| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuo Kitagawa, Masayasu Matsumoto, Masatsugu Hori, Takehiko Yanagihar. Neuroprotective effect of apolipoprotein E against ischemia. Annals of the New York Academy of Sciences. vol 977. 2003-01-21. PMID:12480787. |
the results suggested that apoe exerted the neuroprotective effect against ischemia through its antioxidant action, but not through mitigation of glutamate toxicity or blocking of apoptosis. |
2003-01-21 |
2023-08-12 |
mouse |
| Zhong-Sheng Ji, R Dennis Miranda, Yvonne M Newhouse, Karl H Weisgraber, Yadong Huang, Robert W Mahle. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. The Journal of biological chemistry. vol 277. issue 24. 2002-07-25. PMID:11912196. |
cells preincubated for 4 h with a source of apoe3 or apoe4, followed by removal of apoe from the medium and from the cell surface, still exhibited the isoform-specific response to abeta1-42, indicating that the potentiation of apoptosis required intracellular apoe, presumably in the endosomes or lysosomes. |
2002-07-25 |
2023-08-12 |
Not clear |
| Kazuo Kitagawa, Masayasu Matsumoto, Keisuke Kuwabara, Ken-Ichiro Takasawa, Shigeru Tanaka, Tsutomu Sasaki, Kohji Matsushita, Toshiho Ohtsuki, Takehiko Yanagihara, Masatsugu Hor. Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action. Journal of neuroscience research. vol 68. issue 2. 2002-05-03. PMID:11948667. |
however, the molecular mechanism underlying the protective effect of apoe remains uncertain, even though several mechanisms, including excitotoxicty, free radicals, and apoptosis, have been cited as causes of selective neuronal vulnerability in cerebral ischemia. |
2002-05-03 |
2023-08-12 |
mouse |
| Kazuo Kitagawa, Masayasu Matsumoto, Keisuke Kuwabara, Ken-Ichiro Takasawa, Shigeru Tanaka, Tsutomu Sasaki, Kohji Matsushita, Toshiho Ohtsuki, Takehiko Yanagihara, Masatsugu Hor. Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action. Journal of neuroscience research. vol 68. issue 2. 2002-05-03. PMID:11948667. |
the results suggest that apoe exerted its neuroprotective effect against ischemia through its antioxidant action but not through mitigation of glutamate toxicity or blocking of apoptosis. |
2002-05-03 |
2023-08-12 |
mouse |
| G Chen, L Paka, Y Kako, P Singhal, W Duan, S Pillarisett. A protective role for kidney apolipoprotein E. Regulation of mesangial cell proliferation and matrix expansion. The Journal of biological chemistry. vol 276. issue 52. 2002-01-31. PMID:11579084. |
apoe did not show any cytotoxic effect, and moreover, inhibited mesangial cell apoptosis induced by oxidized low density lipoprotein. |
2002-01-31 |
2023-08-12 |
mouse |
| C L Lendon, B H Han, K Salimi, A M Fagan, M I Behrens, M C Muller, D M Holtzma. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947802. |
we questioned whether poor outcome after brain injury was due to direct modification by apoe protein and its gene variants of susceptibility to glutamate-mediated excitotoxic injury and apoptosis, mechanisms of cell death which occur following ischaemia and trauma. |
2000-09-19 |
2023-08-12 |
mouse |
| W A Pedersen, S L Chan, M P Mattso. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737598. |
this correlated with the differential ability of apoe isoforms to protect against apoptosis induced by hne in cultures of mouse spinal cord motor neurons and by the amyloid beta-peptide in cultures of rat hippocampal neurons. |
2000-04-11 |
2023-08-12 |
mouse |
| K L Moulder, M Narita, L K Chang, G Bu, E M Johnso. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037478. |
these data support the observation that apoe (141-155)2 is neurotoxic but suggest that the neurotoxicity is distinct from classical apoptosis or necrosis. |
1999-03-18 |
2023-08-12 |
Not clear |