All Relations between apoptosis and gem
Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
T Mori, N Kiyokawa, Y U Katagiri, T Taguchi, T Suzuki, T Sekino, N Sato, K Ohmi, H Nakajima, T Takeda, J Fujimot. Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor-mediated apoptosis by regulating lyn kinase activity in human B cells. Experimental hematology. vol 28. issue 11. 2001-01-02. PMID:11063874. |
this study describes the participation of the gem domain in bcr-signaling cascade and suggests a possible role of cd77 as a regulator of bcr-induced apoptosis in human b cells. |
2001-01-02 |
2023-08-12 |
human |
Y Gazitt, M L Rothenberg, S G Hilsenbeck, V Fey, C Thomas, W Montegomre. Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells. International journal of oncology. vol 13. issue 4. 1998-12-09. PMID:9735415. |
we found that both drugs are cytotoxic by inducing apoptosis, however, the extent of apoptosis with tax, but not with gem was dependent on the levels of bcl-2 expression. |
1998-12-09 |
2023-08-12 |
Not clear |
Y Gazitt, M L Rothenberg, S G Hilsenbeck, V Fey, C Thomas, W Montegomre. Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells. International journal of oncology. vol 13. issue 4. 1998-12-09. PMID:9735415. |
in contrast, gem caused apoptosis of cells in the s-phase, regardless of level of bcl-2 expression. |
1998-12-09 |
2023-08-12 |
Not clear |