| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daryl Griffin, Robbie Carson, Debbie Moss, Tamas Sessler, Deborah Lavin, Vijay K Tiwari, Shivaali Karelia, Richard Kennedy, Kienan I Savage, Simon McDade, Adam Carie, Jim Pankovich, Mark Bazett, Sandra Van Schaeybroec. Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation. Molecular cancer research : MCR. 2024-07-31. PMID:39083088. |
importantly, pharmacological blockade of this resistance pathway with atr inhibitors synergistically increased bold-100-induced apoptosis and growth inhibition in brafmt models. |
2024-07-31 |
2024-08-02 |
Not clear |
| Jonathan K M Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H Sorense. The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation. Cell death & disease. vol 15. issue 7. 2024-07-13. PMID:39003251. |
mechanistically, eef2k deficiency blunts the activation of the dna damage response associated atm and atr pathways, in turn preventing p53 activation and therefore compromising induction of cisplatin-induced apoptosis. |
2024-07-13 |
2024-07-16 |
caenorhabditis_elegans |
| Yetunde Makinwa, Yibo Luo, Phillip R Musich, Yue Zo. Canonical and Noncanonical Functions of the BH3 Domain Protein Bid in Apoptosis, Oncogenesis, Cancer Therapeutics, and Aging. Cancers. vol 16. issue 12. 2024-06-27. PMID:38927905. |
we will discuss the roles of bid, mitochondrial atr, and other anti-apoptotic proteins in intrinsic apoptosis, exploring how their interaction sustains cellular viability despite the initiation of upstream death signals. |
2024-06-27 |
2024-06-29 |
Not clear |
| Yetunde Makinwa, Yibo Luo, Phillip R Musich, Yue Zo. Canonical and Noncanonical Functions of the BH3 Domain Protein Bid in Apoptosis, Oncogenesis, Cancer Therapeutics, and Aging. Cancers. vol 16. issue 12. 2024-06-27. PMID:38927905. |
the stable protein associations at the mitochondria between tbid and anti-apoptotic mitochondrial atr play a crucial role in maintaining the viability of cancer cells, suggesting a novel mechanism to induce cancer cell apoptosis by freeing tbid from the atr associations at mitochondria. |
2024-06-27 |
2024-06-29 |
Not clear |
| Monika Majirská, Martina Bago Pilátová, Zuzana Kudličková, Martin Vojtek, Carmen Dini. Targeting hematological malignancies with isoxazole derivatives. Drug discovery today. 2024-06-13. PMID:38871112. |
this review summarizes the knowledge on isoxazole-derived compounds toward hematological malignancies and provides clues on their mechanism(s) of action (apoptosis, cell cycle arrest, ros production) and putative pharmacological targets (c-myc, bet, atr, flt3, hsp90, carm1, tubulin, pd-1/pd-l1, hdacs) wherever known. |
2024-06-13 |
2024-06-16 |
Not clear |
| Cong Zhang, Yu Liu, Peilin Wang, Bo Wang, Shanshan Zhang, Zeao Hua, Yanan Li, Xuebing Wang, Xu Yan. Effects of Se-enriched yeast on the amelioration of atrazine-induced meat quality degradation. Food chemistry. vol 454. 2024-05-25. PMID:38795622. |
atr aggravated oxidative stress and inflammation by inhibiting nrf2 pathway and activating nf-κb pathway, ultimately causing apoptosis. |
2024-05-25 |
2024-05-31 |
human |
| Dina M Gaber, Sherihan S Ibrahim, Ashraf K Awaad, Yasmine M Shahine, Salma Elmallah, Hebatallah S Barakat, Noha I Khami. A drug repurposing approach of Atorvastatin calcium for its antiproliferative activity for effective treatment of breast cancer: International journal of pharmaceutics: X. vol 7. 2024-05-01. PMID:38689601. |
atorvastatin calcium (atr ca) which is used for the treatment of hypercholesterolemia has potential to modulate cell growth and apoptosis. |
2024-05-01 |
2024-05-03 |
Not clear |
| Kirti S Prabhu, Shilpa Kuttikrishnan, Nuha Ahamad, Ummu Habeeba, Zahwa Mariyam, Muhammad Suleman, Ajaz A Bhat, Shahab Uddi. H2AX: A key player in DNA damage response and a promising target for cancer therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-04-30. PMID:38688170. |
the review explains how h2ax phosphorylation, facilitated by the master kinases atm and atr, acts as a signal for dna damage, triggering downstream pathways that govern cell cycle checkpoints, apoptosis, and the cellular fate decision between repair and cell death. |
2024-04-30 |
2024-05-03 |
Not clear |
| Jie Zhao, Guangjun Huang, Yuting Fu, Zhangbo Lou, Hao Yu, Wei Wang, Dagan Ma. Exposure to atrazine stimulates progesterone secretion and induces oxidative stress, inflammation, and apoptosis in the ovary of pseudopregnant rats. Chemosphere. 2024-04-07. PMID:38583534. |
we hypothesized that atr could affect ovarian steroidogenesis, oxidative stress, inflammation, and apoptosis. |
2024-04-07 |
2024-04-10 |
rat |
| Jie Zhao, Guangjun Huang, Yuting Fu, Zhangbo Lou, Hao Yu, Wei Wang, Dagan Ma. Exposure to atrazine stimulates progesterone secretion and induces oxidative stress, inflammation, and apoptosis in the ovary of pseudopregnant rats. Chemosphere. 2024-04-07. PMID:38583534. |
in conclusion, nrf-2/nqo1 signaling pathway and creb might be involved in the regulation of atr in luteal steroidogenesis, oxidative stress, inflammation, and apoptosis in rat ovary. |
2024-04-07 |
2024-04-10 |
rat |
| Jingtao Liu, Xiaomei Tan, Li Li, Liying Cao, Yan Zhou, He Li, Ting Pen. Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage. Cell death discovery. vol 10. issue 1. 2024-03-12. PMID:38467618. |
notably, the inhibitory effect of nol12 against uv-induced apoptosis could be restrained by increasing the expression of atr serine/threonine kinase (atr), a kinase that, when activated by severe dna damage, can result in apoptosis. |
2024-03-12 |
2024-03-14 |
human |
| Jingtao Liu, Xiaomei Tan, Li Li, Liying Cao, Yan Zhou, He Li, Ting Pen. Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage. Cell death discovery. vol 10. issue 1. 2024-03-12. PMID:38467618. |
additionally, inhibiting atr activity reduced apoptosis resulting from both silencing nol12 expression and uv exposure. |
2024-03-12 |
2024-03-14 |
human |
| Yubo Wang, Ruonan Wang, Yanli Zhao, Sheng Cao, Chen Li, Yanjie Wu, Lan Ma, Ying Liu, Yuhong Yao, Yue Jiao, Yukun Chen, Shuangwei Liu, Kun Zhang, Mingming Wei, Cheng Yang, Guang Yan. Discovery of selective and potent ATR degrader for exploration its kinase-independent functions in acute myeloid leukemia cells. Angewandte Chemie (International ed. in English). 2024-03-04. PMID:38433368. |
this would increase the expression of p53 and triggered immediately p53-mediated apoptosis signaling pathway, which was earlier and more effective than atr kinase inhibition. |
2024-03-04 |
2024-03-06 |
Not clear |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Bingyun Li, Yujia Jiang, Ting Wang, Weiwei Liu, Xiaojuan Chen, Jinyi He, Zeyu Du, Ruijiao Yang, Danxiu Miao, Yanshu L. MicroRNA-217-5p triggers dopaminergic neuronal degeneration via autophagy activation under Atrazine exposure. Environmental pollution (Barking, Essex : 1987). vol 340. issue Pt 1. 2023-10-31. PMID:37890694. |
both mir-217-5p overexpression and atr exposure is able to trigger the autophagy process and apoptosis. |
2023-10-31 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Soichi Hirai, Tadaaki Yamada, Yuki Katayama, Masaki Ishida, Hayato Kawachi, Yohei Matsui, Ryota Nakamura, Kenji Morimoto, Mano Horinaka, Toshiyuki Sakai, Yoshitaka Sekido, Shinsaku Tokuda, Koichi Takayam. Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells. Molecular cancer therapeutics. 2023-10-06. PMID:37802502. |
the axl and atr inhibitor combination increased cell apoptosis via the bim protein and suppressed cell migration when compared to each monotherapy. |
2023-10-06 |
2023-10-15 |
Not clear |
| Ping Han, Yingjie Qiao, Jiayi He, Xubo Wan. Stress responses to warming in Japanese flounder (Paralichthys olivaceus) from different environmental scenarios. The Science of the total environment. 2023-07-06. PMID:37414161. |
in this study, we investigated the histological and apoptosis responses, oxidative stress and transcriptomic profile in the liver of japanese flounder exposed to gradual temperature rise (gtr) and abrupt temperature rise (atr). |
2023-07-06 |
2023-08-14 |
cat |
| Ping Han, Yingjie Qiao, Jiayi He, Xubo Wan. Stress responses to warming in Japanese flounder (Paralichthys olivaceus) from different environmental scenarios. The Science of the total environment. 2023-07-06. PMID:37414161. |
the histological results showed liver cells in atr group were the most serious in all three groups including vacuolar degeneration and inflammatory infiltration, and had more apoptosis cells than gtr group detected by tunel staining. |
2023-07-06 |
2023-08-14 |
cat |
| Bhanu Priya, Srimadhavi Ravi, Sivapriya Kirubakara. Targeting ATM and ATR for cancer therapeutics: inhibitors in clinic. Drug discovery today. 2023-06-11. PMID:37302542. |
atr and atm kinases recognize this damage and activate proteins involved in cell cycle checkpoint, dna repair, and apoptosis. |
2023-06-11 |
2023-08-14 |
Not clear |