| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Klaus, Heinke Bastek, Katja Damme, Leonard B Collins, Roland Frötschl, Norbert Benda, Dominik Lutter, Heidrun Ellinger-Ziegelbauer, James A Swenberg, Daniel R Dietrich, Kerstin Stemme. Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats. Archives of toxicology. vol 91. issue 10. 2018-07-19. PMID:28349193. |
eker rats, heterozygous for the tuberous sclerosis (tsc2) tumor suppressor gene and thus highly susceptible towards genotoxic renal carcinogens, were continuously treated with the dna alkylating carcinogen methylazoxymethanol acetate (mamac). |
2018-07-19 |
2023-08-13 |
human |
| Gabriela Caicedo-Herrera, Estephania Candelo, Harry Pachajo. [Novel mutation in TSC2 gene in pediatric patient with clinical diagnosis of tuberous sclerosis]. Archivos argentinos de pediatria. vol 115. issue 5. 2018-06-28. PMID:28895704. |
[novel mutation in tsc2 gene in pediatric patient with clinical diagnosis of tuberous sclerosis]. |
2018-06-28 |
2023-08-13 |
Not clear |
| Gabriela Caicedo-Herrera, Estephania Candelo, Harry Pachajo. [Novel mutation in TSC2 gene in pediatric patient with clinical diagnosis of tuberous sclerosis]. Archivos argentinos de pediatria. vol 115. issue 5. 2018-06-28. PMID:28895704. |
tuberous sclerosis complex (tsc) is a neurocutaneous autosomal dominant disorder that results from mutations within either the tsc1 gene or the tsc2 gene. |
2018-06-28 |
2023-08-13 |
Not clear |
| Hidehiro Ishikawa, Atsushi Niwa, Masaru Asahi, Keita Matsuura, Satoshi Masuzugawa, Yo Niida, Masayuki Maeda, Mineo Kondo, Hidekazu Tomimot. Diffusion tensor imaging and magnetic resonance spectroscopy in a patient with adult onset tuberous sclerosis complex. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 48. 2018-06-27. PMID:29129521. |
tuberous sclerosis complex (tsc) 1 or tsc2 is mutated in most tsc patients. |
2018-06-27 |
2023-08-13 |
Not clear |
| Shruti Bagla, Daniela Cukovic, Eishi Asano, Sandeep Sood, Aimee Luat, Harry T Chugani, Diane C Chugani, Alan A Dombkowsk. A distinct microRNA expression profile is associated with α[ Neurobiology of disease. vol 109. issue Pt A. 2018-06-25. PMID:28993242. |
a distinct microrna expression profile is associated with α[ tuberous sclerosis complex (tsc) is characterized by hamartomatous lesions in various organs and arises due to mutations in the tsc1 or tsc2 genes. |
2018-06-25 |
2023-08-13 |
Not clear |
| Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Meng-Na Zhang, Li-Ying Liu, Li-Ping Zo. Epilepsy may be the major risk factor of mental retardation in children with tuberous sclerosis: A retrospective cohort study. Epilepsy & behavior : E&B. vol 77. 2018-06-08. PMID:29073472. |
the prevalence of mr was 50.0% for the patients with tuberous sclerosis complex-1 (tsc1) mutation, 54.5% for tsc2 (p=0.561), 54.7% for patients with protein-truncating (pt) and 50.0% for patients with nontruncating (nt) (p=0.791), and 54.3% for patients with family history and 53.7% for patients without family history (p=0.748). |
2018-06-08 |
2023-08-13 |
Not clear |
| Laura C Armstrong, Grant Westlake, John P Snow, Bryan Cawthon, Eric Armour, Aaron B Bowman, Kevin C Es. Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming. Human molecular genetics. vol 26. issue 23. 2018-05-24. PMID:28973543. |
tuberous sclerosis complex (tsc) is a pediatric disorder of dysregulated growth and differentiation caused by loss of function mutations in either the tsc1 or tsc2 genes, which regulate mtor kinase activity. |
2018-05-24 |
2023-08-13 |
human |
| Stephen J Murphy, Simone B Terra, Faye R Harris, Aqsa Nasir, Jesse S Voss, James B Smadbeck, Sarah H Johnson, Vishnu Serla, Jay H Ryu, Eunhee S Yi, Benjamin R Kipp, George Vasmatzis, Eva M Carmon. Genomic rearrangements in sporadic lymphangioleiomyomatosis: an evolving genetic story. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 30. issue 9. 2018-05-21. PMID:28643793. |
the migratory/metastasizing properties of the lymphangioleiomyomatosis cell together with the presence of somatic mutations, primarily in the tuberous sclerosis complex gene (tsc2), lead many to consider this a low-grade malignancy. |
2018-05-21 |
2023-08-13 |
Not clear |
| Jonathan O Lipton, Lara M Boyle, Elizabeth D Yuan, Kevin J Hochstrasser, Fortunate F Chifamba, Ashwin Nathan, Peter T Tsai, Fred Davis, Mustafa Sahi. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell reports. vol 20. issue 4. 2018-05-07. PMID:28746872. |
tuberous sclerosis complex (tsc) is a neurodevelopmental disorder characterized by mutations in either the tsc1 or tsc2 genes, whose products form a critical inhibitor of the mechanistic target of rapamycin (mtor). |
2018-05-07 |
2023-08-13 |
mouse |
| Hexige Saiyin, Ning Na, Xu Han, Yuan Fang, Yanhua Wu, Wenhui Lou, Xianmei Yan. BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28591720. |
here we showed that brsk2, a serine/threonine-protein kinase of ampk family, was induced by nutrient deprivation in pdac cells and suppressed mtorc1 activity via phosphorylation of tuberous sclerosis complex 2 (tsc2). |
2018-03-29 |
2023-08-13 |
Not clear |
| Stela Živčić-Ćosić, Karin Mayer, Gordana Đorđević, Mark Nellist, Marianne Hoogeveen-Westerveld, Damir Miletić, Sanjin Rački, Hanns-Georg Klein, Zlatko Trobonjač. Severe bleeding complications and multiple kidney transplants in a patient with tuberous sclerosis complex caused by a novel TSC2 missense variant. Croatian medical journal. vol 58. issue 6. 2018-03-26. PMID:29308833. |
severe bleeding complications and multiple kidney transplants in a patient with tuberous sclerosis complex caused by a novel tsc2 missense variant. |
2018-03-26 |
2023-08-13 |
Not clear |
| Elizabeth P Henske, Sergiusz Jóźwiak, J Christopher Kingswood, Julian R Sampson, Elizabeth A Thiel. Tuberous sclerosis complex. Nature reviews. Disease primers. vol 2. 2018-03-20. PMID:27226234. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder that affects multiple organ systems and is caused by loss-of-function mutations in one of two genes: tsc1 or tsc2. |
2018-03-20 |
2023-08-13 |
Not clear |
| Yi Cai, Hanzhong Li, Yushi Zhan. Assessment of Tuberous Sclerosis Complex Associated With Renal Lesions by Targeted Next-generation Sequencing in Mainland China. Urology. vol 101. 2018-03-14. PMID:28065512. |
to identify the tsc1 and tsc2 mutations in patients with tuberous sclerosis complex (tsc) associated with renal lesions, and to explore the relationship between genotypes and phenotypes. |
2018-03-14 |
2023-08-13 |
Not clear |
| Miriam Schneider, Petrus J de Vries, Kai Schönig, Veit Rößner, Robert Walterei. mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus. European archives of psychiatry and clinical neuroscience. vol 267. issue 5. 2018-01-30. PMID:27263037. |
tuberous sclerosis complex (tsc), caused by tsc1 or tsc2 mutations, is one of the medical conditions most commonly associated with asd and has become an important model to examine molecular pathways associated with asd. |
2018-01-30 |
2023-08-13 |
rat |
| Victoria Stepanova, Konstantin V Dergilev, Kelci R Holman, Yelena V Parfyonova, Zoya I Tsokolaeva, Mimi Teter, Elena N Atochina-Vasserman, Alla Volgina, Sergei V Zaitsev, Shane P Lewis, Fedor G Zabozlaev, Kseniya Obraztsova, Vera P Krymskaya, Douglas B Cine. Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors. The Journal of biological chemistry. vol 292. issue 50. 2018-01-25. PMID:28972182. |
urokinase-type plasminogen activator (upa) is critical for progression of tuberous sclerosis complex 2 (tsc2)-deficient tumors. |
2018-01-25 |
2023-08-13 |
Not clear |
| Alessandro Magini, Alice Polchi, Danila Di Meo, Giuseppina Mariucci, Krizia Sagini, Federico De Marco, Tommaso Cassano, Stefano Giovagnoli, Diego Dolcetta, Carla Emilian. TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells. Human molecular genetics. vol 26. issue 17. 2018-01-11. PMID:28637240. |
tuberous sclerosis complex (tsc) is an autosomal dominant genetic disorder caused by mutations in either of two genes, tsc1 or tsc2, resulting in the constitutive activation of the mammalian target of rapamycin complex 1 (mtorc1). |
2018-01-11 |
2023-08-13 |
Not clear |
| Rebecca Mitchell, Sarah Barton, A Simon Harvey, Katrina William. Risk factors for the development of autism spectrum disorder in children with tuberous sclerosis complex: protocol for a systematic review. Systematic reviews. vol 6. issue 1. 2018-01-04. PMID:28270230. |
tuberous sclerosis complex (tsc) is an autosomal dominant condition, caused by mutations in either the tsc1 or tsc2 gene. |
2018-01-04 |
2023-08-13 |
Not clear |
| Yelena Bykhovskaya, Majid Fardaei, Mariam Lotfy Khaled, Mahmood Nejabat, Ramin Salouti, Hassan Dastsooz, Yutao Liu, Soroor Inaloo, Yaron S Rabinowit. TSC1 Mutations in Keratoconus Patients With or Without Tuberous Sclerosis. Investigative ophthalmology & visual science. vol 58. issue 14. 2017-12-29. PMID:29261847. |
to test candidate genes tsc1 and tsc2 in a family affected by tuberous sclerosis complex (tsc) where proband was also diagnosed with bilateral keratoconus (kc) and to test the hypothesis that defects in the same gene may lead to a nonsyndromic kc. |
2017-12-29 |
2023-08-13 |
Not clear |
| Mark R Woodford, Rebecca A Sager, Elijah Marris, Diana M Dunn, Adam R Blanden, Ryan L Murphy, Nicholas Rensing, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N Loh, David H Gutmann, Dimitra Bourboulia, Gennady Bratslavsky, Michael Wong, Mehdi Mollapou. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. The EMBO journal. vol 36. issue 24. 2017-12-28. PMID:29127155. |
the tumor suppressors tsc1 and tsc2 form the tuberous sclerosis complex (tsc), a regulator of mtor activity. |
2017-12-28 |
2023-08-13 |
Not clear |
| Wenzao Li, Peng Zhou, Congmin Zhao, Yuping Zhan. A novel de novo mutation in the TSC2 gene in a Chinese patient with tuberous sclerosis complex. Journal of neurogenetics. vol 30. issue 3-4. 2017-12-20. PMID:27776463. |
a novel de novo mutation in the tsc2 gene in a chinese patient with tuberous sclerosis complex. |
2017-12-20 |
2023-08-13 |
Not clear |