| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher P Reina, Monica Driscoll, Christopher V Gabe. Neuronal repair: Apoptotic proteins make good. Worm. vol 2. issue 2. 2013-09-23. PMID:24058867. |
other upstream regulators of apoptosis do not influence regeneration, indicating the existence of a novel mechanism for activation of ced-4 and ced-3 in neuronal repair. |
2013-09-23 |
2023-08-12 |
caenorhabditis_elegans |
| Daniel P Denning, Victoria Hatch, H Robert Horvit. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS genetics. vol 9. issue 3. 2013-06-13. PMID:23505386. |
the c. elegans genome contains four caspase genes (ced-3, csp-1, csp-2, and csp-3), of which only ced-3 has been demonstrated to promote apoptosis. |
2013-06-13 |
2023-08-12 |
caenorhabditis_elegans |
| Daniel P Denning, Victoria Hatch, H Robert Horvit. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS genetics. vol 9. issue 3. 2013-06-13. PMID:23505386. |
unlike ced-3, csp-1 is not regulated by the apaf-1 homolog ced-4 or the bcl-2 homolog ced-9, revealing that csp-1 functions independently of the canonical genetic pathway for apoptosis. |
2013-06-13 |
2023-08-12 |
caenorhabditis_elegans |
| Daniel P Denning, Victoria Hatch, H Robert Horvit. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS genetics. vol 9. issue 3. 2013-06-13. PMID:23505386. |
we conclude that both caspase-dependent and caspase-independent pathways promote apoptotic programmed cell death and the phagocytosis of cell corpses in parallel to the canonical apoptosis pathway involving ced-3 activation. |
2013-06-13 |
2023-08-12 |
caenorhabditis_elegans |
| Aymeric Bailly, Anton Gartne. Germ cell apoptosis and DNA damage responses. Advances in experimental medicine and biology. vol 757. 2012-11-29. PMID:22872480. |
we are only beginning to understand how these pathways that all require the ced-9/bcl-2, apaf-1/ced-4 and ced-3 caspase core apoptosis components are regulated. |
2012-11-29 |
2023-08-12 |
mouse |
| Chun-Yi Huang, Jia-Yun Chen, Shu-Chun Wu, Chieh-Hsiang Tan, Ruei-Ying Tzeng, Pei-Ju Lu, Yu-Feng Wu, Ruey-Hwa Chen, Yi-Chun W. C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase. PloS one. vol 7. issue 5. 2012-09-19. PMID:22590572. |
in addition, the loss of eif-3.k significantly suppressed cell death-induced through the overexpression of ced-4, but not ced-3, indicating a distinct requirement for eif-3.k in apoptosis. |
2012-09-19 |
2023-08-12 |
human |
| Shun-Chang Wang, Zhi-Zhong Geng, Yun Wang, Zhong-Hua Tong, Han-Qing Y. Essential roles of p53 and MAPK cascades in microcystin-LR-induced germline apoptosis in Caenorhabditis elegans. Environmental science & technology. vol 46. issue 6. 2012-09-13. PMID:22353034. |
germline apoptosis was absent at all doses in ced-3 and ced-4 loss-of-function strains. |
2012-09-13 |
2023-08-12 |
caenorhabditis_elegans |
| Shun-Chang Wang, Zhi-Zhong Geng, Yun Wang, Zhong-Hua Tong, Han-Qing Y. Essential roles of p53 and MAPK cascades in microcystin-LR-induced germline apoptosis in Caenorhabditis elegans. Environmental science & technology. vol 46. issue 6. 2012-09-13. PMID:22353034. |
our results show that the caspase protein ced-3 and apaf-1 protein ced-4 were absolutely required for the apoptotic processes, and that the p53/cep-1 and mapks cascades played essential roles in modulating mc-lr-induced germline apoptosis in c. elegans. |
2012-09-13 |
2023-08-12 |
caenorhabditis_elegans |
| Berangere Pinan-Lucarre, Christopher V Gabel, Christopher P Reina, S Elizabeth Hulme, Sergey S Shevkoplyas, R Daniel Slone, Jian Xue, Yujie Qiao, Sarah Weisberg, Kevin Roodhouse, Lin Sun, George M Whitesides, Aravinthan Samuel, Monica Driscol. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS biology. vol 10. issue 5. 2012-08-24. PMID:22629231. |
the ced-3 activator, ced-4/apaf-1, similarly promotes regeneration, but the upstream regulators of apoptosis ced-9/bcl2 and bh3-domain proteins egl-1 and ced-13 are not essential. |
2012-08-24 |
2023-08-12 |
caenorhabditis_elegans |
| Qin-Li Ruan, Jing-Juan Ju, Yun-Hui Li, Xiao-Bo Li, Ran Liu, Ge-Yu Liang, Juan Zhang, Yue-Pu Pu, Da-Yong Wang, Li-Hong Yi. Chlorpyrifos exposure reduces reproductive capacity owing to a damaging effect on gametogenesis in the nematode Caenorhabditis elegans. Journal of applied toxicology : JAT. vol 32. issue 7. 2012-08-20. PMID:22180373. |
moreover, expression patterns of the genes spe-10, spe-15, fer-1, prg-1, glp-1, mlh-1, cyb-3, ced-3, ced-4 and ced-9 (which are associated with spermatid size, spermatid activation and morphology, oocyte morphology, oocyte function, and apoptosis) were altered after chlorpyrifos exposure. |
2012-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Chia-Hui Lee, Huang-Meng Chen, Li-Ke Yeh, Meng-Yen Hong, Guewha Steven Huan. Dosage-dependent induction of behavioral decline in Caenorhabditis elegans by long-term treatment of static magnetic fields. Journal of radiation research. vol 53. issue 1. 2012-06-22. PMID:22302042. |
the induction of apoptosis was verified by the increase of fluorescence in a terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assay, by the caspase-3 activity assay, and by immunostaining using an antibody against the ced-3 gene product. |
2012-06-22 |
2023-08-12 |
caenorhabditis_elegans |
| Chia-Hui Lee, Huang-Meng Chen, Li-Ke Yeh, Meng-Yen Hong, Guewha Steven Huan. Dosage-dependent induction of behavioral decline in Caenorhabditis elegans by long-term treatment of static magnetic fields. Journal of radiation research. vol 53. issue 1. 2012-06-22. PMID:22302042. |
mutations in genes involved in major apoptotic pathways, that is, ced-3, ced-4, and ced-9, abolished this smf-induced behavioral decline; this is consistent with the hypothesis that the apoptosis pathways are involved in the smf-induced mobility decline. |
2012-06-22 |
2023-08-12 |
caenorhabditis_elegans |
| E Pourkarimi, S Greiss, A Gartne. Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21886181. |
in c. elegans, the bh3-only domain protein egl-1, the apaf-1 homolog ced-4 and the ced-3 caspase are required for apoptosis induction, whereas the bcl-2 homolog ced-9 prevents apoptosis. |
2012-06-08 |
2023-08-12 |
caenorhabditis_elegans |
| Vince Contreras, Andrew J Friday, J Kaitlin Morrison, Enhui Hao, Brett D Keipe. Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. PloS one. vol 6. issue 9. 2012-01-05. PMID:21909434. |
genetic evidence confirmed that apoptosis induced by loss of ifg-1 p170 mrna was caspase (ced-3) and apoptosome (ced-4/apaf-1) dependent. |
2012-01-05 |
2023-08-12 |
caenorhabditis_elegans |
| Shin Sik Cho. High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction. Nutrition research and practice. vol 5. issue 3. 2011-11-10. PMID:21779524. |
mutation of core apoptotic regulatory genes, ced-3 and ced-4, inhibited the reduction of viability induced by high glucose diet, which indicates that these regulators were required for glucose-induced apoptosis or lifespan shortening. |
2011-11-10 |
2023-08-12 |
caenorhabditis_elegans |
| Hanhua Hu, Jinfeng Kang, Rong Chen, Wulamu Mamuti, Guizhen Wu, Wumei Yua. Drug-induced apoptosis of Echinococcus granulosus protoscoleces. Parasitology research. vol 109. issue 2. 2011-11-07. PMID:21365454. |
our results implied the existence of a ced-3 like apoptosis gene in protoscolces and provide a rationale for further exploring the induction of apoptosis as non-surgical treatment method in treating this parasitic disease. |
2011-11-07 |
2023-08-12 |
Not clear |
| W O Pereira, G P Amarante-Mende. Apoptosis: a programme of cell death or cell disposal? Scandinavian journal of immunology. vol 73. issue 5. 2011-06-14. PMID:21223349. |
inactivation of ced-3 gene prevents developmental cell death in the worm, an observation that reinforces the notion that apoptosis holds the switch between life and death. |
2011-06-14 |
2023-08-12 |
caenorhabditis_elegans |
| W O Pereira, G P Amarante-Mende. Apoptosis: a programme of cell death or cell disposal? Scandinavian journal of immunology. vol 73. issue 5. 2011-06-14. PMID:21223349. |
in mammals, proteins homologous to ced-3, members of the family collectively called caspases, are considered the executioner proteases responsible for generating fundamentally all aspects of apoptosis. |
2011-06-14 |
2023-08-12 |
caenorhabditis_elegans |
| R Nehme, P Grote, T Tomasi, S Löser, H Holzkamp, R Schnabel, B Conrad. Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell death and differentiation. vol 17. issue 8. 2010-10-26. PMID:20150917. |
we found that in the cems, the transcriptional activation of both the egl-1 and ced-3 gene is necessary for apoptosis induction. |
2010-10-26 |
2023-08-12 |
caenorhabditis_elegans |
| Akihisa Nakagawa, Yong Shi, Eriko Kage-Nakadai, Shohei Mitani, Ding Xu. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (New York, N.Y.). vol 328. issue 5976. 2010-04-30. PMID:20223951. |
dcr-1 was cleaved by the ced-3 caspase to generate a c-terminal fragment with deoxyribonuclease activity, which produced 3' hydroxyl dna breaks on chromosomes and promoted apoptosis. |
2010-04-30 |
2023-08-12 |
caenorhabditis_elegans |