| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Gillette-Ferguson, C L Sidma. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. European journal of immunology. vol 24. issue 5. 1994-06-14. PMID:8181528. |
recently, the gene affected by lpr was identified as fas, whose product acts as a trigger for programmed cell death or apoptosis. |
1994-06-14 |
2023-08-12 |
mouse |
| I Gillette-Ferguson, C L Sidma. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. European journal of immunology. vol 24. issue 5. 1994-06-14. PMID:8181528. |
data reported here indicate that the fas receptor and its ligand, the wild-type form of the gld gene product, are essential for antigen-stimulated peripheral t cell apoptosis. |
1994-06-14 |
2023-08-12 |
mouse |
| S Nagat. Mutations in the Fas antigen gene in lpr mice. Seminars in immunology. vol 6. issue 1. 1994-06-01. PMID:7513193. |
the fas antigen is a cell surface protein belonging to the tumor necrosis factor/nerve growth factor receptor family and it mediates apoptosis. |
1994-06-01 |
2023-08-12 |
mouse |
| A D Steinber. MRL-lpr/lpr disease: theories meet Fas. Seminars in immunology. vol 6. issue 1. 1994-06-01. PMID:7513194. |
since the normal fas is thought to be important in programmed cell death, apoptosis, the lpr-associated defect in fas is thought to interfere with normal apoptosis. |
1994-06-01 |
2023-08-12 |
mouse |
| S J Rozzo, R A Eisenberg, P L Cohen, B L Kotzi. Development of the T cell receptor repertoire in lpr mice. Seminars in immunology. vol 6. issue 1. 1994-06-01. PMID:8167303. |
based on studies identifying lpr as a mutation in the fas gene, it has been hypothesized that defective apoptosis in the thymus abnormally affects t cell development and results in the lpr phenotype. |
1994-06-01 |
2023-08-12 |
mouse |
| J D Mountz, H Bluethmann, T Zhou, J W. Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice. Seminars in immunology. vol 6. issue 1. 1994-06-01. PMID:8167304. |
defective expression of the fas apoptosis antigen results from the insertion of the etn retrotransposon. |
1994-06-01 |
2023-08-12 |
mouse |
| J F Kerr, C M Winterford, B V Harmo. Apoptosis. Its significance in cancer and cancer therapy. Cancer. vol 73. issue 8. 1994-05-18. PMID:8156506. |
finally, the demonstration that antibodies against a cell-surface protein designated apo-1 or fas can enhance apoptosis in some human lymphoid cell lines may have therapeutic implications. |
1994-05-18 |
2023-08-12 |
human |
| M Salmon, D Pilling, N J Borthwick, N Viner, G Janossy, P A Bacon, A N Akba. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. European journal of immunology. vol 24. issue 4. 1994-05-09. PMID:8149960. |
the progressive differentiation defined by the shift from cd45rbbright to cd45rbdull is paralleled by the gradual loss of bcl-2 and gain of fas expression, two features associated with an increased propensity for apoptosis. |
1994-05-09 |
2023-08-12 |
Not clear |
| T Yoshino, E Kondo, L Cao, K Takahashi, K Hayashi, S Nomura, T Akag. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood. vol 83. issue 7. 1994-05-05. PMID:7511441. |
to examine the regulatory mechanism of apoptosis in lymphoid cells, expression of both bcl-2 protein and fas antigen was investigated in reactive lymph nodes, in resting lymphocytes from peripheral blood (pbls), and in pbls stimulated with pokeweed mitogen, interleukin-4 (il-4) + anti-igm antibody, il-2 + anti-cd3 antibody, phytohemagglutinin + phorbol myristate acetate using immunohistochemistry and flow cytometry. |
1994-05-05 |
2023-08-12 |
Not clear |
| T Yoshino, E Kondo, L Cao, K Takahashi, K Hayashi, S Nomura, T Akag. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood. vol 83. issue 7. 1994-05-05. PMID:7511441. |
germinal center cells expressed a large amount of fas antigen, which is associated with the induction of apoptosis in lymphoid cell lines, in contrast to the lack of bcl-2 protein as an apoptosis inhibitor. |
1994-05-05 |
2023-08-12 |
Not clear |
| T Yoshino, E Kondo, L Cao, K Takahashi, K Hayashi, S Nomura, T Akag. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood. vol 83. issue 7. 1994-05-05. PMID:7511441. |
these lymphoblasts fell into apoptosis dose-dependently in the presence of anti-fas monoclonal antibody, but resting lymphocytes that expressed both bcl-2 protein and fas antigen did not undergo apoptosis. |
1994-05-05 |
2023-08-12 |
Not clear |
| T Yoshino, E Kondo, L Cao, K Takahashi, K Hayashi, S Nomura, T Akag. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood. vol 83. issue 7. 1994-05-05. PMID:7511441. |
these findings suggest that bcl-2 expression prevents the apoptosis of lymphoid cells induced by the fas antigen-dependent mechanism and that apoptosis of lymphocytes is exquisitely controlled, at least in part, by regulation of the bcl-2 and fas genes. |
1994-05-05 |
2023-08-12 |
Not clear |
| T Takahashi, M Tanaka, C I Brannan, N A Jenkins, N G Copeland, T Suda, S Nagat. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. vol 76. issue 6. 1994-04-22. PMID:7511063. |
the lpr mice have a mutation in a cell-surface protein, fas, that mediates apoptosis. |
1994-04-22 |
2023-08-12 |
mouse |
| T Takahashi, M Tanaka, C I Brannan, N A Jenkins, N G Copeland, T Suda, S Nagat. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. vol 76. issue 6. 1994-04-22. PMID:7511063. |
the recombinant gld fasl expressed in cos cells could not induce apoptosis in cells expressing fas. |
1994-04-22 |
2023-08-12 |
mouse |
| J Wu, T Zhou, J Zhang, J He, W C Gause, J D Mount. Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 6. 1994-04-21. PMID:7510888. |
correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal fas apoptosis gene in the t cells of transgenic mrl-lpr/lpr mice. |
1994-04-21 |
2023-08-12 |
mouse |
| J Wu, T Zhou, J Zhang, J He, W C Gause, J D Mount. Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 6. 1994-04-21. PMID:7510888. |
the lpr genetic defect has been identified as a mutation in the fas apoptosis gene that results in low expression of fas mrna. |
1994-04-21 |
2023-08-12 |
mouse |
| J Cheng, T Zhou, C Liu, J P Shapiro, M J Brauer, M C Kiefer, P J Barr, J D Mount. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (New York, N.Y.). vol 263. issue 5154. 1994-04-19. PMID:7510905. |
protection from fas-mediated apoptosis by a soluble form of the fas molecule. |
1994-04-19 |
2023-08-12 |
mouse |
| J Cheng, T Zhou, C Liu, J P Shapiro, M J Brauer, M C Kiefer, P J Barr, J D Mount. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (New York, N.Y.). vol 263. issue 5154. 1994-04-19. PMID:7510905. |
supernatants from cells transfected with the variant messenger rna blocked apoptosis induced by the antibody to fas. |
1994-04-19 |
2023-08-12 |
mouse |
| G H Wong, D V Goedde. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. Journal of immunology (Baltimore, Md. : 1950). vol 152. issue 4. 1994-04-07. PMID:7509828. |
fas antigen and p55 tnf receptor signal apoptosis through distinct pathways. |
1994-04-07 |
2023-08-12 |
Not clear |
| G H Wong, D V Goedde. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. Journal of immunology (Baltimore, Md. : 1950). vol 152. issue 4. 1994-04-07. PMID:7509828. |
the fas ag and the p55 tnf receptor (tnf-r1) are related molecules that can signal apoptosis. |
1994-04-07 |
2023-08-12 |
Not clear |