| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, Kaname Uno, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Yoshihiko Yamakita, Hiroyuki Tomita, Kiyosumi Shibata, Akihiro Nawa, Yutaka Tomoda, Hiroaki Kajiyam. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. Scientific reports. vol 13. issue 1. 2023-11-06. PMID:37932321. |
in ex vivo human cervical cancer tissues, 9-oxo-odas decreased cdk1 expression and increased cleaved caspase 3, an apoptosis marker. |
2023-11-06 |
2023-11-08 |
human |
| Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, Kaname Uno, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Yoshihiko Yamakita, Hiroyuki Tomita, Kiyosumi Shibata, Akihiro Nawa, Yutaka Tomoda, Hiroaki Kajiyam. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. Scientific reports. vol 13. issue 1. 2023-11-06. PMID:37932321. |
these findings suggest that 9-oxo-odas induce cell cycle arrest and apoptosis in hpv-positive human cervical cancer cells, and this process involves cdk1. |
2023-11-06 |
2023-11-08 |
human |
| Giorgia Massacci, Livia Perfetto, Francesca Sacc. The Cyclin-dependent kinase 1: more than a cell cycle regulator. British journal of cancer. 2023-10-29. PMID:37898722. |
from cell cycle control to gene expression regulation and apoptosis, cdk1 is intimately involved in many cellular events that are vital for cell survival. |
2023-10-29 |
2023-11-08 |
Not clear |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
cdk1 protects against oxygen-glucose deprivation and reperfusion-induced golgi fragmentation and apoptosis through mediating gm130 phosphorylation. |
2023-10-13 |
2023-10-15 |
mouse |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
inhibition of cdk1 significantly attenuated ogdr-induced golgi fragmentation and cell apoptosis. |
2023-10-13 |
2023-10-15 |
mouse |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
the present findings reveal that cdk1 protects against ir-induced ga fragmentation and apoptosis, likely through the mediation of gm130 phosphorylation. |
2023-10-13 |
2023-10-15 |
mouse |
| Yunlong Cui, Ning Jian. CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma. Applied biochemistry and biotechnology. 2023-07-10. PMID:37428386. |
the results of flow cytometry showed that cdca8 regulated cdk1 and cyclin b1 expression to arrest at the s phase, inhibited proliferation, and promoted apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
| Enshuang Guo, Jiankun Yang, Lei Li, Jia Chen, Hongqiang Li. TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells. Journal of biochemical and molecular toxicology. 2023-06-21. PMID:37341435. |
in vitro experimental measurements suggested that a combination of si-tacc3 and cdk1 inhibitor synergistically inhibited cell proliferation and migration, and induced g2 cell cycle arrest and apoptosis of hepg2 or mhcc97h cells. |
2023-06-21 |
2023-08-14 |
Not clear |
| Huihui Tian, Mengxia Ding, Yujie Guo, Zhaoyan Zhu, Yange Yu, Yadong Tian, Kui Li, Guirong Sun, Ruirui Jiang, Ruili Han, Fengbin Yan, Xiangtao Kan. Effect of HSPA8 gene on the proliferation, apoptosis and immune function of HD11\\xe2\\x80\\xafcells. Developmental and comparative immunology. 2023-02-10. PMID:36764422. |
transfection of the hspa8 interference fragment significantly downregulated the level of hspa8 expression in hd11\xe2\x80\xafcells; significantly inhibited the proliferation of hd11\xe2\x80\xafcells and the expression of pcna, ccnd1 and cdk1; increased the number of cells in the g1 phase and decreased the number of cells in the s phase; increased the rate of apoptosis, downregulated the expression of bcl-2 and upregulated the expression levels of fas and fasl; and inhibited the expression of the lps-induced cytokines il-1\xce\xb2 and nf-\xce\xbab. |
2023-02-10 |
2023-08-14 |
chicken |
| Shuai Zhang, Ru Feng, Jiefei Bai, Shangyong Ning, Xiaodong Xu, Jie Sun, Meng Wu, Hui Li. CDK7 inhibition induces apoptosis in acute myeloid leukemia cells and exerts synergistic antileukemic effects with azacitidine Leukemia & lymphoma. 2023-01-19. PMID:36657437. |
thz1 decreased cell viability, induced apoptosis in a dose and time-dependent manner, induced g0/g1 cell cycle arrest, decreased phosphorylated cdk1 and cdk2 expression, and inhibited rna pol ii phosphorylation at multiple serine sites. |
2023-01-19 |
2023-08-14 |
mouse |
| Idir Malki, Inara Liepina, Nora Kogelnik, Hollie Watmuff, Sue Robinson, Adam Lightfoot, Oksana Gonchar, Andrew Bottrill, Andrew M Fry, Cyril Domingue. Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. Nucleic acids research. 2022-12-20. PMID:36537190. |
we established that sam68 is specifically phosphorylated at t33 and t317 by cdk1, and demonstrated that these phosphorylation events reduce the binding of sam68 to rna, control its cellular localization and reduce its alternative splicing activity, leading to a reduction in the induction of apoptosis and an increase in the proliferation of hct116 cells. |
2022-12-20 |
2023-08-14 |
Not clear |
| Deepa Mandal, Paritosh Patel, Suresh K Verma, Bikash Ranjan Sahu, Tithi Parij. Proximal discrepancy in intrinsic atomic interaction arrests G2/M phase by inhibiting Cyclin B1/CDK1 to infer molecular and cellular biocompatibility of D-limonene. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307489. |
the study suggested the arrest of the cell cycle at g2/m phase leading to apoptosis and other discrepancies of molecular activity mediated via significant alteration in protein expression pattern of anti-apoptotic proteins like cyclin b1 and cdk1. |
2022-10-28 |
2023-08-14 |
Not clear |
| Yuan Yuan, Xiaojing Zhang, Kaining Du, Xiaohui Zhu, Shanshan Chang, Yang Chen, Yidan Xu, Jiachun Sun, Xiaonuan Luo, Shiqi Deng, Ying Qin, Xianling Feng, Yanjie Wei, Xinmin Fan, Ziyang Liu, Baixin Zheng, Hassan Ashktorab, Duane Smoot, Song Li, Xiaoxun Xie, Zhe Jin, Yin Pen. Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. Cell death & disease. vol 13. issue 9. 2022-09-27. PMID:36167685. |
these findings suggest that circ_cea protects gc cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and cdk1 proteins. |
2022-09-27 |
2023-08-14 |
Not clear |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human hepg2 cell proliferation by targeting bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Qin Zhang, Li Chen, Mengxi Gao, Shubin Wang, Lingzhen Meng, Liru Gu. Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Molecular and cellular biochemistry. 2022-09-09. PMID:36083512. |
thus, kaempferol can promote hepg2 cell apoptosis, and the regulatory mechanism may be related to the regulation of the expression levels of the apoptosis-related proteins bax, cdk1, and jun. |
2022-09-09 |
2023-08-14 |
human |
| Si Huang, Jingxian Xiao, Junyong Wu, Jiayi Liu, Xueping Feng, Chengdong Yang, Daxiong Xiang, Shilin Lu. Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity. Frontiers in pharmacology. vol 13. 2022-06-13. PMID:35694267. |
tizoxanide promotes apoptosis in glioblastoma by inhibiting cdk1 activity. |
2022-06-13 |
2023-08-14 |
Not clear |
| Libang Yang, Adam Gilbertsen, Karen Smith, Hong Xia, LeeAnn Higgins, Candace Guerrero, Craig A Henk. Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype. Proteomics. 2022-05-28. PMID:35633524. |
interactomics implicated parp1, cdk1, and bach1 as key hub proteins in the dna damage/repair, differentiation, and apoptosis signaling pathways respectively. |
2022-05-28 |
2023-08-13 |
mouse |
| Y-J Yang, S Luo, Z-L X. Effects of miR-490-5p targeting CDK1 on proliferation and apoptosis of colon cancer cells via ERK signaling pathway. European review for medical and pharmacological sciences. vol 26. issue 6. 2022-04-01. PMID:35363355. |
effects of mir-490-5p targeting cdk1 on proliferation and apoptosis of colon cancer cells via erk signaling pathway. |
2022-04-01 |
2023-08-13 |
Not clear |
| Jean Schneider, Ye Won Jeon, Young Jin Suh, Seung Taek Li. Effects of Ruxolitinib and Calcitriol Combination Treatment on Various Molecular Subtypes of Breast Cancer. International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35269680. |
our results revealed the synergistic anticancer effect of ruxolitinib and calcitriol combination treatment in skbr3 and mda-mb-468 cells, but not in mcf-7 cells in vitro, via cell proliferation inhibition, apoptosis induction, cell cycle arrest, and the alteration of cell signaling protein expression, including cell cycle-related (cyclin d1, cdk1, cdk4, p21, and p27), apoptosis-related (c-caspase and c-parp), and cell proliferation-related (c-myc, p-p53, and p-jak2) proteins. |
2022-03-10 |
2023-08-13 |
mouse |
| Xiao Yang, Xingchen Li, Yuan Cheng, Jingyi Zhou, Boqiang Shen, Lijun Zhao, Jianliu Wan. Comprehensive Analysis of the Glycolysis-Related Gene Prognostic Signature and Immune Infiltration in Endometrial Cancer. Frontiers in cell and developmental biology. vol 9. 2022-02-28. PMID:35223866. |
further, the protein of cdk1, a gene in the signature, was found to be closely related to prognosis of ec and inhibition of cdk1 could inhibit migration and promote apoptosis of ec cells. |
2022-02-28 |
2023-08-13 |
Not clear |