| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarbashri Bank, Suman Bhattacharya, Smarajit Maiti, Raja Bhattacharya, Debajyoti Chakraborty, Asru K Sinh. The impaired synthesis of insulin and its inability to inhibit platelet aggregation in cerebrovascular accident. Metabolic brain disease. vol 30. issue 5. 2016-06-24. PMID:26188955. |
it can be concluded that presence of dcn2 in stroke causes a condition similar to type i diabetes and nullified the effect of insulin in the inhibition of platelet aggregation in both is and hs. |
2016-06-24 |
2023-08-13 |
mouse |
| Ai-Lin Lee, Bor-Chyuan Chen, Chih-Hsin Mou, Mao-Feng Sun, Hung-Rong Ye. Association of Traditional Chinese Medicine Therapy and the Risk of Vascular Complications in Patients With Type II Diabetes Mellitus: A Nationwide, Retrospective, Taiwanese-Registry, Cohort Study. Medicine. vol 95. issue 3. 2016-06-01. PMID:26817897. |
after adjustment of age, sex, hypertension, hyperlipidemia, and antidiabetes agent use (including sulfonylureas, α-glucosidase, metformin, meglitinide, thiazolidinediones, and insulin), tcm cohorts were found to have a 33% decreased risk of stroke (95% ci = 0.46-0.97; p < 0.05).this population-based retrospective study showed that the complementary tcm therapy might associate with the decreased risk of stroke in t2dm, suggesting tcm as an adjunctive therapy for t2dm to prevent subsequent stroke. |
2016-06-01 |
2023-08-13 |
Not clear |
| Jason T Connor, Kristine R Broglio, Valerie Durkalski, William J Meurer, Karen C Johnsto. The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study. Trials. vol 16. 2016-05-27. PMID:25885963. |
the stroke hyperglycemia insulin network effort (shine) trial: an adaptive trial design case study. |
2016-05-27 |
2023-08-13 |
Not clear |
| Jason T Connor, Kristine R Broglio, Valerie Durkalski, William J Meurer, Karen C Johnsto. The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study. Trials. vol 16. 2016-05-27. PMID:25885963. |
the stroke hyperglycemia insulin network effort (shine) trial was selected for funding by the nih-ninds at the start of adapt-it and is currently an ongoing phase iii trial of tight glucose control in hyperglycemic acute ischemic stroke patients. |
2016-05-27 |
2023-08-13 |
Not clear |
| L Castilla-Guerra, M C Fernández-Moreno, J Hewit. Treatment of hyperglycaemia in patients with acute stroke. Revista clinica espanola. vol 216. issue 2. 2016-04-15. PMID:26189890. |
there is no evidence that the adminstration of intravenous insulin to these patients offers benefits in terms of the evolution of the stroke. |
2016-04-15 |
2023-08-13 |
Not clear |
| L Castilla-Guerra, M C Fernández-Moreno, J Hewit. Treatment of hyperglycaemia in patients with acute stroke. Revista clinica espanola. vol 216. issue 2. 2016-04-15. PMID:26189890. |
new studies in development, such as the shine study (stroke hyperglycemia insulin network effort), may contribute to clarifying the role of intensive control of glycaemia during the acute phase of the stroke. |
2016-04-15 |
2023-08-13 |
Not clear |
| Walter N Kernan, Catherine M Viscoli, Karen L Furie, Lawrence H Young, Silvio E Inzucchi, Mark Gorman, Peter D Guarino, Anne M Lovejoy, Peter N Peduzzi, Robin Conwit, Lawrence M Brass, Gregory G Schwartz, Harold P Adams, Leo Berger, Antonio Carolei, Wayne Clark, Bruce Coull, Gary A Ford, Dawn Kleindorfer, John R O'Leary, Mark W Parsons, Peter Ringleb, Souvik Sen, J David Spence, David Tanne, David Wang, Toni R Winde. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. The New England journal of medicine. vol 374. issue 14. 2016-04-12. PMID:26886418. |
the identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease. |
2016-04-12 |
2023-08-13 |
Not clear |
| Vasileios-Arsenios Lioutas, Freddy Alfaro-Martinez, Francisco Bedoya, Chen-Chih Chung, Daniela A Pimentel, Vera Nova. Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke. Translational stroke research. vol 6. issue 4. 2016-03-21. PMID:26040423. |
this review summarizes the neuroprotective potential of intranasally administered insulin and igf-1 in stroke patients. |
2016-03-21 |
2023-08-13 |
human |
| Johnathan de Sousa Parreira, Ana Paula Kallaur, Marcio Francisco Lehmann, Sayonara Rangel Oliveira, Daniela Frizon Alfieri, Daniela Alfieri Frizon, Francieli Delongui, Franceili Delongui, Maria Caroline Martins de Araújo, Carolina Rossato, Jessica Tavares de Almeida, Larissa Muliterno Pelegrino, Erick Frank Bragato, Helena Kaminami Morimoto, Andrea Name Colado Simão, Damacio Ramon Kaimen-Maciel, Edna Maria Vissoci Reich. Tumor necrosis factor beta NcoI polymorphism (rs909253) is associated with inflammatory and metabolic markers in acute ischemic stroke. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:25063351. |
stroke patients presented higher white blood cell counts, hscrp, esr, glucose, insulin, and homa-ir, and lower hdl cholesterol than controls (p < 0.01). |
2016-03-17 |
2023-08-13 |
Not clear |
| Johnathan de Sousa Parreira, Ana Paula Kallaur, Marcio Francisco Lehmann, Sayonara Rangel Oliveira, Daniela Frizon Alfieri, Daniela Alfieri Frizon, Francieli Delongui, Franceili Delongui, Maria Caroline Martins de Araújo, Carolina Rossato, Jessica Tavares de Almeida, Larissa Muliterno Pelegrino, Erick Frank Bragato, Helena Kaminami Morimoto, Andrea Name Colado Simão, Damacio Ramon Kaimen-Maciel, Edna Maria Vissoci Reich. Tumor necrosis factor beta NcoI polymorphism (rs909253) is associated with inflammatory and metabolic markers in acute ischemic stroke. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:25063351. |
however, stroke patients carrying the tnfb2/b2 genotype presented higher levels of tnf-α, white blood cell counts, total cholesterol, ldl cholesterol, glucose, insulin, and homa-ir than those with other genotypes (p < 0.05). |
2016-03-17 |
2023-08-13 |
Not clear |
| Charlotte Rosso, Christine Pires, Jean-Christophe Corvol, Flore Baronnet, Sophie Crozier, Anne Leger, Sandrine Deltour, Romain Valabregue, Mélika Amor-Sahli, Stéphane Lehéricy, Didier Dormont, Yves Samso. Hyperglycaemia, insulin therapy and critical penumbral regions for prognosis in acute stroke: further insights from the INSULINFARCT trial. PloS one. vol 10. issue 3. 2016-03-04. PMID:25793765. |
hyperglycaemia, insulin therapy and critical penumbral regions for prognosis in acute stroke: further insights from the insulinfarct trial. |
2016-03-04 |
2023-08-13 |
Not clear |
| Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D'Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, Giuseppe Mandraffin. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem cells international. vol 2016. 2016-02-03. PMID:26839569. |
medline was searched using keywords related to "endothelial progenitor cells" and "endothelium" and, for the different categories, respectively, "smoking"; "blood pressure"; "diabetes mellitus" or "insulin resistance"; "dyslipidemia"; "aging" or "elderly"; "angina pectoris" or "myocardial infarction"; "stroke" or "cerebrovascular disease"; "homocysteine"; "c-reactive protein"; "vitamin d". |
2016-02-03 |
2023-08-13 |
Not clear |
| Figen Amber Cicek, Cicek Figen Amber, Zeynep Tokcaer-Keskin, Tokcaer-Keskin Zeynep, Evren Ozcinar, Ozcinar Evren, Yosuf Bozkus, Bozkus Yusuf, Kamil Can Akcali, Akcali Kamil Can, Belma Turan, Turan Belm. Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: possible role of epigenetic regulation. Molecular biology reports. vol 41. issue 8. 2015-10-22. PMID:24838371. |
metabolic syndrome (mets) is a complex medical disorder characterized by insulin resistance, hypertension, and high risk of coronary disease and stroke. |
2015-10-22 |
2023-08-13 |
rat |
| Wan Aliaa Wan Sulaiman, Hasnur Zaman Hashim, Shahrin Tarmizi Che Abdullah, Fan Kee Hoo, Hamidon Basr. Managing post stroke hyperglycaemia: moderate glycaemic control is better? An update. EXCLI journal. vol 13. 2015-09-29. PMID:26417305. |
insulin has been proven to attenuate glucose effectively in stroke patients, thus many trials over the years had studied the efficacy of intensive treatment aiming at normalization of blood sugar level in order to improve the bleak outcomes of psh. |
2015-09-29 |
2023-08-13 |
Not clear |
| Giovanna Gentile, Andrea Negro, Lidia D'Alonzo, Laura Aimati, Maurizio Simmaco, Paolo Martelletti, Marina Borr. Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population. Expert review of neurotherapeutics. vol 15. issue 2. 2015-09-18. PMID:25585507. |
migraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease. |
2015-09-18 |
2023-08-13 |
Not clear |
| Jonathan F Easton, Christopher R Stephens, Maia Angelov. Risk factors and prediction of very short term versus short/intermediate term post-stroke mortality: a data mining approach. Computers in biology and medicine. vol 54. 2015-07-17. PMID:25303114. |
in this paper we illustrate the benefits of a data mining inspired approach to statistically analysing a bespoke data set, the academic multicentre randomised control trial, u.k glucose insulin in stroke trial (gist-uk), with a view to discovering new insights distinct from the original hypotheses of the trial. |
2015-07-17 |
2023-08-13 |
Not clear |
| Patrick Reeson, Kelly A Tennant, Kim Gerrow, Josh Wang, Sammy Weiser Novak, Kelsey Thompson, Krista-Linn Lockhart, Andrew Holmes, Patrick C Nahirney, Craig E Brow. Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 13. 2015-06-19. PMID:25834040. |
correlating with this, bbb permeability was markedly increased in diabetic mice, which could not be prevented with insulin treatment after stroke. |
2015-06-19 |
2023-08-13 |
mouse |
| Duo L. Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. Asia Pacific journal of clinical nutrition. vol 24. issue 1. 2015-04-24. PMID:25740737. |
n-3 pufas have the following beneficial effects; cardio-protective effects, reduce ischemic stroke risk in both men and women and total stroke risk in women, increase insulin sensitivity in asians, decrease risk of breast cancer and colorectal cancer in men. |
2015-04-24 |
2023-08-13 |
human |
| Catherine M Viscoli, Lawrence M Brass, Antonio Carolei, Robin Conwit, Gary A Ford, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Anne M Lovejoy, Mark W Parsons, Peter N Peduzzi, Peter A Ringleb, Gregory G Schwartz, J David Spence, David Tanne, Lawrence H Young, Walter N Kerna. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. American heart journal. vol 168. issue 6. 2015-02-09. PMID:25458644. |
pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the insulin resistance intervention after stroke trial. |
2015-02-09 |
2023-08-13 |
Not clear |
| Catherine M Viscoli, Lawrence M Brass, Antonio Carolei, Robin Conwit, Gary A Ford, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Anne M Lovejoy, Mark W Parsons, Peter N Peduzzi, Peter A Ringleb, Gregory G Schwartz, J David Spence, David Tanne, Lawrence H Young, Walter N Kerna. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. American heart journal. vol 168. issue 6. 2015-02-09. PMID:25458644. |
specifically, iris will test the effectiveness of pioglitazone, an insulin-sensitizing drug of the thiazolidinedione class, for reducing the risk for stroke and myocardial infarction (mi) among insulin resistant, nondiabetic patients with a recent ischemic stroke or tia. |
2015-02-09 |
2023-08-13 |
Not clear |