| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siqi Wang, Fang Ji, Xiaoli Gao, Zhiyi Li, Si Lv, Juan Zhang, Jiarui Luo, Dan Li, Jie Yan, Huayang Zhang, Kaicheng Fang, Lin Wu, Miaoling L. Tyrosine Kinase Inhibitor Lenvatinib Causes Cardiotoxicity by Inducing Endoplasmic Reticulum Stress and Apoptosis through Activating ATF6, IRE1α and PERK Signaling Pathways. Recent patents on anti-cancer drug discovery. 2024-07-12. PMID:38994620. |
tyrosine kinase inhibitor lenvatinib causes cardiotoxicity by inducing endoplasmic reticulum stress and apoptosis through activating atf6, ire1α and perk signaling pathways. |
2024-07-12 |
2024-07-14 |
Not clear |
| Yu-Chen Liu, Xue Bai, Bing Liao, Xu-Bo Chen, Li-Hua Li, Yue-Hui Liu, Hai-Jun Hu, Kai X. Activating transcription factor 6 contributes to cisplatin‑induced ototoxicity via regulating the unfolded proteins response. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941893. |
in this study, we observed that cisplatin exposure induced apoptosis of mouse auditory oc-1 cells, accompanied by a significant increase in the expression of atf6 and c/ebp homologous protein (chop). |
2024-06-28 |
2024-07-01 |
mouse |
| Yu-Chen Liu, Xue Bai, Bing Liao, Xu-Bo Chen, Li-Hua Li, Yue-Hui Liu, Hai-Jun Hu, Kai X. Activating transcription factor 6 contributes to cisplatin‑induced ototoxicity via regulating the unfolded proteins response. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941893. |
collectively, our results revealed the underlying mechanism by which activation of atf6 significantly improved cisplatin-induced hair cell apoptosis, at least in part by inhibiting apoptosis signal-regulating kinase 1 expression, and demonstrated that pharmacological activation of atf6-mediated unfolded protein response is a potential treatment for cisplatin-induced ototoxicity. |
2024-06-28 |
2024-07-01 |
mouse |
| Jiajie Gan, Haoming Ma, Yeyun Ma, Mengyuan Zhou, Ying Li, Weiping Yan, Zibo Don. Silybin prevented avermectin-induced cardiotoxicity in carp by modulating oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial apoptosis, and autophagy. Fish & shellfish immunology. 2024-05-13. PMID:38740228. |
silybin exerted anti-inflammatory effects through the nuclear factor kappa b (nf-κb) pathway, antioxidant effects through the nuclear factor erythroid 2-related factor 2 (nrf2) - kelch-like ech-associated protein 1 (keap1) pathway, alleviated cardiac er stress through the glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6)/c/ebp homologous protein (chop) axis, suppressed apoptosis through the mitochondrial pathway, and inhibited excessive autophagy initiation through the pten-induced putative kinase 1 (pink1)/ parkin rbr e3 ubiquitin protein ligase (parkin) signaling pathway. |
2024-05-13 |
2024-05-27 |
Not clear |
| Kezia Rachellea Mustakim, Mi Young Eo, Mi Hyun Seo, Hyeong-Cheol Yang, Min-Keun Kim, Hoon Myoung, Soung Min Ki. Ultrastructural and immunohistochemical evaluation of hyperplastic soft tissues surrounding dental implants in fibular jaws. Scientific reports. vol 14. issue 1. 2024-05-10. PMID:38730018. |
in immunohistochemical analysis, unfolded protein-response markers atf6, perk, xbp1, inflammatory marker nfκb, necroptosis marker mlkl, apoptosis marker gadd153, autophagy marker lc3, epithelial-mesenchymal transition, and angiogenesis markers were expressed variably in hyperplastic tissue surrounding fff implants, peri-implantitis, and fbg tissues. |
2024-05-10 |
2024-05-27 |
Not clear |
| Huimin Liu, Ye Zheng, Shaoning Kan, Ming Hao, Huan Jiang, Shuangji Li, Rong Li, Yinyu Wang, Dongxu Wang, Weiwei Li. Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644851. |
mt also promoted the expression of atf4, atf6, bip, bap31 and chop in crl-1623 cells leading to endoplasmic reticulum stress, and induced autophagy and apoptosis in crl-1623 cells. |
2024-04-22 |
2024-04-24 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Doyoung Kwon, Hyeji Seo, Sou Hyun Kim, Ki Wung Chung, Jaewon Lee, Young-Suk Jun. Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-03-31. PMID:38556155. |
diclofenac-promoted hepatic oxidative stress (oxidized proteins, 4-hydroxynonenal, and malondialdehyde), endoplasmic reticulum (er) stress (bip, atf6, and chop), and apoptosis (cleaved caspase-3 and cleaved parp) were enhanced by fasting. |
2024-03-31 |
2024-04-03 |
mouse |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Fusen Yue, Jinsheng Xu, Linyi Meng, Qi Wang, Mingtao Tan, Aoying Zhang, Shanchun Yan, Dun Jian. A new insight into Cd exposure-induced hemocyte reduction in Lymantria dispar larvae: Involvement of the ROS-ATF6-ER stress-apoptosis pathway. Journal of hazardous materials. vol 469. 2024-03-20. PMID:38508113. |
studies using inhibitors confirmed that apoptosis mediated the decrease in hemocyte count, er stress mediated apoptosis, atf6 pathway mediated er stress, and ros or oxidative stress mediated er stress through the activation of the atf6 pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fan. Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine. Computational and structural biotechnology journal. vol 23. 2024-01-23. PMID:38261917. |
experimental results showed that echinacoside and danthron were able to effectively reduce er stress-mediated neuronal apoptosis by inhibiting the expression levels of bip, p-perk, atf6, and chop in app-sh-sy5y cells. |
2024-01-23 |
2024-01-26 |
Not clear |
| Jinuk Seo, Doyoung Kwon, Sou Hyun Kim, Mi Ran Byun, Yun-Hee Lee, Young-Suk Jun. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. Current research in food science. vol 8. 2024-01-15. PMID:38222825. |
in addition, it reduced the cdahfd-induced er stress (bip, atf6, and chop) and apoptosis (bax, cleaved caspase-3, and cleaved parp); however, it induced autophagy (lc3ii/i and p62) which was downregulated by cdahfd. |
2024-01-15 |
2024-01-17 |
mouse |
| Chang Liu, Rong J. Potential Role of Endoplasmic Reticulum Stress in Modulating Protein Homeostasis in Oligodendrocytes to Improve White Matter Injury in Preterm Infants. Molecular neurobiology. 2024-01-05. PMID:38180617. |
3) ire1 and atf6 pathways enhanced various gene transcription associated with protein folding, secreting, eard, and erqc to prompt cell protein homeostasis micro-environment; however, sustained ire1 and/or atf6 activity could prompt cell survival toward apoptosis via the pro-apoptotic pathway, inflammation, and other patterns. |
2024-01-05 |
2024-01-07 |
Not clear |
| Jie-Xiang Zhang, Wei-Chen Yuan, Cheng-Gang Li, Hai-Yan Zhang, Shu-Yan Han, Xiao-Hong L. A review on the mechanisms underlying the antitumor effects of natural products by targeting the endoplasmic reticulum stress apoptosis pathway. Frontiers in pharmacology. vol 14. 2023-12-04. PMID:38044941. |
when ers is under- or overexpressed, it activates the protein kinase r (pkr)-like endoplasmic reticulum kinase (perk)-, inositol-requiring enzyme 1 (ire1)- and activating transcription factor 6 (atf6)-related apoptotic pathways to induce apoptosis. |
2023-12-04 |
2023-12-10 |
human |
| Lulu Ding, Huali Zhu, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Bianhua Zhou, Hongwei Wang, Zijun Yang, Zongping Liu, Jicang Wan. Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway. Environmental science and pollution research international. 2023-11-24. PMID:38001299. |
the mrna and protein expression levels of ers and apoptosis related factors such as grp78, ire1α, xbp1, atf6, caspase-12, caspase-3 and bax in the cells were significantly increased (p < 0.01), while the mrna and protein expression levels of bcl-2 were significantly reduced (p < 0.01). |
2023-11-24 |
2023-11-28 |
rat |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Biswadeep Das, Sagnika Samal, Hamida Hamdi, Aditi Pal, Arpita Biswas, Jyotika Behera, Gyanraj Singh, Chinmay Kumar Behera, Debee Prasad Sahoo, Sanghamitra Pat. Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development. Life sciences. 2023-07-30. PMID:37517582. |
this could be attributed to the uncontrolled activation of the key upr signaling pathways: inositol-requiring transmembrane kinase/endoribonuclease 1 (ire1), protein kinase r (pkr)-like endoplasmic reticulum kinase (perk), and activating transcription factor-6 (atf6), which promote cell autophagy under normal and diseased conditions through the downstream regulation of apoptosis promoting factors such as x-box binding protein (xbp1), gadd34, and atf-6. |
2023-07-30 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
atf6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. |
2023-07-28 |
2023-08-14 |
Not clear |
| Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, Xiang-Shun Cu. ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions. Zoological research. vol 44. issue 5. 2023-07-28. PMID:37501400. |
activating transcription factor 6 (atf6), one of the three sensor proteins in the endoplasmic reticulum (er), is an important regulator of er stress-induced apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |