| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ungefroren, M Voss, M Jansen, C Roeder, D Henne-Bruns, B Kremer, H Kalthof. Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563493. |
human pancreatic adenocarcinomas express fas and fas ligand yet are resistant to fas-mediated apoptosis. |
1998-05-21 |
2023-08-12 |
human |
| H Ungefroren, M Voss, M Jansen, C Roeder, D Henne-Bruns, B Kremer, H Kalthof. Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563493. |
however, despite fas expression, pancreatic tumor cells have become largely resistant toward recombinant fasl- or anti-apo-1 agonistic antibody-induced apoptosis. |
1998-05-21 |
2023-08-12 |
human |
| F P Huang, D Xu, E O Esfandiari, W Sands, X Q Wei, F Y Lie. Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 9. 1998-05-21. PMID:9574511. |
mrl/mp-lpr/lpr (mrl/lpr) mice have a single mutation (lpr) of the fas apoptosis gene. |
1998-05-21 |
2023-08-12 |
mouse |
| F P Huang, D Xu, E O Esfandiari, W Sands, X Q Wei, F Y Lie. Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 9. 1998-05-21. PMID:9574511. |
thus, fas expression is essential for resistance against leishmaniasis, and fas-mediated apoptosis may form an integral part of the th1-mediated microbicidal function. |
1998-05-21 |
2023-08-12 |
mouse |
| S Fournel, E Robinet, N Bonnefoy-Bérard, O Assossou, M Flacher, H Waldmann, G Bismuth, J P Revillar. A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 9. 1998-05-21. PMID:9574534. |
clonal expansion of activated t and b cells is controlled by homeostatic mechanisms resulting in apoptosis of a large proportion of activated cells, mostly through interaction between cd95 (fas or apo-1) receptor and its ligand cd95-l. cd2, which is considered as a cd3/tcr alternative pathway of t cell activation, may trigger activation-induced cell death, but the role of cd95/cd95-l interaction in cd2-mediated apoptosis remains controversial. |
1998-05-21 |
2023-08-12 |
Not clear |
| L G Radvanyi, K Raju, D Spaner, G B Mills, R G Mille. Interleukin-2 reverses the defect in activation-induced apoptosis in T cells from autoimmune lpr mice. Cellular immunology. vol 183. issue 1. 1998-05-21. PMID:9578714. |
our results suggest that before the onset of severe lymphoaccumulation, activated t cells from young lpr mice possess the capability to undergo tcr-induced apoptosis despite defective fas expression; il-2 participates in sensitizing the cells to this death pathway. |
1998-05-21 |
2023-08-12 |
mouse |
| M Sioud, O Mellbye, O Førr. Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clinical and experimental rheumatology. vol 16. issue 2. 1998-05-14. PMID:9536387. |
to investigate the nuclear localization of the transcription factor nf-kappa b, the status of apoptosis and the expression of the fas antigen, fas ligand, bcl-2, bcl-xl and bax by synovial cells. |
1998-05-14 |
2023-08-12 |
Not clear |
| A E Tollefson, T W Hermiston, D L Lichtenstein, C F Colle, R A Tripp, T Dimitrov, K Toth, C E Wells, P C Doherty, W S Wol. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature. vol 392. issue 6677. 1998-05-14. PMID:9565035. |
forced degradation of fas inhibits apoptosis in adenovirus-infected cells. |
1998-05-14 |
2023-08-12 |
Not clear |
| A E Tollefson, T W Hermiston, D L Lichtenstein, C F Colle, R A Tripp, T Dimitrov, K Toth, C E Wells, P C Doherty, W S Wol. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature. vol 392. issue 6677. 1998-05-14. PMID:9565035. |
occupation of the cell-surface receptor fas, a member of the tnf-receptor superfamily that is expressed on most cell types, triggers apoptosis of that cell. |
1998-05-14 |
2023-08-12 |
Not clear |
| A E Tollefson, T W Hermiston, D L Lichtenstein, C F Colle, R A Tripp, T Dimitrov, K Toth, C E Wells, P C Doherty, W S Wol. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature. vol 392. issue 6677. 1998-05-14. PMID:9565035. |
here we show that the adenovirus rid (for receptor internalization and degradation) protein complex, which is an inhibitor of tnf-induced apoptosis, mediates internalization of cell-surface fas and its destruction inside lysosomes within the cell. |
1998-05-14 |
2023-08-12 |
Not clear |
| M Sugimoto, M Shimaoka, K Hosotsubo, H Tanigami, N Taenaka, H Kiyono, I Yoshiy. Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery. Clinical and experimental immunology. vol 112. issue 1. 1998-05-14. PMID:9566799. |
fasl, which is expressed mainly on activated lymphocytes, can induce apoptosis (programmed cell death) of cells which express fas. |
1998-05-14 |
2023-08-12 |
Not clear |
| E S Sobel, V N Kakkanaiah, J Schiffenbauer, E A Reap, P L Cohen, R A Eisenber. Novel immunoregulatory B cell pathways revealed by lpr-+ mixed chimeras. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 3. 1998-05-14. PMID:9570572. |
lpr, a murine mutation of the fas apoptosis receptor, causes lymphadenopathy and autoantibody production, with lymphadenopathy primarily due to a population of cd4-cd8-b220+ t cells. |
1998-05-14 |
2023-08-12 |
mouse |
| J Lotem, L Sach. Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 8. 1998-05-13. PMID:9539784. |
this suppression of apoptosis by a23187 or tg was associated with suppression of caspase activation but not with suppression of wild-type-p53-induced expression of waf-1, mdm-2, or fas. |
1998-05-13 |
2023-08-12 |
Not clear |
| D Hasegawa, S Kojima, E Tatsumi, A Hayakawa, Y Kosaka, H Nakamura, M Sako, Y Osugi, S Nagata, K San. Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackfan anemia. Blood. vol 91. issue 8. 1998-05-12. PMID:9531589. |
fasl binds to fas on target cells and induces apoptosis. |
1998-05-12 |
2023-08-12 |
Not clear |
| M T Esser, D M Haverstick, C L Fuller, C A Gullo, V L Bracial. Ca2+ signaling modulates cytolytic T lymphocyte effector functions. The Journal of experimental medicine. vol 187. issue 7. 1998-05-08. PMID:9529322. |
fasl/fas (cd95 ligand/cd95)-mediated cytolysis requires de novo protein synthesis of fasl by the ctl and the presence of the death receptor fas on the target cell to induce apoptosis. |
1998-05-08 |
2023-08-12 |
Not clear |
| S Sainio-Pöllänen, S Erkkilä, S Alanko, A Hänninen, P Pöllänen, O Simel. The role of Fas ligand in the development of insulitis in nonobese diabetic mice. Pancreas. vol 16. issue 2. 1998-05-07. PMID:9510138. |
the role of fas ligand-induced lymphocyte apoptosis in the development of insulitis was studied in nonobese diabetic (nod) mice. |
1998-05-07 |
2023-08-12 |
mouse |
| S Sainio-Pöllänen, S Erkkilä, S Alanko, A Hänninen, P Pöllänen, O Simel. The role of Fas ligand in the development of insulitis in nonobese diabetic mice. Pancreas. vol 16. issue 2. 1998-05-07. PMID:9510138. |
the present results on an increase in density of apoptotic cells in pancreatic islets of nod mice simultaneously with the onset of insulitis and appearance of fas ligand suggest that the pancreas infiltrating lymphocytes may be destroyed by fas ligand-induced apoptosis. |
1998-05-07 |
2023-08-12 |
mouse |
| R Takahashi, Q Deveraux, I Tamm, K Welsh, N Assa-Munt, G S Salvesen, J C Ree. A single BIR domain of XIAP sufficient for inhibiting caspases. The Journal of biological chemistry. vol 273. issue 14. 1998-05-07. PMID:9525868. |
the ring domain of xiap failed to inhibit the activity of recombinant caspases-3 or -7, whereas a fragment of xiap encompassing the three tandem bir domains potently inhibited these caspases in vitro and blocked fas (cd95)-induced apoptosis when expressed in cells. |
1998-05-07 |
2023-08-12 |
Not clear |
| M Faris, N Kokot, K Latinis, S Kasibhatla, D R Green, G A Koretzky, A Ne. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 1. 1998-05-07. PMID:9551965. |
the c-jun n-terminal kinase cascade plays a role in stress-induced apoptosis in jurkat cells by up-regulating fas ligand expression. |
1998-05-07 |
2023-08-12 |
Not clear |
| S H Lee, S Y Kim, J Y Lee, M S Shin, S M Dong, E Y Na, W S Park, K M Kim, C S Kim, S H Kim, N J Yo. Detection of soluble Fas mRNA using in situ reverse transcription-polymerase chain reaction. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564889. |
fas protein (fas) is known to induce cell death by apoptosis in susceptible cells. |
1998-05-07 |
2023-08-12 |
human |