| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen Williams, Steven Simmonds, Andrew Bond, Alexandros Somos, Ze Li, Tessa Forbes, Rosaria Bianco, Celyn Dugdale, Zoe Brown, Helen Rice, Andrew Herman, Jason Johnson, Sarah Georg. CCN4 (WISP-1) reduces apoptosis and atherosclerotic plaque burden in an ApoE mouse model. Atherosclerosis. vol 397. 2024-09-14. PMID:39276419. |
ccn4 (wisp-1) reduces apoptosis and atherosclerotic plaque burden in an apoe mouse model. |
2024-09-14 |
2024-09-18 |
mouse |
| Jian Wu, Chaoye Wang, Shuhui Sun, Tianmin Ren, Lijie Pan, Hongyi Liu, Simeng Hou, Shen Wu, Xuejing Yan, Jingxue Zhang, Xiaofang Zhao, Weihai Liu, Sirui Zhu, Shuwen Wei, Chi Zhang, Xu Jia, Qi Zhang, Ziyu Yu, Yehong Zhuo, Qi Zhao, Chenlong Yang, Ningli Wan. Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues. Protein & cell. 2024-02-17. PMID:38366188. |
our work further demonstrated that silencing the apoe gene could increase migration and reduce apoptosis by releasing the inhibition on the pi3k-akt pathway and downregulating the expression of extracellular matrix components, thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal range. |
2024-02-17 |
2024-02-19 |
monkey |
| Cheng Cheng, Jie Zhang, Xiaodong Li, Fei Xue, Lei Cao, Linlin Meng, Wenhai Sui, Meng Zhang, Yuxia Zhao, Bo Xi, Xiao Yu, Feng Xu, Jianmin Yang, Yun Zhang, Cheng Zhan. Correction: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-04. PMID:37666826. |
correction: nprc deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in apoe knockout mice. |
2023-09-04 |
2023-09-07 |
mouse |
| Laura Atehortua, Scott E Street, Jamie Morris, Nicholas Bedel, W Sean Davidson, Claire A Chougne. Apolipoprotein E-containing HDL decrease caspase-dependent apoptosis of memory regulatory T lymphocytes. Journal of lipid research. 2023-08-14. PMID:37579971. |
hdl particles reconstituted with apoe and synthetic phospholipids blunted treg apoptosis at physiological concentrations. |
2023-08-14 |
2023-09-07 |
Not clear |
| Laura Atehortua, Scott E Street, Jamie Morris, Nicholas Bedel, W Sean Davidson, Claire A Chougne. Apolipoprotein E-containing HDL decrease caspase-dependent apoptosis of memory regulatory T lymphocytes. Journal of lipid research. 2023-08-14. PMID:37579971. |
overall, our results show that apoe interaction with treg results in blunted caspase-dependent apoptosis and increased survival. |
2023-08-14 |
2023-09-07 |
Not clear |
| Cheng Cheng, Jie Zhang, Xiaodong Li, Fei Xue, Lei Cao, Linlin Meng, Wenhai Sui, Meng Zhang, Yuxia Zhao, Bo Xi, Xiao Yu, Feng Xu, Jianmin Yang, Yun Zhang, Cheng Zhan. NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-08. PMID:37553374. |
nprc deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in apoe knockout mice. |
2023-08-08 |
2023-08-16 |
mouse |
| Li-Qun Lu, Nian-Sheng Li, Ming-Rui Li, Jiao-Yang Peng, Li-Jing Tang, Xiu-Ju Luo, Jun Pen. DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE European journal of pharmacology. 2023-08-03. PMID:37536623. |
dl-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed apoe impaired endothelium-dependent vasodilation in atherosclerosis is a high-risk factor for myocardial infarction and ischemic stroke, and inflammation, necroptosis and apoptosis contribute to endothelial dysfunction in atherosclerosis. |
2023-08-03 |
2023-08-14 |
Not clear |
| Rebecca Piccarducci, Chiara Giacomelli, Maria Sofia Bertilacchi, Andrea Benito-Martinez, Nicoletta Di Giorgi, Simona Daniele, Giovanni Signore, Silvia Rocchiccioli, Marçal Vilar, Laura Marchetti, Claudia Martin. Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells. Biochimica et biophysica acta. Molecular basis of disease. 2023-06-19. PMID:37336366. |
increased intracellular apoe, amyloid precursor protein (app), and aβ levels, elevated apoptosis, and reduced cell survival) were recapitulated. |
2023-06-19 |
2023-08-14 |
Not clear |
| Phuong Thi Thanh Nguyen, Hayoung Song, Boyoung Kim, Yoo Yeon Kim, Chulho Kim, Jun Ho Lee, Jun Gyo Su. Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia. Frontiers in neurology. vol 13. 2022-11-21. PMID:36408520. |
age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in apoe ko mice with hyperglycemia and hyperlipidemia. |
2022-11-21 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biological trace element research. 2022-07-07. PMID:35798913. |
the genes casp3, bax, bcl2, il6, tnf, apoe, hmox1, and igf were found to be mutually affected by the heavy metal mixture studied, suggesting the importance of apoptosis, inflammation, lipid, heme, and glucose metabolism in mets and cognitive impairment, as well as the potentiality of targeting these genes in prospective therapeutic intervention for these diseases. |
2022-07-07 |
2023-08-14 |
Not clear |
| Chandrakala Aluganti Narasimhulu, Dinender Singl. Metabolic Alterations in Aorta Induces Brain Cholesterolemia, Memory Loss and Cognitive Dysfunction in Diabetic Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555993. |
in this study, we investigated whether hypercholesterolemia induces apoptosis and cognitive dysfunction, in diabetic apolipoprotein e (apoe) and paraoxonase 1 (pon1) double knockout (dko) mice brains. |
2022-05-13 |
2023-08-13 |
mouse |
| Mike T Veling, Dan T Nguyen, Nicole N Thadani, Michela E Oster, Nathan J Rollins, Kelly P Brock, Neville P Bethel, Samuel Lim, David Baker, Jeffrey C Way, Debora S Marks, Roger L Chang, Pamela A Silve. Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells. ACS synthetic biology. 2022-02-18. PMID:35176859. |
notably, we identify a region of the human apoe protein with similarity to extremotolerance-associated proteins that also protects against apoptosis. |
2022-02-18 |
2023-08-13 |
human |
| Yung-Chih Kuo, Yung-I Lou, Rajendiran Rajes. Dual functional liposomes carrying antioxidants against tau hyperphosphorylation and apoptosis of neurons. Journal of drug targeting. vol 28. issue 9. 2021-10-14. PMID:32338078. |
quercetin (qu) and rosmarinic acid (ra) were loaded in phosphatidic acid-liposomes (qu/ra-pa-liposomes) with surface apolipoprotein e (apoe) using a process of thin-film hydration, followed by covalent crosslinking to activate biological pathways for penetrating the blood-brain barrier (bbb) and redeeming the neuronal apoptosis from attack of β-amyloid 1-42 (aβ |
2021-10-14 |
2023-08-13 |
Not clear |
| Heather M Wilkins, Xiaowan Wang, Blaise W Menta, Scott J Koppel, Rebecca Bothwell, Annette M Becker, Heidi Anderson, Erin Schwartz, Dong Pei, Nanda K Yellapu, Prabhakar Chalise, Cynthia M Gouvion, Mohammad Haeri, Jeffrey M Burns, Russell H Swerdlo. Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers. Aging cell. vol 20. issue 5. 2021-07-28. PMID:33939248. |
mean platelet mitochondrial cytochrome oxidase vmax activity was lower in apoe ε4 carriers and lymphocyte annexin v, a marker of apoptosis, was significantly higher. |
2021-07-28 |
2023-08-13 |
human |
| V Kh Khavinson, N S Lin'kova, R S Umno. Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease. Bulletin of experimental biology and medicine. vol 171. issue 2. 2021-06-30. PMID:34173097. |
analysis of published reports and our experimental findings suggests that ked regulates the expression of genes of cell aging and apoptosis (р16, р21), genes (nes, gap43) and proteins (nestin, gap43) of the neuronal differentiation, and genes involved in ad pathogenesis (sumo, apoe, and igf1). |
2021-06-30 |
2023-08-13 |
Not clear |
| Li Cong, Xiaolin Xie, Sujuan Liu, Liping Xiang, Yong Zhang, Jianguo Cao, Xiaohua F. 7-Difluoromethoxy-5,4'-dimethoxy-genistein attenuates macrophages apoptosis to promote plaque stability via TIPE2/TLR4 axis in high fat diet-fed ApoE International immunopharmacology. vol 96. 2021-06-22. PMID:33813367. |
7-difluoromethoxy-5,4'-dimethoxy-genistein attenuates macrophages apoptosis to promote plaque stability via tipe2/tlr4 axis in high fat diet-fed apoe promoting plaque stability is of great significance for prevention and treatment of cardiovascular diseases. |
2021-06-22 |
2023-08-13 |
Not clear |
| Fei Xue, Jianmin Yang, Jing Cheng, Wenhai Sui, Cheng Cheng, Hongxuan Li, Meng Zhang, Jie Zhang, Xingli Xu, Jing Ma, Lin Lu, Jinfeng Xu, Meng Zhang, Yun Zhang, Cheng Zhan. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. British journal of pharmacology. vol 177. issue 8. 2021-06-21. PMID:31658493. |
to test the hypothesis that angiotensin-(1-7) [ang-(1-7)] may attenuate abdominal aortic aneurysm (aaa) via inhibiting vascular inflammation, extracellular matrix degradation, and smooth muscle cell (smc) apoptosis, an animal model of aaa was established by angiotensin ii (ang ii) infusion to apolipoprotein e-knockout (apoe |
2021-06-21 |
2023-08-13 |
mouse |
| Changho Chun, Alec S T Smith, Hyejin Kim, Dana S Kamenz, Jung Hyun Lee, Jong Bum Lee, David L Mack, Mark Bothwell, Claire D Clelland, Deok-Ho Ki. Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro. Biomaterials. vol 271. 2021-05-25. PMID:33631652. |
ev cargos were found to include neuroprotective proteins such as heat shock proteins, alpha-synuclein, and lipoprotein receptor-related protein 1 (lrp1), as well as apolipoprotein e (apoe), which negatively regulates neuronal apoptosis, and a peroxidasin homolog that supports neuronal oxidative stress management. |
2021-05-25 |
2023-08-13 |
human |
| Liang-Yin Ke, Hua-Chen Chan, Chih-Chieh Chen, Chuan-Fa Chang, Po-Liang Lu, Chih-Sheng Chu, Wen-Ter Lai, Shyi-Jang Shin, Fu-Tong Liu, Chu-Huang Che. Increased APOE glycosylation plays a key role in the atherogenicity of L5 low-density lipoprotein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32501643. |
importantly, l5 containing glycosylated apoe induced apoptosis in cultured endothelial cells through lectin-like oxidized ldl receptor-1 (lox-1) signaling, and glycosylation removal from l5 attenuated l5-induced apoptosis. |
2021-03-01 |
2023-08-13 |
human |
| Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G Younkin, Neill R Graff-Radford, Zbigniew K Wszolek, David A Brafman, Yan W Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun B. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature communications. vol 11. issue 1. 2020-11-19. PMID:33139712. |
cerebral organoids from ad patients carrying apoe ε4/ε4 show greater apoptosis and decreased synaptic integrity. |
2020-11-19 |
2023-08-13 |
human |