| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Su. Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. Cell proliferation. 2024-07-24. PMID:39045886. |
rev-erbα deficiency accelerated needle puncture or aging-induced ivd degeneration, characterized by increased extracellular matrix (ecm) catabolism and nucleus pulposus (np) cell apoptosis. |
2024-07-24 |
2024-07-26 |
Not clear |
| Mingxiang Zou, Wenkang Chen, Jing Li, Xin Qi, Xiaobin Wang, Fubing Liu, Jiarui Hu, Qianshi Zhan. Apoptosis signal-regulated kinase-1 promotes nucleus pulposus cell senescence and apoptosis to regulate intervertebral disc degeneration. The American journal of pathology. 2024-06-15. PMID:38879082. |
ask1 inhibition promoted cell viability and repressed the senescence and apoptosis of np cells; promoted collagen ii and aggrecan; inhibited mmp3, mmp9, adamts4, and adamts5 protein levels; and increased np cells in rat ivd tissues. |
2024-06-15 |
2024-06-18 |
rat |
| Lei Li, Guangzhi Zhang, Zhili Yang, Xuewen Kan. Stress-Activated Protein Kinases in Intervertebral Disc Degeneration: Unraveling the Impact of JNK and p38 MAPK. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672411. |
these factors prevent normal intervertebral disc (ivd) development, reduce the number of ivd cells, and induce senescence and apoptosis. |
2024-04-27 |
2024-04-29 |
Not clear |
| Shuai Li, Jinpeng Du, Yunfei Huang, Shenglong Gao, Zhigang Zhao, Zhen Chang, Xuefang Zhang, BaoRong H. From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration. Frontiers in immunology. vol 15. 2024-03-06. PMID:38444852. |
diabetes and advanced glycation end products (ages) accumulation- can lead to various adverse effects on the ivd, including cell senescence, apoptosis, pyroptosis, proliferation, and extracellular matrix (ecm) degradation. |
2024-03-06 |
2024-03-08 |
Not clear |
| Yuao Tao, Xiaoyu Yu, Xiaolong Li, Yuzhu Xu, Hui Wang, Lele Zhang, Rubing Lin, Yuntao Wang, Pan Fa. M6A methylation-regulated autophagy may be a new therapeutic target for intervertebral disc degeneration. Cell biology international. 2024-02-06. PMID:38317355. |
the intervertebral disc (ivd) is characterized by its susceptibility to various stressors that accelerate the senescence and apoptosis of nucleus pulposus cells, resulting in the loss of these cells and dysfunction of the intervertebral disc. |
2024-02-06 |
2024-02-09 |
Not clear |
| Chuan Guo, Yuheng Liu, Zhen Zhao, Ye Wu, Qingquan Kong, Yu Wan. Regulating inflammation and apoptosis: A smart microgel gene delivery system for repairing degenerative nucleus pulposus. Journal of controlled release : official journal of the Controlled Release Society. 2023-12-21. PMID:38128882. |
therefore, it is crucial to address the inflammatory microenvironment and rectify the excessive apoptosis of nucleus pulposus cells (npcs) to achieve intervertebral disc (ivd) regeneration. |
2023-12-21 |
2023-12-24 |
Not clear |
| Yidian Wang, Shouye Hu, Weisong Zhang, Binfei Zhang, Zhi Yan. Emerging role and therapeutic implications of p53 in intervertebral disc degeneration. Cell death discovery. vol 9. issue 1. 2023-12-01. PMID:38040675. |
recently, p53 was shown to play an important role in maintaining ivd microenvironment homeostasis by regulating ivd cell senescence, apoptosis, and metabolism by activating downstream target genes. |
2023-12-01 |
2023-12-10 |
Not clear |
| Qingchen Meng, En Xie, Heng Sun, Huan Wang, Jiaying Li, Zhao Liu, Kexin Li, Jie Hu, Qianglong Chen, Chaoyong Liu, Bin Li, Fengxuan Ha. High-Strength Smart Microneedles with "Offensive and Defensive" Effects for Intervertebral Disc Repair. Advanced materials (Deerfield Beach, Fla.). 2023-09-08. PMID:37681640. |
in vivo experiments showed that the mns mitigated the inflammatory response, promoted ecm deposition, reduced the level of apoptosis, and restored the biomechanical properties of the intervertebral disc (ivd) in rats. |
2023-09-08 |
2023-10-07 |
rat |
| Libangxi Liu, Yuyao Zhang, Jiawei Fu, Xuezheng Ai, Dan Long, Xue Leng, Yang Zhang, Bo Huang, Changqing Li, Yue Zhou, Chencheng Fen. Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration. Journal of orthopaedic translation. vol 40. 2023-07-17. PMID:37457313. |
oxidative stress and apoptosis of nucleus pulposus (np) cells disrupt intervertebral disc (ivd) homeostasis, which is the main cause of idd. |
2023-07-17 |
2023-08-14 |
Not clear |
| Hao Xu, Juan Li, Qinming Fei, Libo Jian. Contribution of Immune Cells to Intervertebral Disc Degeneration and the Potential of Immunotherapy. Connective tissue research. 2023-05-10. PMID:37161923. |
the ivd is considered to be an immunologically-privileged site given the presence of physical and biological barriers that include an avascular microenvironment, a high proteoglycan concentration, high physical pressure, the presence of apoptosis inducers such as fas ligand, and the presence of notochordal cells. |
2023-05-10 |
2023-08-14 |
Not clear |
| Sobia Ekram, Shumaila Khalid, Faiza Ramzan, Asmat Salim, Imtiaz Bashir, Marie Christine Durrieu, Irfan Kha. Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect Rat Nucleus Pulposus Cells from Oxidative Stress. Cartilage. 2023-05-04. PMID:37139781. |
oxidative stress (os) is mainly associated with the pathogenesis of intervertebral disc (ivd) degeneration; it causes nucleus pulposus cells (npcs) to undergo senescence and triggers autophagy and apoptosis. |
2023-05-04 |
2023-08-14 |
human |
| Hongtao Li, Xiaoqiang Wang, Hongyu Pan, Changming Xiao, Chenglong Wang, Sheng Guo, Longhai Long, Houyin Shi, Hui Chen, Sen L. The mechanisms and functions of IL-1β in intervertebral disc degeneration. Experimental gerontology. 2023-04-23. PMID:37088216. |
however, in recent years, il-1β is considered to be able to regulate ivd cell death in many ways, such as apoptosis, pyroptosis, ferroptosis, and so on. |
2023-04-23 |
2023-08-14 |
Not clear |
| Shuang Chen, Yi Wang, Huanxi Wu, Xiaoyang Fang, Chenyu Wang, Nan Wang, Lin Xi. Research hotspots and trends of microRNAs in intervertebral disc degeneration: a comprehensive bibliometric analysis. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-04-15. PMID:37061725. |
micrornas (mirnas) are involved in various pathological processes, such as proliferation, growth, and apoptosis, of intervertebral disc (ivd) cells and play an important role in the development of intervertebral disc degeneration (idd). |
2023-04-15 |
2023-08-14 |
Not clear |
| Koki Kawaguchi, Koji Akeda, Junichi Yamada, Takahiro Hasegawa, Norihiko Takegami, Tatsuhiko Fujiwara, Akihiro Sud. Expression of GADD45G and CAPRIN1 in Human Nucleus Pulposus: Implications for Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982840. |
the expression of cell-cycle-associated proteins (gadd45g and caprin1) was enhanced in human np cells at an advanced stage of degeneration, suggesting that it may be regulated during the progression of ivd degeneration to maintain the integrity of human np tissues by controlling cell proliferation and apoptosis under epigenetic alteration. |
2023-03-29 |
2023-08-14 |
human |
| Xiao-Tao Wu, Yong-Xiang Wang, Xin-Min Feng, Min Feng, Hui-Hui Su. Update on the roles of macrophages in the degeneration and repair process of intervertebral discs. Joint bone spine. 2022-12-18. PMID:36529418. |
the process of ivd degeneration involves a complex of pathologic changes on both extracellular matrix degradation and resident cell apoptosis. |
2022-12-18 |
2023-08-14 |
Not clear |
| Rui Ran, Yi Wu, Hai-Hong Zhan. Acid-Sensing Ion Channels: Implications For Intervertebral Disc Degeneration. Current pharmaceutical biotechnology. 2022-12-12. PMID:36503387. |
matrix acidity potentially negatively affects gene expression, activity, proliferation, and apoptosis of ivd cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen L. Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration. Clinical physiology and functional imaging. 2022-11-18. PMID:36400723. |
intervertebral disc degeneration (idd) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ecm), which will impair the structure and function of the intervertebral disc(ivd), and cause low back pain. |
2022-11-18 |
2023-08-14 |
Not clear |
| Yuying Ge, Yuying Chen, Chijiao Guo, Huan Luo, Fangda Fu, Weifeng Ji, Chengliang Wu, Hongfeng Rua. Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications. Journal of inflammation research. vol 15. 2022-10-20. PMID:36263145. |
in this review, we summarize the characteristics of pyroptosis and emphasize the effects of ivd cell pyroptosis on the pathological progression of ivdd, including secretion of cytokines, nucleus pulposus cell apoptosis and autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory and sympathetic fiber neoinnervation, and infiltrating lymphatic vessels. |
2022-10-20 |
2023-08-14 |
Not clear |
| Hai-Wei Chen, Jian-Wei Zhou, Guang-Zhi Zhang, Zhang-Bin Luo, Lei Li, Xue-Wen Kan. Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration. Cell proliferation. 2022-10-04. PMID:36193577. |
recent studies have shown that mtor signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ecm homeostasis, cellular senescence, and apoptosis in ivd cells. |
2022-10-04 |
2023-08-14 |
Not clear |
| Kaiqiang Sun, Jialin Jiang, Yuan Wang, Xiaofei Sun, Jian Zhu, Ximing Xu, Jingchuan Sun, Jiangang Sh. The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration. Ageing research reviews. 2022-09-16. PMID:36113765. |
abnormal apoptosis, senescence, and pyroptosis of ivd cells, extracellular matrix (ecm) degradation, and infiltration of immune cells are the major molecular alternations during ivdd. |
2022-09-16 |
2023-08-14 |
Not clear |