| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiwei Xing, Yuxia Yin, Saina Yang, Guang L. GEM on proliferation and apoptosis of childhood AL cells through inhibiting c-myc expression by upregulating miR-125a-3p. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218841. |
compared with those in the control group, gem inhibited proliferation and promoted apoptosis of childhood al cells, and impeded the protein expression of c-myc in these cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Weiwei Xing, Yuxia Yin, Saina Yang, Guang L. GEM on proliferation and apoptosis of childhood AL cells through inhibiting c-myc expression by upregulating miR-125a-3p. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218841. |
compared with those in the gem group, gem + mir-125a-3p mimic notably reduced the proliferation and enhanced apoptosis of cells, and the protein expression of c-myc in cells was overtly reduced. |
2020-09-28 |
2023-08-13 |
Not clear |
| Weiwei Xing, Yuxia Yin, Saina Yang, Guang L. GEM on proliferation and apoptosis of childhood AL cells through inhibiting c-myc expression by upregulating miR-125a-3p. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218841. |
it is suggested in this study that gem can inhibit the proliferation and promote apoptosis of childhood al cells, and the mechanism may be related to upregulated mir-125a-3p inhibiting the expression of c-myc. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yuan Zhang, Xin Bush, Bingfang Yan, Justin A Che. Gemcitabine nanoparticles promote antitumor immunity against melanoma. Biomaterials. vol 189. 2020-03-06. PMID:30388589. |
in the syngeneic mouse model of b16f10 melanoma, compared with free gem, the lcp-formulated gmp (lcp-gmp) significantly induced apoptosis and reduced immunosuppression in the tumor microenvironment (tme). |
2020-03-06 |
2023-08-13 |
mouse |
| Guanggai Xia, Hongbo Zhang, Ruoyu Cheng, Hongcheng Wang, Ziliang Song, Lianfu Deng, Xinyu Huang, Hélder A Santos, Wenguo Cu. Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence. Advanced healthcare materials. vol 7. issue 18. 2019-11-08. PMID:30062854. |
furthermore, immunohistochemistry results show that gem-loaded fibers promote a higher cell apoptosis rate than does systemically injected gem in residual tumors. |
2019-11-08 |
2023-08-13 |
Not clear |
| Na Yao, Qiuyang Chen, Weihai Shi, Liming Tang, Yue F. PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-κB pathway. Molecular carcinogenesis. vol 58. issue 7. 2019-11-07. PMID:30968979. |
using loss-of-function studies in vitro and in vivo, we showed that the knockdown of parp14 led to enhanced apoptosis, repressed proliferation, and gemcitabine (gem) resistance of pc cells. |
2019-11-07 |
2023-08-13 |
human |
| Emilie A G Molins, William J Jusk. Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells. The AAPS journal. vol 20. issue 5. 2019-09-11. PMID:29951754. |
the phenothiazine tfp was chosen for its potential activity on cancer stem cells, while gem and ptx cause apoptosis. |
2019-09-11 |
2023-08-13 |
Not clear |
| Zhiming Zhu, Chuanfu Dong, Shaoping Weng, Jianguo H. Identification of outer membrane protein TolC as the major adhesin and potential vaccine candidate for Vibrio harveyi in hybrid grouper, Epinephelus fuscoguttatus (♀) × E. lanceolatus (♂). Fish & shellfish immunology. vol 86. 2019-05-03. PMID:30453046. |
we observed that pathogenic v. harveyi adhered to the surface of grouper embryonic cells (gem cells) and induced apoptosis of them. |
2019-05-03 |
2023-08-13 |
Not clear |
| Yan Dai, Xuelei Ma, Yanhong Zhang, Kai Chen, James Z Tang, Qiyong Gong, Kui Lu. A biocompatible and cathepsin B sensitive nanoscale system of dendritic polyHPMA-gemcitabine prodrug enhances antitumor activity markedly. Biomaterials science. vol 6. issue 11. 2019-02-04. PMID:30255871. |
the prodrug demonstrates enzyme-responsive drug release features; over 95% gem was released from the carrier in the presence of cathepsin b within 3 h. investigation of the cellular mechanism underlying the dendritic prodrug suggests that cytotoxicity is associated with cellular uptake and cell apoptosis. |
2019-02-04 |
2023-08-13 |
Not clear |
| Jinhui Zhu, Yan Chen, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zho. Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells. Biotechnology and applied biochemistry. vol 65. issue 5. 2018-11-13. PMID:29575133. |
our data showed that gem treatment inhibits cell growth, induces apoptosis, and activates autophagy via the amp-activated protein kinase (ampk) pathway. |
2018-11-13 |
2023-08-13 |
Not clear |
| Jinhui Zhu, Yan Chen, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zho. Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells. Biotechnology and applied biochemistry. vol 65. issue 5. 2018-11-13. PMID:29575133. |
the combination of gem treatment and ampk knockdown resulted in a dramatic increase of apoptosis and inhibition of autophagy. |
2018-11-13 |
2023-08-13 |
Not clear |
| Rammohan Devulapally, Kira Foygel, Thillai V Sekar, Juergen K Willmann, Ramasamy Paulmuruga. Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. ACS applied materials & interfaces. vol 8. issue 49. 2018-11-01. PMID:27960411. |
flow cytometry analysis showed that control nps and antisense-mirna-21-loaded nps are not cytotoxic to both hcc cell lines, whereas treatment with free gem and gem-loaded nps resulted in ∼9% and ∼15% apoptosis, respectively. |
2018-11-01 |
2023-08-13 |
human |
| Bi-Dan Hu, Jia Guo, Yuan-Zi Ye, Ting Du, Chun-Song Cheng, Qian Jiang, Ruo-Nan Liu, Yan-Bei Zhan. Specific inhibitor of Notch‑3 enhances the sensitivity of NSCLC cells to gemcitabine. Oncology reports. vol 40. issue 1. 2018-10-11. PMID:29781034. |
both cell lines were subsequently treated with either dapt or dapt combined with gem and then viability, apoptosis, colony formation and cell count assays were performed. |
2018-10-11 |
2023-08-13 |
Not clear |
| Xin Xie, Yiran Zhou, Xue Wang, Jian Guo, Jingwen Li, Hongye Fan, Jie Dou, Baiyong Shen, Changlin Zho. Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo. Carbohydrate polymers. vol 173. 2018-07-19. PMID:28732877. |
moreover, sep reversed atrophy and apoptosis caused by gem in both spleen and bone marrow through suppressing ros secretion in vivo. |
2018-07-19 |
2023-08-13 |
mouse |
| Zenghuang Ma, Xiaojie Xu. Differentially expressed proteins in the human esophageal cancer cell line Eca‑109, in the presence and absence of gemcitabine. Molecular medicine reports. vol 17. issue 1. 2018-07-12. PMID:29138856. |
gem significantly inhibits the growth and promotes apoptosis of the eca‑109 cells, due to the alterations in the expression levels of the differential proteins, including asc, mcl‑1 and bax‑α. |
2018-07-12 |
2023-08-13 |
human |
| Wei Jing, Na Song, Yunpeng Liu, Xiujuan Qu, Kezuo Hou, Xianghong Yang, Xiaofang Ch. DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53‑deficient pancreatic cancer cells. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115606. |
in the present study, the effect and mechanisms of dnmt3a on gem and oxa chemosensitivity in p53‑deficient pdac cells were investigated using mtt assay, cell cycle analysis, apoptosis analysis and western blotting. |
2018-07-05 |
2023-08-13 |
Not clear |
| Wei Jing, Na Song, Yunpeng Liu, Xiujuan Qu, Kezuo Hou, Xianghong Yang, Xiaofang Ch. DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53‑deficient pancreatic cancer cells. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115606. |
further research demonstrated that activation inhibition of chk1 and akt, as well as an increase in apoptosis, were involved in dnmt3a‑mediated chemosensitivity to gem and oxa. |
2018-07-05 |
2023-08-13 |
Not clear |
| Yao-Min Chen, Yu Liu, Hai-Yan Wei, Ke-Zhen Lv, Pei-Fen F. Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells. Oncotarget. vol 7. issue 37. 2018-02-06. PMID:27449099. |
the purpose of this study was to elucidate the potential role of long intergenic non-protein coding rna, regulator of reprogramming (linc-ror) in gemcitabine (gem)-induced autophagy and apoptosis in breast cancer cells. |
2018-02-06 |
2023-08-13 |
Not clear |
| Yao-Min Chen, Yu Liu, Hai-Yan Wei, Ke-Zhen Lv, Pei-Fen F. Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells. Oncotarget. vol 7. issue 37. 2018-02-06. PMID:27449099. |
gem treatment alone decreased cell survival and increased both apoptosis and autophagy. |
2018-02-06 |
2023-08-13 |
Not clear |
| Florian Thuma, Sarah Heiler, Martina Schnölzer, Margot Zölle. Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules. Oncotarget. vol 7. issue 21. 2017-12-18. PMID:27120791. |
an association of cld7mpalm with the major pten phosphorylating kinases does not restore apoptosis resistance as phosphorylated pten is not guided towards gem to compete with non-phosphorylated pten. |
2017-12-18 |
2023-08-13 |
rat |