| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoo Yeon Kim, Janet Ren Chao, Chulho Kim, Boyoung Kim, Phuong Thi-Thanh Nguyen, Harry Jung, Jiwon Chang, Jun Ho Lee, Jun Gyo Su. Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. Biochemical and biophysical research communications. vol 523. issue 3. 2020-09-08. PMID:31948760. |
reactive oxygen species (ros) and apoptosis rates were detected in the cochlea of the apoe ko male mice. |
2020-09-08 |
2023-08-13 |
mouse |
| Yoo Yeon Kim, Janet Ren Chao, Chulho Kim, Boyoung Kim, Phuong Thi-Thanh Nguyen, Harry Jung, Jiwon Chang, Jun Ho Lee, Jun Gyo Su. Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. Biochemical and biophysical research communications. vol 523. issue 3. 2020-09-08. PMID:31948760. |
cells positive for active caspase-3 and terminal deoxynucleotidyl transferase biotin-dutp nick end labeling (tunel) in the sgns were significantly increased in apoe ko-wd male mice indicating an increased rate of cellular apoptosis. |
2020-09-08 |
2023-08-13 |
mouse |
| Yoo Yeon Kim, Janet Ren Chao, Chulho Kim, Boyoung Kim, Phuong Thi-Thanh Nguyen, Harry Jung, Jiwon Chang, Jun Ho Lee, Jun Gyo Su. Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. Biochemical and biophysical research communications. vol 523. issue 3. 2020-09-08. PMID:31948760. |
in conclusion, ros in the sgns were activated by increased s100b expression in apoe ko-wd male mice, and this resulted in an increased apoptosis rate. |
2020-09-08 |
2023-08-13 |
mouse |
| Fang-da Li, Hao Nie, Cui Tian, Hong-Xia Wang, Bao-Hua Sun, Hua-Liang Ren, Xu Zhang, Peng-Zhi Liao, Duan Liu, Hui-Hua Li, Yue-Hong Zhen. Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 4. 2019-10-24. PMID:30642978. |
histological alterations, including aortic wall thickening, collagen deposition, elastin fragmentation, and vascular smooth muscle cell apoptosis in aaa tissue of apoe ko mice, were also significantly attenuated in lmp7/apoe dko mice. |
2019-10-24 |
2023-08-13 |
mouse |
| Huan Wang, Yang Yang, Xin Sun, Fang Tian, Shuyuan Guo, Wei Wang, Zhen Tian, Hong Jin, Zhiguo Zhang, Ye Tia. Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque. Theranostics. vol 8. issue 18. 2019-09-04. PMID:30429880. |
in the current research, we sought to explore ala-sdt-induced apoptosis of phagocytes and the effects of cholesterol efflux and efferocytosis in advanced apoe |
2019-09-04 |
2023-08-13 |
Not clear |
| Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Qing Zhu, Jin-Ling Ren, Yan-Rong Yu, Xiu-Ying Liu, Xiu-Jie Wang, Mei Han, Qing Jing, Jie Du, Chao-Shu Tang, Yong-Fen Q. Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice. Endocrine. vol 62. issue 1. 2019-02-18. PMID:29943223. |
imd infusion promoted the phosphorylation of adenosine 5'-monophosphate (amp)-activated protein kinase (ampk) in aortas in apoe ko mice, and the ampk inhibitor compound c abolished the protective effect of imd on vsmc ers and apoptosis induced by angii. |
2019-02-18 |
2023-08-13 |
mouse |
| Yihui Xiao, Ming He, Xiao Liang, Jianqing She, Lan He, Yan Liu, Juan Zou, Zuyi Yua. Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF- Oxidative medicine and cellular longevity. vol 2018. 2018-12-18. PMID:30210650. |
pu-erh tea ameliorates atherosclerosis associated with promoting macrophage apoptosis by reducing nf- we explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein e-deficient (apoe |
2018-12-18 |
2023-08-13 |
Not clear |
| Shanshan Cui, Xin Lv, Wen Li, Zhenshu Li, Huan Liu, Yuxia Gao, Guowei Huan. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox biology. vol 19. 2018-12-11. PMID:30125807. |
our data showed that folic acid reduced 8-ohdg levels and decreased apoptosis in the aortic tissue of apoe |
2018-12-11 |
2023-08-13 |
mouse |
| Jie Li, Jian Chen. Apolipoprotein E4 exacerbates ethanol-induced neurotoxicity through augmentation of oxidative stress and apoptosis in N2a-APP cells. Neuroscience letters. vol 665. 2018-11-13. PMID:29174637. |
inhibition of apoptosis using a pan-caspase inhibitor z-vad resulted in abolishment of the apoe isoform-specific effect on high-concentration ethanol-induced neurotoxicity. |
2018-11-13 |
2023-08-13 |
human |
| Jie Li, Jian Chen. Apolipoprotein E4 exacerbates ethanol-induced neurotoxicity through augmentation of oxidative stress and apoptosis in N2a-APP cells. Neuroscience letters. vol 665. 2018-11-13. PMID:29174637. |
taken together, our results for the first time demonstrate that apoe4 and high-concentration ethanol synergistically enhance neurotoxicity through elevating cellular oxidative stress and increasing neuronal apoptosis, and support the notion that avoiding excessive alcohol consumption can help to prevent ad especially in apoe ε4 carriers. |
2018-11-13 |
2023-08-13 |
human |
| Thais A Jacinto, Giselle S Meireles, Ananda T Dias, Rafaela Aires, Marcella L Porto, Agata L Gava, Elisardo C Vasquez, Thiago Melo C Pereira, Bianca P Campagnaro, Silvana S Meyrelle. Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis. Biological research. vol 51. issue 1. 2018-09-14. PMID:30185234. |
in this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, dna damage and apoptosis in monocytes from apolipoprotein e-deficient (apoe |
2018-09-14 |
2023-08-13 |
Not clear |
| Samson Jamesdaniel, Rita Rosati, Judy Westrick, Douglas M Rude. Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss. Toxicology letters. vol 292. 2018-06-12. PMID:29746905. |
chronic lead exposure downregulated cochlear sod1, gpx1, and gstk1, which encode critical antioxidant enzymes, and upregulated apoe, hspa1a, ercc2, prnp, ccl5, and sqstm1, which are indicative of cellular apoptosis. |
2018-06-12 |
2023-08-13 |
mouse |
| Koichiro Irie, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Toshiki Yoneda, Yoshihiro Shimazaki, Manabu Morit. Hyperlipidemia is involved in apoptosis in rat submandibular glands. Archives of oral biology. vol 81. 2018-06-05. PMID:28528308. |
the aim of the present study was to investigate the effects of hyperlipidemia on histological changes and apoptosis in submandibular glands using apolipoprotein e (apoe)-deficient rats. |
2018-06-05 |
2023-08-13 |
rat |
| Shengbing Li, Cong Wang, Ke Li, Ling Li, Mingyuan Tian, Jing Xie, Mengliu Yang, Yanjun Jia, Junying He, Lin Gao, Guenther Boden, Hua Liu, Gangyi Yan. NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. Scientific reports. vol 6. 2018-04-02. PMID:27229177. |
we demonstrated that a specific nampt knockdown increased plasma hdl-c levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased macrophage number and apoptosis, and promoted rct in hfd-fed apoe ko mice. |
2018-04-02 |
2023-08-13 |
mouse |
| Valentina Medici, Karl-Heinz Weis. Genetic and environmental modifiers of Wilson disease. Handbook of clinical neurology. vol 142. 2018-03-22. PMID:28433108. |
in particular, previously studied genes include copper metabolism domain-containing 1 (commd1), antioxidant 1 copper chaperone (atox1), x-linked inhibitor of apoptosis (xiap), apolipoprotein e (apoe), hemochromatosis (hfe), and 5,10-methylenetetrahydrofolate reductase (mthfr). |
2018-03-22 |
2023-08-13 |
Not clear |
| Janina Dose, Almut Nebel, Stefanie Piegholdt, Gerald Rimbach, Patricia Huebb. Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27130033. |
therefore, we studied biomarkers of oxidative status (glutathione levels, 3-nitrotyrosine adducts, protein carbonyl concentration), er stress (xbp1(s), bip, ddit3), proteasome activity, mitochondrial function (respiratory complexes, atp levels and mitochondrial membrane potential as well as biomarkers of mitochondrial biogenesis, fission and fusion), autophagy (lc3, lamp2a), apoptosis (bcl2, bax, cycs) and dna damage in the liver of apoe targeted replacement (tr) mice and in huh7 hepatocytes overexpressing the apoe3 and the apoe4 isoform, respectively. |
2018-01-09 |
2023-08-13 |
mouse |
| Zhi-Gang She, Juliana Hamzah, Venkata R Kotamraju, Hong-Bo Pang, Shirley Jansen, Erkki Ruoslaht. Plaque-penetrating peptide inhibits development of hypoxic atherosclerotic plaque. Journal of controlled release : official journal of the Controlled Release Society. vol 238. 2017-12-25. PMID:27423327. |
here we show, using three different atherosclerosis models in apoe null mice that prolonged systemic treatment with lyp-1 triggers apoptosis of plaque macrophages and reduces plaque in advanced hypoxic plaques, and that it does so without increasing necrotic core of plaques or causing detectable side effects. |
2017-12-25 |
2023-08-13 |
mouse |
| Yan-Wei Hu, Shao-Guo Wu, Jing-Jing Zhao, Xin Ma, Jing-Bo Lu, Jian-Cheng Xiu, Yuan Zhang, Chuan Huang, Yu-Rong Qiu, Yan-Hua Sha, Ji-Juan Gao, Yan-Chao Wang, Shu-Fen Li, Jia-Yi Zhao, Lei Zheng, Qian Wan. VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. Journal of lipid research. vol 57. issue 8. 2017-09-05. PMID:27281478. |
we explored the effect of vnn1 on cholesterol metabolism, inflammation, apoptosis in vitro, and progression of atherosclerotic plaques in apoe(-/-) mice. |
2017-09-05 |
2023-08-13 |
mouse |
| Xue-Shan Zhao, Qi Wu, Juan Peng, Li-Hong Pan, Zhong Ren, Hui-Ting Liu, Zhi-Sheng Jiang, Gui-Xue Wang, Zhi-Han Tang, Lu-Shan Li. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28000893. |
hyperlipidemia-induced apoptosis of hippocampal neurons in apoe(-/-) mice may be associated with increased pcsk9 expression. |
2017-04-21 |
2023-08-13 |
mouse |
| Guangzhi Cong, Ru Yan, Hui Huang, Kai Wang, Ning Yan, Ping Jin, Na Zhang, Jianjun Hou, Dapeng Chen, Shaobin Ji. Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE Life sciences. vol 173. 2017-03-15. PMID:28188730. |
involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic apoe hyperhomocysteinemia (hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. |
2017-03-15 |
2023-08-13 |
Not clear |