All Relations between apoptosis and ko

Publication Sentence Publish Date Extraction Date Species
Lifei Hou, Yi-Cheng Sin, Yue Chen, Koichi Yuk. Integrin CD11c regulates B cell homeostasis. Frontiers in immunology. vol 15. 2024-02-21. PMID:38380335. we found that cd11c ko recirculating and mature b cells was significantly fewer compared with wild type, associated with exaggerated proliferation and apoptosis. 2024-02-21 2024-02-23 mouse
Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhan. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO reports. 2023-11-15. PMID:37965894. consistent with this, blocking apoptosis by co-deletion of fadd in rip1-deficient t cells significantly rescues lymphopenia, the imbalance between naïve and memory t cells, and aging-like phenotypes, and prolongs life span in t-cell-specific rip1 ko mice. 2023-11-15 2023-11-20 mouse
Shan Hu, Min Huang, Shuai Mao, Manqi Yang, Hao Ju, Zheyu Liu, Mian Cheng, Gang W. Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis. Biochemical pharmacology. 2023-11-02. PMID:37918695. serinc2 knockout (ko) exacerbated sepsis-induced myocardial inflammation, necroptosis, apoptosis, myocardial damage, and contractility impairment. 2023-11-02 2023-11-08 rat
Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. compared to the wild type (wt) group, gmfb knockout (ko) significantly improved visual function, attenuated gliosis, reduced the apoptosis of neurons, and decreased the mrna levels of tumor necrosis factor α (tnf-α) and interleukin-1β (il-1β) in diabetic retinas. 2023-10-31 2023-11-08 rat
Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. the protection of gmfb ko in primary müller cells against high glucose (hg)-induced photoreceptor apoptosis was partially counteracted by tgf-β3 antibody and administration of tgfbr1/2 inhibitors. 2023-10-31 2023-11-08 rat
Yan Liu, Yi-Hui Shao, Jun-Meng Zhang, Ying Wang, Mei Zhou, Hui-Qin Li, Cong-Cong Zhang, Pei-Jie Yu, Shi-Juan Gao, Xue-Rui Wang, Li-Xin Jia, Chun-Mei Piao, Jie Du, Yu-Lin L. Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-12. PMID:37828006. additionally, card9 ko suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase (mmp) expression. 2023-10-12 2023-10-15 mouse
Jiangman Gao, Wei Guo, Rong Li, Jie Qiao, Xiaoyu Lon. The impact of fibronectin knockout on invasion and migration of endometrial cell in adenomyosis. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809570. cell proliferation was markedly suppressed in the fn knockout (ko) group compared with the control group, while apoptosis significantly increased. 2023-10-09 2023-10-15 Not clear
Yingmei Zhang, Rongjun Zou, Miyesaier Abudureyimu, Qiong Liu, Jipeng Ma, Haixia Xu, Wei Yu, Jian Yang, Jianguo Jia, Sanli Qian, Haichang Wang, Yang Yang, Xin Wang, Xiaoping Fan, Jun Re. Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of Mitochondrial integrity and parkin-mediated mitophagy. Journal of molecular cell biology. 2023-09-29. PMID:37771085. stz challenge prompted reduced respiratory exchange ratio (rer), dampened fractional shortening, ejection fraction, increased lv end systolic and diastolic diameters, cardiac remodeling, cardiomyocyte contractile and intracellular ca2+ defects (depressed peak shortening and maximal velocity of shortening/relengthening, prolonged relengthening, dampened intracellular ca2+ rise and clearance), myocardial ultrastructural injury, oxidative stress, apoptosis and mitochondrial damage, the effects of which were overtly attenuated and accentuated by aldh2 oe and ko, respectively. 2023-09-29 2023-10-07 mouse
Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. in rna-seq analysis comparing wt and dact2 ko mice after cisplatin treatment, genes related to "apoptosis" and "activation of mitogen-activated protein kinase (mapk) activity" were among the downregulated degs in ko mice. 2023-08-21 2023-09-07 mouse
Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. these results were corroborated in western blotting of proteins related to apoptosis and proapoptotic mapk pathway; the expression of which was found to be lower in cisplatin-treated ko mice. 2023-08-21 2023-09-07 mouse
Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. 2023-08-06 2023-08-14 mouse
Yeongseok Oh, Maho Kasu, Constence J Bottoms, Jenna C Douglas, Nikola Sekulovski, Kanako Hayashi, James A MacLean I. Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†. Biology of reproduction. 2023-07-20. PMID:37471646. fertility analysis showed a low fecundity in rhox8 ko adult males, with disrupted spermatogenic cycles, increased germ cell apoptosis, and reduced sperm count and motility. 2023-07-20 2023-08-14 mouse
Qiwen Yu, Sanyang Chen, Jiye Li, Hongwei Tang, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway. Scientific reports. vol 13. issue 1. 2023-07-10. PMID:37429895. mkp5 ko or knockdown significantly increased liver injury, as demonstrated by elevated serum transaminases, hepatocyte necrosis, infiltrating inflammatory cells, secretion of pro-inflammatory cytokines, apoptosis, oxidative stress. 2023-07-10 2023-08-14 mouse
Qicai Han, Penghui Yan, Ruipeng Song, Feifei Liu, Qing Tia. HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth. Cell death & disease. vol 14. issue 7. 2023-07-05. PMID:37407582. timm13 ko also induced akt-mtor inactivation, atp depletion, oxidative injury, and apoptosis in the in situ os tumors. 2023-07-05 2023-08-14 mouse
Brian M Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misagh. Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling. Biotechnology progress. 2023-05-10. PMID:37161726. perk knockout (ko) cell lines displayed reduced growth and viability due to higher rates of apoptosis despite having stabilized pdgfra levels. 2023-05-10 2023-08-14 Not clear
Brian M Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misagh. Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling. Biotechnology progress. 2023-05-10. PMID:37161726. knocking out perk in an apoptosis impaired (bax/bak double ko) antibody-expressing cell line prevented apoptotic cell death and revealed that apoptosis was likely triggered by increased er stress and reactive oxygen species levels in the perk ko hosts. 2023-05-10 2023-08-14 Not clear
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. kcp ko aggravated the imbalance of oxidants and antioxidants and increased the expression of proinflammatory cytokines and cardiomyocyte apoptosis in aged mice. 2023-05-06 2023-08-14 mouse
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. our study demonstrated that kcp ko aggravated cardiac aging in mice by increasing the levels of oxidative stress, inflammation, and cardiomyocyte apoptosis. 2023-05-06 2023-08-14 mouse
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. kcp ko aggravated cardiac aging by increasing the levels of oxidative stress, inflammation, and cardiomyocyte apoptosis. 2023-05-06 2023-08-14 mouse
Yingchen Xia, Chunyan He, Zhi Hu, Zhichao Wu, Yin Hui, Yuan-Yuan Liu, Chuanyong Mu, Jianhua Zh. The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth. International journal of biological sciences. vol 19. issue 6. 2023-04-17. PMID:37063426. in nsclc cells, shrna-mediated silence of yme1l or dcas9/sgrna-induced knockout (ko) of yme1l robustly suppressed cell growth and migration, and provoking apoptosis. 2023-04-17 2023-08-14 human