| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Long Huang, Hao Zhang, Xiao-Yu Yang, Xiao-Yong Dong, Xiang-Yu Xie, Hu-Bin Yin, Xin Gou, Yong Lin, Wei-Yang H. Activation of a c-Jun N-terminal kinase-mediated autophagy pathway attenuates the anticancer activity of gemcitabine in human bladder cancer cells. Anti-cancer drugs. vol 28. issue 6. 2017-10-26. PMID:28430744. |
gem killed bladder cancer cells, which was associated with apoptosis induction. |
2017-10-26 |
2023-08-13 |
human |
| Xiao-Long Huang, Hao Zhang, Xiao-Yu Yang, Xiao-Yong Dong, Xiang-Yu Xie, Hu-Bin Yin, Xin Gou, Yong Lin, Wei-Yang H. Activation of a c-Jun N-terminal kinase-mediated autophagy pathway attenuates the anticancer activity of gemcitabine in human bladder cancer cells. Anti-cancer drugs. vol 28. issue 6. 2017-10-26. PMID:28430744. |
gem kills bladder cancer cells through apoptosis. |
2017-10-26 |
2023-08-13 |
human |
| Fei Feng, Bin Wang, Xiuxuan Sun, Yumeng Zhu, Hao Tang, Gang Nan, Lijuan Wang, Bo Wu, Muren Huhe, Shuangshuang Liu, Tengyue Diao, Rong Hou, Yang Zhang, Zheng Zhan. Metuzumab enhanced chemosensitivity and apoptosis in non-small cell lung carcinoma. Cancer biology & therapy. vol 18. issue 1. 2017-09-22. PMID:28055291. |
flow cytometric analysis showed that metuzumab combined with gemcitabine (gem) treatment led to an obvious g1 arrest and an elevated apoptosis in a549, nci-h460 and nci-h520 cells. |
2017-09-22 |
2023-08-13 |
human |
| Gui Yong-Xian, Li Xiao-Huan, Zhang Fan, Tian Guo-Fan. Gemcitabine inhibits proliferation and induces apoptosis in human pancreatic cancer PANC-1 cells. Journal of cancer research and therapeutics. vol 12. issue Supplement. 2017-03-16. PMID:27721241. |
the aim of the study is to investigate the underlying molecular mechanisms by which gemcitabine (gem) inhibits proliferation and induces apoptosis in human pancreatic cancer panc-1 cells in vitro. |
2017-03-16 |
2023-08-13 |
human |
| Xiao Zhi, Wei Chen, Fei Xue, Chao Liang, Bryan Wei Chen, Yue Zhou, Liang Wen, Liqiang Hu, Jian Shen, Xueli Bai, Tingbo Lian. OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo. Oncotarget. vol 6. issue 28. 2016-07-22. PMID:26213847. |
moreover, osi-027 also downregulated multidrug resistance (mdr)-1, which has been implicated in chemotherapy resistance in pdac cells and enhanced apoptosis induced by gem in the three pdac cell lines. |
2016-07-22 |
2023-08-13 |
mouse |
| Chen Liang, Zhen Wang, Ying-Yi Li, Bao-Hua Yu, Fei Zhang, Hong-Yu L. miR-33a suppresses the nuclear translocation of β-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-21. PMID:26113407. |
thus, mir-33a might function as a tumor suppressor to downregulate β-catenin expression, affecting cell growth, apoptosis, the emt, and gem resistance. |
2016-04-21 |
2023-08-13 |
human |
| Hui Zhang, Huanwen Wu, Jian Guan, Li Wang, Xinyu Ren, Xiaohua Shi, Zhiyong Liang, Tonghua Li. Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells. Oncotarget. vol 6. issue 5. 2016-03-28. PMID:25609203. |
psc-conditioned medium (psc-cm) inhibited gemcitabine (gem)-induced cytotoxicity and apoptosis in the human pcc line panc-1, which was antagonized by an sdf-1α neutralizing ab. |
2016-03-28 |
2023-08-13 |
human |
| Yong Yu, Jinghan Wang, Nianxin Xia, Bin Li, Xiaoqing Jian. Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-κB-mediated survival signaling pathways in human gallbladder cancer cells. Oncology reports. vol 33. issue 4. 2016-01-29. PMID:25633045. |
ma inhibited the in vitro proliferation of various gbc cell lines and potentiated the apoptosis and cell invasion inhibition induced by gem. |
2016-01-29 |
2023-08-13 |
mouse |
| Yong-Hui Wang, Ya-Na Sui, Kai Yan, Li-Shan Wang, Fei Wang, Jia-Hua Zho. BRD4 promotes pancreatic ductal adenocarcinoma cell proliferation and enhances gemcitabine resistance. Oncology reports. vol 33. issue 4. 2016-01-29. PMID:25647019. |
combination treatment of gem and brd4 silencing had a synergistic effect on the chemotherapeutic efficacy in the panc-1 and miapaca-2 cell lines, and significantly promoted apoptosis. |
2016-01-29 |
2023-08-13 |
human |
| Fan Xu, Hui Huang, Yu Wu, Lu Lu, Li Jiang, Lifei Chen, Siming Zeng, Li Li, Min L. Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats. Journal of molecular histology. vol 45. issue 5. 2015-05-12. PMID:24948002. |
upregulation of gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats. |
2015-05-12 |
2023-08-13 |
rat |
| Fan Xu, Hui Huang, Yu Wu, Lu Lu, Li Jiang, Lifei Chen, Siming Zeng, Li Li, Min L. Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats. Journal of molecular histology. vol 45. issue 5. 2015-05-12. PMID:24948002. |
based on the present results, it is suggested that gem might play a crucial role in rgcs apoptosis after onc, which might be involved in rock pathway. |
2015-05-12 |
2023-08-13 |
rat |
| Mitchell E Menezes, Swadesh K Das, Luni Emdad, Jolene J Windle, Xiang-Yang Wang, Devanand Sarkar, Paul B Fishe. Genetically engineered mice as experimental tools to dissect the critical events in breast cancer. Advances in cancer research. vol 121. 2015-04-16. PMID:24889535. |
distinct molecular changes that drive various aspects of tumorigenesis, such as alterations in tumor cell proliferation and apoptosis, invasion and metastasis, angiogenesis, and drug resistance have been evaluated using the currently available gem breast cancer models. |
2015-04-16 |
2023-08-13 |
mouse |
| Chubiao Zhao, Weijie Gao, Tongsheng Che. Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24337869. |
this report is designed to study the ability of the combined treatment with gemcitabine (gem) and dihydroartemisinin (dha) to induce apoptosis in a non-small-cell lung cancer cell line (a549 cells). |
2015-02-26 |
2023-08-12 |
Not clear |
| Chubiao Zhao, Weijie Gao, Tongsheng Che. Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24337869. |
collectively, the present study demonstrates a strong synergistic action of the combined treatment with gem and dha in inducing apoptosis of a549 cells via both the bak-mediated intrinsic pathway and the fas-caspase-8-mediated extrinsic pathway. |
2015-02-26 |
2023-08-12 |
Not clear |
| Ming-Wan Zhang, Xiao-Jun Xu, Jia-Xin Fan, Yu-Xian Hung, Yong-Bin Ye, Jing Wang, Kun-Yuan Gu. [Honokiol combined with Gemcitabine synergistically inhibits the proliferation of human Burkitt lymphoma cells and induces their apoptosis]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 1. 2014-07-03. PMID:24598658. |
this study was aimed to investigate the effect of honokiol (hnk) combined with gemcitabine (gem) on the proliferation and apoptosis of human burkitt lymphoma raji cells. |
2014-07-03 |
2023-08-12 |
human |
| Xiao Du, Yu-Pei Zhao, Tai-Ping Zhang, Li Zhou, Ge Chen, Tian-Xiao Wang, Lei You, Hong Sh. Alteration of the intrinsic apoptosis pathway is involved in Notch-induced chemoresistance to gemcitabine in pancreatic cancer. Archives of medical research. vol 45. issue 1. 2014-06-13. PMID:24316112. |
the current study aims to investigate the role of alterations of the intrinsic apoptosis pathway in notch-induced gem resistance of pc. |
2014-06-13 |
2023-08-12 |
Not clear |
| Eun Sun Lee, Jae Young Lee, Haeri Kim, YoonSeok Choi, Jisuk Park, Joon Koo Han, Byung Ihn Cho. Pulsed high-intensity focused ultrasound enhances apoptosis of pancreatic cancer xenograft with gemcitabine. Ultrasound in medicine & biology. vol 39. issue 11. 2014-05-20. PMID:23972483. |
in the first study, overall rates of apoptosis were significantly higher in the higem group than in the gem group (p = 0.02). |
2014-05-20 |
2023-08-12 |
mouse |
| Eun Sun Lee, Jae Young Lee, Haeri Kim, YoonSeok Choi, Jisuk Park, Joon Koo Han, Byung Ihn Cho. Pulsed high-intensity focused ultrasound enhances apoptosis of pancreatic cancer xenograft with gemcitabine. Ultrasound in medicine & biology. vol 39. issue 11. 2014-05-20. PMID:23972483. |
in a subgroup analysis, higem was superior to gem in enhancing apoptosis at gemcitabine dosages of 150-200 mg/kg gemcitabine and intervals between gemcitabine and hifu less than 2 h (p = 0.01). |
2014-05-20 |
2023-08-12 |
mouse |
| Xin-Yu Zhao, Chun-Lai Nie, Shu-Fang Liang, Zhu Yuan, Hong-Xin Deng, Yu-Quan We. Enhanced gemcitabine-mediated cell killing of human lung adenocarcinoma by vector-based RNA interference against PLK1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 8. 2013-04-30. PMID:23153503. |
moreover, the combination of plk1-shrna plus low-dose gemcitabine (gem) produced an additive antitumor activity on the lung tumors owing to an inhibition of cancer cell survival and augmented apoptosis. |
2013-04-30 |
2023-08-12 |
mouse |
| Elisa Dalla Pozza, Claudia Fiorini, Ilaria Dando, Marta Menegazzi, Anna Sgarbossa, Chiara Costanzo, Marta Palmieri, Massimo Donadell. Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine. Biochimica et biophysica acta. vol 1823. issue 10. 2012-11-19. PMID:22705884. |
here, we demonstrate that chemical uncouplers or ucp2 over-expression strongly decrease mitochondrial superoxide induction by the anticancer drug gemcitabine (gem) and protect cancer cells from gem-induced apoptosis. |
2012-11-19 |
2023-08-12 |
Not clear |