| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingyun Li, Yujia Jiang, Ting Wang, Weiwei Liu, Xiaojuan Chen, Jinyi He, Zeyu Du, Ruijiao Yang, Danxiu Miao, Yanshu L. MicroRNA-217-5p triggers dopaminergic neuronal degeneration via autophagy activation under Atrazine exposure. Environmental pollution (Barking, Essex : 1987). vol 340. issue Pt 1. 2023-10-31. PMID:37890694. |
both mir-217-5p overexpression and atr exposure is able to trigger the autophagy process and apoptosis. |
2023-10-31 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Soichi Hirai, Tadaaki Yamada, Yuki Katayama, Masaki Ishida, Hayato Kawachi, Yohei Matsui, Ryota Nakamura, Kenji Morimoto, Mano Horinaka, Toshiyuki Sakai, Yoshitaka Sekido, Shinsaku Tokuda, Koichi Takayam. Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells. Molecular cancer therapeutics. 2023-10-06. PMID:37802502. |
the axl and atr inhibitor combination increased cell apoptosis via the bim protein and suppressed cell migration when compared to each monotherapy. |
2023-10-06 |
2023-10-15 |
Not clear |
| Ping Han, Yingjie Qiao, Jiayi He, Xubo Wan. Stress responses to warming in Japanese flounder (Paralichthys olivaceus) from different environmental scenarios. The Science of the total environment. 2023-07-06. PMID:37414161. |
in this study, we investigated the histological and apoptosis responses, oxidative stress and transcriptomic profile in the liver of japanese flounder exposed to gradual temperature rise (gtr) and abrupt temperature rise (atr). |
2023-07-06 |
2023-08-14 |
cat |
| Ping Han, Yingjie Qiao, Jiayi He, Xubo Wan. Stress responses to warming in Japanese flounder (Paralichthys olivaceus) from different environmental scenarios. The Science of the total environment. 2023-07-06. PMID:37414161. |
the histological results showed liver cells in atr group were the most serious in all three groups including vacuolar degeneration and inflammatory infiltration, and had more apoptosis cells than gtr group detected by tunel staining. |
2023-07-06 |
2023-08-14 |
cat |
| Bhanu Priya, Srimadhavi Ravi, Sivapriya Kirubakara. Targeting ATM and ATR for cancer therapeutics: inhibitors in clinic. Drug discovery today. 2023-06-11. PMID:37302542. |
atr and atm kinases recognize this damage and activate proteins involved in cell cycle checkpoint, dna repair, and apoptosis. |
2023-06-11 |
2023-08-14 |
Not clear |
| Yongpeng Li, Lin Li, Haoyu Fu, Qing Yao, Lei Wang, Liguang Lo. Combined inhibition of PARP and ATR synergistically potentiates the antitumor activity of HER2-targeting antibody-drug conjugate in HER2-positive cancers. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777513. |
effects of the her2-targeted adc, ds-8201, in combination with parpi (azd2281), a dna damage repair inhibitor that targets poly(adp-ribose) polymerase, and atri (bay1895344), which inhibits the serine/threonine kinase atr, were determined by assessing cell-growth inhibition, apoptosis and cell-cycle arrest, as well as using |
2023-02-13 |
2023-08-14 |
Not clear |
| Miki Suemura, Shusaku Shibutani, Hiroyuki Iwat. The endocytosis inhibitor dynasore induces a DNA damage response pathway that can be manipulated for enhanced apoptosis. Biochemical and biophysical research communications. vol 645. 2023-01-19. PMID:36657293. |
furthermore, an atr inhibitor sensitized the dynasore-induced apoptosis. |
2023-01-19 |
2023-08-14 |
Not clear |
| Vignesh Sundararajan, Tuan Zea Tan, Diana Lim, Yanfen Peng, Antje Margret Wengner, Natalie Yan Li Ngoi, Anand D Jeyasekharan, David Shao Peng Ta. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition. The Journal of pathology. 2022-11-14. PMID:36373784. |
rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention toward targeting cell cycle checkpoint kinases (such as atr, chk1, wee1 and others) along the dna damage response and replicative stress response pathways, thereby allowing unrepaired dna damage to be carried forward towards mitotic catastrophe and apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| Weicai Huang, Zhen Han, Zepang Sun, Hao Feng, Liying Zhao, Qingyu Yuan, Chuanli Chen, Shitong Yu, Yanfeng Hu, Jiang Yu, Hao Liu, Guoxin Li, Yuming Jian. PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer. Cell death & disease. vol 13. issue 7. 2022-07-28. PMID:35902562. |
activation of atr is the necessary step for pak6 mediated hr repair to protect gc cells from oxaliplatin-induced apoptosis, and atr inhibitor (azd6738) could block the pak6-mediated hr repair, thereby reversing the resistance to oxaliplatin and even promoting the sensitivity to oxaliplatin regardless of high expression of pak6. |
2022-07-28 |
2023-08-14 |
Not clear |
| Francis M Barnieh, Goreti Ribeiro Morais, Herbie Garland, Paul M Loadman, Robert A Falcone. Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells. Biochemical pharmacology. 2022-05-22. PMID:35598808. |
we also explore synergism between ict2588 and atr inhibition, since colchicine, in addition to its vascular-disrupting properties, is known to induce g2/m arrest, dna damage, and trigger apoptosis. |
2022-05-22 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
atractylodin (atr) has anticancer effects on some tumor cells by inducing apoptosis, but its mechanism in lung cancer remains unclear. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
results showed that the effect of atr on the apoptosis of a549 cells was negatively correlated with the change in mitochondrial membrane potential. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
western blot analysis showed that atr regulated apoptosis induced by mitogen-activated protein kinase, signal transducer and activator of transcription 3, and nuclear factor kappa b signaling pathways. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
results showed that atr can inhibit cell proliferation, induce cell apoptosis, induce cell cycle arrest, and inhibit the migration of a549 cells ( |
2022-05-14 |
2023-08-13 |
Not clear |
| Merve Yildirim, Ozgecan Kayalar, Ersan Atahan, Fusun Ozta. Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis. Journal of biochemical and molecular toxicology. 2022-04-13. PMID:35416377. |
the effects of atr on myofibroblast differentiation, apoptosis, and tgf-\xce\xb2 and wnt/\xce\xb2-catenin signaling activations were examined by western blot analysis and flow cytometry in mrc5s. |
2022-04-13 |
2023-08-13 |
mouse |
| Merve Yildirim, Ozgecan Kayalar, Ersan Atahan, Fusun Ozta. Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis. Journal of biochemical and molecular toxicology. 2022-04-13. PMID:35416377. |
moreover, atr caused myofibroblast apoptosis via caspase-3 activation. |
2022-04-13 |
2023-08-13 |
mouse |
| Michel M Ouellette, Sumin Zhou, Ying Ya. Cell Signaling Pathways That Promote Radioresistance of Cancer Cells. Diagnostics (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35328212. |
however, radiation also concomitantly activates multiple prosurvival signaling pathways, which include those mediated by atm, atr, akt, erk, and nf-\xce\xbab that promote dna damage checkpoint activation/dna repair, autophagy induction, and/or inhibition of apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Meiran Chu, Xinglan An, Daoyu Zhang, Qi Li, Xiangpeng Dai, Hao Yu, Ziyi L. Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint. Biochimica et biophysica acta. Molecular cell research. vol 1869. issue 2. 2021-12-10. PMID:34763028. |
combined treatment with 6-tg and dsf/cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-rad3-related kinase (atr), suggesting that dsf/cu promoted 6-tg-induced dna damage by suppressing atr protein kinases, therefore enhancing cell apoptosis. |
2021-12-10 |
2023-08-13 |
human |
| Shaohua Dou, Chao Yang, Danfeng Zou, Wa Da, Muqaddas Masood, Salah Adlat, Yang-Jin Baima, M I Nasser, Bin Li, Nan Jian. Atractylenolide II induces cell cycle arrest and apoptosis in breast cancer cells through ER pathway. Pakistan journal of pharmaceutical sciences. vol 34. issue 4. 2021-11-22. PMID:34799321. |
in this research, atractylenolide ii (atr ii) on apoptosis, cell cycle cells via er pathway in breast cancer (mda-mb-231 and mcf-7) cells are assessed. |
2021-11-22 |
2023-08-13 |
Not clear |