| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Geng, Q H Zhou, E Kage-Nakadai, Y Shi, N Yan, S Mitani, D Xu. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell death and differentiation. vol 16. issue 10. 2009-12-22. PMID:19575016. |
we found that csp-3, a caspase homolog that blocks ced-3 autoactivation and apoptosis in somatic cells, does not affect apoptosis in germ cells. |
2009-12-22 |
2023-08-12 |
caenorhabditis_elegans |
| Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, Chonglin Yan. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Molecular and cellular biology. vol 29. issue 14. 2009-07-13. PMID:19414600. |
in cells destined to die, egl-1 binds to ced-9 and results in the release of ced-4 from the mitochondrion-tethered ced-9-ced-4 complex to the perinucleus, which facilitates processing of the ced-3 caspase to cause apoptosis. |
2009-07-13 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Lijun Wu, Yun Wang, Xun Luo, Yun L. Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades. Chemico-biological interactions. vol 180. issue 2. 2009-06-26. PMID:19497412. |
the knockout of the caspase gene ced-3 and the apaf-1 homolog ced-4 abrogated both copper-induced and physiological germline apoptosis. |
2009-06-26 |
2023-08-12 |
caenorhabditis_elegans |
| J Li, J Yua. Caspases in apoptosis and beyond. Oncogene. vol 27. issue 48. 2008-11-14. PMID:18931687. |
the demonstration of protein sequence and functional homology of the caenorhabditis elegans programmed cell death gene product, ced-3, with human caspase-1 in 1993 triggered an explosion of research activities toward the understanding of molecular mechanisms of apoptosis. |
2008-11-14 |
2023-08-12 |
human |
| Xin Geng, Yong Shi, Akihisa Nakagawa, Sawako Yoshina, Shohei Mitani, Yigong Shi, Ding Xu. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nature structural & molecular biology. vol 15. issue 10. 2008-10-27. PMID:18776901. |
inhibition of ced-3 zymogen activation and apoptosis in caenorhabditis elegans by caspase homolog csp-3. |
2008-10-27 |
2023-08-12 |
caenorhabditis_elegans |
| Xin Geng, Yong Shi, Akihisa Nakagawa, Sawako Yoshina, Shohei Mitani, Yigong Shi, Ding Xu. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nature structural & molecular biology. vol 15. issue 10. 2008-10-27. PMID:18776901. |
here we show that inactivation of the c. elegans csp-3 gene, which encodes a protein similar to the small subunit of the ced-3 caspase, causes cells that normally live to undergo apoptosis in a ced-3-dependent manner. |
2008-10-27 |
2023-08-12 |
caenorhabditis_elegans |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
these results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the dna damage response (ddr) genes hus-1, clk-2, and egl-1 and that the c. elegans caspase gene ced-3, apaf-1 homologue ced-4, and the mapk signaling pathways are essential for germline apoptosis. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Anton Gartner, Peter R Boag, T Keith Blackwel. Germline survival and apoptosis. WormBook : the online review of C. elegans biology. 2008-09-22. PMID:18781708. |
germline apoptosis shares with somatic apoptosis a reliance on key components of the core apoptotic machinery, including ced-3 and ced-4. |
2008-09-22 |
2023-08-12 |
caenorhabditis_elegans |
| E S Blum, M Driscoll, S Shaha. Noncanonical cell death programs in the nematode Caenorhabditis elegans. Cell death and differentiation. vol 15. issue 7. 2008-08-28. PMID:18437162. |
genetic studies of the nematode caenorhabditis elegans have uncovered four genes, egl-1 (bh3 only), ced-9 (bcl-2 related), ced-4 (apoptosis protease activating factor-1), and ced-3 (caspase), which function in a linear pathway to promote developmental cell death in this organism. |
2008-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. |
egl-1 and ced-13 proteins inactivate bcl-2 like ced-9 to trigger ced-4 and ced-3 caspase dependent germ cell apoptosis. |
2008-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
however, in contrast to lin-35, dpl-1 (and probably also efl-1 and efl-2) promotes germ cell apoptosis by inducing the expression of the pro-apoptotic genes ced-4 and ced-3, which encode an apaf1-like adaptor protein and a pro-caspase, respectively. |
2008-02-15 |
2023-08-12 |
human |
| Rebecca C Taylor, Gabriela Brumatti, Shu Ito, Michael O Hengartner, W Brent Derry, Seamus J Marti. Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. The Journal of biological chemistry. vol 282. issue 20. 2007-07-18. PMID:17371877. |
notably, the endoplasmic reticulum chaperone calreticulin, which has been implicated in the recognition of apoptotic cells by phagocytes, was cleaved by ced-3 and was also cleaved by human caspases during apoptosis. |
2007-07-18 |
2023-08-12 |
human |
| Jasper Harris, Mia Lowden, Iuval Clejan, Monika Tzoneva, James H Thomas, Jonathan Hodgkin, Shawn Ahme. Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants. Genetics. vol 174. issue 2. 2007-01-05. PMID:16951081. |
although dna-damage-induced apoptosis is abrogated in the mrt-2, hus-1, and clk-2 mutant backgrounds, lack of the apoptotic branch of the dna damage response pathway in cep-1/p53, ced-3, and ced-4 mutants did not result in a mutator phenotype. |
2007-01-05 |
2023-08-12 |
caenorhabditis_elegans |
| Soo-Ung Lee, Sun Hu. Cloning of the novel putative apoptosis-related gene of Spirometra erinacei (Order Pseudophyllidae). The Korean journal of parasitology. vol 44. issue 3. 2006-10-17. PMID:16969061. |
we cloned the novel putative apoptosis-associated gene from s. erinacei via screening of a s. erinacei cdna library with a ced-3 gene (activator of apoptosis) probe from caenorhabditis elegans. |
2006-10-17 |
2023-08-12 |
caenorhabditis_elegans |
| W D Fairlie, M A Perugini, M Kvansakul, L Chen, D C S Huang, P M Colma. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell death and differentiation. vol 13. issue 3. 2006-04-20. PMID:16167070. |
in cells undergoing apoptosis, the bcl-2 homology domain 3 (bh3)-only protein egl-1 binds to ced-9 at the mitochondrial membrane to cause the release of ced-4, which oligomerises and facilitates the activation of the caspase ced-3. |
2006-04-20 |
2023-08-12 |
caenorhabditis_elegans |
| A A Conti, D Lippi, G F Gensin. The historical evolution of the concept of apoptosis in rheumatic diseases. Reumatismo. vol 57. issue 1. 2006-01-19. PMID:15776148. |
in the '80s ced-3 was described and at the beginning of the '90s apoptosis genes were identified. |
2006-01-19 |
2023-08-12 |
chicken |
| G V Putcha, E M Johnso. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:14647239. |
their studies of lineage determination in worms established the 'central dogma' of apoptosis: the bh3-only protein egl-1 is induced in cells destined to die, interacts with the bcl-2-like inhibitor ced-9, displacing the adaptor ced-4, which then promotes activation of the caspase ced-3. |
2004-08-25 |
2023-08-12 |
human |
| Takako Takanami, Yongzhao Zhang, Hidetoshi Aoki, Tomoko Abe, Shigeo Yoshida, Hideyuki Takahashi, Saburo Horiuchi, Atsushi Higashitan. Efficient repair of DNA damage induced by heavy ion particles in meiotic prophase I nuclei of Caenorhabditis elegans. Journal of radiation research. vol 44. issue 3. 2004-03-12. PMID:14646232. |
the pachytene nuclei of ced-3 mutants, which are defective in apoptosis, are similarly resistant to ionizing radiation, but pachytene nuclei depleted for ce-atl-1 (ataxia-telangiectasia like 1) or ce-rdh-1/rad-51 are more sensitive. |
2004-03-12 |
2023-08-12 |
caenorhabditis_elegans |
| Shai Shaha. Apoptosis: a process with a (beta)NAC for complexity. Cell. vol 114. issue 6. 2003-11-06. PMID:14505566. |
in a recent paper, reveal a new c. elegans death inhibitor, icd-1, whose loss can promote apoptosis independently of ced-3. |
2003-11-06 |
2023-08-12 |
caenorhabditis_elegans |
| Tim A Bloss, Eric S Witze, Joel H Rothma. Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans. Nature. vol 424. issue 6952. 2003-09-23. PMID:12944970. |
although this apoptosis requires ced-4, it occurs independently of ced-3--the caspase essential for developmental apoptosis--showing that these core pro-apoptotic proteins have separable roles. |
2003-09-23 |
2023-08-12 |
human |