Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
João Marcos Oliveira-Silva, Leilane Sales Oliveira, Carolina Berraut Chiminazo, Rafael Fonseca, Carlos Vinicius Expedito de Souza, Alexandre Ferro Aissa, Graziela Domingues de Almeida Lima, Marisa Ionta, Angel Mauricio Castro-Gamer. WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells. Cancer chemotherapy and pharmacology. vol 95. issue 1. 2025-01-17. PMID:39821335. |
wt161, a selective hdac6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells. |
2025-01-17 |
2025-01-20 |
Not clear |
Johannes Jungwirth, Andreas O Mieland, Andrea Piée-Staffa, Tino Heimburg, Walburgis Brenner, Christina Ehrhardt, Wolfgang Sippl, Andreas Henke, Oliver H Kräme. Pharmacologically induced proteolysis of histone deacetylase-6 attenuates influenza virus replication despite limited anti-tumor effects. Life sciences. 2025-01-15. PMID:39814129. |
unlike the specific elimination of hdac6 that low doses of th170 evoke, this fragmentation of hdac6 is linked to apoptosis and an accumulation of acetylated histones. |
2025-01-15 |
2025-01-19 |
human |
Xiaonan Zhou, Peng Jiang, Huangqi Tan, Yanfang Wang, Lunhao Ba. KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis. Communications biology. vol 8. issue 1. 2025-01-09. PMID:39779910. |
the use of the hdac6 inhibitor tubastatina also abolished the effects of grk5 overexpression on chondrocyte ecm degradation and apoptosis. |
2025-01-09 |
2025-01-13 |
rat |
Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. Corrigendum to "HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway'[Neurochemistry International 99 (2016) 239-251]. Neurochemistry international. 2024-09-15. PMID:39278807. |
corrigendum to "hpob, an hdac6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma pc12 cells by inhibiting mitochondrial gr translocation and the intrinsic apoptosis pathway'[neurochemistry international 99 (2016) 239-251]. |
2024-09-15 |
2024-09-18 |
rat |
Ziqian Huang, Ling Li, Binbin Cheng, Deping L. Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 178. 2024-07-31. PMID:39084081. |
histone deacetylase 6 (hdac6) plays a crucial role in the initiation and progression of various cancers, as its overexpression is linked to tumor growth, invasion, migration, survival, apoptosis, and angiogenesis. |
2024-07-31 |
2024-08-03 |
Not clear |
Zhicheng Gu, Shuxian Lin, Junhui Yu, Fei Jin, Qingqing Zhang, Keli Xia, Lei Chen, Yan Li, Bin H. Advances in dual-targeting inhibitors of HDAC6 for cancer treatment. European journal of medicinal chemistry. vol 275. 2024-06-10. PMID:38857566. |
histone deacetylase 6 (hdac6) is an essential regulator of histone acetylation processes, exerting influence on a multitude of cellular functions such as cell motility, endocytosis, autophagy, apoptosis, and protein trafficking through its deacetylation activity. |
2024-06-10 |
2024-06-14 |
Not clear |
Yukun Jiang, Ya Tang, Yuxuan Li, Lu Liu, Kairui Yue, Xiaoyang Li, Peiju Qiu, Ruijuan Yin, Tao Jian. Psammaplin A analogues with modified disulfide bond targeting histone deacetylases: Synthesis and biological evaluation. European journal of medicinal chemistry. vol 275. 2024-06-08. PMID:38851056. |
among the prepared analogues, diselenide analogue p-503 and p-116 significantly increased the ability of inhibiting hdac6 and induced apoptosis and g2/m cell cycle arrest. |
2024-06-08 |
2024-06-11 |
Not clear |
Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Zi-Yuan Wei, Yi-Chin Chen, Yi-Chang Chiang, Jui-Ling Hsu, She-Hung Chan, Lih-Ching Hsu, Ji-Wang Chern, Chao-Wu Yu, Jih-Hwa Gu. A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer. The Prostate. 2024-02-20. PMID:38375594. |
a novel hdac6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer. |
2024-02-20 |
2024-02-22 |
Not clear |
Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
hepatic ischemia-reperfusion injury (iri) continues to limit the prognosis of patients receiving lt. histone deacetylase 6 (hdac6) is a unique hdac member involved in inflammation and apoptosis. |
2024-02-09 |
2024-02-11 |
mouse |
Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
in conclusion, hdac6 is a key mediator of hepatic iri that functions to promote inflammation and apoptosis via pi3k/akt/mtor signaling. |
2024-02-09 |
2024-02-11 |
mouse |
Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
compared with control mice, hdac6 deficiency mitigated liver iri by inhibiting inflammatory responses and apoptosis, whereas hdac6-ltg mice displayed the opposite phenotype. |
2024-02-09 |
2024-02-11 |
mouse |
b' Ana Vuleti\\xc4\\x87, Katarina Mirja\\xc4\\x8di\\xc4\\x87 Martinovi\\xc4\\x87, Jelena Spasi\\xc4\\x8. Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258065.' |
histone deacetylase 6 (hdac6), by deacetylation of multiple substrates and association with interacting proteins, regulates many physiological processes that are involved in cancer development and invasiveness such as cell proliferation, apoptosis, motility, epithelial to mesenchymal transition, and angiogenesis. |
2024-01-23 |
2024-01-25 |
Not clear |
Se-In Lee, Yuri Seo, Hoang Thi Oanh, Thi Tuyet Hanh Vo, Hyeonbin Go, Myung Hun Kim, Joo-Yong Le. HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320. Biochemical and biophysical research communications. vol 691. 2023-12-03. PMID:38043200. |
hdac6 has been reported as a deacetylase of p53 at multiple lysine residues, associated with the canonical functions of p53, such as apoptosis and tumor suppression. |
2023-12-03 |
2023-12-10 |
mouse |
Milan Beljkas, Aleksandra Ilic, Alen Cebzan, Branko Radovic, Nemanja Djokovic, Dusan Ruzic, Katarina Nikolic, Slavica Oljaci. Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer. Pharmaceutics. vol 15. issue 11. 2023-11-25. PMID:38004560. |
therefore, the overexpression of hdac6 is associated with tumorigenesis, invasion, migration, survival, apoptosis and growth of various malignancies. |
2023-11-25 |
2023-11-28 |
Not clear |
O V Tinkov, V Y Grigorev, L D Grigoreva, V N Osipov, A V Kolotaev, D S Khachatrya. HDAC6 detector: online application for evaluating compounds as potential histone deacetylase 6 inhibitors. SAR and QSAR in environmental research. 2023-08-11. PMID:37565331. |
the hdac6 (histone deacetylase 6) enzyme plays a key role in many biological processes, including cell division, apoptosis, and immune response. |
2023-08-11 |
2023-08-16 |
Not clear |
Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
further in vivo and in vitro mechanism studies have found that the reduction of hdac6 alleviated riri by inhibiting ros mediated apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
remarkably, a renal protective protein, klotho, has been proven to be a target of hdac6, and the degradation of hdac6 restored kl expression, thereby ameliorating ros mediated apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
overall, our results illustrated that the degradation of hdac6 restrained ros mediated apoptosis by restoring klotho expression during riri. |
2023-07-10 |
2023-08-14 |
Not clear |
Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jian. Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage PeerJ. vol 11. 2023-05-04. PMID:37138816. |
selective hdac6 inhibitor tuba offers neuroprotection after intracerebral hemorrhage a large body of evidence has demonstrated that neuronal apoptosis is involved in the pathological process of secondary brain injury following intracerebral hemorrhage (ich). |
2023-05-04 |
2023-08-14 |
Not clear |
Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jian. Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage PeerJ. vol 11. 2023-05-04. PMID:37138816. |
additionally, our previous studies determined that the inhibition of hdac6 activity by tubacin or specific shrna can attenuate neuronal apoptosis in an oxygen-glucose deprivation reperfusion model. |
2023-05-04 |
2023-08-14 |
Not clear |