| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Socratis Avgeris, Florentia Fostira, Andromachi Vagena, Yiannis Ninios, Angeliki Delimitsou, Radek Vodicka, Radek Vrtel, Sotirios Youroukos, Dimitrios J Stravopodis, Metaxia Vlassi, Aristotelis Astrinidis, Drakoulis Yannoukakos, Gerassimos E Voutsina. Mutational analysis of TSC1 and TSC2 genes in Tuberous Sclerosis Complex patients from Greece. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29196670. |
mutational analysis of tsc1 and tsc2 genes in tuberous sclerosis complex patients from greece. |
2019-07-05 |
2023-08-13 |
Not clear |
| Enping Huang, Hongyan Huang, Tianshan Guan, Chao Liu, Dong Qu, Yue Xu, Jiao Yang, Lei Yan, Yahui Xiong, Ting Liang, Qi Wang, Ling Che. Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicology letters. vol 312. 2019-07-01. PMID:31059759. |
we also measured the levels of phosphorylated tuberous sclerosis complex 2 (tsc2) protein and parkin protein level in sh-sy5y cells. |
2019-07-01 |
2023-08-13 |
human |
| Roger Y Tam, Julien Yockell-Lelièvre, Laura J Smith, Lisa M Julian, Alexander E G Baker, Chandarong Choey, Mohamed S Hasim, Jim Dimitroulakos, William L Stanford, Molly S Shoiche. Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High-Content Drug Screening. Advanced materials (Deerfield Beach, Fla.). vol 31. issue 7. 2019-05-30. PMID:30589121. |
to test the lung-mimetic hydrogel platform, a kinase inhibitor screen is performed using tuberous sclerosis complex 2 (tsc2) hypomorphic cells, identifying cdk2 inhibition as a putative lam therapeutic. |
2019-05-30 |
2023-08-13 |
Not clear |
| Ruixiao Zhang, Jianhong Wang, Qing Wang, Yue Han, Xuejun Liu, Irene Bottillo, Yanhua Lang, Leping Sha. Identification of a novel TSC2 c.3610G > A, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report. BMC medical genetics. vol 19. issue 1. 2019-05-23. PMID:30236073. |
identification of a novel tsc2 c.3610g > a, p.g1204r mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report. |
2019-05-23 |
2023-08-13 |
Not clear |
| Ruixiao Zhang, Jianhong Wang, Qing Wang, Yue Han, Xuejun Liu, Irene Bottillo, Yanhua Lang, Leping Sha. Identification of a novel TSC2 c.3610G > A, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report. BMC medical genetics. vol 19. issue 1. 2019-05-23. PMID:30236073. |
mutations in the tsc1 or tsc2 gene lead to the dysfunction of hamartin or tuberin proteins, which cause tuberous sclerosis complex. |
2019-05-23 |
2023-08-13 |
Not clear |
| John D Blair, Dirk Hockemeyer, Helen S Bateu. Genetically engineered human cortical spheroid models of tuberous sclerosis. Nature medicine. vol 24. issue 10. 2019-05-10. PMID:30127391. |
tuberous sclerosis complex (tsc) is a multisystem developmental disorder caused by mutations in the tsc1 or tsc2 genes, whose protein products are negative regulators of mechanistic target of rapamycin complex 1 signaling. |
2019-05-10 |
2023-08-13 |
human |
| Rachel Michelle Saré, Tianjian Huang, Tom Burlin, Inna Loutaev, Carolyn Beebe Smit. Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin. Journal of neurochemistry. vol 145. issue 5. 2019-05-08. PMID:29364507. |
tuberous sclerosis complex (tsc) is an autosomal dominant neurogenetic disorder affecting about 1 in 6000 people and is caused by mutations in either tsc1 or tsc2. |
2019-05-08 |
2023-08-13 |
mouse |
| Alberto Bartolomé, Ana García-Aguilar, Shun-Ichiro Asahara, Yoshiaki Kido, Carlos Guillén, Utpal B Pajvani, Manuel Benit. MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Molecular and cellular biology. vol 37. issue 23. 2019-04-15. PMID:28894028. |
to test this, we used cells lacking tuberous sclerosis complex 2 (tsc2 |
2019-04-15 |
2023-08-13 |
Not clear |
| Yong Wang, Juan Liu, Jie-Sen Zhou, Hua-Qiong Huang, Zhou-Yang Li, Xu-Chen Xu, Tian-Wen Lai, Yue Hu, Hong-Bin Zhou, Hai-Pin Chen, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhi-Hua Che. MTOR Suppresses Cigarette Smoke-Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease. Journal of immunology (Baltimore, Md. : 1950). vol 200. issue 8. 2019-04-10. PMID:29507104. |
expression of mtor was significantly decreased and its suppressive signaling protein, tuberous sclerosis 2 (tsc2), was increased in the airway epithelium of human copd and in mouse lungs with chronic cs exposure. |
2019-04-10 |
2023-08-13 |
mouse |
| D Bessis, M-C Malinge, C Girar. Isolated and unilateral facial angiofibromas revealing a type 1 segmental postzygotic mosaicism of tuberous sclerosis complex with c.4949_4982del TSC2 mutation. The British journal of dermatology. vol 178. issue 1. 2019-04-09. PMID:29315486. |
isolated and unilateral facial angiofibromas revealing a type 1 segmental postzygotic mosaicism of tuberous sclerosis complex with c.4949_4982del tsc2 mutation. |
2019-04-09 |
2023-08-13 |
Not clear |
| Bozena Kuzniewska, Krzysztof Sadowski, Katarzyna Urbanska, Malgorzata Urbanska, Katarzyna Kotulska, Ewa Liszewska, Wieslawa Grajkowska, Sergiusz Jóźwiak, Magdalena Dziembowsk. The level of microRNA 21 is upregulated by rapamycin in serum of tuberous sclerosis complex patients and subependymal giant cell astrocytoma (SEGA)-derived cell cultures. Folia neuropathologica. vol 56. issue 3. 2019-03-28. PMID:30509037. |
tuberous sclerosis complex (tsc) represents a genetic condition, in which the clinical manifestations are caused by the disinhibition of the mammalian target of rapamycin (mtor) pathway due to mutations in the tsc1 (hamartin) or tsc2 (tuberin) genes. |
2019-03-28 |
2023-08-13 |
Not clear |
| James D Mills, Anand M Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J Anink, Bart Janssen, Till S Zimmer, Wim G Spliet, Peter C van Rijen, Floor E Jansen, Martha Feucht, Johannes A Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J Kwiatkowski, R Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von Oerthel, Marco F Hoekman, Jan A Gorter, Peter B Crino, Angelika Mühlebner, Brendon P Scicluna, Eleonora Aronic. Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Scientific reports. vol 7. issue 1. 2019-03-05. PMID:28808237. |
tuberous sclerosis complex (tsc) is a rare genetic disorder that results from a mutation in the tsc1 or tsc2 genes leading to constitutive activation of the mechanistic target of rapamycin complex 1 (mtorc1). |
2019-03-05 |
2023-08-13 |
mouse |
| Avery J Zucco, Valentina Dal Pozzo, Alina Afinogenova, Ronald P Hart, Orrin Devinsky, Gabriella D'Arcangel. Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. Molecular and cellular neurosciences. vol 92. 2019-03-05. PMID:30144504. |
tuberous sclerosis complex (tsc) is a disease caused by autosomal dominant mutations in the tsc1 or tsc2 genes, and is characterized by tumor susceptibility, brain lesions, seizures and behavioral impairments. |
2019-03-05 |
2023-08-13 |
Not clear |
| Annamalai Muthiah, Morgan S Angulo, Natalie N Walker, Susanna R Keller, Jae K Le. Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator. PloS one. vol 13. issue 9. 2019-03-04. PMID:30240435. |
we experimentally confirmed that klf4 controls the expression of two key insulin signaling molecules, the insulin receptor substrate 2 (irs2) and tuberous sclerosis complex 2 (tsc2). |
2019-03-04 |
2023-08-13 |
mouse |
| Charlotte E Johnson, Elaine A Dunlop, Sara Seifan, Henry D McCann, Trevor Hay, Geraint J Parfitt, Ashley T Jones, Peter J Giles, Ming H Shen, Julian R Sampson, Rachel J Errington, D Mark Davies, Andrew R Te. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene. vol 37. issue 45. 2019-02-28. PMID:29980790. |
tuberous sclerosis complex 1 (tsc1) and tsc2 play a fundamental role in cell homeostasis, where signal transduction through tsc1/tsc2 is often compromised in cancer, leading to aberrant activation of mechanistic target of rapamycin complex 1 (mtorc1). |
2019-02-28 |
2023-08-13 |
mouse |
| Naresh Kumar Meena, Shakti Prasad Pattanayak, Yael Ben-Nun, Sandrine Benhamron, Saran Kumar, Emmanuelle Merquiol, Nadine Hövelmeyer, Galia Blum, Boaz Tiros. mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. Immunology. vol 155. issue 4. 2019-02-28. PMID:30144045. |
it is inhibited by the tuberous sclerosis complex (tsc), a heterodimer of tsc1 and tsc2. |
2019-02-28 |
2023-08-13 |
mouse |
| Y Cai, H Guo, H Z Li, W D Wang, Y S Zhan. [MicroRNA differential expression profile in tuberous sclerosis complex cell line TSC2 Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 49. issue 4. 2019-02-20. PMID:28816269. |
[microrna differential expression profile in tuberous sclerosis complex cell line tsc2 tuberous sclerosis complex (tsc) is a multisystem genetic disorder caused by mutations in the tsc1 and tsc2 genes, but the molecular events contributing to tsc are not well understood. |
2019-02-20 |
2023-08-13 |
Not clear |
| Y Cai, H Guo, H Z Li, W D Wang, Y S Zhan. [MicroRNA differential expression profile in tuberous sclerosis complex cell line TSC2 Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 49. issue 4. 2019-02-20. PMID:28816269. |
to explore the microrna differential expression profile between tuberous sclerosis complex cell line tsc2 |
2019-02-20 |
2023-08-13 |
Not clear |
| Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayash. Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. Neuroscience letters. vol 684. 2019-02-20. PMID:29966750. |
transcriptional activation of foxo1 has been reported to initiate autophagy by inhibiting the expression of mechanistic target of rapamycin (mtor), mediated by sestrin 3 (sesn3) and tuberous sclerosis complex 2 (tsc2). |
2019-02-20 |
2023-08-13 |
mouse |
| Feng Wang, Shiyi Xiong, Lin Wu, Maya Chopra, Xihong Hu, Bingbing W. A novel TSC2 missense variant associated with a variable phenotype of tuberous sclerosis complex: case report of a Chinese family. BMC medical genetics. vol 19. issue 1. 2019-02-19. PMID:29843636. |
a novel tsc2 missense variant associated with a variable phenotype of tuberous sclerosis complex: case report of a chinese family. |
2019-02-19 |
2023-08-13 |
Not clear |