| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Massaia, P Borrione, C Attisano, P Barral, E Beggiato, L Montacchini, A Bianchi, M Boccadoro, A Piler. Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood. vol 85. issue 12. 1995-07-20. PMID:7540069. |
activated t cells are highly susceptible to apoptosis, a form of programmed cell death involved in the modulation of immune responses and regulated by molecules such as fas (cd95) and bcl-2. |
1995-07-20 |
2023-08-12 |
Not clear |
| M Massaia, P Borrione, C Attisano, P Barral, E Beggiato, L Montacchini, A Bianchi, M Boccadoro, A Piler. Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood. vol 85. issue 12. 1995-07-20. PMID:7540069. |
the aim of this study was to determine the expression of fas and bcl-2 antigens and the susceptibility to apoptosis in t cells of mm patients. |
1995-07-20 |
2023-08-12 |
Not clear |
| M Massaia, P Borrione, C Attisano, P Barral, E Beggiato, L Montacchini, A Bianchi, M Boccadoro, A Piler. Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood. vol 85. issue 12. 1995-07-20. PMID:7540069. |
susceptibility to apoptosis was then investigated to evaluate the consequence of dysregulated fas and bcl-2 expression. |
1995-07-20 |
2023-08-12 |
Not clear |
| M Massaia, P Borrione, C Attisano, P Barral, E Beggiato, L Montacchini, A Bianchi, M Boccadoro, A Piler. Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood. vol 85. issue 12. 1995-07-20. PMID:7540069. |
in conclusion, mm t cells have a dysregulated expression of fas and bcl-2 antigens that is associated with an enhanced susceptibility to apoptosis. |
1995-07-20 |
2023-08-12 |
Not clear |
| G H Fisher, F J Rosenberg, S E Straus, J K Dale, L A Middleton, A Y Lin, W Strober, M J Lenardo, J M Puc. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. vol 81. issue 6. 1995-07-19. PMID:7540117. |
dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. |
1995-07-19 |
2023-08-12 |
human |
| G H Fisher, F J Rosenberg, S E Straus, J K Dale, L A Middleton, A Y Lin, W Strober, M J Lenardo, J M Puc. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. vol 81. issue 6. 1995-07-19. PMID:7540117. |
each child had defective fas-mediated t lymphocyte apoptosis associated with a unique, deleterious fas gene mutation. |
1995-07-19 |
2023-08-12 |
human |
| G H Fisher, F J Rosenberg, S E Straus, J K Dale, L A Middleton, A Y Lin, W Strober, M J Lenardo, J M Puc. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. vol 81. issue 6. 1995-07-19. PMID:7540117. |
the occurrence of fas mutations together with abnormal t cell apoptosis in alps patients suggests an involvement of fas in this recently recognized disorder of lymphocyte homeostasis and peripheral self-tolerance. |
1995-07-19 |
2023-08-12 |
human |
| K Utsugisawa, M Yamagata, K Saitoh, A Kawamorita, H Tohg. [Fas antigen gene in thymuses from patients with myasthenia gravis]. Rinsho shinkeigaku = Clinical neurology. vol 35. issue 2. 1995-07-18. PMID:7540122. |
the fas antigen is a cell surface protein that can mediate apoptosis, and plays a major role in functional maturity in clonal deletion of autoreactive t cells in the thymus. |
1995-07-18 |
2023-08-12 |
human |
| T Takizawa, R Fukuda, T Miyawaki, K Ohashi, Y Nakanish. Activation of the apoptotic Fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon. Virology. vol 209. issue 2. 1995-07-11. PMID:7539967. |
these results suggested that the activation of fas ag gene in the early phase of infection is an important event for apoptosis, and that it is regulated by the double-stranded rna/interferon system involving protein phosphorylation. |
1995-07-11 |
2023-08-12 |
Not clear |
| S Tabibzadeh, E Zupi, A Babaknia, R Liu, D Marconi, C Romanin. Site and menstrual cycle-dependent expression of proteins of the tumour necrosis factor (TNF) receptor family, and BCL-2 oncoprotein and phase-specific production of TNF alpha in human endometrium. Human reproduction (Oxford, England). vol 10. issue 2. 1995-07-05. PMID:7539446. |
therefore, endometrial epithelium by virtue of expression of receptors of tnf alpha as well as fas protein is properly poised to respond to ligand signals that regulate apoptosis. |
1995-07-05 |
2023-08-12 |
human |
| A M Chinnaiyan, K O'Rourke, M Tewari, V M Dixi. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. vol 81. issue 4. 1995-06-29. PMID:7538907. |
fadd, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis. |
1995-06-29 |
2023-08-12 |
Not clear |
| P D Katsikis, E S Wunderlich, C A Smith, L A Herzenberg, L A Herzenber. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539037. |
fas antigen stimulation induces marked apoptosis of t lymphocytes in human immunodeficiency virus-infected individuals. |
1995-06-23 |
2023-08-12 |
human |
| P D Katsikis, E S Wunderlich, C A Smith, L A Herzenberg, L A Herzenber. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539037. |
activation of fas (cd95) can either result in costimulation of proliferation and cytokine production or in the induction of apoptosis of t lymphocytes. |
1995-06-23 |
2023-08-12 |
human |
| P D Katsikis, E S Wunderlich, C A Smith, L A Herzenberg, L A Herzenber. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539037. |
this raises the possibility that fas is involved in the observed t cell apoptosis during hiv disease. |
1995-06-23 |
2023-08-12 |
human |
| P D Katsikis, E S Wunderlich, C A Smith, L A Herzenberg, L A Herzenber. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539037. |
in this report we show that peripheral blood cd4+ and cd8+ t lymphocytes from hiv-infected individuals undergo apoptosis in vitro in response to antibody stimulation (cross-linking) of fas at a much higher frequency than from uninfected controls. |
1995-06-23 |
2023-08-12 |
human |
| P D Katsikis, E S Wunderlich, C A Smith, L A Herzenberg, L A Herzenber. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539037. |
these findings show that cd4+ and cd8+ t lymphocytes in hiv-infected individuals are primed in vivo to undergo apoptosis in response to fas stimulation, suggesting that fas signaling may be responsible for the t lymphocyte functional defects and depletion observed in hiv disease. |
1995-06-23 |
2023-08-12 |
human |
| S C Chow, M Weis, G E Kass, T H Holmström, J E Eriksson, S Orreniu. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes. FEBS letters. vol 364. issue 2. 1995-06-22. PMID:7538469. |
the mechanism of fas antigen-mediated apoptosis is at present unclear. |
1995-06-22 |
2023-08-12 |
Not clear |
| T Wrone-Smith, T Johnson, B Nelson, L H Boise, C B Thompson, G Núñez, B J Nickolof. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. The American journal of pathology. vol 146. issue 5. 1995-06-15. PMID:7747803. |
in this report, we examined the expression of proteins associated with promoting (fas) or preventing (bcl-2, bcl-x, cd40) apoptosis in the normal, psoriatic, and malignant keratinocyte. |
1995-06-15 |
2023-08-12 |
Not clear |
| F Silvestris, D Ribatti, B Nico, N Silvestris, A Romito, F Dammacc. [Apoptosis or programmed cell death: regulatory and pathophysiological mechanisms]. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. vol 10. issue 1. 1995-05-26. PMID:7727211. |
these structures (including fas, müllerian inhibiting substance, p53 and the c-myc oncogene) contribute, by interactive regulatory mechanisms, to the promotion or inhibition of apoptosis, on the basis of both external stimulus and cell activation state. |
1995-05-26 |
2023-08-12 |
Not clear |
| F Silvestris, D Ribatti, B Nico, N Silvestris, A Romito, F Dammacc. [Apoptosis or programmed cell death: regulatory and pathophysiological mechanisms]. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. vol 10. issue 1. 1995-05-26. PMID:7727211. |
conversely, early activation of fas, an apoptosis-inducing gene on hiv-infected cd4+ lymphocytes, is thought to aggravate t cell lymphopenia in hiv infection by increasing the level of normal apoptosis. |
1995-05-26 |
2023-08-12 |
Not clear |