| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiuping Li, Jingyang Shan, Xia Liu, Zhengzheng Huang, Gelin Xu, Lijie Re. Microglial repopulation induced by PLX3397 protects against ischemic brain injury by suppressing neuroinflammation in aged mice. International immunopharmacology. vol 138. 2024-06-29. PMID:38943977. |
although studies have demonstrated the inflammatory profile of aged microglia in several neurological diseases, this issue is largely uncertain in stroke. |
2024-06-29 |
2024-07-02 |
mouse |
| Heidi Harjunpää, Robert Tallberg, Yunhao Cui, Carla Guenther, Hock-Kean Liew, Anna Seelbach, Guillem Saldo Rubio, Mikko Airavaara, Susanna C Fagerhol. β2-Integrins Regulate Microglial Responses and the Functional Outcome of Hemorrhagic Stroke In Vivo. Journal of immunology (Baltimore, Md. : 1950). 2024-06-26. PMID:38921973. |
depending on their phenotype, microglia, the main leukocytes in the cns, are capable of either causing further tissue damage or promoting brain restoration after stroke. |
2024-06-26 |
2024-06-29 |
mouse |
| Lin-Yan Huang, Yi-De Zhang, Jie Chen, Hai-Di Fan, Wan Wang, Bin Wang, Ju-Yun Ma, Peng-Peng Li, Hai-Wei Pu, Xin-Yian Guo, Jian-Gang Shen, Su-Hua Q. Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke. Neural regeneration research. vol 20. issue 3. 2024-06-18. PMID:38886957. |
we found that in the early stage (within 24 hours) of ischemic stroke, neutrophils produced a large amount of hypochlorous acid, while in the recovery phase (10 days after stroke), microglia were activated and produced a small amount of hypochlorous acid. |
2024-06-18 |
2024-06-21 |
rat |
| Flavia Semida Ghinea, Marius Viorel Ionică, Ilona Mihaela Liliac, Simion Pătru, Denisa Greta Olaru, Aurel Popa-Wagne. The Impact of Juvenile Microglia Transcriptomics on the Adult Brain Regeneration after Cerebral Ischemia. Current health sciences journal. vol 50. issue 1. 2024-06-08. PMID:38846476. |
following a stroke in the adult brain, inflammation, neurodegeneration, or disruptions in neural equilibrium trigger alterations in both the genetic blueprint and the structure and roles of microglia, a state often described as "activated" microglia. |
2024-06-08 |
2024-06-10 |
Not clear |
| Yuan Zhao, Wenzhe Sun, Qinlin Fan, Yanjie Huang, Yufan Ma, Shuang Zhang, Changxiong Gong, Bingqiao Wang, Wanyun Zhang, Qingwu Yang, Sen Li. Exploring the potential molecular intersection of stroke and major depression disorder. Biochemical and biophysical research communications. vol 720. 2024-05-17. PMID:38759300. |
single-cell sequencing analysis indicated that mlkl and nlrp3 are mainly influential on endothelial cells and microglia, suggesting that the impairment of these two cell types may be a factor in the relationship between stroke and major depression. |
2024-05-17 |
2024-05-27 |
mouse |
| Weizhuo Lu, Yilin Wang, Jiyue We. The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-05-16. PMID:38753217. |
on the contrary, anti-inflammatory microglia facilitate recovery following stroke. |
2024-05-16 |
2024-05-27 |
Not clear |
| Yujing Liu, Changlong Leng, Youwei Li, Meiling Zhou, Xiansheng Ye, Chaoxing Li, Xianmin Xia, Binlian Sun, Xiji Shu, Wei Li. A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2024-04-28. PMID:38679216. |
microglia undergo rapid activation and initiate inflammatory cascade reactions by phenotypic polarization, participating in the regulation of inflammatory injury and tissue repair post-ischemic stroke. |
2024-04-28 |
2024-05-01 |
Not clear |
| Jennifer A Liu, William H Walker, O Hecmarie Meléndez-Fernández, Jacob R Bumgarner, Ning Zhang, James C Walton, Gordon P Meares, A Courtney DeVries, Randy J Nelso. Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice. Experimental neurology. 2024-04-27. PMID:38677449. |
dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice. |
2024-04-27 |
2024-04-30 |
mouse |
| Yinli Cao, Yuanman Yu, Lina Pan, Weili Han, Feng Zeng, Jing Wang, Qiyong Mei, Changsheng Li. Sulfated Polysaccharide-Based Nanocarrier Drives Microenvironment-Mediated Cerebral Neurovascular Remodeling for Ischemic Stroke Treatment. Nano letters. 2024-04-22. PMID:38649327. |
when encountering high levels of intracellular ros in ischemic brain tissues, the release of scs combined with rapa from nanoparticle disintegration facilitates effective microglia polarization and, in turn, maintains blood-brain barrier integrity, reduces cerebral infarction, and promotes cerebral neurovascular remodeling in a mouse stroke model involving transient middle cerebral artery occlusion (tmcao). |
2024-04-22 |
2024-04-26 |
mouse |
| Wen Jiang, Yan Wu, Ailan Pang, Peiyao Li, Song Me. M1-type microglia-derived exosomes contribute to blood-brain barrier damage. Brain research. 2024-04-08. PMID:38588846. |
activated microglia disrupt the integrity of blood-brain barrier (bbb) to facilitate the stroke process. |
2024-04-08 |
2024-04-11 |
Not clear |
| George Andrew S Ingli. HDAC3 stokes microglia in stroke. Nature neuroscience. vol 27. issue 4. 2024-04-08. PMID:38589547. |
hdac3 stokes microglia in stroke. |
2024-04-08 |
2024-04-11 |
Not clear |
| Ran Liu, Raymond Berry, Linshu Wang, Kiran Chaudhari, Ali Winters, Yuanhong Sun, Claire Caballero, Hannah Ampofo, Yiwei Shi, Bibek Thata, Luis Colon-Perez, Nathalie Sumien, Shao-Hua Yan. Experimental Ischemic Stroke Induces Secondary Bihemispheric White Matter Degeneration and Long-Term Cognitive Impairment. Translational stroke research. 2024-03-15. PMID:38488999. |
additionally, microglia and astrocyte activation were identified in the bilateral corpus callosum after stroke. |
2024-03-15 |
2024-03-18 |
rat |
| Yue Zhang, Jiaying Li, Yongfang Zhao, Yichen Huang, Ziyu Shi, Hailian Wang, Hui Cao, Chenran Wang, Yana Wang, Di Chen, Shuning Chen, Shan Meng, Yangfan Wang, Yueyan Zhu, Yan Jiang, Ye Gong, Yanqin Ga. Arresting the bad seed: HDAC3 regulates proliferation of different microglia after ischemic stroke. Science advances. vol 10. issue 10. 2024-03-06. PMID:38446877. |
rna-seq analysis revealed mitosis as the primary process affected in hdac3-deficent microglia following stroke. |
2024-03-06 |
2024-03-09 |
Not clear |
| Zhongbin An, Qiong He, Ling Jiang, Yuan Wang, Yongyue Zhang, Yang Sun, Mengxin Wang, Shiyuan Yang, Lijie Huang, Huiwen Li, Yu Hao, Xiaolong Liang, Shumin Wan. A One-Stone-Two-Birds Strategy of Targeting Microbubbles with "Dual" Anti-Inflammatory and Blood-Brain Barrier "Switch" Function for Ischemic Stroke Treatment. ACS biomaterials science & engineering. 2024-02-29. PMID:38420991. |
in the treatment of stroke inflammation, it was found that hydrocortisone itself has anti-inflammatory effects and can also change the polarization of microglia from the harmful pro-inflammatory m1 phenotype to the beneficial anti-inflammatory m2 phenotype, thus achieving dual anti-inflammatory effects and enhancing the anti-inflammatory effects in ischemic areas after stroke, well reducing the cerebellar infarction volume by inhibiting the inflammatory response after cerebral ischemia. |
2024-02-29 |
2024-03-02 |
Not clear |
| Weizhuo Lu, Jiyue We. Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes. Aging and disease. 2024-02-29. PMID:38421829. |
during the neuroinflammation after ischemic stroke onset, both astrocytes and microglia undergo a series of morphological and functional changes and play pro-inflammatory or anti-inflammatory effect in the pathological process of stroke. |
2024-02-29 |
2024-03-03 |
Not clear |
| Xiao-Di Xie, Shan-Shan Dong, Ru-Juan Liu, Liu-Liu Shi, Ting Zh. Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution-Diving into Microglia/Macrophage Functions and Therapeutic Modality. Molecular neurobiology. 2024-02-27. PMID:38409642. |
the genetic reprogramming of macrophages and brain-resident microglia after an ischaemic stroke has been equated by some researchers to that of the peripheral blood and brain. |
2024-02-27 |
2024-03-02 |
Not clear |
| Xiao-Di Xie, Shan-Shan Dong, Ru-Juan Liu, Liu-Liu Shi, Ting Zh. Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution-Diving into Microglia/Macrophage Functions and Therapeutic Modality. Molecular neurobiology. 2024-02-27. PMID:38409642. |
exacerbated stroke outcomes are brought on by defective efferocytosis and improper modulation of pertinent signalling pathways in blood-borne macrophages and brain microglia, which also results in subsequent tissue inflammatory damage. |
2024-02-27 |
2024-03-02 |
Not clear |
| Szilvia Benkő, Ádám Déne. Microglial inflammatory mechanisms in stroke: the jury is still out. Neuroscience. 2024-02-16. PMID:38364965. |
because extensive review articles discussing the role of inflammatory mechanisms in different forms of acute brain injury are available, here we focus on some specific pathways that appear to be important for stroke pathophysiology with assumed contribution by microglia. |
2024-02-16 |
2024-02-19 |
Not clear |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
in this study, we investigated the potential involvement of tnfsf9 in reperfusion injury associated with ferroptosis in acute ischaemic stroke patients, mouse models and bv2 microglia. |
2024-02-12 |
2024-02-15 |
mouse |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
we first examined tnfsf9 changes in peripheral blood from stroke patients with successful reperfusion, and constructed oxygen-glucose deprivation-reperfusion (ogd-r) on bv2 microglia, oxygen-glucose deprivation for 6 h followed by reoxygenation and re-glucose for 24 h, and appropriate over-expression or knockdown of tnfsf9 manipulation on bv2 cells and found that in the case of bv2 cells encountering ogd-r over-expression of tnfsf9 resulted in increased bv2 apoptosis. |
2024-02-12 |
2024-02-15 |
mouse |