| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stanislav Drápela, Prashant Khirsariya, Wytske M van Weerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souče. The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe. Molecular oncology. vol 14. issue 10. 2021-09-10. PMID:32579780. |
mu380 alone or in combination with gem significantly reduced spheroid size and increased apoptosis in all patient-derived xenograft 3d cultures, with a higher impact in dr models. |
2021-09-10 |
2023-08-13 |
mouse |
| Jianlin Song, Jianbiao Xu, Jianhui Guo, Yun Shang, Junyu Wang, Tongmin Wan. The enhancement of Tetrandrine to gemcitabine-resistant PANC-1 cytochemical sensitivity involves the promotion of PI3K/Akt/mTOR-mediated apoptosis and AMPK-regulated autophagy. Acta histochemica. vol 123. issue 6. 2021-08-30. PMID:34416437. |
in the process of tumor development, the resistance of pancreatic cancer cells to gemcitabine (gem) is mainly due to the suppression and dysregulation of apoptosis signals to a large extent. |
2021-08-30 |
2023-08-13 |
Not clear |
| Yang Yang, Tao Cheng, Peng Xie, Lishan Wang, Hong Chen, Zhangjun Cheng, Jiahua Zho. PMEPA1 interference activates PTEN/PI3K/AKT, thereby inhibiting the proliferation, invasion and migration of pancreatic cancer cells and enhancing the sensitivity to gemcitabine and cisplatin. Drug development research. 2021-06-30. PMID:34189738. |
after gem or ddp treatment, cell viability was observed by commercial kits and cell apoptosis by flow cytometry. |
2021-06-30 |
2023-08-13 |
human |
| Liyun Sun, Huoli Shang, Yuzhen Wu, Xiujuan Xi. Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level. The Journal of pharmacy and pharmacology. 2021-06-05. PMID:34089613. |
the combination of gemcitabine (gem) and hypericin (hy) enhances the apoptosis of capan-2 cells, providing a promising option for the treatment of pancreatic cancer. |
2021-06-05 |
2023-08-13 |
Not clear |
| Elham Hatami, Prashanth K B Nagesh, Meena Jaggi, Subhash C Chauhan, Murali M Yallap. Gambogic acid potentiates gemcitabine induced anticancer activity in non-small cell lung cancer. European journal of pharmacology. vol 888. 2021-05-17. PMID:32805254. |
hence, we report an adjuvant therapeutic regimen based on natural compound, gambogic acid (ga) which has been shown to enhanced gem induced inhibition of cancer cell growth, arrest cell cycle, and induce apoptosis by enhanced accumulation of gem. |
2021-05-17 |
2023-08-13 |
mouse |
| Panpan Wu, Xiao Wang, Yuran Ma, Xuetao Xu, Wenfeng Liu, Zhaojun Sheng, Min Chen, Renping Zhou, Kun Zhang, Susan Goodin, Xi Zheng, Dongli L. (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32599367. |
in the present study, we investigated the effects of fn2 in combination with gem on growth inhibition and apoptosis in human pancreatic cancer panc-1 cells. |
2021-03-29 |
2023-08-13 |
human |
| Panpan Wu, Xiao Wang, Yuran Ma, Xuetao Xu, Wenfeng Liu, Zhaojun Sheng, Min Chen, Renping Zhou, Kun Zhang, Susan Goodin, Xi Zheng, Dongli L. (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32599367. |
treatment with fn2 in combination with gem strongly inhibited the growth and stimulated apoptosis in the gem resistant panc-1 cells. |
2021-03-29 |
2023-08-13 |
human |
| Panpan Wu, Xiao Wang, Yuran Ma, Xuetao Xu, Wenfeng Liu, Zhaojun Sheng, Min Chen, Renping Zhou, Kun Zhang, Susan Goodin, Xi Zheng, Dongli L. (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32599367. |
mechanistic studies showed that inhibition of cell growth and induction of apoptosis in the gem resistant panc-1 cells were associated with decreases in activation of nf-κb and akt. |
2021-03-29 |
2023-08-13 |
human |
| Marco Cordani, Esther Resines-Urien, Arturo Gamonal, Paula Milán-Rois, Lionel Salmon, Azzedine Bousseksou, Jose Sanchez Costa, Álvaro Somoz. Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer. Antioxidants (Basel, Switzerland). vol 10. issue 1. 2021-02-18. PMID:33430324. |
importantly, the tested compounds enhanced the effect of gem, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mtor pathway. |
2021-02-18 |
2023-08-13 |
Not clear |
| Fang-Tao Wang, Hui Wang, Qi-Wei Wang, Mu-Su Pan, Xin-Ping Li, Wei Sun, Yue-Zu Fa. Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer. Cancer chemotherapy and pharmacology. vol 86. issue 2. 2021-02-17. PMID:32654071. |
in the present study, we demonstrated that gem induced apoptosis and protective autophagy in gbc cells, which may be related to the akt/mtor signaling pathway, and gem in combination with autophagy inhibitor chloroquine can strengthen the cytotoxic effect of gem on gbc in vitro and in vivo. |
2021-02-17 |
2023-08-13 |
Not clear |
| Hui Wang, Runling Ren, Zizhong Yang, Jun Cai, Shaoxia Du, Xiaohong She. The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function. Journal of Cancer. vol 12. issue 5. 2021-02-06. PMID:33531986. |
next, we investigated the mechanism by which col11a1 affects growth, gemcitabine (gem) resistance and apoptosis in pancreatic cancer cells. |
2021-02-06 |
2023-08-13 |
Not clear |
| Dingyuan Luo, Matthew G Digiovanni, Ran Wei, Joseph F Lacomb, Jennie L Williams, Basil Rigas, Gerardo G Mackenzi. Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine. Carcinogenesis. vol 41. issue 7. 2021-02-05. PMID:31584613. |
furthermore, mdc-1112 enhanced gem's effect on colony formation, apoptosis, cell migration, and cell invasion. |
2021-02-05 |
2023-08-13 |
mouse |
| Yu Mu, Dezhi Wang, Liangyu Bie, Suxia Luo, Xiaoqian Mu, Yanqiu Zha. Glypican-1-targeted and gemcitabine-loaded liposomes enhance tumor-suppressing effect on pancreatic cancer. Aging. vol 12. issue 19. 2020-12-19. PMID:33035197. |
this study aimed to investigate the effect of glypican-1 (gpc1)-targeted and gemcitabine (gem)-loaded lp [gpc1-lp (gem)] on cell proliferation and apoptosis in panc-1s, as well as on orthotopic pancreatic cancer (pdac) mice. |
2020-12-19 |
2023-08-13 |
mouse |
| Yu Shi, Yan Wang, Jing Qian, Xiaodi Yan, Yong Han, Ninghua Yao, Jianbo M. MGMT expression affects the gemcitabine resistance of pancreatic cancer cells. Life sciences. vol 259. 2020-10-15. PMID:32721465. |
mgmt inhibition induced by lomeguatrib (lm) suppressed the proliferation, invasion, migration and autophagy, promoted the apoptosis of panc-1/gem cells and up-regulated the gem inhibition rates for panc-1/gem cells. |
2020-10-15 |
2023-08-13 |
mouse |
| Jinhui Zhu, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zhou, Yan Che. Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805615. |
cell cycle and apoptosis analyses were performed in order to investigate the mechanisms underlying the effects induced by ppp5c silencing combined with gem treatment. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jinhui Zhu, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zhou, Yan Che. Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805615. |
western blot analysis was applied to detect the expression of certain key regulators of cell apoptosis in panc-1 cells treated with gem. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hangbin Jin, Yanyan Zhao, Jianfeng Yang, Xiaofeng Zhang, Shenglin M. Hyperthermia enhances the sensitivity of pancreatic cancer SW1990 cells to gemcitabine through ROS/JNK signaling. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30405817. |
the results revealed that mild hyperthermia (at 42°c) effectively increased the inhibitory effect of gem on cell viability, as determined using an mtt assay, and increased the effect of gem-induced apoptosis, as determined using an annexin v-fluorescein isothiocyanate/propidium iodide assay, in pc sw1990 cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hangbin Jin, Yanyan Zhao, Jianfeng Yang, Xiaofeng Zhang, Shenglin M. Hyperthermia enhances the sensitivity of pancreatic cancer SW1990 cells to gemcitabine through ROS/JNK signaling. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30405817. |
the introduction of ros and jnk inhibitors suppressed hyperthermia-induced apoptosis in gem-treated cells, suggesting that hyperthermia increased gem cytotoxicity in pc sw1990 cells by inducing apoptosis via the ros/jnk signaling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Weiwei Xing, Yuxia Yin, Saina Yang, Guang L. GEM on proliferation and apoptosis of childhood AL cells through inhibiting c-myc expression by upregulating miR-125a-3p. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218841. |
gem on proliferation and apoptosis of childhood al cells through inhibiting c-myc expression by upregulating mir-125a-3p. |
2020-09-28 |
2023-08-13 |
Not clear |
| Weiwei Xing, Yuxia Yin, Saina Yang, Guang L. GEM on proliferation and apoptosis of childhood AL cells through inhibiting c-myc expression by upregulating miR-125a-3p. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218841. |
effect of gemcitabine (gem) on proliferation and apoptosis of childhood acute leukemia (al) cells and the mechanism of action were investigated. |
2020-09-28 |
2023-08-13 |
Not clear |