| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shadi Yaghi, Karen L Furie, Catherine M Viscoli, Hooman Kamel, Mark Gorman, Jennifer Dearborn, Lawrence H Young, Silvio E Inzucchi, Anne M Lovejoy, Scott E Kasner, Robin Conwit, Walter N Kerna. Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). Circulation. vol 137. issue 5. 2019-04-09. PMID:29084736. |
the iris trial (insulin resistance intervention after stroke) demonstrated that pioglitazone reduced the risk for a composite outcome of stroke or myocardial infarction among nondiabetic patients with insulin resistance and a recent stroke or transient ischemic attack. |
2019-04-09 |
2023-08-13 |
Not clear |
| Jiwon Yang, Keun Woo Park, Sunghee Ch. Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF- The Journal of biological chemistry. vol 293. issue 34. 2019-02-28. PMID:29914985. |
inhibition of the cd36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the bdnf- obesity-induced metabolic dysfunctions increase the risk for vascular diseases, including type ii diabetes and stroke. |
2019-02-28 |
2023-08-13 |
mouse |
| Jonathan P Piccini, Christopher B Grange. Insulin Therapy and Stroke Risk in Patients With Diabetes and Atrial Fibrillation: Guilty by Association? Journal of the American College of Cardiology. vol 69. issue 4. 2019-02-13. PMID:28126159. |
insulin therapy and stroke risk in patients with diabetes and atrial fibrillation: guilty by association? |
2019-02-13 |
2023-08-13 |
Not clear |
| Ashok Kumar Datusalia, Piyush Agarwal, Jitendra Narain Singh, Shyam Sunder Sharm. Hyper-insulinemia increases the glutamate-excitotoxicity in cortical neurons: A mechanistic study. European journal of pharmacology. vol 833. 2018-11-05. PMID:30017861. |
insulin resistance in type-2 diabetic condition increases the risk of stroke and cognitive deficits in which involvement of glutamate has been postulated. |
2018-11-05 |
2023-08-13 |
Not clear |
| Jesus M Pradillo, Katie N Murray, Graham A Coutts, Ana Moraga, Fernando Oroz-Gonjar, Herve Boutin, Maria A Moro, Ignacio Lizasoain, Nancy J Rothwell, Stuart M Alla. Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:27856349. |
aged lean, aged corpulent (a model of atherosclerosis, obesity and insulin resistance) and young wistar male rats were exposed to transient cerebral ischemia, received subcutaneous il-1ra 3 and 6h during reperfusion, and effects on stroke outcome and neurogenesis were analyzed. |
2018-08-10 |
2023-08-13 |
rat |
| Esra Adışen, Selda Uzun, Funda Erduran, Mehmet Ali Güre. Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis. Anais brasileiros de dermatologia. vol 93. issue 2. 2018-05-29. PMID:29723384. |
coexistence of obesity, hypertension, insulin resistance and dyslipidemia is defined as metabolic syndrome (mbs), which is among the important risk indicators for cardiovascular diseases, diabetes and stroke. |
2018-05-29 |
2023-08-13 |
Not clear |
| Cheng-Jin You, Dan Liu, Li-Li Liu, Guo-Zhong L. Correlation between acute stroke-induced white matter lesions and insulin resistance. Medicine. vol 97. issue 11. 2018-03-21. PMID:29538217. |
the present study was to examine the relationship between white matter lesions (wmls) and insulin resistance (ir) in patients with acute stroke and evaluate clinical prognosis.around 200 patients with initial onset of acute stroke including 146 patients (73.0%) with wmls and 54 patients (27%) without wmls were analyzed by neuropsychological scales. |
2018-03-21 |
2023-08-13 |
Not clear |
| George Ntaios, Thomas A Ken. Insulin Resistance Intervention After Stroke Trial of Pioglitazone: Is This Perhaps the End of the Beginning? Stroke. vol 47. issue 7. 2018-03-09. PMID:27222525. |
insulin resistance intervention after stroke trial of pioglitazone: is this perhaps the end of the beginning? |
2018-03-09 |
2023-08-13 |
Not clear |
| Pablo Ameijeira, Yago Leira, Juan Blanco, Rogelio Leir. Periodontal disease as a potential factor of migraine chronification. Medical hypotheses. vol 102. 2018-03-01. PMID:28478842. |
hypertension, hypercholesterolemia, insulin resistance, stroke or coronary artery disease are comorbidities that periodontal disease and migraine could share. |
2018-03-01 |
2023-08-13 |
Not clear |
| Valery S Effoe, Lynne E Wagenknecht, Justin B Echouffo Tcheugui, Haiying Chen, Joshua J Joseph, Rita R Kalyani, Ronny A Bell, Wen-Chih H Wu, Ramon Casanova, Alain G Berton. Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study. Journal of the American Heart Association. vol 6. issue 2. 2018-02-28. PMID:28154164. |
sex differences in the association between insulin resistance and incident coronary heart disease and stroke among blacks without diabetes mellitus: the jackson heart study. |
2018-02-28 |
2023-08-13 |
Not clear |
| Mamza Jil, Mehta Rajnikant, Donnelly Richard, Idris Iskanda. The effects of dual-therapy intensification with insulin or dipeptidylpeptidase-4 inhibitor on cardiovascular events and all-cause mortality in patients with type 2 diabetes: A retrospective cohort study. Diabetes & vascular disease research. vol 14. issue 4. 2017-12-12. PMID:28330386. |
to compare time to a composite endpoint of non-fatal acute myocardial infarction, non-fatal stroke or all-cause mortality in patients with type 2 diabetes mellitus who had their treatment intensified with a dipeptidylpeptidase-4 inhibitor or insulin following dual-therapy (metformin plus sulfonylurea) failure. |
2017-12-12 |
2023-08-13 |
Not clear |
| Alice S Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M Ive. Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 26. issue 5. 2017-12-04. PMID:27955950. |
resistive training (rt) reduces hyperinsulinemia and improves insulin action in chronic stroke. |
2017-12-04 |
2023-08-13 |
Not clear |
| Philip M Bath, Jason P Appleton, Nikola Sprig. The Insulin Resistance Intervention after Stroke trial: A perspective on future practice and research. International journal of stroke : official journal of the International Stroke Society. vol 11. issue 7. 2017-10-26. PMID:27405860. |
the insulin resistance intervention after stroke trial: a perspective on future practice and research. |
2017-10-26 |
2023-08-13 |
Not clear |
| Silvio E Inzucchi, Catherine M Viscoli, Lawrence H Young, Karen L Furie, Mark Gorman, Anne M Lovejoy, Samuel Dagogo-Jack, Faramarz Ismail-Beigi, Mary T Korytkowski, Richard E Pratley, Gregory G Schwartz, Walter N Kerna. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes care. vol 39. issue 10. 2017-10-16. PMID:27465265. |
the insulin resistance intervention after stroke (iris) trial recently found that pioglitazone reduced risk for stroke and myocardial infarction in patients with insulin resistance but without diabetes who had had a recent ischemic stroke or transient ischemic attack (tia). |
2017-10-16 |
2023-08-13 |
Not clear |
| Demet Funda Bas, Atilla Ozcan Ozdemir, Ertuğrul Colak, Nur Kebapc. Higher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. Translational stroke research. vol 7. issue 3. 2017-09-25. PMID:26830777. |
insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke. |
2017-09-25 |
2023-08-13 |
Not clear |
| Guntram Schernthaner, Marie Helene Schernthaner-Reiter, Gerit-Holger Schernthane. EMPA-REG and Other Cardiovascular Outcome Trials of Glucose-lowering Agents: Implications for Future Treatment Strategies in Type 2 Diabetes Mellitus. Clinical therapeutics. vol 38. issue 6. 2017-09-15. PMID:27210264. |
the recent iris (insulin resistance intervention after stroke) study documented a significant reduction in stroke and mi when pioglitazone instead of placebo was given to nondiabetic patients presenting with both stroke/transient ischemic attack and insulin resistance, confirming results from the proactive (prospective pioglitazone clinical trial in macrovascular events) study in patients with t2dm. |
2017-09-15 |
2023-08-13 |
Not clear |
| Mariana Angela Rossaneis, Maria do Carmo Fernandez Lourenço Haddad, Maria de Fátima Mantovani, Sonia Silva Marcon, Paloma de Souza Cavalcante Pissinat. Foot ulceration in patients with diabetes: a risk analysis. British journal of nursing (Mark Allen Publishing). vol 26. issue 6. 2017-08-29. PMID:28345969. |
the risk of foot ulceration was of higher significance in male patients with diabetes (adjusted odds ratio (or)=1.39 (95% confidence interval (ci) 1.11 to 1.73); p=0.020), who did not practise a regular physical activity (adjusted or=1.58 (95% ci 1.15 to 2.15); p=0.013), with time since diagnosis over 10 years (adjusted or=1.42 (95% ci 1.10 to 1.86); p=0.011), who used insulin (adjusted or=1.40 (95% ci 1.09 to 1.84); p=0.012), with retinopathy (adjusted or=1.84 (95% ci 1.38 to 2.45); p=0.001) and who had had a previous stroke (adjusted or=1.47 (95% ci 1.09 to 2.04); p=0.018). |
2017-08-29 |
2023-08-13 |
Not clear |
| Lawrence H Young, Catherine M Viscoli, Jeptha P Curtis, Silvio E Inzucchi, Gregory G Schwartz, Anne M Lovejoy, Karen L Furie, Mark J Gorman, Robin Conwit, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Steven E Pfau, Frederick S Ling, Walter N Kerna. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. vol 135. issue 20. 2017-08-18. PMID:28246237. |
insulin resistance is highly prevalent among patients with atherosclerosis and is associated with an increased risk for myocardial infarction (mi) and stroke. |
2017-08-18 |
2023-08-13 |
Not clear |
| Lawrence H Young, Catherine M Viscoli, Jeptha P Curtis, Silvio E Inzucchi, Gregory G Schwartz, Anne M Lovejoy, Karen L Furie, Mark J Gorman, Robin Conwit, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Steven E Pfau, Frederick S Ling, Walter N Kerna. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. vol 135. issue 20. 2017-08-18. PMID:28246237. |
the iris trial (insulin resistance intervention after stroke) demonstrated that pioglitazone decreased the composite risk for fatal or nonfatal stroke and mi in patients with insulin resistance without diabetes mellitus, after a recent ischemic stroke or transient ischemic attack. |
2017-08-18 |
2023-08-13 |
Not clear |
| Francesco Paneni, Thomas F Lüsche. Cardiovascular Protection in the Treatment of Type 2 Diabetes: A Review of Clinical Trial Results Across Drug Classes. The American journal of cardiology. vol 120. issue 1S. 2017-08-03. PMID:28606340. |
the recent trials empagliflozin cardiovascular outcome event trial in type 2 diabetes mellitus patients-removing excess glucose (empa-reg outcome); trial to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes (sustain-6); liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (leader); and insulin resistance intervention after stroke (iris) have shed some light on this important clinical issue, thus showing a convincing effect of empagliflozin, liraglutide, and pioglitazone on cvd outcomes. |
2017-08-03 |
2023-08-13 |
human |