| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Yasuda, C D'Sa-Eipper, X L Gong, G Chinnadura. Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog. Oncogene. vol 17. issue 19. 1998-12-10. PMID:9824163. |
transfection of cebnip3 and ced-3 results in enhanced proteolytic processing of the ced-3 zymogen and in cooperative induction of apoptosis. |
1998-12-10 |
2023-08-12 |
human |
| M Yasuda, C D'Sa-Eipper, X L Gong, G Chinnadura. Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog. Oncogene. vol 17. issue 19. 1998-12-10. PMID:9824163. |
in cells coexpressing ced-9, cebnip3 and ced-3, all three proteins exist as a ternary complex suggesting that ced-9 may suppress cooperative apoptosis induced by ced-3 and cebnip3 by simultaneous complex formation with ced-3 and cebnip3. |
1998-12-10 |
2023-08-12 |
human |
| M Yasuda, C D'Sa-Eipper, X L Gong, G Chinnadura. Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog. Oncogene. vol 17. issue 19. 1998-12-10. PMID:9824163. |
our results suggest that cebnip3 may be a novel component of the c. elegans apoptosis paradigm and may initiate apoptosis by recruiting ced-3 to mitochondria and other cytoplasmic membranes. |
1998-12-10 |
2023-08-12 |
human |
| J Han, H D Wallen, G Nuñez, E Whit. E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis. Molecular and cellular biology. vol 18. issue 10. 1998-11-05. PMID:9742122. |
this trimolecular complex of ced-4, ced-3, and ced-9 is functional in that ced-9 inhibits ced-4 from activating ced-3 and thereby inhibits apoptosis in heterologous systems. |
1998-11-05 |
2023-08-12 |
caenorhabditis_elegans |
| X Yang, H Y Chang, D Baltimor. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science (New York, N.Y.). vol 281. issue 5381. 1998-09-09. PMID:9721101. |
essential role of ced-4 oligomerization in ced-3 activation and apoptosis. |
1998-09-09 |
2023-08-12 |
caenorhabditis_elegans |
| R W Watson, O D Rotstein, J Parodo, R Bitar, J C Marshall, R William, G Watso. The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 2. 1998-07-30. PMID:9670975. |
it processes newly synthesized pro-il-1 beta to yield the active cytokine and, as the human homologue of the caenorhabditis elegans gene product, ced-3, it also induces cellular apoptosis through the cleavage of key intracellular structural and regulatory proteins and through the catalytic activation of other caspase family members. |
1998-07-30 |
2023-08-12 |
human |
| E W Humke, J Ni, V M Dixi. ERICE, a novel FLICE-activatable caspase. The Journal of biological chemistry. vol 273. issue 25. 1998-07-09. PMID:9624166. |
the caspase family of mammalian proteases, related to the nematode death protein ced-3, plays a crucial role in apoptosis and inflammation. |
1998-07-09 |
2023-08-12 |
human |
| R A Jones, V L Johnson, N R Buck, M Dobrota, R H Hinton, S C Chow, G E Kas. Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. Hepatology (Baltimore, Md.). vol 27. issue 6. 1998-06-30. PMID:9620337. |
investigation of the in situ proteolytic cleavage of the ced-3 related caspases substrate, poly(adp-ribose) polymerase, revealed that this protein was not degraded in hepatocytes undergoing fas-mediated apoptosis. |
1998-06-30 |
2023-08-12 |
mouse |
| V J Kid. Proteolytic activities that mediate apoptosis. Annual review of physiology. vol 60. 1998-06-12. PMID:9558476. |
the discovery that the ced-3 gene of caenorhabditis elegans encodes a cysteine protease essential for developmentally regulated apoptosis ignited interest in this area of research. |
1998-06-12 |
2023-08-12 |
caenorhabditis_elegans |
| T Koseki, N Inohara, S Chen, G Núñe. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 9. 1998-06-04. PMID:9560245. |
arc inhibited apoptosis induced by caspase-8 and ced-3 but not that mediated by caspase-9. |
1998-06-04 |
2023-08-12 |
human |
| W W Won. ICE family proteases in inflammation and apoptosis. Agents and actions. Supplements. vol 49. 1998-01-29. PMID:9426822. |
subsequent revelation that a c. elegans cell death gene ced-3 bears sequence homology to ice has led to rapid identification of at least nine other members of this gene family in humans, some of which are involved in apoptosis. |
1998-01-29 |
2023-08-12 |
mouse |
| N A Thornberr. The caspase family of cysteine proteases. British medical bulletin. vol 53. issue 3. 1997-12-09. PMID:9374032. |
the discovery that ced-3, the product of a gene necessary for programmed cell death in the nematode caenorhabditis elegans, is related to the mammalian cysteine protease interleukin-1 beta converting enzyme (ice/caspase-1) has led to intense interest in the role of proteases in apoptosis. |
1997-12-09 |
2023-08-12 |
human |
| Z Estrov, M Talpa. Role of interleukin-1 beta converting enzyme (ICE) in leukemia. Cytokines and molecular therapy. vol 2. issue 1. 1997-12-08. PMID:9384684. |
although ice was first thought to be a unique enzyme with a single biologic activity, several investigators have demonstrated that ice shares sequence homology with the protein product of ced-3, the gene for cell death of the nematode caenorhabditis elegans, and can induce apoptosis in different cellular systems. |
1997-12-08 |
2023-08-12 |
caenorhabditis_elegans |
| H R Stennicke, G S Salvese. Biochemical characteristics of caspases-3, -6, -7, and -8. The Journal of biological chemistry. vol 272. issue 41. 1997-11-13. PMID:9325297. |
the observation that the nematode cell death effector gene product ced-3 is homologous to human interleukin-1beta-converting enzyme (caspase-1) has led to the discovery of at least nine other human caspases, many of which are implicated as mediators of apoptosis. |
1997-11-13 |
2023-08-12 |
human |
| D Wu, H D Wallen, N Inohara, G Nuñe. Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9. The Journal of biological chemistry. vol 272. issue 34. 1997-09-15. PMID:9261161. |
expression of wild-type ced-4 promotes the ability of ced-3 to induce apoptosis in mammalian cells, which is inhibited by ced-9. |
1997-09-15 |
2023-08-12 |
caenorhabditis_elegans |
| S Seshagiri, L K Mille. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis. Current biology : CB. vol 7. issue 7. 1997-08-28. PMID:9210374. |
caenorhabditis elegans ced-4 stimulates ced-3 processing and ced-3-induced apoptosis. |
1997-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| S Seshagiri, L K Mille. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis. Current biology : CB. vol 7. issue 7. 1997-08-28. PMID:9210374. |
genetic studies in the nematode c. elegans have identified three key genes involved in apoptosis, ced-3, ced-4 and ced-9. |
1997-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| N A Thornberry, T A Rano, E P Peterson, D M Rasper, T Timkey, M Garcia-Calvo, V M Houtzager, P A Nordstrom, S Roy, J P Vaillancourt, K T Chapman, D W Nicholso. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. The Journal of biological chemistry. vol 272. issue 29. 1997-08-18. PMID:9218414. |
the specificity of caspases 2, 3, and 7 and caenorhabditis elegans ced-3 (dexd) suggests that all of these enzymes function to incapacitate essential homeostatic pathways during the effector phase of apoptosis. |
1997-08-18 |
2023-08-12 |
caenorhabditis_elegans |
| R W Keane, A Srinivasan, L M Foster, M P Testa, T Ord, D Nonner, H G Wang, J C Reed, D E Bredesen, C Kayala. Activation of CPP32 during apoptosis of neurons and astrocytes. Journal of neuroscience research. vol 48. issue 2. 1997-07-24. PMID:9130145. |
cell extracts from neurons induced to undergo apoptosis contained ice/ ced-3 protease activity. |
1997-07-24 |
2023-08-12 |
Not clear |
| Z Estrov, M Talpa. Role of interleukin-1 beta converting enzyme (ICE) in acute myelogenous leukemia cell proliferation and programmed cell death. Leukemia & lymphoma. vol 24. issue 5-6. 1997-07-08. PMID:9086432. |
although ice was first thought to be a unique enzyme with a single biologic activity, several investigators have demonstrated that ice shares sequence homology with the protein product of ced-3, the gene for cell death of the nematode caenorhabditis elegans, and induces apoptosis in different experimental models. |
1997-07-08 |
2023-08-12 |
caenorhabditis_elegans |