024-02-14 |
rat |
| Thanigaivelan Kanagasabai, Zerick Dunbar, Salvador González Ochoa, Tonie Farris, Sivanesan Dhandayuthapani, E M Kithsiri Wijeratne, A A Leslie Gunatilaka, Anil Shanke. Bortezomib in Combination with Physachenolide C Reduces the Tumorigenic Properties of KRAS Cancers. vol 16. issue 3. 2024-02-10. PMID:38339421. |
bortezomib in combination with physachenolide c reduces the tumorigenic properties of kras defects in apoptosis regulation are one of the classical features of cancer cells, often associated with more aggressiveness and failure to therapeutic options. |
2024-02-10 |
2024-02-12 |
Not clear |
| Gamze Bildik, Joshua P Gray, Weiqun Mao, Hailing Yang, Rumeysa Ozyurt, Vivian R Orellana, Olivier De Wever, Mark S Carey, Robert C Bast, Zhen L. DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas. Autophagy. 2024-01-03. PMID:38169324. |
here, we found that diras3-mediated kras inhibition induces ros-mediated apoptosis in pdac and lgsoc cells with kras mutations, but not in cells with wild-type kras, by downregulating nfe2l2/nrf2 transcription, reducing antioxidants, and inducing oxidative stress. |
2024-01-03 |
2024-01-06 |
Not clear |
| Harmand A Hama, Bestoon S Hasan, Basak Barzngy, Saman S Abdulla, Abdulkarim Y Karim, Rozhgar A Khailany, Monika Miasko, Janusz M Dabrowski, Barbara Puceli. KRAS and MT-CO1 genes in colorectal cancer: a molecular investigation. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015545. |
the tumor suppressor gene mt-co1, and kristen rat sarcoma virus (kras), an oncogene are primarily responsible for controlling cell apoptosis, cell cycle arrest, and cell proliferation, and any irregularities in these genes could lead to cancer. |
2023-11-28 |
2023-11-29 |
rat |
| Shuta Tamura, Hiroshi Tazawa, Naoto Hori, Yuncheng Li, Motohiko Yamada, Satoru Kikuchi, Shinji Kuroda, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwar. p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells. PloS one. vol 18. issue 11. 2023-11-16. PMID:37972012. |
p53-armed oncolytic adenovirus induces autophagy and apoptosis in kras and braf-mutant colorectal cancer cells. |
2023-11-16 |
2023-11-20 |
human |
| Yingying Zhang, Yinan Jiang, Zhu Zhu, Xinrui Xu, Hui Yan. Polyacrylonitrile microfibers pose a significant threat to the early-stage survival of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). vol 265. 2023-11-09. PMID:37944326. |
high concentration of mfs had the most profound impact on signal transduction-related pathways, and possibly triggering micromitophagy and apoptosis in zebrafish intestinal epithelial cells through the kras/mapk signaling pathway, with potential roles for kras and mapk9. |
2023-11-09 |
2023-11-20 |
zebrafish |
| Nora M Aborehab, Maha M Salama, Shahira M Ezza. A novel lupene derivative from Thymus capitatus possesses an apoptosis-inducing effect via Let-7 miRNA/Cyclin D1/VEGF cascade in the A549 cell line. BMC complementary medicine and therapies. vol 23. issue 1. 2023-10-16. PMID:37845669. |
our results revealed that the three isolated compounds alup, lup, and ba caused cell cycle arrest at the g2/m phase with an increase in the apoptosis which may be attributed to their significant effect on raising bax, casp-8, and cd95 and reducing the mrna expression levels of bcl-2, kras, vegf, and cyclin d1 compared to control cells. |
2023-10-16 |
2023-11-08 |
Not clear |
| Israa J Hakeem, Fatmah Hazza Alsharif, Majidah Aljadani, Ibrahim Fahad Alabbas, Mohammed Saud Faqihi, Ahmed Hamdan Aloufi, Wael Abdullah Almutairi, Asif Hussain Akber, Qamre Ala. Molecular docking analysis of KRAS inhibitors for cancer management. Bioinformation. vol 19. issue 4. 2023-10-12. PMID:37822837. |
targeting the kras protein, which plays a crucial role in regulating cell growth, differentiation, and apoptosis, shows great potential as a strategy for fighting cancer. |
2023-10-12 |
2023-10-15 |
human |
| Kuang-Chen Hung, Ni Tien, Da-Tian Bau, Chun-Hsu Yao, Chan-Hung Chen, Jiun-Long Yang, Meng-Liang Lin, Shih-Shun Che. Cells. vol 12. issue 18. 2023-09-28. PMID:37759534. |
subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of kirsten rat sarcoma viral oncogene homolog (kras) with p110α in lipid rafts with the use of naringenin (ngn), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (pi3k)-gtp-ras-related c3 botulinum toxin substrate 1 (rac1)-protein kinase b (akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (oxphos), leading to apoptosis in human nasopharyngeal carcinoma (npc) cells. |
2023-09-28 |
2023-10-07 |
human |
| Krishnan K Mahadevan, Valerie S LeBleu, Elena V Ramirez, Yang Chen, Bingrui Li, Amari M Sockwell, Mihai Gagea, Hikaru Sugimoto, Lakshmi Kavitha Sthanam, Desiree Tampe, Michael Zeisberg, Haoqiang Ying, Abhinav K Jain, Ronald A DePinho, Anirban Maitra, Kathleen M McAndrews, Raghu Kallur. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8 Developmental cell. 2023-08-25. PMID:37625403. |
elimination of oncogenic kras in genetic mouse models eradicates pancreatic cancer by inducing fas-dependent apoptosis by cd8 oncogenic kras |
2023-08-25 |
2023-09-07 |
mouse |
| Kaja Kostyrko, Marta Román, Alex G Lee, David R Simpson, Phuong T Dinh, Stanley G Leung, Kieren D Marini, Marcus R Kelly, Joshua Broyde, Andrea Califano, Peter K Jackson, E Alejandro Sweet-Corder. UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma. Nature communications. vol 14. issue 1. 2023-07-05. PMID:37407562. |
in human lung cancer models uhrf1 knock-out selectively impaired growth and induced apoptosis only in kras mutant cells. |
2023-07-05 |
2023-08-14 |
mouse |
| Leonardo Mercanti, Maria Sindaco, Mariangela Mazzone, Maria Carmela Di Marcantonio, Mariagrazia Piscione, Raffaella Muraro, Gabriella Mincion. PDAC, the Influencer Cancer: Cross-Talk with Tumor Microenvironment and Connected Potential Therapy Strategies. Cancers. vol 15. issue 11. 2023-06-11. PMID:37296886. |
other experimental therapy options are being currently studied, aiming to interfere with the kras pathway, dna-repairing proteins, and apoptosis resistance in pdac cells. |
2023-06-11 |
2023-08-14 |
Not clear |
| Sajid Khan, Vivekananda Budamagunta, Daohong Zho. Targeting KRAS in pancreatic cancer: Emerging therapeutic strategies. Advances in cancer research. vol 159. 2023-06-02. PMID:37268395. |
mutations in kras lead to its constitutive activation and activation of its downstream signaling pathways such as raf/mek/erk and pi3k/akt/mtor that promote cell proliferation and provide apoptosis evasion capabilities to cancer cells. |
2023-06-02 |
2023-08-14 |
human |
| Miao Deng, Jiaxin Guo, Zihang Ling, Chi Zhang, Lihong He, Zhaona Fan, Bin Cheng, Juan Xi. KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma. Molecular carcinogenesis. 2023-05-24. PMID:37222390. |
mechanistically, kras mutations can significantly upregulate runx1 to promote oral epithelial cell proliferation and migration and inhibit apoptosis. |
2023-05-24 |
2023-08-14 |
Not clear |
| Vildan Betul Yenigun, Hasan Acar, Ebru Kanimdan, Alper Yenigun, Abdurrahim Kocyigit, Tulin Cor. KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis. Anti-cancer agents in medicinal chemistry. 2023-05-17. PMID:37194932. |
kras mutation reduces thymoquinone anticancer effects on viability of cells and apoptosis. |
2023-05-17 |
2023-08-14 |
Not clear |
| Zhujiang Dai, Jie Zhang, Weimin Xu, Peng Du, Zhongchuan Wang, Yun Li. Single-Cell Sequencing-Based Validation of T Cell-Associated Diagnostic Model Genes and Drug Response in Crohn's Disease. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047025. |
tnf-centered 5-gene diagnostic model not only has excellent diagnostic efficacy, but is also closely associated with kras, p53, and il6/jak/stat3 pathways and physiological processes, such as emt, coagulation, and apoptosis. |
2023-04-13 |
2023-08-14 |
Not clear |
| Faliang Xing, Yi Qin, Jin Xu, Wei Wang, Bo Zhan. Stress granules dynamics and promising functions in pancreatic cancer. Biochimica et biophysica acta. Reviews on cancer. 2023-03-29. PMID:36990249. |
in this review, we talk about the dynamics of sgs and their positive effects on pancreatic cancer such as sgs promote pdac viability and repress apoptosis, meanwhile emphasizing the connection between sgs in pancreatic cancer and signature mutations such kras, p53, and smad4 as well as the functions of sgs in antitumor drug resistance. |
2023-03-29 |
2023-08-14 |
Not clear |
| Pedro Barrios-Bernal, José Lucio-Lozada, Maritza Ramos-Ramírez, Norma Hernández-Pedro, Oscar Arriet. A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901764. |
the combination of metformin with sotorasib synergistically enhanced cytotoxicity and apoptosis induction in lung cancer cells, regardless of kras mutational status. |
2023-03-11 |
2023-08-14 |
Not clear |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |
| Wen-Hsuan Chang, Yinzhe Liu, Emma A Hammes, Kirsten L Bryant, Richard A Cerione, Marc A Antonya. Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein (IAP) family member Survivin. The Journal of biological chemistry. 2022-12-29. PMID:36581205. |
here, we identify how this essential signaling connection between oncogenic kras and myc expression is mediated by the inhibitor of apoptosis protein (iap) family member survivin. |
2022-12-29 |
2023-08-14 |
Not clear |