All Relations between apoptosis and bcl2

Publication Sentence Publish Date Extraction Date Species
Min Liu, Yuanyuan Li, Zhilin Deng, Ke Zhang, Shuying Huang, Jiamin Xia, Yi Feng, Yundan Liang, Chengfu Sun, Xindong Liu, Shurong Li, Bingyin Su, Yong Dong, Sizhou Huan. Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell death & disease. vol 16. issue 1. 2025-02-10. PMID:39929806. detailed analyses demonstrated that the immature t lymphocytes undergo rapid apoptosis via upregulation of tp53 and downregulation of bcl2 transcription in mcm5 mutants. 2025-02-10 2025-02-13 mouse
H A D B Amarasiri, Danushka Arachchige, Matthew J K Vince, Justin M Holu. Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. Journal of molecular recognition : JMR. vol 38. issue 2. 2025-02-05. PMID:39905677. the b-cell lymphoma 2 (bcl2) proteins are a class of apoptosis regulators that control the release of apoptogenic factors from mitochondria. 2025-02-05 2025-02-07 Not clear
H A D B Amarasiri, Danushka Arachchige, Matthew J K Vince, Justin M Holu. Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. Journal of molecular recognition : JMR. vol 38. issue 2. 2025-02-05. PMID:39905677. under normal physiological conditions, apoptosis is inhibited through the actions of anti-apoptotic (repressor) bcl2 proteins that bind semi-indiscriminately to the helical bh3 domains of pro-apoptotic (effector) bcl2 proteins. 2025-02-05 2025-02-07 Not clear
Amisha Bisht, Anita Nayal, Disha Tewari, Sanjay Kumar, Subhash Chandr. Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach. Biogerontology. vol 26. issue 2. 2025-02-05. PMID:39907831. key targets such as akt1, bcl2, esr1, and gsk3b were linked to aging-related pathways, with go and kegg enrichment analyses highlighting processes like apoptosis, oxidative stress response, and pathways like pi3k-akt signaling. 2025-02-05 2025-02-07 Not clear
Tao Huang, Bo Shao, Zhong-Cheng Gon. The Impact of miR-141 Overexpression on Apoptosis and Proliferation in Tscca and Tca8113 Cell Lines. Journal of stomatology, oral and maxillofacial surgery. 2025-02-05. PMID:39909369. these findings indicate that mir-141 may regulate the expression of pten and bcl2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. 2025-02-05 2025-02-08 Not clear
Xiaopeng Li, Xiaoyong He, Guibi Li, Zhujun Wang, Fuli Huang, Jiasen Chen, Yang Song, Tanze Liu, Zhaoyan Chen, Xiangfeng Wang, Jiwei Hu, Hua He, Hehe Liu, Liang Li, Jiwen Wang, Shenqiang H. Identification of the crucial circ-mi-mRNA interaction networks regulating testicular development and spermatogenesis in ganders. Poultry science. vol 104. issue 3. 2025-02-04. PMID:39904178. by constructing the core cerna regulatory networks, several key decircrnas, including 1:98100313|98104995, 1:171413706|171419341, 6:3414226|3418193, and 2:115876735|115880760, were identified to regulate the expression of tgfb2 and bcl2 through interactions with specific mirnas such as novel-mir-265 and novel-mir-266, and such interactions could play crucial roles in regulating the gander testicular cell apoptosis, proliferation, and spermatogenesis. 2025-02-04 2025-02-07 Not clear
Rigzin Dolkar, Gourav Paudwal, Davinder Singh, Chittaranjan Behera, Sumera Banoo Malik, Syed Mudassir Ali, Harjot Kaur, Amit Nargotra, Ravi Shankar, Shashank K Singh, Prem N Gupt. Mechanistic Approach into 1,2,3-triazoles-based IIIM(S)-RS98 Mediated Apoptosis in Lung Cancer Cells. The AAPS journal. vol 27. issue 1. 2025-02-03. PMID:39900819. additionally, the downregulation of pi3k and p-akt pathway leads to the activation of pro-apoptotic proteins bax, downregulation of bcl2, activation of caspase 9, cleaved caspase 3, and cleaved parp1 expression and finally contribute towards apoptosis. 2025-02-03 2025-02-06 Not clear
Haobo Li, Shuai Yuan, Zhipeng Yue, Lei Zhang, Shu Chen, Qirong Qian, Qiwei Fu, Yi Che. Suppressive effect of curcumin on apoptosis of articular chondrocytes via regulation on NF-κB pathway and NLRP3 inflammasome. Cytotechnology. vol 77. issue 2. 2025-02-03. PMID:39897107. il-1β treatment notably diminished chondrocyte viability and increased apoptosis, evidenced by elevated level of bax and cleaved caspase-3, and reduced level of bcl2, while such expression patterns were reversed by curcumin treatment in a concentration-dependent fashion. 2025-02-03 2025-02-05 Not clear
Xiaohui Jiang, Liming Xu, Boyue Xu, Haotian Peng, Tonghe Yang, Yinying Zhao, Nanxin Wu, Yun-E Zha. SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway. iScience. vol 28. issue 2. 2025-02-03. PMID:39898036. under hg conditions, cell proliferation decreased, while migration and apoptosis, alongside changes in bcl2 and caspase-3 expression, increased. 2025-02-03 2025-02-05 mouse
Ki-Fong Man, Omeed Darweesh, Jinghui Hong, Alexandra Thompson, Charlotte O'Connor, Chiara Bonaldo, Mark N Melkonyan, Mo Sun, Rajnikant Patel, Leif W Ellisen, Tim Robinson, Dong Song, Siang-Boon Ko. CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance. Oncogene. 2025-01-31. PMID:39890967. both proteins decorate mitochondria, where the high levels of mitochondrial rasal2-induced bcl2 expression render the organelles refractory to apoptosis. 2025-01-31 2025-02-04 Not clear
Abhishek Kumar, Yogita Thakur, Reshma Sinh. Physiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity. Environmental monitoring and assessment. vol 197. issue 2. 2025-01-30. PMID:39885038. neural system exposure to nps induces abnormal expression of genes like neurogenin1, gfap, fbj murine osteosarcoma viral oncogene, gap-43, synapsin iia, apoptosis regulator a, bcl2 and caspase a, and apoptosis-related cysteine peptidase. 2025-01-30 2025-02-02 zebrafish
Yilin Yuan, Jianxiu Zhang, Hui Li, Fengxia Yuan, Qinglong Cui, Di Wu, Haidan Yuan, Guangchun Pia. Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway. International immunopharmacology. vol 148. 2025-01-27. PMID:39870009. sp inhibited apap-induced hepatocyte apoptosis by regulating the protein levels of apoptosis-related proteins (cytochrome c, bax, caspase-3, bcl2, and parp). 2025-01-27 2025-01-30 mouse
Marwa M Khalaf, Emad H M Hassanein, Hamada S Qebesy, Abdullatif A Ahmed, Heba M Mahmou. Granisetron ameliorates doxorubicin-evoked nephrotoxicity via modulation of Nrf2 and TLR4/p38 MAPK/NLRP3 signals in rats. Tissue & cell. vol 93. 2025-01-24. PMID:39855027. gran prevented apoptosis by controlling renal expression of bax, caspase-3 and bcl2. 2025-01-24 2025-01-28 rat
Xinyu Yan, Yiyi Zhang, Jingwen Mo, Lindong Xu, Keyu Shi, Yi Zho. Molecular docking and network pharmacology research on the Danggui Sini Decoction's mechanism of action for treating erectile dysfunction. Medicine. vol 103. issue 47. 2025-01-14. PMID:39809170. this study demonstrates that dgsnd's compounds stimulate no synthesis and reduce inflammation and cell apoptosis to improve ed by acting on akti, alb, il6, tnf, tp53, and bcl2. 2025-01-14 2025-01-17 Not clear
Qian Feng, Jin-Xiu Zhi, Xue-Yu Wang, Yi-Di Chen, Guan-Cheng Liu, Cai-Yan Wang, Xia Yang, Fang-Ju Feng, Rong Zhang, Zhong-Qiu Liu, Rong-Rong Zhan. Cynanchum wallichii Wight and CW1 reversed docetaxel resistance effects by inhibiting P-gp and promoting PI3K/Akt-mediated apoptosis in prostate cancer. Biochemical pharmacology. vol 232. 2025-01-10. PMID:39788386. in addition, dtx + cw/cw1 co-treatment significantly increased the apoptosis effects in 22rv1/dtx cells by regulating the relative expressions of bax, bcl2, cytochrome c, and caspase 3/9. 2025-01-10 2025-01-13 Not clear
Shuqing Lv, Xinlu Zhang, Fangfang Lang, Yanmei Wu, Cancan Zhang, Qi Qi, Jie Jian. Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway. BioFactors (Oxford, England). vol 51. issue 1. 2025-01-09. PMID:39780463. knockdown of linc01224 in ec cell lines (hec-1-b and ishikawa) inhibited proliferation, migration, and promoted apoptosis, alongside increased bax and decreased bcl2 expression. 2025-01-09 2025-01-13 Not clear
Mahrokh Abouali Gale Dari, Bahar Jaberian Asl, Dian Dayer, Shirin Azizidoost, Maryam Farzaneh, Abdolah Mousavi Saleh. miR-34 as a Critical Regulator in Ovarian Cancer. Current molecular medicine. 2025-01-08. PMID:39773049. elevated levels of this mirna are associated with the induction of apoptosis and the inhibition of oc cell proliferation by targeting various signaling pathways, including notch1, p21/p53, stat3, and bcl2 in oc. 2025-01-08 2025-01-13 Not clear
Kumaresan Priyanka, Jilnasree Naduvile Purayil, Kathirvel Preeth. Valorization of pineapple (ANANAS comosus) peel waste for levan production: Assessment of biological activities. International journal of biological macromolecules. 2025-01-08. PMID:39778827. anticancerous activity of levan towards mda-mb-231 cell line was apparent with the down regulation of the anti-apoptotic gene bcl2 and upregulation the apoptosis genes comparable to cisplatin. 2025-01-08 2025-01-13 Not clear
Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhan. Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma. Scientific reports. vol 15. issue 1. 2025-01-03. PMID:39747460. then, the expression of bax and bcl2 was imbalance, and the cascade cleavage of parp and caspase 3 was increased, ultimately triggering cell apoptosis. 2025-01-03 2025-01-05 mouse
Ru Guo, Youjuan Wu, Tingting Yu, Chen Guo, Zijia Yin, Guannan Zhao, Meifeng Li, Huiling Mao, Chengyu Hu, Xiaowen X. Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 279. 2025-01-01. PMID:39742649. furthermore, tctp induced brain cells apoptosis, as evidenced by the upregulation of pro-apoptotic genes (bax, p53, tnfα, caspase3 and caspase9) and the downregulation of anti-apoptotic gene (bcl2). 2025-01-01 2025-01-04 human