| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milton H Hamblin, Austin C Boese, Rabi Murad, Jean-Pyo Le. MMP-3 Knockout Induces Global Transcriptional Changes and Reduces Cerebral Infarction in Both Male and Female Models of Ischemic Stroke. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000490. |
functional pathway analysis revealed that inflammation, integrin cell surface signaling, endothelial- and epithelial-mesenchymal transition (endmt/emt), and apoptosis gene signatures were decreased in mmp-3 ko stroke brains. |
2024-07-13 |
2024-07-15 |
mouse |
| Wen-Lei Yang, Wei-Feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zh. Origin recognition complex 6 overexpression promotes growth of glioma cells. Cell death & disease. vol 15. issue 7. 2024-07-06. PMID:38971772. |
in primary and immortalized (a172) glioma cells, depleting orc6 using specific shrna or cas9-sgrna knockout (ko) significantly decreased cell viability and proliferation, disrupted cell cycle progression and mobility, and triggered apoptosis. |
2024-07-06 |
2024-07-11 |
mouse |
| Wen-Lei Yang, Wei-Feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zh. Origin recognition complex 6 overexpression promotes growth of glioma cells. Cell death & disease. vol 15. issue 7. 2024-07-06. PMID:38971772. |
orc6 depletion, inhibited proliferation, decreased expression of cyclin a2/b2/top2a, and increased apoptosis were detected within these orc6 ko intracranial glioma xenografts. |
2024-07-06 |
2024-07-11 |
mouse |
| Zhenghui Tang, Zhongyang Liang, Bin Zhang, Xiaohui Xu, Peng Li, Lejun Li, Lin-Yu Lu, Yidan Li. MRE11 is essential for the long-term viability of undifferentiated spermatogonia. Cell proliferation. 2024-06-19. PMID:38894566. |
in addition, mre11 ko, but not nbs1 ko, undifferentiated spermatogonia are rapidly exhausted due to dsb accumulation, proliferation defects, and elevated apoptosis. |
2024-06-19 |
2024-06-21 |
Not clear |
| Matthieu Lewis, Valérie Prouzet-Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François-Xavier Maho. A genome-scale CRISPR knock-out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling. Cancer medicine. vol 9. issue 18. 2024-06-04. PMID:38831555. |
specifically, reestablishing apoptosis in bim knock-out (ko) cells with bh3 mimetics, or inhibiting mapk signaling in spred2 ko cells with mek inhibitors restores sensitivity to imatinib. |
2024-06-04 |
2024-06-06 |
Not clear |
| Kazuhiro Nishiyama, Joji Horikoshi, Toko Maehara, Miyuu Tanaka, Takashi Tanida, Koichi Kawada, Susumu Takeshita, Naoshige Ono, Takeshi Izawa, Mitsuru Kuwamura, Yasu-Taka Azum. Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid. Journal of pharmacological sciences. vol 155. issue 3. 2024-05-26. PMID:38797538. |
little apoptosis was detected in lung injury in wt mice, whereas apoptosis was observed in exacerbated area of lung injury in il-19 ko mice. |
2024-05-26 |
2024-05-31 |
mouse |
| Yingying Chen, Hui Liu, Chaomeng Wang, Weixin Chen, Liyan Li, Junshu Wu, Guanrou Wang, Guang Sheng Ling, Rong F. The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of paroxysmal nocturnal haemoglobinuria clones through cell metabolic reprogramming. British journal of haematology. 2024-04-23. PMID:38650379. |
knocking down jmjd1c in k562 ko cells upregulated cps1 and h3k36me3 expression, decreased cell proliferation and increased cell apoptosis. |
2024-04-23 |
2024-04-26 |
mouse |
| Jun He, Xuyang Hou, Junyong Wu, Kunpeng Wang, Xiaoyan Qi, Zuxing Wei, Yin Sun, Cong Wang, Hongliang Yao, Kuijie Li. Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481805. |
we found that ko or inhibition of hspb1 promoted acinar cell death through apoptosis and ferroptosis but not necroptosis or autophagy by increasing reactive oxygen species (ros) and lipid ros levels. |
2024-03-14 |
2024-03-16 |
mouse |
| Lifei Hou, Yi-Cheng Sin, Yue Chen, Koichi Yuk. Integrin CD11c regulates B cell homeostasis. Frontiers in immunology. vol 15. 2024-02-21. PMID:38380335. |
we found that cd11c ko recirculating and mature b cells was significantly fewer compared with wild type, associated with exaggerated proliferation and apoptosis. |
2024-02-21 |
2024-02-23 |
mouse |
| Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhan. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO reports. 2023-11-15. PMID:37965894. |
consistent with this, blocking apoptosis by co-deletion of fadd in rip1-deficient t cells significantly rescues lymphopenia, the imbalance between naïve and memory t cells, and aging-like phenotypes, and prolongs life span in t-cell-specific rip1 ko mice. |
2023-11-15 |
2023-11-20 |
mouse |
| Shan Hu, Min Huang, Shuai Mao, Manqi Yang, Hao Ju, Zheyu Liu, Mian Cheng, Gang W. Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis. Biochemical pharmacology. 2023-11-02. PMID:37918695. |
serinc2 knockout (ko) exacerbated sepsis-induced myocardial inflammation, necroptosis, apoptosis, myocardial damage, and contractility impairment. |
2023-11-02 |
2023-11-08 |
rat |
| Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. |
compared to the wild type (wt) group, gmfb knockout (ko) significantly improved visual function, attenuated gliosis, reduced the apoptosis of neurons, and decreased the mrna levels of tumor necrosis factor α (tnf-α) and interleukin-1β (il-1β) in diabetic retinas. |
2023-10-31 |
2023-11-08 |
rat |
| Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. |
the protection of gmfb ko in primary müller cells against high glucose (hg)-induced photoreceptor apoptosis was partially counteracted by tgf-β3 antibody and administration of tgfbr1/2 inhibitors. |
2023-10-31 |
2023-11-08 |
rat |
| Yan Liu, Yi-Hui Shao, Jun-Meng Zhang, Ying Wang, Mei Zhou, Hui-Qin Li, Cong-Cong Zhang, Pei-Jie Yu, Shi-Juan Gao, Xue-Rui Wang, Li-Xin Jia, Chun-Mei Piao, Jie Du, Yu-Lin L. Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-12. PMID:37828006. |
additionally, card9 ko suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase (mmp) expression. |
2023-10-12 |
2023-10-15 |
mouse |
| Jiangman Gao, Wei Guo, Rong Li, Jie Qiao, Xiaoyu Lon. The impact of fibronectin knockout on invasion and migration of endometrial cell in adenomyosis. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809570. |
cell proliferation was markedly suppressed in the fn knockout (ko) group compared with the control group, while apoptosis significantly increased. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yingmei Zhang, Rongjun Zou, Miyesaier Abudureyimu, Qiong Liu, Jipeng Ma, Haixia Xu, Wei Yu, Jian Yang, Jianguo Jia, Sanli Qian, Haichang Wang, Yang Yang, Xin Wang, Xiaoping Fan, Jun Re. Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of Mitochondrial integrity and parkin-mediated mitophagy. Journal of molecular cell biology. 2023-09-29. PMID:37771085. |
stz challenge prompted reduced respiratory exchange ratio (rer), dampened fractional shortening, ejection fraction, increased lv end systolic and diastolic diameters, cardiac remodeling, cardiomyocyte contractile and intracellular ca2+ defects (depressed peak shortening and maximal velocity of shortening/relengthening, prolonged relengthening, dampened intracellular ca2+ rise and clearance), myocardial ultrastructural injury, oxidative stress, apoptosis and mitochondrial damage, the effects of which were overtly attenuated and accentuated by aldh2 oe and ko, respectively. |
2023-09-29 |
2023-10-07 |
mouse |
| Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. |
in rna-seq analysis comparing wt and dact2 ko mice after cisplatin treatment, genes related to "apoptosis" and "activation of mitogen-activated protein kinase (mapk) activity" were among the downregulated degs in ko mice. |
2023-08-21 |
2023-09-07 |
mouse |
| Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. |
these results were corroborated in western blotting of proteins related to apoptosis and proapoptotic mapk pathway; the expression of which was found to be lower in cisplatin-treated ko mice. |
2023-08-21 |
2023-09-07 |
mouse |
| Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. |
importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. |
2023-08-06 |
2023-08-14 |
mouse |
| Yeongseok Oh, Maho Kasu, Constence J Bottoms, Jenna C Douglas, Nikola Sekulovski, Kanako Hayashi, James A MacLean I. Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†. Biology of reproduction. 2023-07-20. PMID:37471646. |
fertility analysis showed a low fecundity in rhox8 ko adult males, with disrupted spermatogenic cycles, increased germ cell apoptosis, and reduced sperm count and motility. |
2023-07-20 |
2023-08-14 |
mouse |