| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yulong Li, Shu Wang, Rui Fen. Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway. Poultry science. vol 104. issue 4. 2025-03-13. PMID:40081173. |
selenium (se) is known to possess antagonistic effects against cd toxicity, yet the precise mechanisms through which se counteracts cd-induced testicular damage in chickens through nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (nrf2/ho-1) signaling pathway, oxidative stress (os), apoptosis, and inflammation remained unclear. |
2025-03-13 |
2025-03-16 |
chicken |
| Emad H M Hassanein, Mohammed F Alotaibi, Reem S Alruhaimi, Mostafa Sabry, Ghadir A Sayed, Ahmed M Atwa, Ayman M Mahmou. Targeting TLR4/NF-κB signaling, oxidative stress, and apoptosis by farnesol mitigates cadmium-induced testicular toxicity in rats. Tissue & cell. vol 94. 2025-02-28. PMID:40020518. |
cd administration caused testicular tissue damage, altered hormone levels, oxidative stress and apoptosis, upregulated tlr4/nf-κb signaling and diminished antioxidants. |
2025-02-28 |
2025-03-04 |
rat |
| Farzaneh Motafeghi, Maryam S Fakhri B, Nasrin Ghassemi Bargh. Mechanisms of ARA290 in counteracting cadmium-triggered neurotoxicity in PC12 cells. Toxicology research. vol 14. issue 1. 2025-02-19. PMID:39968520. |
cadmium (cd), a prevalent environmental toxin, causes neurotoxic damage through mechanisms such as oxidative stress, genotoxicity, apoptosis, and inflammation. |
2025-02-19 |
2025-02-23 |
Not clear |
| Ju Huang, Jing Li, Zhijun Geng, Lixia Yin, Minzhu Niu, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo H. Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway. Frontiers in pharmacology. vol 15. 2025-02-04. PMID:39902073. |
patients with crohn's disease (cd) exhibit excessive apoptosis of intestinal epithelial cells (iecs), which contributes to damage to the intestinal barrier structure and function, thereby playing a role in the progression of colitis. |
2025-02-04 |
2025-02-06 |
Not clear |
| Atsushi Shiga, Chinatsu Fujiwara, Yoshitaka Katoh, Tsuyoshi Ito, Aya Ohnuma-Koyama, Naofumi Takahashi, Takanori Harad. The relationship between spontaneous cystic degeneration and pseudocapillarization in sinusoids in the liver of aged Sprague-Dawley rats. Journal of toxicologic pathology. vol 38. issue 1. 2025-01-22. PMID:39839718. |
cd areas exhibited enhanced vimentin expression in a diffuse linear pattern in their septa with occasional focal linear α-smooth muscle actin expression and the fluid containing hyaluronic acid accumulated in their lumen that are thought to be formed by hepatocellular apoptosis. |
2025-01-22 |
2025-01-24 |
rat |
| Slavena Davidova, Viktor Milushev, Galina Satchansk. The Mechanisms of Cadmium Toxicity in Living Organisms. Toxics. vol 12. issue 12. 2025-01-08. PMID:39771090. |
molecular aspects of carcinogenesis, apoptosis, autophagy, specific gene expression, stress protein synthesis, and ros formation caused by cd were discussed as well. |
2025-01-08 |
2025-01-13 |
human |
| Xiaofeng Zhang, Lugen Zuo, Xue Song, Wenjing Zhang, Zi Yang, Zhiyuan Wang, Yibing Guo, Sitang Ge, Lian Wang, Yueyue Wang, Zhijun Geng, Jing Li, Jianguo H. The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease. iScience. vol 27. issue 12. 2025-01-06. PMID:39759008. |
the results of this study revealed that the level of sfpr5 increased in the diseased mat (htmat) of cd patients and aggregated among intestinal epithelial cells in the diseased intestine and that it could ameliorate intestinal barrier dysfunction in tumor necrosis factor alpha (tnf-α)-stimulated colonic organoids and 2,4,6-trinitrobenzenesulfonic acid (tnbs)-induced mice at least in part through the inhibition of wnt5a-mediated apoptosis in epithelial cells. |
2025-01-06 |
2025-01-08 |
mouse |
| Minzhu Niu, Lixia Yin, Ting Duan, Ju Huang, Jing Li, Zhijun Geng, Jianguo Hu, Chuanwang Son. [Asperosaponin VI alleviates TNBS-induced Crohn's disease-like colitis in mice by reducing intestinal epithelial cell apoptosis via inhibiting the PI3K/AKT/NF-κB signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 44. issue 12. 2024-12-26. PMID:39725622. |
to investigate the effects of asperosaponin vi (avi) on intestinal epithelial cell apoptosis and intestinal barrier function in a mouse model of crohn's disease (cd)-like colitis and explore its mechanisms. |
2024-12-26 |
2024-12-29 |
mouse |
| Liang Qian, Ling Wu, Xiaohui Miao, Jiao Xu, Yao Zho. The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC. Apoptosis : an international journal on programmed cell death. 2024-12-26. PMID:39725799. |
this study investigates the regulatory role of the t cell immunoglobulin and itim domain (tigit)-cd226-pvr signaling axis in the exhaustion and apoptosis of cluster of differentiation (cd)27+/cd127+t cells in nsclc. |
2024-12-26 |
2024-12-29 |
mouse |
| Han Wang, Zhihai Xu, Jing Guo, Lei Li, Yu Tian, Shengjie F. Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm. European journal of medical research. vol 29. issue 1. 2024-11-21. PMID:39568082. |
in vitro validation using an angiotensin ii-induced aaa model in human aortic smooth muscle cells demonstrated that sirna-mediated knockdown of abi1 significantly reduced cell apoptosis, migration, and the expression of pro-apoptotic proteins, confirming abi1's crucial role in promoting cd and aaa progression. |
2024-11-21 |
2024-11-23 |
human |
| Xiao Li, Xin Yao, Jieying Wen, Qiaoling Chen, Ziming Zhu, Xinyue Zhang, Song Wang, Weixuan Lan, Yunsi Huang, Shanneng Tang, Xuan Zhou, Xuedong Han, Tao Zhan. The application of sphingomyelin in mediating the causal role of the T-cell surface glycoprotein CD5 in Crohn's disease: A two-step Mendelian randomization study. Medicine. vol 103. issue 46. 2024-11-19. PMID:39560554. |
the mediating function of sm in the link between cd5 and cd is anticipated to be realized through the regulation of immune cell transportation, apoptosis of intestinal barrier cells, and maintenance of the intestinal microenvironment. |
2024-11-19 |
2024-11-22 |
Not clear |
| L Liu, Q Zhao, J Huang, S Le. Cadmium-Induced Hepatotoxicity in Mice - Prophylactic Supplementation of Quercetin Exerts Hepatoprotective Effect by Modulating PI3K/Akt/NF-kappaB Signaling Pathway. Physiological research. vol 73. issue 5. 2024-11-12. PMID:39530906. |
in conclusion, quercetin protects against cd induced liver injury via several pathways, including oxidative stress, inflammation and apoptosis, and its protective effect correlates with antioxidant activity. |
2024-11-12 |
2024-11-17 |
mouse |
| Dandan Li, Chen Xie, Ziwu Fan, Rui Ding, Xiaoyu Wang, Yipeng Lia. Evidence that cadmium aggravate the toxicity of triphenyl phosphate in aquatic sediments to Corbicula fluminea. Journal of hazardous materials. vol 480. 2024-11-10. PMID:39522218. |
these disruptions weakened the repair capacity and aggravated apoptosis in digestive glands, potentially contributing to the synergistic toxicity of tphp and cd. |
2024-11-10 |
2024-11-17 |
Not clear |
| b' Mehmet Resit Tays\\xc4\\xb. Assessing the effects of cadmium on antioxidant enzymes and histological structures in rainbow trout liver and kidney. Scientific reports. vol 14. issue 1. 2024-11-10. PMID:39523429.' |
the present study aimed to assess the effects of cadmium (cd) exposure on key biomarkers of oxidative stress, dna damage, apoptosis, and enzyme activity in the liver and kidney tissues of rainbow trout (oncorhynchus mykiss). |
2024-11-10 |
2024-11-17 |
Not clear |
| Ting Duan, Zhijun Geng, Jingjing Yang, Lixia Yin, Mingxi Sun, Shunyin Wang, Xiaofeng Zhang, Jing Li, Jianguo Hu, Guoyu L. [Isongifolene Improves Crohn's Disease-Like Colitis in Mice by Reducing Apoptosis of Intestinal Epithelial Cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 55. issue 5. 2024-11-07. PMID:39507978. |
to investigate the effect and molecular mechanism of isolongifolene (iso) on the apoptosis of intestinal epithelial cells and 2,4,6-trinitrobenzenesulfonic acid (tnbs)-induced crohn's disease (cd)-like colitis in mice. |
2024-11-07 |
2024-11-09 |
mouse |
| Xishuai Tong, Guoshuai Wang, Xinrui Zhao, Jiatao Zhou, Panting Wang, Han Xia, Jianchun Bian, Xuezhong Liu, Yan Yuan, Hui Zou, Zongping Liu, Jianhong G. Angelica sinensis polysaccharides mitigate cadmium-induced apoptosis in layer chicken chondrocytes by inhibiting the JNK signaling pathway. International journal of biological macromolecules. 2024-11-01. PMID:39486695. |
cadmium (cd), a toxic heavy metal pollutant, inflicts widespread damage on various organs and tissues, including cartilage, where it induces chondrocyte apoptosis. |
2024-11-01 |
2024-11-05 |
chicken |
| Xishuai Tong, Guoshuai Wang, Xinrui Zhao, Jiatao Zhou, Panting Wang, Han Xia, Jianchun Bian, Xuezhong Liu, Yan Yuan, Hui Zou, Zongping Liu, Jianhong G. Angelica sinensis polysaccharides mitigate cadmium-induced apoptosis in layer chicken chondrocytes by inhibiting the JNK signaling pathway. International journal of biological macromolecules. 2024-11-01. PMID:39486695. |
we found that cd triggered apoptosis in the chondrocytes; however, the use of the jnk inhibitor sp 600125 mitigated mitochondrial structural damage casused by cd, indicating the involvement of jnk signaling in this process. |
2024-11-01 |
2024-11-05 |
chicken |
| Damini Singh, Priyanka Bist, Sangeeta Choudhar. Effect of co-exposure to multiple metals (Pb, Cd, Cr, Hg, Fe, Mn and Ni) and metalloid (As) on liver function in Swiss albino mice. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-10-16. PMID:39414706. |
the study examined the cumulative toxic effect of multiple elements, as, pb, cd, cr, hg, fe, mn and ni on the liver function and their association with inflammation and apoptosis. |
2024-10-16 |
2024-10-19 |
mouse |
| Dian Wang, Yi Xiang, Zhaoxuan Zhu, Jiyue Liu, Yisheng Wang, Zeyu Xu, Si Chen, Chunyuan Dai, Jiasen Feng, Jie Chen, Qianhui Ma, Ping Yan. Cytological Effects of Cadmium Poisoning and the Protective Effect of Quercetin: A Mechanism Exploration based on the Testicular Lamina Propria. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 2024-10-15. PMID:39405407. |
the findings illustrated that cd exposure results in significant morphological and cellular modifications within the lp, including the apoptosis of peritubular myoid cells, an upsurge in cd34+ stromal cells displaying anti-apoptotic behaviors, and an excessive production of collagen type i fibers and extracellular matrix. |
2024-10-15 |
2024-10-18 |
mouse |
| Dian Wang, Yi Xiang, Zhaoxuan Zhu, Jiyue Liu, Yisheng Wang, Zeyu Xu, Si Chen, Chunyuan Dai, Jiasen Feng, Jie Chen, Qianhui Ma, Ping Yan. Cytological Effects of Cadmium Poisoning and the Protective Effect of Quercetin: A Mechanism Exploration based on the Testicular Lamina Propria. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 2024-10-15. PMID:39405407. |
remarkably, quercetin effectively counteracted these adverse changes by reversing apoptosis, reducing the proliferation of cd34+ stromal cells, and addressing fibrosis markers, thereby mitigating the cellular damage induced by cd. |
2024-10-15 |
2024-10-18 |
mouse |