| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mehdi Nadiri, Mortaza Raeisi, Seyed Ali Mousavi Aghda. A Novel Mutation in TSC2 Gene: A 34-Year-Old Female with Pulmonary Lymphangioleiomyomatosis with Concomitant Hepatic Lesions. Case reports in pulmonology. vol 2018. 2020-10-01. PMID:29666741. |
tuberous sclerosis complex (tsc) is an autosomal dominant disease resulting from mutation(s) in tsc1 or tsc2 genes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jinhyun Cho, Jeeyun Lee, Jusun Kim, Seung Tae Kim, Sujin Lee, Sun Young Kim, Sang Yun Ha, Cheol-Keun Park, Ho Yeong Li. Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma. Translational oncology. vol 9. issue 5. 2020-09-30. PMID:27751352. |
loss of tuberous sclerosis complex 2 (tsc2) as a predictive biomarker of response to mtor inhibitor treatment in patients with hepatocellular carcinoma. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jinhyun Cho, Jeeyun Lee, Jusun Kim, Seung Tae Kim, Sujin Lee, Sun Young Kim, Sang Yun Ha, Cheol-Keun Park, Ho Yeong Li. Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma. Translational oncology. vol 9. issue 5. 2020-09-30. PMID:27751352. |
tumors with loss of tuberous sclerosis complex 2 (tsc2), a negative regulator of mtor signaling, tend to respond well to mtor inhibitors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Clévia Rosset, Cristina Brinckmann Oliveira Netto, Patricia Ashton-Proll. TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review. Genetics and molecular biology. vol 40. issue 1. 2020-09-30. PMID:28222202. |
tsc1 and tsc2 gene mutations and their implications for treatment in tuberous sclerosis complex: a review. |
2020-09-30 |
2023-08-13 |
Not clear |
| Clévia Rosset, Cristina Brinckmann Oliveira Netto, Patricia Ashton-Proll. TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review. Genetics and molecular biology. vol 40. issue 1. 2020-09-30. PMID:28222202. |
tuberous sclerosis is caused by the mutation of one of two tumor suppressor genes, tsc1 or tsc2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Henry D McCann, Charlotte E Johnson, Rachel J Errington, D Mark Davies, Elaine A Dunlop, Andrew R Te. Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment. Cancers. vol 10. issue 10. 2020-09-30. PMID:30308940. |
to find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within tuberous sclerosis complex 2 (tsc2)-deficient cells with mechanistic target of rapamycin complex 1 (mtorc1) hyperactivity. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ming Hong Shen, Paulina Samsel, Louise L Shen, Kalin Narov, Jian Yang, Julian R Sampso. Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1 Translational oncology. vol 10. issue 5. 2020-09-29. PMID:28844017. |
tuberous sclerosis (tsc) is a tumor syndrome caused by tsc1 or tsc2 mutations that lead to aberrant activation of mtor and tumor formation in multiple organs. |
2020-09-29 |
2023-08-13 |
mouse |
| Chunjia Li, Hongyu Chen, Zhou Lan, Shaozong He, Rongrong Chen, Fang Wang, Zhibo Liu, Kai Li, Lili Cheng, Ye Liu, Kun Sun, Xiaofeng Wan, Xinxin Chen, Haiyong Peng, Li Li, Yanjun Zhang, Yanling Jing, Min Huang, Yanan Wang, Yan Wang, Jiandong Jiang, Xiaojun Zha, Ligong Chen, Hongbing Zhan. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell death and differentiation. vol 26. issue 10. 2020-09-28. PMID:30760873. |
loss of either tsc1 or tsc2 causes tuberous sclerosis complex (tsc) via activation of mtor signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sonal Goswami, Jenny Hsie. One-Hit Wonders and 2-Hit Tubers: A Second-Hit to TSC2 Causes Tuber-Like Cells in Spheroids. Epilepsy currents. vol 19. issue 1. 2020-09-28. PMID:30838931. |
tuberous sclerosis complex (tsc) is a multisystem developmental disorder caused by mutations in the tsc1 or tsc2 genes, whose protein products are negative regulators of mechanistic target of rapamycin complex 1 signaling. |
2020-09-28 |
2023-08-13 |
human |
| Wenda Wang, Xu Wang, Hao Guo, Yi Cai, Yushi Zhang, Hanzhong L. PTEN inhibitor VO-OHpic suppresses TSC2 Experimental and therapeutic medicine. vol 19. issue 6. 2020-09-28. PMID:32346419. |
pten inhibitor vo-ohpic suppresses tsc2 tuberous sclerosis complex (tsc) is a relatively rare autosomal dominant disease which involves multiple organs, including the brain, kidney, lung, skin and heart. |
2020-09-28 |
2023-08-13 |
Not clear |
| Wei Ge, Hai-Yan Wang, Hai-Mei Zhao, Xue-Ke Liu, You-Bao Zhong, Jian Long, Zheng-Yun Zuo, Duan-Yong Li. Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32714185. |
furthermore, ssp markedly inhibited activation of pi3k, akt, phospho-akt, id2, t-bet, forkhead box o3a, noxa, and c-myc proteins in the pi3k/akt signaling pathway and activated rictor, raptor, tuberous sclerosis complex (tsc)1, tsc2, phospho-amp-activated kinase (ampk)- |
2020-09-28 |
2023-08-13 |
human |
| Matthildi Valianou, Natalia Filippidou, Daniel L Johnson, Peter Vogel, Erik Y Zhang, Xiaolei Liu, Yiyang Lu, Jane J Yu, John J Bissler, Aristotelis Astrinidi. Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells. Scientific reports. vol 9. issue 1. 2020-09-17. PMID:30816188. |
tuberous sclerosis complex (tsc) and lymphangioleiomyomatosis (lam) are caused by inactivating mutations in tsc1 or tsc2, leading to mtorc1 hyperactivation. |
2020-09-17 |
2023-08-13 |
mouse |
| Maria A Frias, Suman Mukhopadhyay, Elyssa Lehman, Aleksandra Walasek, Matthew Utter, Deepak Menon, David A Foste. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. The Journal of biological chemistry. vol 295. issue 1. 2020-09-08. PMID:31767684. |
we observed that precancerous cells with constitutive rheb activation through loss of tuberous sclerosis complex subunit 2 (tsc2) exploit the pld-pa pathway and thereby sustain mtorc1 activation at the lysosome in the absence of amino acids. |
2020-09-08 |
2023-08-13 |
human |
| Kohei Sase, Kohei Kido, Satoru Ato, Satoshi Fujit. The effect of a bout of resistance exercise on skeletal muscle protein metabolism after severe fasting. Physiological reports. vol 7. issue 21. 2020-08-27. PMID:31691510. |
the tuberous sclerosis complex 2 (tsc2) ser1387 and autophagy marker of microtubule-associated protein 1a/1b-light chain 3-ii (lc3b-ii) expression of the f group increased twice that of the c group in sedentary state (p < 0.05). |
2020-08-27 |
2023-08-13 |
rat |
| Ming Lyu, Alai Shalitana, Jun Luo, Huanshan He, Shuang Sun, Ping Wan. Overexpression of the Tuberous sclerosis complex 2 (TSC2) gene inhibits goat myoblasts proliferation and differentiation in understanding the underlying mechanism of muscle development. Gene. vol 757. 2020-08-26. PMID:32652105. |
overexpression of the tuberous sclerosis complex 2 (tsc2) gene inhibits goat myoblasts proliferation and differentiation in understanding the underlying mechanism of muscle development. |
2020-08-26 |
2023-08-13 |
Not clear |
| Ming Lyu, Alai Shalitana, Jun Luo, Huanshan He, Shuang Sun, Ping Wan. Overexpression of the Tuberous sclerosis complex 2 (TSC2) gene inhibits goat myoblasts proliferation and differentiation in understanding the underlying mechanism of muscle development. Gene. vol 757. 2020-08-26. PMID:32652105. |
an increasing number of studies are focusing on the functions of tuberous sclerosis complex 2 (tsc2) during the process of cell protein synthesis and growth. |
2020-08-26 |
2023-08-13 |
Not clear |
| Anika Bongaarts, Jackelien van Scheppingen, Anatoly Korotkov, Caroline Mijnsbergen, Jasper J Anink, Floor E Jansen, Wim G M Spliet, Wilfred F A den Dunnen, Victoria E Gruber, Theresa Scholl, Sharon Samueli, Johannes A Hainfellner, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Wieslawa Grajkowska, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Roland Coras, Ingmar Blümcke, Pavel Krsek, Josef Zamecnik, Lisethe Meijer, Brendon P Scicluna, Antoinette Y N Schouten-van Meeteren, Angelika Mühlebner, James D Mills, Eleonora Aronic. The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834371. |
tuberous sclerosis complex (tsc) is an autosomal dominantly inherited neurocutaneous disorder caused by inactivating mutations in tsc1 or tsc2, key regulators of the mechanistic target of rapamycin complex 1 (mtorc1) pathway. |
2020-08-18 |
2023-08-13 |
Not clear |
| Paula Rocktäschel, Arjune Sen, M Zameel Cade. High glucose concentrations mask cellular phenotypes in a stem cell model of tuberous sclerosis complex. Epilepsy & behavior : E&B. vol 101. issue Pt B. 2020-08-05. PMID:31761686. |
tuberous sclerosis complex (tsc) is a neurodevelopmental disorder caused by deletions in the tsc1 or tsc2 genes that is associated with epilepsy in up to 90% of patients. |
2020-08-05 |
2023-08-13 |
human |
| Zhixiang Wu, Hongguang Wu, Shafiquzzaman Md, Guo Yu, Samy L Habib, Baojie Li, Jing L. Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse. Scientific reports. vol 9. issue 1. 2020-08-04. PMID:30696882. |
tuberous sclerosis complex (tsc) is caused by mutations in tsc1 or tsc2, which encode negative regulators of the mtor signaling pathway. |
2020-08-04 |
2023-08-13 |
mouse |
| Jürgen Klinner, Marcus Krüger, Theresa Brunet, Christine Makowski, Korbinian M Riedhammer, Andreas Mollweide, Matias Wagner, Julia Hoefel. Congenital lymphedema as a rare and first symptom of tuberous sclerosis complex. Gene. vol 753. 2020-07-31. PMID:32479982. |
lymphedema can rarely be observed in patients with tuberous sclerosis complex (tsc), which is a neurocutaneous syndrome caused by pathogenic variants in the genes tsc1 or tsc2. |
2020-07-31 |
2023-08-13 |
Not clear |