| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Vasilakos, T Ghayur, R T Carroll, D A Giegel, J M Saunders, L Quintal, K M Keane, B D Shiver. IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line. Journal of immunology (Baltimore, Md. : 1950). vol 155. issue 7. 1995-10-27. PMID:7561038. |
the cysteine protease, il-1 beta converting enzyme (ice), is implicated in apoptosis based on its structural similarity to the pcd gene, ced-3, in caenorhabditis elegans and the induction of pcd in fibroblasts transfected with recombinant ice. |
1995-10-27 |
2023-08-12 |
caenorhabditis_elegans |
| D Xue, H R Horvit. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature. vol 377. issue 6546. 1995-10-17. PMID:7675111. |
here we show that p35 protein is a substrate for and inhibitor of the caenorhabditis elegans cell-death protease ced-3 (refs 6, 7) and a substrate for four ced-3-like vertebrate cysteine protease activities implicated in apoptosis in mammals. |
1995-10-17 |
2023-08-12 |
caenorhabditis_elegans |
| D Xue, H R Horvit. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature. vol 377. issue 6546. 1995-10-17. PMID:7675111. |
introduction of the ced-3 cleavage site in p35 into the cowpox virus protein crma, which inhibits mammalian apoptosis but not programmed cell death in c. elegans, caused crma to block ced-3-mediated cell death. |
1995-10-17 |
2023-08-12 |
caenorhabditis_elegans |
| S Kuma. ICE-like proteases in apoptosis. Trends in biochemical sciences. vol 20. issue 5. 1995-08-17. PMID:7610484. |
the discovery of structural and functional similarities between the product of the nematode cell-death gene ced-3 and mammalian interleukin-1 beta-converting enzyme (ice) is providing important insights into the molecular mechanism of apoptosis. |
1995-08-17 |
2023-08-12 |
Not clear |
| M Los, M Van de Craen, L C Penning, H Schenk, M Westendorp, P A Baeuerle, W Dröge, P H Krammer, W Fiers, K Schulze-Osthof. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature. vol 375. issue 6526. 1995-05-25. PMID:7536901. |
we report here that fas/apo-1-mediated apoptosis requires the activation of a new class of cysteine proteases, including interleukin-1 beta-converting enzyme (ice), which are homologous to the product of the caenorhabditis elegans cell-death gene ced-3 (refs 11, 12). |
1995-05-25 |
2023-08-12 |
caenorhabditis_elegans |
| M Irmler, S Hertig, H R MacDonald, R Sadoul, J D Becherer, A Proudfoot, R Solari, J Tschop. Granzyme A is an interleukin 1 beta-converting enzyme. The Journal of experimental medicine. vol 181. issue 5. 1995-05-25. PMID:7722467. |
apoptosis is critically dependent on the presence of the ced-3 gene in caenorhabditis elegans, which encodes a protein homologous to the mammalian interleukin (il)-1 beta-converting enzyme (ice). |
1995-05-25 |
2023-08-12 |
caenorhabditis_elegans |
| M Irmler, S Hertig, H R MacDonald, R Sadoul, J D Becherer, A Proudfoot, R Solari, J Tschop. Granzyme A is an interleukin 1 beta-converting enzyme. The Journal of experimental medicine. vol 181. issue 5. 1995-05-25. PMID:7722467. |
overexpression of ice or ced-3 promotes apoptosis. |
1995-05-25 |
2023-08-12 |
caenorhabditis_elegans |
| P Li, H Allen, S Banerjee, S Franklin, L Herzog, C Johnston, J McDowell, M Paskind, L Rodman, J Salfel. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell. vol 80. issue 3. 1995-03-20. PMID:7859282. |
ice is homologous to other proteins that have been implicated in apoptosis, including ced-3 and nedd-2/lch-1. |
1995-03-20 |
2023-08-12 |
mouse |
| M Tewari, V M Dixi. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. The Journal of biological chemistry. vol 270. issue 7. 1995-03-15. PMID:7531702. |
ice, by virtue of its homology to the caenorhabditis elegans cell death protein ced-3, has been suggested to play a fundamentally important role in mammalian apoptosis. |
1995-03-15 |
2023-08-12 |
caenorhabditis_elegans |
| S Kumar, M Kinoshita, M Noda, N G Copeland, N A Jenkin. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes & development. vol 8. issue 14. 1994-12-01. PMID:7958843. |
induction of apoptosis by the mouse nedd2 gene, which encodes a protein similar to the product of the caenorhabditis elegans cell death gene ced-3 and the mammalian il-1 beta-converting enzyme. |
1994-12-01 |
2023-08-12 |
mouse |
| S Kumar, M Kinoshita, M Noda, N G Copeland, N A Jenkin. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes & development. vol 8. issue 14. 1994-12-01. PMID:7958843. |
both ice and ced-3 are known to encode putative cysteine proteases and induce apoptosis when overexpressed in cultured cells. |
1994-12-01 |
2023-08-12 |
mouse |
| S Kumar, M Kinoshita, M Noda, N G Copeland, N A Jenkin. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes & development. vol 8. issue 14. 1994-12-01. PMID:7958843. |
overexpression of nedd2 in cultured fibroblast and neuroblastoma cells also resulted in cell death by apoptosis, which was suppressed by the expression of the human bcl-2 gene, indicating that nedd2 is functionally similar to the ced-3 gene in c. elegans. |
1994-12-01 |
2023-08-12 |
mouse |
| N P Walker, R V Talanian, K D Brady, L C Dang, N J Bump, C R Ferenz, S Franklin, T Ghayur, M C Hackett, L D Hammil. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Cell. vol 78. issue 2. 1994-09-01. PMID:8044845. |
ice is homologous to the c. elegans cell death gene product, ced-3, and these may represent a novel class of cytoplasmic cysteine proteases that are important in programmed cell death (apoptosis). |
1994-09-01 |
2023-08-12 |
human |
| M Miura, H Zhu, R Rotello, E A Hartwieg, J Yua. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell. vol 75. issue 4. 1993-12-29. PMID:8242741. |
induction of apoptosis in fibroblasts by il-1 beta-converting enzyme, a mammalian homolog of the c. elegans cell death gene ced-3. |
1993-12-29 |
2023-08-12 |
mouse |