| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Villunger, A Egle, M Kos, B L Hartmann, S Geley, R Kofler, R Grei. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer research. vol 57. issue 16. 1997-09-09. PMID:9269989. |
drug-induced apoptosis is associated with enhanced fas (apo-1/cd95) ligand expression but occurs independently of fas (apo-1/cd95) signaling in human t-acute lymphatic leukemia cells. |
1997-09-09 |
2023-08-12 |
human |
| A Villunger, A Egle, M Kos, B L Hartmann, S Geley, R Kofler, R Grei. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer research. vol 57. issue 16. 1997-09-09. PMID:9269989. |
it has recently been proposed that induction of fas ligand (fasl) expression with subsequent autocrine and/or paracrine induction of cell death through binding to the fas (apo-1/cd95) membrane accounts for chemotherapy-associated apoptosis. |
1997-09-09 |
2023-08-12 |
human |
| A Villunger, A Egle, M Kos, B L Hartmann, S Geley, R Kofler, R Grei. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer research. vol 57. issue 16. 1997-09-09. PMID:9269989. |
we also raised the question of whether apoptosis induced by these drugs occurs through the fas pathway and hence can be blocked by the cowpox virus protein crma, a specific inhibitor of this pathway. |
1997-09-09 |
2023-08-12 |
human |
| A Villunger, A Egle, M Kos, B L Hartmann, S Geley, R Kofler, R Grei. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer research. vol 57. issue 16. 1997-09-09. PMID:9269989. |
moreover, neither incubation with inhibitory monoclonal antibodies against fas that completely prevented fas-induced apoptosis in these cells nor pretreatment with a monoclonal antibody to fasl affected drug-induced cell death. |
1997-09-09 |
2023-08-12 |
human |
| M Ludgate, B Jasan. Apoptosis in autoimmune and non-autoimmune thyroid disease. The Journal of pathology. vol 182. issue 2. 1997-09-08. PMID:9274519. |
an accompanying paper in this issue has addressed the question by facs and immunocytochemical analysis of fas expression and apoptosis in thyrocytes grown in culture and in intact thyroid tissues obtained from hashimoto's thyroiditis, multinodular goitre and graves' disease. |
1997-09-08 |
2023-08-12 |
mouse |
| M Ludgate, B Jasan. Apoptosis in autoimmune and non-autoimmune thyroid disease. The Journal of pathology. vol 182. issue 2. 1997-09-08. PMID:9274519. |
the overall results suggest that the degree of fas expression on target cells may determine their sensitivity to t-cell mediated cytotoxicity in the absence of perforin or granzyme directed apoptosis mechanisms. |
1997-09-08 |
2023-08-12 |
mouse |
| T Tsubat. [Mechanisms for B cell tolerance and their defects in systemic autoimmune diseases]. Nihon rinsho. Japanese journal of clinical medicine. vol 55. issue 6. 1997-09-05. PMID:9200917. |
these self-tolerance mechanisms appear to involve b cell apoptosis induced by signaling via the antigen receptor (surface immunoglobulin) or fas. |
1997-09-05 |
2023-08-12 |
mouse |
| K Becker, P Schneider, K Hofmann, C Mattmann, J Tschop. Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway. FEBS letters. vol 412. issue 1. 1997-09-05. PMID:9257699. |
fas(apo-1/cd95), a receptor belonging to the tumor necrosis factor receptor family, induces apoptosis when triggered by fas ligand. |
1997-09-05 |
2023-08-12 |
Not clear |
| B R Gochuico, M C Williams, A Fin. Simultaneous in situ hybridization and TUNEL to identify cells undergoing apoptosis. The Histochemical journal. vol 29. issue 5. 1997-09-04. PMID:9184856. |
taking advantage of the specific expression of surfactant protein c mrna in type ii alveolar epithelial cells, we demonstrate that this technique has the ability to localize alveolar type ii cells undergoing apoptosis in vivo after the intratracheal instillation of an antibody that activates the cell surface fas protein. |
1997-09-04 |
2023-08-12 |
Not clear |
| C Gratas, Y Tohma, E G Van Meir, M Klein, M Tenan, N Ishii, O Tachibana, P Kleihues, H Ohgak. Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors. Brain pathology (Zurich, Switzerland). vol 7. issue 3. 1997-09-04. PMID:9217971. |
fas/apo-1 (cd95) is a cell surface receptor that mediates apoptosis when it reacts with fas ligand (fasl) or fas antibody. |
1997-09-04 |
2023-08-12 |
human |
| C Gratas, Y Tohma, E G Van Meir, M Klein, M Tenan, N Ishii, O Tachibana, P Kleihues, H Ohgak. Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors. Brain pathology (Zurich, Switzerland). vol 7. issue 3. 1997-09-04. PMID:9217971. |
we previously reported that fas expression is predominantly induced in perinecrotic glioma cells, suggesting that fas induction is associated with apoptosis and necrosis formation, a histological hallmark of glioblastomas. |
1997-09-04 |
2023-08-12 |
human |
| C Gratas, Y Tohma, E G Van Meir, M Klein, M Tenan, N Ishii, O Tachibana, P Kleihues, H Ohgak. Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors. Brain pathology (Zurich, Switzerland). vol 7. issue 3. 1997-09-04. PMID:9217971. |
these results suggest that fasl expression is common in human astrocytic brain tumors and may cause apoptosis of glioma cells if fas expression is induced. |
1997-09-04 |
2023-08-12 |
human |
| M A Phelouzat, T Laforge, A Arbogast, R A Quadri, S Boutet, J J Prous. Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mechanisms of ageing and development. vol 96. issue 1-3. 1997-09-04. PMID:9223109. |
susceptibility to apoptosis of t lymphocytes from elderly humans is associated with increased in vivo expression of functional fas receptors. |
1997-09-04 |
2023-08-12 |
Not clear |
| M A Phelouzat, T Laforge, A Arbogast, R A Quadri, S Boutet, J J Prous. Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mechanisms of ageing and development. vol 96. issue 1-3. 1997-09-04. PMID:9223109. |
because this excessive apoptosis is unrelated to either the age-associated decrease in il-2 production, a differential bcl-2 expression or to a modification of the antioxidant pathway, we examined the possibility that the fas receptor (fasr) is directly implicated in the generation of the unwarranted death signal. |
1997-09-04 |
2023-08-12 |
Not clear |
| K Kimura, M Yamamot. Rapid induction of Fas antigen mRNA expression in vivo by cycloheximide. Cell biochemistry and function. vol 15. issue 2. 1997-09-04. PMID:9253159. |
the effect of administration into rats of cycloheximide on the expression of genes, such as tissue transglutaminase, testosterone-repressed prostate message-2, fas antigen, bcl-2, dnase i, and poly(adp-ribose) polymerase, which were believed to be involved in the mechanism of apoptosis, was studied. |
1997-09-04 |
2023-08-12 |
rat |
| A Fine, N L Anderson, T L Rothstein, M C Williams, B R Gochuic. Fas expression in pulmonary alveolar type II cells. The American journal of physiology. vol 273. issue 1 Pt 1. 1997-09-03. PMID:9252541. |
fas, a type i membrane receptor protein, transduces a signal culminating in apoptosis after binding to the fas ligand. |
1997-09-03 |
2023-08-12 |
mouse |
| A Fine, N L Anderson, T L Rothstein, M C Williams, B R Gochuic. Fas expression in pulmonary alveolar type II cells. The American journal of physiology. vol 273. issue 1 Pt 1. 1997-09-03. PMID:9252541. |
we found 1) fas gene expression in rna derived from fresh isolates of primary rat type ii cells; 2) restriction of fas expression to a subset of alveolar type ii cells by in situ hybridization and immunohistochemistry of the normal mouse lung; 3) induction of apoptosis in a mouse lung type ii epithelial cell line (mle) after activation of fas; and 4) induction of apoptosis in a subpopulation of type ii cells after the intratracheal instillation of an activating anti-fas antibody in mice. |
1997-09-03 |
2023-08-12 |
mouse |
| P A Kiener, P M Davis, B M Rankin, S J Klebanoff, J A Ledbetter, G C Starling, W C Lile. Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 4. 1997-08-28. PMID:9257817. |
human monocytes express both fas and fas ligand (fasl) on the cell surface, and the interaction of these molecules induces spontaneous apoptosis. |
1997-08-28 |
2023-08-12 |
human |
| C D Chung, L A Lewis, M C Micel. T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 4. 1997-08-28. PMID:9257838. |
tcr-induced fas ligand (fasl) expression is demonstrated to be dependent on lck sh2 and kinase activities, although fasl expression cannot be correlated with apoptosis. |
1997-08-28 |
2023-08-12 |
Not clear |
| C D Chung, L A Lewis, M C Micel. T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 4. 1997-08-28. PMID:9257838. |
together, these data indicate that tcr-induced apoptosis in bi-141 is regulated through a mechanism(s) distinct from the lck-induced expression of fas, fasl, or il-2 production. |
1997-08-28 |
2023-08-12 |
Not clear |