| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideyuki Hirasawa, Shinya Tanaka, Akinori Sakai, Masato Tsutsui, Hiroaki Shimokawa, Hironori Miyata, Sawako Moriwaki, Shumpei Niida, Masako Ito, Toshitaka Nakamur. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 22. issue 7. 2007-09-13. PMID:17388726. |
apoe gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. |
2007-09-13 |
2023-08-12 |
mouse |
| Hideyuki Hirasawa, Shinya Tanaka, Akinori Sakai, Masato Tsutsui, Hiroaki Shimokawa, Hironori Miyata, Sawako Moriwaki, Shumpei Niida, Masako Ito, Toshitaka Nakamur. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 22. issue 7. 2007-09-13. PMID:17388726. |
osteoblast apoptosis increased in the tibias of apoe(-/-) mice fed with a high-fat diet, decreasing bone formation. |
2007-09-13 |
2023-08-12 |
mouse |
| Hideyuki Hirasawa, Shinya Tanaka, Akinori Sakai, Masato Tsutsui, Hiroaki Shimokawa, Hironori Miyata, Sawako Moriwaki, Shumpei Niida, Masako Ito, Toshitaka Nakamur. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 22. issue 7. 2007-09-13. PMID:17388726. |
ldl or oxidized ldl increased apoptosis in the calvarial cells of apoe(-/-) mice. |
2007-09-13 |
2023-08-12 |
mouse |
| Hideyuki Hirasawa, Shinya Tanaka, Akinori Sakai, Masato Tsutsui, Hiroaki Shimokawa, Hironori Miyata, Sawako Moriwaki, Shumpei Niida, Masako Ito, Toshitaka Nakamur. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 22. issue 7. 2007-09-13. PMID:17388726. |
the increase in p53-mediated apoptosis is apparently related to a high-fat diet-induced osteopenia in apoe(-/-) mice. |
2007-09-13 |
2023-08-12 |
mouse |
| C Frey, A Bonert, T Kratzsch, G Rexroth, W Rösch, F Müller-Spahn, K Maurer, W E Müller, A Ecker. Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16736246. |
in the present study, we investigated whether abnormalities in apoptosis and caspase-3 activity can be found at the level of lymphocytes and a t cell subtype, cd4 t cells, from ad patients compared to aged sex- and apoe genotype-matched non-demented controls. |
2007-09-05 |
2023-08-12 |
Not clear |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
apolipoprotein-e (apoe) regulates brain lipid transport and specific neuronal functions and previous research, investigating non-neuronal cell types, identified an association between apoptosis and increased apoe expression. |
2007-06-22 |
2023-08-12 |
human |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
in the present study we used the human sk-n-sh neuronal cell line to investigate potential changes in apoe expression during apoptosis which occurs as a consequence of extended culture (up to 5 days) without replenishing trophic factors. |
2007-06-22 |
2023-08-12 |
human |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
apoe protein levels were low in the absence of apoptosis but increased by 8-fold when apoptosis was induced. |
2007-06-22 |
2023-08-12 |
human |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
these data indicate that apoe is up-regulated during neuronal apoptosis and raise the possibility that apoe may play a role in the clearance of apoptotic bodies through apoe-receptor interactions. |
2007-06-22 |
2023-08-12 |
human |
| R W Mahley, Y Huan. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta neurologica Scandinavica. Supplementum. vol 185. 2006-10-02. PMID:16866905. |
two examples of how the structure of apoe4 determines the pathological outcome in neurons include apoe4 potentiation of amyloid beta-induced lysosomal leakage and apoptosis and the proteolytic cleavage of apoe synthesized by neurons. |
2006-10-02 |
2023-08-12 |
Not clear |
| Koichi Kozak. [Current concepts of vascular calcification]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 42. issue 6. 2006-01-31. PMID:16408509. |
besides apoptosis and pi uptake, such proteins as osteoprotegerin (opg), matrix gla protein (mgp), klotho, fetuin-a, and apoe have been shown to negatively affect vascular calcification. |
2006-01-31 |
2023-08-12 |
human |
| John Mercer, Nichola Figg, Victoria Stoneman, Denise Braganza, Martin R Bennet. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circulation research. vol 96. issue 6. 2005-09-22. PMID:15746445. |
endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in apoe knockout mice. |
2005-09-22 |
2023-08-12 |
mouse |
| Hao Li, Joyce J Repa, Mark A Valasek, Eduardo P Beltroy, Stephen D Turley, Dwight C German, John M Dietsch. Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. Journal of neuropathology and experimental neurology. vol 64. issue 4. 2005-05-24. PMID:15835268. |
nevertheless, neurodegeneration proceeds utilizing apoptosis with activation of glial cells, increased apoe and apod synthesis, and increased cholesterol turnover across the cns. |
2005-05-24 |
2023-08-12 |
mouse |
| Yu-Chi Chen, Gudrun Pohl, Tian-Li Wang, Patrice J Morin, Björn Risberg, Gunnar B Kristensen, Albert Yu, Ben Davidson, Ie-Ming Shi. Apolipoprotein E is required for cell proliferation and survival in ovarian cancer. Cancer research. vol 65. issue 1. 2005-03-02. PMID:15665311. |
inhibition of apoe expression using an apoe-specific sirna led to g(2) cell cycle arrest and apoptosis in an apoe-expressing ovarian cancer cell line, ovcar3, but not in apoe-negative cell lines. |
2005-03-02 |
2023-08-12 |
human |
| Nicodemus Tedla, Elias N Glaros, Ulf T Brunk, Wendy Jessup, Brett Garne. Heterogeneous expression of apolipoprotein-E by human macrophages. Immunology. vol 113. issue 3. 2004-12-14. PMID:15500620. |
apoe over-expressing thp-1 macrophages contained condensed/fragmented nuclei and increased levels of activated caspase-3 indicating induction of apoptosis. |
2004-12-14 |
2023-08-12 |
human |
| Carmel M Quinn, Katarina Kågedal, Alexei Terman, Uri Stroikin, Ulf T Brunk, Wendy Jessup, Brett Garne. Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. The Biochemical journal. vol 378. issue Pt 3. 2004-06-24. PMID:14656220. |
fibroblast apoe mrna and protein levels were up-regulated during staurosporine-induced apoptosis and this was correlated with increased caspase-3 activity and apoptotic morphological alterations. |
2004-06-24 |
2023-08-12 |
human |
| Carmel M Quinn, Katarina Kågedal, Alexei Terman, Uri Stroikin, Ulf T Brunk, Wendy Jessup, Brett Garne. Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. The Biochemical journal. vol 378. issue Pt 3. 2004-06-24. PMID:14656220. |
the expression of abca1 (atp-binding cassette transporter a1) mrna, which is also regulated by lxralpha, was increased in parallel with apoe mrna, indicating that lxralpha probably promotes apoe and abca1 transcription during apoptosis. |
2004-06-24 |
2023-08-12 |
human |
| Robert M DeKroon, Mirta Mihovilovic, Zoe V Goodger, Jennifer B Robinette, Patrick M Sullivan, Ann M Saunders, Warren J Strittmatte. ApoE genotype-specific inhibition of apoptosis. Journal of lipid research. vol 44. issue 8. 2004-06-14. PMID:12754278. |
apoe genotype-specific inhibition of apoptosis. |
2004-06-14 |
2023-08-12 |
Not clear |
| Ramón Cacabelo. The application of functional genomics to Alzheimer's disease. Pharmacogenomics. vol 4. issue 5. 2004-02-06. PMID:12943467. |
the analysis of genotype-phenotype correlations has revealed that the presence of the apoe-4 allele in ad, in conjunction with other loci distributed across the genome, influence disease onset, brain atrophy, cerebrovascular perfusion, blood pressure, beta-amyloid deposition, apoe secretion, lipid metabolism, brain bioelectrical activity, cognition, apoptosis and treatment outcome. |
2004-02-06 |
2023-08-12 |
Not clear |
| Kazuo Kitagawa, Masayasu Matsumoto, Masatsugu Hori, Takehiko Yanagihar. Neuroprotective effect of apolipoprotein E against ischemia. Annals of the New York Academy of Sciences. vol 977. 2003-01-21. PMID:12480787. |
however, the molecular mechanism underlying the protective effect of apoe remains uncertain, even though several mechanisms including excitotoxicity, free radicals, and apoptosis have been cited as causes of selective neuronal vulnerability in cerebral ischemia. |
2003-01-21 |
2023-08-12 |
mouse |