| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Ma, Mingchang Liu, Zhuo Chen, Shiyang Liu, Huijuan Yang, Mengjia Dua. NANOG regulate the JAK/STAT3 pathway to promote trophoblast cell migration and epithelial-mesenchymal transition (EMT) in hypertensive disorders of pregnancy (HDP) through protein interaction with CDK1. American journal of reproductive immunology (New York, N.Y. : 1989). vol 91. issue 5. 2024-05-26. PMID:38796740. |
nanog and cyclin-dependent kinase 1 (cdk1) are essential for regulating the function of cell proliferation and apoptosis. |
2024-05-26 |
2024-05-31 |
Not clear |
| Ying-Xiu Hu, Ding-Ding Zhang, Chao Chen, Ang Li, Ding-Ping Ba. Mechanism of fibroblast growth factor 1 regulating fatty liver disorder in mule ducks. Poultry science. vol 103. issue 7. 2024-05-11. PMID:38733755. |
hepatocytes were induced by adding 1,500:750 µmol/l oleic and palmitic acid concentrations for 36 h, which were stimulated with fgf1 concentrations of 0, 10, 100, and 1000 ng/ml for 12 h. the results showed that fgf1 significantly reduced the hepatic lipid droplet deposition and triglyceride content induced by complex fatty acids; it also reduced oxidative stress; decreased reactive oxygen species fluorescence intensity and malondialdehyde content; upregulated the expression of antioxidant factors nuclear factor erythroid 2 related factor 2 (nrf2), ho-1, and nqo-1; significantly enhanced liver cell activity; promoted cell cycle progression; inhibited cell apoptosis; upregulated cyclin-dependent kinase 1 (cdk1) and bcl-2 mrna expression; and downregulated bax and caspase-3 expression. |
2024-05-11 |
2024-05-27 |
Not clear |
| James C Fazioli, Margaret K Mulligan, Erin K Ison, J Alex Pasterna. Impact of methimazole-induced hypothyroidism on postnatal swine. Physiological reports. vol 12. issue 8. 2024-04-25. PMID:38658325. |
hepatic expression of genes associated with thyroid metabolism (dio1, dio2, and dio3), lipid utilization (cd36, fasn, and acaca), apoptosis (tp53, perp, siva1, and sfn) and proliferation (cdk1, cdk2, cdk4, and cdkn1a) were unaffected by treatment. |
2024-04-25 |
2024-04-28 |
Not clear |
| Fiona Simpkins, Haineng Xu, Erin Geroge, David Gallo, Sergey Medvedev, Xiaolei Wang, Rosie Kryczka, Marc Hyer, Jimmy Fourtounis, Rino Stocco, Elia Aguado-Fraile, Adam Petrone, Shou Yun Yin, Ariya Shiwram, Matthew Anderson, Hyoung Kim, Fang Liu, Gary Marshal. Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR. Research square. 2024-02-27. PMID:38410486. |
mechanistically, low doses of rp-6306 with rp-3500 increase cdk1 activation more so than monotherapy, triggering rapid and robust induction of premature mitosis, dna damage and apoptosis in a ccne1-dependent manner. |
2024-02-27 |
2024-03-02 |
Not clear |
| Stefan Djordjevic, Raphaël Itzykson, Frédéric Hague, Delphine Lebon, Julien Legrand, Hakim Ouled-Haddou, Guillaume Jedraszak, Juliette Harbonnier, Louison Collet, Etienne Paubelle, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boye. STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells. Molecular oncology. 2024-01-18. PMID:38234211. |
phenotypically, stim2 knockdown drastically inhibited cell proliferation and induced genomic stress with dna double-strand breaks, as shown by increased levels of phosphorylate histone h2axγ (p-h2axγ), followed by activation of the cellular tumor antigen p53 pathway, decreased expression of cell cycle regulators such as cyclin-dependent kinase 1 (cdk1)-cyclin b1 and m-phase inducer phosphatase 3 (cdc25c), and a decreased apoptosis threshold with a low antiapoptotic/proapoptotic protein ratio. |
2024-01-18 |
2024-01-20 |
human |
| Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. |
in vitro experiments show that xihuang pills can inhibit the proliferation of mcf-10a cells, promote the apoptosis of mcf-10a cells, and reduce the expression of jak1, src, and cdk1 targets in cells. |
2024-01-11 |
2024-01-14 |
human |
| Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. |
to sum up, xihuang pills can promote the apoptosis of mammary epithelial cells by regulating the expression of jak1, src, and cdk1 and then play an anti-hyperplasia role, which provides an experimental basis for clarifying the material basis of xihuang pills for anti-hyperplasia effect. |
2024-01-11 |
2024-01-14 |
human |
| Hui Zhang, Ke Hu, Yumeng Lu, Zhijian Xu, Gege Chen, Dandan Yu, Xuejie Gao, Qilin Feng, Xinyan Jia, Li Xu, Jinfeng Zhou, Xiaosong Wu, Dongliang Song, Huabin Zhu, Bo Li, Weiliang Zhu, Jumei Sh. A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory. International immunopharmacology. vol 127. 2023-12-29. PMID:38157697. |
using flow cytometry, this study found that dcz0825 induced caspase-dependent apoptosis in mm cells and arrested the cell cycle in the g2/m phase by down-regulating cyclinb1, cdk1 and cdc25. |
2023-12-29 |
2024-01-05 |
Not clear |
| Xinmei Kang, Huaxin Chen, Zhuowei Zhou, Silin Tu, Bo Cui, Yanli Li, Shuai Dong, Qi Zhang, Yan X. Targeting Cyclin-Dependent Kinase 1 Induces Apoptosis and Cell Cycle Arrest of Activated Hepatic Stellate Cells. Advanced biology. 2023-12-16. PMID:38103005. |
in vitro, cdk1 is upregulated in spontaneously activated hscs, and inhibiting cdk1 with specific small-molecule inhibitors (cgp74514a, ro-3306, or purvalanol a) orshort hairpin rnas (shrnas) resulted in hsc apoptosis and cell cycle arrest by regulating survivin expression. |
2023-12-16 |
2023-12-18 |
Not clear |
| Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, Kaname Uno, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Yoshihiko Yamakita, Hiroyuki Tomita, Kiyosumi Shibata, Akihiro Nawa, Yutaka Tomoda, Hiroaki Kajiyam. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. Scientific reports. vol 13. issue 1. 2023-11-06. PMID:37932321. |
in ex vivo human cervical cancer tissues, 9-oxo-odas decreased cdk1 expression and increased cleaved caspase 3, an apoptosis marker. |
2023-11-06 |
2023-11-08 |
human |
| Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, Kaname Uno, Satoshi Tamauchi, Akira Yokoi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Yoshihiko Yamakita, Hiroyuki Tomita, Kiyosumi Shibata, Akihiro Nawa, Yutaka Tomoda, Hiroaki Kajiyam. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. Scientific reports. vol 13. issue 1. 2023-11-06. PMID:37932321. |
these findings suggest that 9-oxo-odas induce cell cycle arrest and apoptosis in hpv-positive human cervical cancer cells, and this process involves cdk1. |
2023-11-06 |
2023-11-08 |
human |
| Giorgia Massacci, Livia Perfetto, Francesca Sacc. The Cyclin-dependent kinase 1: more than a cell cycle regulator. British journal of cancer. 2023-10-29. PMID:37898722. |
from cell cycle control to gene expression regulation and apoptosis, cdk1 is intimately involved in many cellular events that are vital for cell survival. |
2023-10-29 |
2023-11-08 |
Not clear |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
cdk1 protects against oxygen-glucose deprivation and reperfusion-induced golgi fragmentation and apoptosis through mediating gm130 phosphorylation. |
2023-10-13 |
2023-10-15 |
mouse |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
inhibition of cdk1 significantly attenuated ogdr-induced golgi fragmentation and cell apoptosis. |
2023-10-13 |
2023-10-15 |
mouse |
| Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye M. Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation. Journal of molecular histology. 2023-10-13. PMID:37831422. |
the present findings reveal that cdk1 protects against ir-induced ga fragmentation and apoptosis, likely through the mediation of gm130 phosphorylation. |
2023-10-13 |
2023-10-15 |
mouse |
| Yunlong Cui, Ning Jian. CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma. Applied biochemistry and biotechnology. 2023-07-10. PMID:37428386. |
the results of flow cytometry showed that cdca8 regulated cdk1 and cyclin b1 expression to arrest at the s phase, inhibited proliferation, and promoted apoptosis. |
2023-07-10 |
2023-08-14 |
Not clear |
| Enshuang Guo, Jiankun Yang, Lei Li, Jia Chen, Hongqiang Li. TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells. Journal of biochemical and molecular toxicology. 2023-06-21. PMID:37341435. |
in vitro experimental measurements suggested that a combination of si-tacc3 and cdk1 inhibitor synergistically inhibited cell proliferation and migration, and induced g2 cell cycle arrest and apoptosis of hepg2 or mhcc97h cells. |
2023-06-21 |
2023-08-14 |
Not clear |
| Huihui Tian, Mengxia Ding, Yujie Guo, Zhaoyan Zhu, Yange Yu, Yadong Tian, Kui Li, Guirong Sun, Ruirui Jiang, Ruili Han, Fengbin Yan, Xiangtao Kan. Effect of HSPA8 gene on the proliferation, apoptosis and immune function of HD11 cells. Developmental and comparative immunology. 2023-02-10. PMID:36764422. |
transfection of the hspa8 interference fragment significantly downregulated the level of hspa8 expression in hd11 cells; significantly inhibited the proliferation of hd11 cells and the expression of pcna, ccnd1 and cdk1; increased the number of cells in the g1 phase and decreased the number of cells in the s phase; increased the rate of apoptosis, downregulated the expression of bcl-2 and upregulated the expression levels of fas and fasl; and inhibited the expression of the lps-induced cytokines il-1β and nf-κb. |
2023-02-10 |
2023-08-14 |
chicken |
| Shuai Zhang, Ru Feng, Jiefei Bai, Shangyong Ning, Xiaodong Xu, Jie Sun, Meng Wu, Hui Li. CDK7 inhibition induces apoptosis in acute myeloid leukemia cells and exerts synergistic antileukemic effects with azacitidine Leukemia & lymphoma. 2023-01-19. PMID:36657437. |
thz1 decreased cell viability, induced apoptosis in a dose and time-dependent manner, induced g0/g1 cell cycle arrest, decreased phosphorylated cdk1 and cdk2 expression, and inhibited rna pol ii phosphorylation at multiple serine sites. |
2023-01-19 |
2023-08-14 |
mouse |
| Idir Malki, Inara Liepina, Nora Kogelnik, Hollie Watmuff, Sue Robinson, Adam Lightfoot, Oksana Gonchar, Andrew Bottrill, Andrew M Fry, Cyril Domingue. Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. Nucleic acids research. 2022-12-20. PMID:36537190. |
we established that sam68 is specifically phosphorylated at t33 and t317 by cdk1, and demonstrated that these phosphorylation events reduce the binding of sam68 to rna, control its cellular localization and reduce its alternative splicing activity, leading to a reduction in the induction of apoptosis and an increase in the proliferation of hct116 cells. |
2022-12-20 |
2023-08-14 |
Not clear |