| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Gulbins, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lan. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536620. |
fas receptor-induced apoptosis plays critical roles in immune homeostasis. |
1995-05-25 |
2023-08-12 |
Not clear |
| E Gulbins, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lan. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536620. |
furthermore, ligation of fas also resulted in stimulation of the sphingomyelin signalling pathway to produce ceramides, which, in turn, are capable of inducing both ras activation and apoptosis. |
1995-05-25 |
2023-08-12 |
Not clear |
| E Gulbins, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lan. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536620. |
thus, ligation of the fas molecule on lymphocyte lines induces activation of ras via the action of ceramide, and this activation is necessary, but not sufficient, for subsequent apoptosis. |
1995-05-25 |
2023-08-12 |
Not clear |
| X Su, T Zhou, Z Wang, P Yang, R S Jope, J D Mount. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536621. |
protein tyrosine dephosphorylation after fas cross-linking occurred in fas apoptosis-sensitive cem-6 cells but not in fas apoptosis-resistant molt-4 cells, and apoptosis in the cem-6 cells could be inhibited by the protein tyrosine phosphatase inhibitor, pervanadate. |
1995-05-25 |
2023-08-12 |
mouse |
| X Su, T Zhou, Z Wang, P Yang, R S Jope, J D Mount. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536621. |
the level of expression of hcp was correlated with fas apoptosis function in eleven human and murine fas-positive lymphoid cell lines. |
1995-05-25 |
2023-08-12 |
mouse |
| X Su, T Zhou, Z Wang, P Yang, R S Jope, J D Mount. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536621. |
expression of recombinant hcp in the molt-4 cell line converted this fas apoptosis-resistant cell line to fas apoptosis sensitive. |
1995-05-25 |
2023-08-12 |
mouse |
| X Su, T Zhou, Z Wang, P Yang, R S Jope, J D Mount. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536621. |
hcp-mutant mev/mev mice exhibited increased expression of fas but decreased fas-mediated apoptosis function in lymphoid organs after anti-mouse fas antibody treatment in vivo. |
1995-05-25 |
2023-08-12 |
mouse |
| X Su, T Zhou, Z Wang, P Yang, R S Jope, J D Mount. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. vol 2. issue 4. 1995-05-25. PMID:7536621. |
thus, hcp-mediated protein dephosphorylation is involved in the delivery of the fas apoptosis signal in lymphoid cells. |
1995-05-25 |
2023-08-12 |
mouse |
| Y Yang, M Merćep, C F Ware, J D Ashwel. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. The Journal of experimental medicine. vol 181. issue 5. 1995-05-25. PMID:7536793. |
fas and activation-induced fas ligand mediate apoptosis of t cell hybridomas: inhibition of fas ligand expression by retinoic acid and glucocorticoids. |
1995-05-25 |
2023-08-12 |
Not clear |
| Y Yang, M Merćep, C F Ware, J D Ashwel. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. The Journal of experimental medicine. vol 181. issue 5. 1995-05-25. PMID:7536793. |
to determine if fas is involved in activation-induced apoptosis, two different reagents that specifically bind fas without killing the t cell hybridomas, a monoclonal antibody and a soluble fas:fc chimeric molecule, were added to activated t cell hybridomas. |
1995-05-25 |
2023-08-12 |
Not clear |
| Y Yang, M Merćep, C F Ware, J D Ashwel. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. The Journal of experimental medicine. vol 181. issue 5. 1995-05-25. PMID:7536793. |
we conclude that up-regulated expression of fasl and its subsequent interaction with fas accounts for the apoptotic response of t cell hybridomas to activation, and that retinoic acid and corticosteroids inhibit activation-induced apoptosis by preventing up-regulation of fasl. |
1995-05-25 |
2023-08-12 |
Not clear |
| M Enari, H Hug, S Nagat. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature. vol 375. issue 6526. 1995-05-25. PMID:7536900. |
binding of fas ligand or agonistic anti-fas antibody to fas kills the cells by apoptosis. |
1995-05-25 |
2023-08-12 |
caenorhabditis_elegans |
| R Ettinger, D J Panka, J K Wang, B Z Stanger, S T Ju, A Marshak-Rothstei. Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen. Journal of immunology (Baltimore, Md. : 1950). vol 154. issue 9. 1995-05-24. PMID:7536768. |
fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal cd4+ t cells responding to a bacterial superantigen. |
1995-05-24 |
2023-08-12 |
mouse |
| R Ettinger, D J Panka, J K Wang, B Z Stanger, S T Ju, A Marshak-Rothstei. Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen. Journal of immunology (Baltimore, Md. : 1950). vol 154. issue 9. 1995-05-24. PMID:7536768. |
the rapid onset of apoptosis in normal t cells subsequent to restimulation with seb was in direct contrast to the proliferative response of the initial cultures, even though comparable levels of fas and fasl rna were found in t cells after 1 degree and 2 degrees challenge. |
1995-05-24 |
2023-08-12 |
mouse |
| M Tanaka, T Suda, T Takahashi, S Nagat. Expression of the functional soluble form of human fas ligand in activated lymphocytes. The EMBO journal. vol 14. issue 6. 1995-05-22. PMID:7536672. |
fas is a type i membrane protein which mediates apoptosis. |
1995-05-22 |
2023-08-12 |
human |
| G G Singer, A C Carrera, A Marshak-Rothstein, C Martínez, A K Abba. Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Current opinion in immunology. vol 6. issue 6. 1995-05-18. PMID:7536012. |
apoptosis, fas and systemic autoimmunity: the mrl-lpr/lpr model. |
1995-05-18 |
2023-08-12 |
mouse |
| S M Quirk, R G Cowan, S G Joshi, K P Henrikso. Fas antigen-mediated apoptosis in human granulosa/luteal cells. Biology of reproduction. vol 52. issue 2. 1995-05-18. PMID:7536048. |
fas antigen-mediated apoptosis in human granulosa/luteal cells. |
1995-05-18 |
2023-08-12 |
human |
| S M Quirk, R G Cowan, S G Joshi, K P Henrikso. Fas antigen-mediated apoptosis in human granulosa/luteal cells. Biology of reproduction. vol 52. issue 2. 1995-05-18. PMID:7536048. |
the fas antigen is a transmembrane receptor that can trigger apoptosis in a variety of tumor and hematopoietic cells. |
1995-05-18 |
2023-08-12 |
human |
| S M Quirk, R G Cowan, S G Joshi, K P Henrikso. Fas antigen-mediated apoptosis in human granulosa/luteal cells. Biology of reproduction. vol 52. issue 2. 1995-05-18. PMID:7536048. |
an anti-human fas antigen monoclonal antibody (fas mab; clone ch-11), which induces apoptosis in other cell types by binding to the fas antigen, induced significant cell death (30%) in cultures pretreated with interferon gamma (ifn gamma). |
1995-05-18 |
2023-08-12 |
human |
| S M Quirk, R G Cowan, S G Joshi, K P Henrikso. Fas antigen-mediated apoptosis in human granulosa/luteal cells. Biology of reproduction. vol 52. issue 2. 1995-05-18. PMID:7536048. |
dna fragmentation into oligonucleosomal units of approximately 180 bp, typical of apoptosis, was detected at elevated levels in fas mab-treated cultures via 3' end-labeling and gel electrophoresis. |
1995-05-18 |
2023-08-12 |
human |