| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catrin Heim, Leonie Hartig, Nadine Weinelt, Laura M Moser, Emilia Salzmann-Manrique, Michael Merker, Winfried S Wels, Torsten Tonn, Peter Bader, Jan-Henning Klusmann, Sjoerd J L van Wijk, Eva Rettinge. Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation. Molecular therapy. Oncology. vol 32. issue 2. 2024-05-06. PMID:38706988. |
chimeric antigen receptor (car)-based immunotherapies, such as the erbb2 (her2)-car-engineered natural killer (nk) cell line nk-92/5.28.z, provide antitumor cytotoxicity primarily through car-mediated cytotoxic granule release and thereafter-even in cases with low surface antigen expression or tumor escape-by triggering intrinsic nk cell-mediated apoptosis induction via additional ligand/receptors. |
2024-05-06 |
2024-05-08 |
Not clear |
| Monu Kumar Kashyap, Shubhada V Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B Kale, Nitu L Wankhede, Brijesh G Taksande, Aman B Upaganlawar, Milind J Umekar, Sushruta Koppula, Spandana Rajendra Kopall. Recent Perspectives on Cardiovascular Toxicity Associated with Colorectal Cancer Drug Therapy. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895912. |
the precise mechanisms underlying cardiotoxicity associated with crc treatment are complex and may involve the modulation of various signaling pathways crucial for maintaining cardiac health including tki erbb2 or nrg-1, vegf, pdgf, braf/ras/raf/mek/erk, and the pi3/erk/ampk/mtor pathway, resulting in oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis, ultimately damaging cardiac tissue. |
2023-10-30 |
2023-11-08 |
Not clear |
| Kimiya Matsuda, Daiki Hirayama, Naoya Hino, Sota Kuno, Asako Sakaue-Sawano, Atsushi Miyawaki, Michiyuki Matsuda, Kenta Tera. Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration. Journal of cell science. 2023-07-31. PMID:37519219. |
thus, the ligand-independent erbb2 activity is sufficient for preventing apoptosis at high cell density. |
2023-07-31 |
2023-08-14 |
Not clear |
| Dong Wang, Siyu Hao, Hongjie He, Jian Zhang, Ge You, Xin Wu, Rui Zhang, Xiangning Meng, Xiaobo Cui, Jing Bai, Songbin Fu, Jingcui Y. Contribution of PGAP3 co-amplified and co-overexpressed with ERBB2 at 17q12 involved poor prognosis in gastric cancer. Journal of cellular and molecular medicine. 2023-06-30. PMID:37386793. |
in vitro, knockdown of the endogenous pgap3 or erbb2 decreased cell proliferation and invasion, increased g1 phase accumulation and induced apoptosis in nci-n87 cells. |
2023-06-30 |
2023-08-14 |
Not clear |
| Sanaz Ranapour, Nasrin Motame. Effect of Silibinin on the Expression of Mir-20b, Bcl2L11, and Erbb2 in Breast Cancer Cell Lines. Molecular biotechnology. 2023-03-11. PMID:36905464. |
molecular simulation studies were carried out to analyze erbb2, as a potential target of sb, to direct the breast cancer cells toward apoptosis. |
2023-03-11 |
2023-08-14 |
Not clear |
| Jian Wang, Li Wei, Keyong Tian, Min Xu, Xiaodong Chen, Fuquan Chen, Dingjun Zha, Tao Xu. NRG1/ErbB2 axis regulated mitochondrial function and antioxidant enzymes of neural stem cells in the cochlear nucleus partially through PGC-1α. Neuroscience letters. 2022-11-03. PMID:36328292. |
neuregulin-1 (nrg1)/erythroblastic leukaemia viral oncogene homologues 2 (erbb2) pathway had been implicated in promoting differentiation and suppressing apoptosis of neuronal stem cells (nscs) isolated from cochlear nucleus. |
2022-11-03 |
2023-08-14 |
Not clear |
| Xiao-Fei Qin, Ying-Guang Shan, Min Dou, Feng-Xiang Li, Yu-Xi Gu. Notch1 signaling activation alleviates coronary microvascular dysfunction through histone modification of Nrg-1 via the interaction between NICD and GCN5. Apoptosis : an international journal on programmed cell death. 2022-10-14. PMID:36241947. |
meanwhile, the activation of the notch signaling pathway increased the levels of nrg-1 and the phosphorylation of erbb2 and erbb4, as well as inhibited the apoptosis induced by hcy. |
2022-10-14 |
2023-08-14 |
Not clear |
| Simeng Hou, Haotian Wu, Si Chen, Xubo Li, Zhenxing Zhang, Yiwen Cheng, Yuanyuan Chen, Meirong He, Qi An, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wan. Bovine skin fibroblasts mediated immune responses to defend against bovine Acinetobacter baumannii infection. Microbial pathogenesis. 2022-09-30. PMID:36179976. |
in addition, casp3 and jun were the core functional genes of apoptosis, while il-6, erbb2, egfr, chuk and mapk8 were the core functional genes of immunity by protein-protein interaction (ppi) analysis. |
2022-09-30 |
2023-08-14 |
cattle |
| Zhang Yang, Wang Yaling, Liu Tao, Rao Mingyue, Li Yongju. Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 1. 2022-07-09. PMID:35809324. |
while shrna group showed decreased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while increased caspase3 and bax expressions, as well as promoted cell proliferation and cell apoptosis when compared with the shrna nc group (p<0.05); while compared with pcdna3.1(-) nc group, pcdna3.1(-) group had highly increased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while decreased caspase3 and bax expressions, inhibited cell proliferation and cell apoptosis (all p<0.05). |
2022-07-09 |
2023-08-14 |
rat |
| Ekaterina Kots, Coraline Mlynarczyk, Ari Melnick, George Khelashvil. Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical journal. 2022-04-23. PMID:35459639. |
b-cell translocation gene 1 (btg1) protein belongs to the btg/tob (transducer of erbb2) family of antiproliferative proteins whose members regulate various key cellular processes such as cell cycle progression, apoptosis, and differentiation. |
2022-04-23 |
2023-08-13 |
Not clear |
| Bharti Sharma, Vikram Jeet Singh, Pooja A Chawl. Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34628226. |
epidermal growth factor receptor (egfr) is a vital intermediate in cell signaling pathway including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having four divergent members with similar structural features, such as egfr (her1/erbb1), erbb2 (her2/neu), erbb3 (her3), and erbb4 (her4). |
2021-11-15 |
2023-08-13 |
Not clear |
| Angel Y F Kam, Sadhna O Piryani, Chang-Lung Lee, David A Rizzieri, Neil L Spector, Stefanie Sarantopoulos, Phuong L Doa. Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells. Molecular cancer research : MCR. vol 19. issue 5. 2021-11-02. PMID:33514658. |
selective erbb2 and bcl2 inhibition is synergistic for mitochondrial-mediated apoptosis in mds and aml cells. |
2021-11-02 |
2023-08-13 |
Not clear |
| Jie Cui, Jiale Tian, Weiwei Wang, Tao He, Xin Li, Chenzheng Gu, Lixin Wang, Jian Wu, Anquan Shan. IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism. Cancer science. vol 112. issue 10. 2021-10-07. PMID:34309973. |
high expressions of igf2bp2, yap, and erbb2 promoted the proliferation, migration and invasion of crc cells and reduced their apoptosis. |
2021-10-07 |
2023-08-13 |
mouse |
| Jie Cui, Jiale Tian, Weiwei Wang, Tao He, Xin Li, Chenzheng Gu, Lixin Wang, Jian Wu, Anquan Shan. IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism. Cancer science. vol 112. issue 10. 2021-10-07. PMID:34309973. |
therefore, igf2bp2 promoted the expression of erbb2 to enhance the proliferation, invasion and migration of crc cells, to repress cell apoptosis, and to promote solid tumor formation in nude mice. |
2021-10-07 |
2023-08-13 |
mouse |
| Jie Cui, Jiale Tian, Weiwei Wang, Tao He, Xin Li, Chenzheng Gu, Lixin Wang, Jian Wu, Anquan Shan. IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism. Cancer science. vol 112. issue 10. 2021-10-07. PMID:34309973. |
igf2bp2 activates the expression of erbb2 by recognizing the m6a of yap, thus affecting the cell cycle of crc, inhibiting cell apoptosis, and promoting proliferation. |
2021-10-07 |
2023-08-13 |
mouse |
| Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Cade Owens, Kumuda C Da. Nrg1β Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy. Arteriosclerosis, thrombosis, and vascular biology. vol 41. issue 8. 2021-08-30. PMID:34039018. |
mitochondrial trx2 (thioredoxin) is degraded in i/r, butrescue of erbb2 by nrg1β prevents trx-2 degradation that decreased myocardial apoptosis in i/r.conclusions: nrg1β is a ripc factor that interacts with endothelial erbb2 and prevents its degradation, which in turnprevents trx2 degradation due to phosphorylation and inactivation of atg5 (autophagy-related 5) by erbb2. |
2021-08-30 |
2024-02-28 |
Not clear |
| Alexi Surette, Byong Hoon Yoo, Tallal Younis, Kara Matheson, Tarek Rameh, Jaime Snowdon, Gillian Bethune, Kirill V Rose. Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. Breast cancer research and treatment. vol 187. issue 3. 2021-06-23. PMID:33728523. |
we found previously that erbb2 blocks breast tumor cell anoikis, apoptosis induced by cell detachment from the extracellular matrix, by downregulating the pro-apoptotic protein irf6 and upregulating the anti-apoptotic protein epidermal growth factor receptor (egfr) in the cells and, thus, promotes their three-dimensional growth. |
2021-06-23 |
2023-08-13 |
Not clear |
| Vijaya Lakshmi Bodiga, Praveen Kumar Vemuri, Greeshma Nimmagadda, Sreedhar Bodig. Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation. Biological chemistry. vol 401. issue 11. 2021-06-15. PMID:32549180. |
myocardial zinc dyshomeostasis is associated with caspase-3 activation, erbb2 degradation and apoptosis during hypoxia/reoxygenation. |
2021-06-15 |
2023-08-13 |
Not clear |
| Vijaya Lakshmi Bodiga, Praveen Kumar Vemuri, Greeshma Nimmagadda, Sreedhar Bodig. Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation. Biological chemistry. vol 401. issue 11. 2021-06-15. PMID:32549180. |
zinc depletion using tpen also resulted in lowered erbb2 and increased apoptosis, along with nox2 mrna upregulation, increased oxidative and er stress. |
2021-06-15 |
2023-08-13 |
Not clear |
| Fuhai Li, Jingfeng Wang, Yu Song, Dongli Shen, Yongchao Zhao, Chaofu Li, Mingqiang Fu, Yanyan Wang, Baozheng Qi, Xueting Han, Aijun Sun, Jingmin Zhou, Junbo G. Qiliqiangxin alleviates Ang II-induced CMECs apoptosis by downregulating autophagy via the ErbB2-AKT-FoxO3a axis. Life sciences. vol 273. 2021-04-07. PMID:33652033. |
furthermore, inhibition of erbb2 phosphorylation with lapatinib in cmecs revealed that qlqx-induced downregulation of ang ii-activated autophagy and apoptosis was erbb2 phosphorylation-dependent via the akt-foxo3a axis. |
2021-04-07 |
2023-08-13 |
Not clear |