| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Milton H Hamblin, Austin C Boese, Rabi Murad, Jean-Pyo Le. MMP-3 Knockout Induces Global Transcriptional Changes and Reduces Cerebral Infarction in Both Male and Female Models of Ischemic Stroke. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000490. |
functional pathway analysis revealed that inflammation, integrin cell surface signaling, endothelial- and epithelial-mesenchymal transition (endmt/emt), and apoptosis gene signatures were decreased in mmp-3 ko stroke brains. |
2024-07-13 |
2024-07-15 |
mouse |
| Wang Lei, Shen Yiming, Peng Qiang, Chu Xin, Gu Peng, Zhu Baofen. Unleashing the Neurotherapeutic Potential: The Crucial Role of miR-206-3p in Facilitating Hsp90aa1-Mediated Central Nervous System Injuries During Heat Stroke. Molecular neurobiology. 2024-07-12. PMID:38995443. |
this study revealed the regulatory relationship between mir-206-3p and hsp90aa1, suggesting that mir-206-3p could regulate the expression of hsp90aa1, inhibit neuronal cell viability, and promote apoptosis, thereby contributing to cns injury in heat stroke. |
2024-07-12 |
2024-07-14 |
rat |
| Gayathri Rajamanickam, Andy Thiam Huat Lee, Ping Lia. Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain. Neurochemical research. 2024-06-10. PMID:38856889. |
bdnf-tyrosine kinase receptors b (trkb) pathway promotes neurite outgrowth, neurogenesis, and the prevention of apoptosis, which helps in stroke recovery. |
2024-06-10 |
2024-06-14 |
Not clear |
| Meirong Chen, Yang Qin, Yongmei Peng, Ruyu Mai, Huanyao Teng, Zhongquan Qi, Jingxin M. Advancing stroke therapy: the potential of MOF-based nanozymes in biomedical applications. Frontiers in bioengineering and biotechnology. vol 12. 2024-05-27. PMID:38798955. |
we have reported the potential of mof in treating stroke by regulating ros levels, alleviation inflammation, and reducing neuron apoptosis. |
2024-05-27 |
2024-05-31 |
Not clear |
| Sedigheh Behrouzifar, Habibollah Esmail. The biological efficacy of Apelin against focal transient cerebral ischemia-reperfusion injury. A systematic review and meta-analysis of animal studies. Brain research. 2024-03-29. PMID:38552935. |
apelin has been extensively studied, and emerging experimental evidence suggests that apelin may have effects on stroke by reducing infarct volume and neurological deficits, inhibiting the apoptosis process and reducing brain water content. |
2024-03-29 |
2024-04-01 |
Not clear |
| Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Mi. Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure. Toxicological research. vol 40. issue 2. 2024-03-25. PMID:38525134. |
in conclusion, our results confirmed that cilostazol exerted a protective effect on the brain and kidney function, specifically in vascular injury, oxidative stress, cell apoptosis, cell autophagy, and inflammation response in crf combined with stroke rats which were related to the upregulation of jak/stat3/mtor signal pathway. |
2024-03-25 |
2024-03-27 |
rat |
| Lingling Meng, Bufan Wu, Ling OuYang, Rou Peng, Yonglin Chen, Zhijuan Tang, Min Zhang, Tanqing Xu, Yaling Wang, Shengfeng Lu, Xinyue Jing, Shuping F. Electroacupuncture regulates histone acetylation of Bcl-2 and Caspase-3 genes to improve ischemic stroke injury. Heliyon. vol 10. issue 6. 2024-03-19. PMID:38500994. |
imbalances between bcl-2 and caspase-3 are significant evidence of apoptosis, which is considered an influential factor in rapidly occurring neuronal cell death and the decline of neurological function after stroke. |
2024-03-19 |
2024-03-21 |
Not clear |
| Jeong-Ah Hwang, Seung Kyu Choi, Seong Hwan Kim, Dong Woon Ki. Pharmacological Inhibition of LRRK2 Exhibits Neuroprotective Activity in Mouse Photothrombotic Stroke Model. Experimental neurobiology. vol 33. issue 1. 2024-03-12. PMID:38471803. |
these results suggest that pharmacological inhibition of lrrk2 kinase activity could attenuate mitochondrial apoptosis, ultimately leading to neuroprotective potential in stroke progression. |
2024-03-12 |
2024-03-15 |
mouse |
| b' P Josi\\xc4\\x87 Dominovi\\xc4\\x87, M Dobrivojevi\\xc4\\x87 Radmilovi\\xc4\\x87, S Srako\\xc4\\x8di\\xc4\\x87, I Mi\\xc5\\xa1eri\\xc4\\x87, S \\xc5\\xa0koki\\xc4\\x87, S Gajovi\\xc4\\x8. Validation and application of caged Z-DEVD-aminoluciferin bioluminescence for assessment of apoptosis of wild type and TLR2-deficient mice after ischemic stroke. Journal of photochemistry and photobiology. B, Biology. vol 253. 2024-02-25. PMID:38402658.' |
programmed cell death or apoptosis is a critically important mechanism of tissue remodeling and regulates conditions such as cancer, neurodegeneration or stroke. |
2024-02-25 |
2024-02-28 |
mouse |
| b' P Josi\\xc4\\x87 Dominovi\\xc4\\x87, M Dobrivojevi\\xc4\\x87 Radmilovi\\xc4\\x87, S Srako\\xc4\\x8di\\xc4\\x87, I Mi\\xc5\\xa1eri\\xc4\\x87, S \\xc5\\xa0koki\\xc4\\x87, S Gajovi\\xc4\\x8. Validation and application of caged Z-DEVD-aminoluciferin bioluminescence for assessment of apoptosis of wild type and TLR2-deficient mice after ischemic stroke. Journal of photochemistry and photobiology. B, Biology. vol 253. 2024-02-25. PMID:38402658.' |
apoptosis was investigated for 28 days after stroke in mice which ubiquitously expressed the firefly luciferase transgene. |
2024-02-25 |
2024-02-28 |
mouse |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
we first examined tnfsf9 changes in peripheral blood from stroke patients with successful reperfusion, and constructed oxygen-glucose deprivation-reperfusion (ogd-r) on bv2 microglia, oxygen-glucose deprivation for 6 h followed by reoxygenation and re-glucose for 24 h, and appropriate over-expression or knockdown of tnfsf9 manipulation on bv2 cells and found that in the case of bv2 cells encountering ogd-r over-expression of tnfsf9 resulted in increased bv2 apoptosis. |
2024-02-12 |
2024-02-15 |
mouse |
| Rehnuma Islam, Jan-Eric Ahlfors, Ricky Siu, Humna Noman, Roya Akbary, Cindi M Morshea. Inhibition of Apoptosis in a Model of Ischemic Stroke Leads to Enhanced Cell Survival, Endogenous Neural Precursor Cell Activation and Improved Functional Outcomes. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339065. |
apoptosis inhibitors demonstrate efficacy in improving neuronal cell survival in animal models of stroke. |
2024-02-10 |
2024-02-12 |
mouse |
| Antoine Beurton, Maxime Michot, François-Xavier Hérion, Mario Rienzo, Claire Oddos, Thierry Couffinhal, Julien Imbault, Alexandre Ouattar. Systemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2024-01-23. PMID:38261663. |
venoarterial extracorporeal membrane oxygenation may also increase myocardial wall stress and stroke work, possibly affecting the cellular cardioprotective and apoptosis signaling pathways, and thus the infarct size. |
2024-01-23 |
2024-01-26 |
Not clear |
| Dina M Mahmoud, Mohammed R A Ali, Basmah Nasser Aldosari, Randa Mohammed Zaki, Obaid Afzal, Alaa S Tulbah, Demiana M Naguib, Mohamed I Zanaty, Mary Eskander Attia, Fatma I Abo El-Ela, Amr Gamal Foua. Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro International journal of pharmaceutics: X. vol 7. 2024-01-23. PMID:38260917. |
candesartan has been used to prevent stroke due to its inhibitory effects on blood pressure, angiogenesis, oxidative damage, and apoptosis. |
2024-01-23 |
2024-01-25 |
rat |
| BioMed Research Internationa. Retracted: Influence of miR-1 on Nerve Cell Apoptosis in Rats with Cerebral Stroke via Regulating ERK Signaling Pathway. BioMed research international. vol 2024. 2024-01-17. PMID:38230012. |
retracted: influence of mir-1 on nerve cell apoptosis in rats with cerebral stroke via regulating erk signaling pathway. |
2024-01-17 |
2024-01-19 |
rat |
| Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhan. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochemistry international. 2023-12-11. PMID:38081419. |
activated microglia participate in the pathological processes after stroke through polarization, autophagy, phagocytosis, pyroptosis, ferroptosis, apoptosis, and necrosis, thereby influencing the injury and repair following stroke. |
2023-12-11 |
2023-12-17 |
Not clear |
| Chujuan Liu, Hui Chen, Xi Tao, Chen Li, Aiping Li, Wen W. ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m Experimental neurology. 2023-12-06. PMID:38056583. |
alkbh5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the stat5/perk/eif2α/chop signaling pathway in an m endoplasmic reticulum (er) stress causes neuroinflammation and neuronal apoptosis during ischemic stroke progression. |
2023-12-06 |
2023-12-10 |
Not clear |
| Shengjie Feng, Miaoxian Yang, Shengpeng Liu, Yu He, Shuixiang Deng, Ye Gon. Oxidative stress as a bridge between age and stroke: A narrative review. Journal of intensive medicine. vol 3. issue 4. 2023-12-01. PMID:38028635. |
a rapid increase in the levels of reactive oxygen species (ros) post stroke can overwhelm antioxidant defenses and trigger a series of pathophysiologic events including the inflammatory response, blood-brain barrier (bbb) disruption, apoptosis, and autophagy, ultimately leading to neuron degeneration and apoptosis. |
2023-12-01 |
2023-12-10 |
Not clear |
| Tai Zhou, Lei Zhang, Li He, Yan Lan, Lei Ding, Li Li, Zhongcheng Wan. GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis. Molecular neurobiology. 2023-11-22. PMID:37989985. |
since the expression of many antiapoptotic genes is inhibited in the ischemic brains, here we aimed to offer an epigenetic solution to cell apoptosis after stroke by reversing h3k27me3 levels after ischemia. |
2023-11-22 |
2023-11-29 |
Not clear |
| Victoria Jiménez Carretero, Eva Ramos, Pedro Segura-Chama, Adan Hernández, Andrés M Baraibar, Iris Álvarez-Merz, Francisco López Muñoz, Javier Egea, José M Solís, Alejandro Romero, Jesús M Hernández-Guij. Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891922. |
they can attenuate oxidative stress, modulate calcium homeostasis, and inhibit apoptosis, thereby safeguarding neurons against damage induced by stroke and aging processes. |
2023-10-30 |
2023-11-08 |
Not clear |