| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhicheng Gu, Shuxian Lin, Junhui Yu, Fei Jin, Qingqing Zhang, Keli Xia, Lei Chen, Yan Li, Bin H. Advances in dual-targeting inhibitors of HDAC6 for cancer treatment. European journal of medicinal chemistry. vol 275. 2024-06-10. PMID:38857566. |
histone deacetylase 6 (hdac6) is an essential regulator of histone acetylation processes, exerting influence on a multitude of cellular functions such as cell motility, endocytosis, autophagy, apoptosis, and protein trafficking through its deacetylation activity. |
2024-06-10 |
2024-06-14 |
Not clear |
| Yukun Jiang, Ya Tang, Yuxuan Li, Lu Liu, Kairui Yue, Xiaoyang Li, Peiju Qiu, Ruijuan Yin, Tao Jian. Psammaplin A analogues with modified disulfide bond targeting histone deacetylases: Synthesis and biological evaluation. European journal of medicinal chemistry. vol 275. 2024-06-08. PMID:38851056. |
among the prepared analogues, diselenide analogue p-503 and p-116 significantly increased the ability of inhibiting hdac6 and induced apoptosis and g2/m cell cycle arrest. |
2024-06-08 |
2024-06-11 |
Not clear |
| Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Zi-Yuan Wei, Yi-Chin Chen, Yi-Chang Chiang, Jui-Ling Hsu, She-Hung Chan, Lih-Ching Hsu, Ji-Wang Chern, Chao-Wu Yu, Jih-Hwa Gu. A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer. The Prostate. 2024-02-20. PMID:38375594. |
a novel hdac6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer. |
2024-02-20 |
2024-02-22 |
Not clear |
| Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
hepatic ischemia-reperfusion injury (iri) continues to limit the prognosis of patients receiving lt. histone deacetylase 6 (hdac6) is a unique hdac member involved in inflammation and apoptosis. |
2024-02-09 |
2024-02-11 |
mouse |
| Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
in conclusion, hdac6 is a key mediator of hepatic iri that functions to promote inflammation and apoptosis via pi3k/akt/mtor signaling. |
2024-02-09 |
2024-02-11 |
mouse |
| Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Che. Histone deacetylase 6 deficiency protects the liver against ischemia/reperfusion injury by activating PI3K/AKT/mTOR signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-09. PMID:38334424. |
compared with control mice, hdac6 deficiency mitigated liver iri by inhibiting inflammatory responses and apoptosis, whereas hdac6-ltg mice displayed the opposite phenotype. |
2024-02-09 |
2024-02-11 |
mouse |
| b' Ana Vuleti\\xc4\\x87, Katarina Mirja\\xc4\\x8di\\xc4\\x87 Martinovi\\xc4\\x87, Jelena Spasi\\xc4\\x8. Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258065.' |
histone deacetylase 6 (hdac6), by deacetylation of multiple substrates and association with interacting proteins, regulates many physiological processes that are involved in cancer development and invasiveness such as cell proliferation, apoptosis, motility, epithelial to mesenchymal transition, and angiogenesis. |
2024-01-23 |
2024-01-25 |
Not clear |
| Se-In Lee, Yuri Seo, Hoang Thi Oanh, Thi Tuyet Hanh Vo, Hyeonbin Go, Myung Hun Kim, Joo-Yong Le. HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320. Biochemical and biophysical research communications. vol 691. 2023-12-03. PMID:38043200. |
hdac6 has been reported as a deacetylase of p53 at multiple lysine residues, associated with the canonical functions of p53, such as apoptosis and tumor suppression. |
2023-12-03 |
2023-12-10 |
mouse |
| Milan Beljkas, Aleksandra Ilic, Alen Cebzan, Branko Radovic, Nemanja Djokovic, Dusan Ruzic, Katarina Nikolic, Slavica Oljaci. Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer. Pharmaceutics. vol 15. issue 11. 2023-11-25. PMID:38004560. |
therefore, the overexpression of hdac6 is associated with tumorigenesis, invasion, migration, survival, apoptosis and growth of various malignancies. |
2023-11-25 |
2023-11-28 |
Not clear |
| O V Tinkov, V Y Grigorev, L D Grigoreva, V N Osipov, A V Kolotaev, D S Khachatrya. HDAC6 detector: online application for evaluating compounds as potential histone deacetylase 6 inhibitors. SAR and QSAR in environmental research. 2023-08-11. PMID:37565331. |
the hdac6 (histone deacetylase 6) enzyme plays a key role in many biological processes, including cell division, apoptosis, and immune response. |
2023-08-11 |
2023-08-16 |
Not clear |
| Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
further in vivo and in vitro mechanism studies have found that the reduction of hdac6 alleviated riri by inhibiting ros mediated apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
| Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
remarkably, a renal protective protein, klotho, has been proven to be a target of hdac6, and the degradation of hdac6 restored kl expression, thereby ameliorating ros mediated apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
| Kang Xia, Tao Qiu, Yonghong Jian, Hao Liu, Hui Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wan. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-10. PMID:37429230. |
overall, our results illustrated that the degradation of hdac6 restrained ros mediated apoptosis by restoring klotho expression during riri. |
2023-07-10 |
2023-08-14 |
Not clear |
| Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jian. Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage PeerJ. vol 11. 2023-05-04. PMID:37138816. |
selective hdac6 inhibitor tuba offers neuroprotection after intracerebral hemorrhage a large body of evidence has demonstrated that neuronal apoptosis is involved in the pathological process of secondary brain injury following intracerebral hemorrhage (ich). |
2023-05-04 |
2023-08-14 |
Not clear |
| Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jian. Selective HDAC6 inhibitor TubA offers neuroprotection after intracerebral hemorrhage PeerJ. vol 11. 2023-05-04. PMID:37138816. |
additionally, our previous studies determined that the inhibition of hdac6 activity by tubacin or specific shrna can attenuate neuronal apoptosis in an oxygen-glucose deprivation reperfusion model. |
2023-05-04 |
2023-08-14 |
Not clear |
| An-Min Zhou, Meng-Meng Wang, Yan Su, Zheng-Hong Yu, Hong-Ke Liu, Zhi S. Cell Death Mode Switching Between Apoptosis and Autophagy by Inhibitory Level of Histone Deacetylase 6. ChemMedChem. 2022-12-28. PMID:36578101. |
in this work, we have developed a new agent ir-vpa, which exhibits the cell death mode switching between apoptosis and autophagy due to the distinct level of hdac6 inhibition. ir-vpa indicates the best anticancer activity to hela cells, and could be hydrolyzed due to the high expression of the esterase in hela cells. ir-vpa could accumulate in nuclei, induce severe dna damages and cell cycle arrest at g2/m phase. |
2022-12-28 |
2023-08-14 |
Not clear |
| An-Min Zhou, Meng-Meng Wang, Yan Su, Zheng-Hong Yu, Hong-Ke Liu, Zhi S. Cell Death Mode Switching Between Apoptosis and Autophagy by Inhibitory Level of Histone Deacetylase 6. ChemMedChem. 2022-12-28. PMID:36578101. |
the anticancer mechanism of ir-vpa to hela cells was dependent on the hdac6 inhibitory performance, as the caspase dependent apoptosis at low concentration (ic50) and autophagy with the autophagy flux blockage at high concentration (2xic50). |
2022-12-28 |
2023-08-14 |
Not clear |
| Mazhar Hussain, Farjana Ahmed, Bennett Henzeler, Matloob Husai. Anti-microbial host factor HDAC6 is antagonised by the influenza A virus through host caspases and viral PA. The FEBS journal. 2022-12-14. PMID:36516338. |
collectively, these data indicated that iav antagonises the hdac6 by decreasing its expression level in infected cells, both at mrna and polypeptide level via pa gene, which has been implicated in auxiliary functions like degradation of host mrna and induction of apoptosis. |
2022-12-14 |
2023-08-14 |
human |
| Sumeet Kaur, Prerna Rajoria, Madhu Chopr. HDAC6: A unique HDAC family member as a cancer target. Cellular oncology (Dordrecht). 2022-08-29. PMID:36036883. |
hdac6, a structurally and functionally distinct member of the hdac family, is an integral part of multiple cellular functions such as cell proliferation, apoptosis, senescence, dna damage and genomic stability, all of which when deregulated contribute to carcinogenesis. |
2022-08-29 |
2023-08-14 |
mouse |
| Xuefeng Pang, Qigang Guan, Xue Lin, Ning Chan. Knockdown of HDAC6 alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy. Cell biology and toxicology. 2022-06-28. PMID:35764897. |
besides, in dox-injured cardiomyocytes, hdac6 silencing also diminished nlrp3 inflammasome activation and cell apoptosis but enhanced cell autophagy, whereas ectopic nlrp3 expression negated the effects of hdac6 silencing. |
2022-06-28 |
2023-08-14 |
rat |