| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Magdalena Górny, Anna Bilska-Wilkosz, Małgorzata Iciek, Zofia Rogóż, Elżbieta Lorenc-Koc. Treatment with aripiprazole and N-acetylcysteine affects anaerobic cysteine metabolism in the hippocampus and reverses schizophrenia-like behavior in the neurodevelopmental rat model of schizophrenia. The FEBS journal. 2023-08-30. PMID:37646112. |
treatment with aripiprazole and n-acetylcysteine affects anaerobic cysteine metabolism in the hippocampus and reverses schizophrenia-like behavior in the neurodevelopmental rat model of schizophrenia. |
2023-08-30 |
2023-09-07 |
rat |
| Muhammad S Abbas, Sondos T Nassar, Tasniem Tasha, Anjali Desai, Anjana Bajgain, Asna Ali, Chandrani Dutta, Khadija Pasha, Salomi Paul, Sathish Venugopa. Exercise as an Adjuvant Treatment of Schizophrenia: A Review. Cureus. vol 15. issue 7. 2023-08-21. PMID:37602139. |
to date, we are still unsure about the exact etiology of schizophrenia, but there are many factors, such as genetics, diminished hippocampal volume, and imbalance of neurotransmitters, that lead to the pathogenies of the disease. antipsychotics are the most effective treatment option for schizophrenia so far, yet they are associated with a wide array of side effects, ranging from extrapyramidal side effects to conditions, such as metabolic syndrome. |
2023-08-21 |
2023-09-07 |
Not clear |
| Thamyris Santos-Silva, Débora Dos Santos Fabris, Cilene Lino de Oliveira, Francisco S Guimarães, Felipe V Gome. Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis. Schizophrenia bulletin. 2023-08-16. PMID:37584417. |
prefrontal and hippocampal parvalbumin interneurons in animal models for schizophrenia: a systematic review and meta-analysis. |
2023-08-16 |
2023-09-07 |
Not clear |
| Thamyris Santos-Silva, Débora Dos Santos Fabris, Cilene Lino de Oliveira, Francisco S Guimarães, Felipe V Gome. Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis. Schizophrenia bulletin. 2023-08-16. PMID:37584417. |
consistent with postmortem findings in patients, most animal models for schizophrenia (scz) present abnormal levels of parvalbumin (pv), a marker of fast-spiking gabaergic interneurons, in the prefrontal cortex (pfc) and hippocampus (hip). |
2023-08-16 |
2023-09-07 |
Not clear |
| Anthony A Grace, Daniela L Ulian. Insights into the Mechanism of Action of Antipsychotic Drugs Derived from Animal Models: Standard of Care versus Novel Targets. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569748. |
on this basis, a novel class of drugs that can reverse schizophrenia at the site of pathology, i.e., the hippocampal overdrive, could be effective in alleviating all three classes of symptoms of schizophrenia while also being better tolerated. |
2023-08-12 |
2023-08-16 |
Not clear |
| Peiyu Cao, Congxin Chen, Qi Si, Yuting Li, Fangfang Ren, Chongyang Han, Jingjing Zhao, Xiying Wang, Guoxin Xu, Yuxiu Su. Volumes of hippocampal subfields suggest a continuum between schizophrenia, major depressive disorder and bipolar disorder. Frontiers in psychiatry. vol 14. 2023-08-07. PMID:37547217. |
converging evidence suggests that alterations in hippocampal volume are a common sign in psychiatric disorders; however, there is still no consensus on the nature and extent of hippocampal atrophy in schizophrenia (sz), major depressive disorder (mdd) and bipolar disorder (bd). |
2023-08-07 |
2023-08-14 |
Not clear |
| Naohiro Okada, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Junya Matsumoto, Naoki Hashimoto, Masahiro Kiyota, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Takahiko Kawashima, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-Ichiro Hashimoto, Khin K Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Theo G M van Erp, Neda Jahanshad, Reiji Yoshimura, Osamu Abe, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Jessica A Turner, Paul M Thompson, Norio Ozaki, Kiyoto Kasai, Ryota Hashimot. Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification. Molecular psychiatry. 2023-08-03. PMID:37537281. |
we demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. |
2023-08-03 |
2023-08-14 |
human |
| Ziyi Zhang, Hua Lin, Zijuan Feng, Hongsheng Xie, Peng Liu, Yang Shu, Zhiyun Jia, Shuting Zhan. Impaired calcium channel function and pronounced hippocampal atrophy in a schizophrenia patient with cognitive impairment carrying Presenilin-2 Ser130Leu mutation: A case report and literature review. Schizophrenia research. vol 258. 2023-07-30. PMID:37517367. |
impaired calcium channel function and pronounced hippocampal atrophy in a schizophrenia patient with cognitive impairment carrying presenilin-2 ser130leu mutation: a case report and literature review. |
2023-07-30 |
2023-08-14 |
Not clear |
| Chun Zhang, Jian-Guo Niu, Xue-Rui Kong, Xiao-Juan Mi, Qiang Liu, Fei-Fei Chen, Wei-Fang Rong, Juan Li. G protein-coupled estrogen receptor 1 deficiency impairs adult hippocampal neurogenesis in mice with schizophrenia. Journal of chemical neuroanatomy. 2023-07-26. PMID:37495162. |
g protein-coupled estrogen receptor 1 deficiency impairs adult hippocampal neurogenesis in mice with schizophrenia. |
2023-07-26 |
2023-08-14 |
mouse |
| Chun Zhang, Jian-Guo Niu, Xue-Rui Kong, Xiao-Juan Mi, Qiang Liu, Fei-Fei Chen, Wei-Fang Rong, Juan Li. G protein-coupled estrogen receptor 1 deficiency impairs adult hippocampal neurogenesis in mice with schizophrenia. Journal of chemical neuroanatomy. 2023-07-26. PMID:37495162. |
this study aimed to confirm that g protein-coupled estrogen receptor 1 (gper1) deficiency affects cognitive function by reducing hippocampal neurogenesis via the pka/erk/igf-i signaling pathway in mice with schizophrenia (sz). |
2023-07-26 |
2023-08-14 |
mouse |
| Marta Perez-Rando, Carlota Penades-Gomiz, Pablo Martinez-Marin, Gracián García-Martí, Eduardo J Aguilar, Maria J Escarti, Eva Grasa, Iluminada Corripio, Julio Sanjuan, Juan Nache. Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations. Revista de psiquiatria y salud mental. 2023-07-26. PMID:37495479. |
volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations. |
2023-07-26 |
2023-08-14 |
Not clear |
| Gabriel D Flores-Gómez, David Javier Apam-Castillejos, Ismael Juárez-Díaz, Estefania Fuentes-Medel, Alfonso Díaz, Hiram Tendilla-Beltrán, Gonzalo Flore. Aripiprazole attenuates the medial prefrontal cortex morphological and biochemical alterations in rats with neonatal ventral hippocampus lesion. Journal of chemical neuroanatomy. 2023-07-22. PMID:37481172. |
in this study, it was evaluated the effect of the atypical antipsychotic aripiprazole (ari) on the behavioral and mpfc neuronal disturbances of rats with neonatal ventral hippocampus lesion (nvhl), which is a heuristic developmental model relevant to the study of schizophrenia. |
2023-07-22 |
2023-08-14 |
rat |
| Sazid M Hasan, Munajj S Huq, Asadur Z Chowdury, Shahira Baajour, John Kopchick, A J Robison, Katherine N Thakkar, Luay Haddad, Alireza Amirsadri, Patricia Thomas, Dalal Khatib, Usha Rajan, Jeffrey A Stanley, Vaibhav A Diwadka. Learning without contingencies: A loss of synergy between memory and reward circuits in schizophrenia. Schizophrenia research. vol 258. 2023-07-19. PMID:37467677. |
ufc was estimated and inter-group differences (between schizophrenia patients and controls, n = 54 total, n = 28 patients) were assessed within and between reward (vta and nacc) and learning/memory (basal ganglia, dpfc, hippocampus, parahippocampus, occipital lobe) sub-networks. |
2023-07-19 |
2023-08-14 |
human |
| Kangcheng Wang, Xingyan Li, Xiaotong Wang, Bernhard Hommel, Xiaodi Xia, Jiang Qiu, Yixiao Fu, Zheyi Zho. In vivo analyses reveal hippocampal subfield volume reductions in adolescents with schizophrenia, but not with major depressive disorder. Journal of psychiatric research. vol 165. 2023-07-17. PMID:37459779. |
adult studies have reported atypicalities in the hippocampus and subfields in patients with schizophrenia (scz) and major depressive disorder (mdd). |
2023-07-17 |
2023-08-14 |
human |
| Qiao Mao, Shiren Huang, Xinqun Luo, Ping Liu, Xiaoping Wang, Kesheng Wang, Yong Zhang, Bin Chen, Xingguang Lu. Spatial Multiomics Analysis in Psychiatric Disorders. EC psychology and psychiatry. vol 12. issue 6. 2023-07-10. PMID:37424930. |
spatial proteogenomics has identified autism spectrum disorder (asd)-risk genes in specific cell types, while schizophrenia risk loci have been linked to transcriptional signatures in the human hippocampus. |
2023-07-10 |
2023-08-14 |
mouse |
| Kenta Deriha, Eri Hashimoto, Wataru Ukai, Francesca Marchisella, Emi Nishimura, Hanako Hashiguchi, Masaya Tayama, Takao Ishii, Marco A Riva, Chiaki Kawanish. Reduced sociability in a prenatal immune activation model: Modulation by a chronic blonanserin treatment through the amygdala-hippocampal axis. Journal of psychiatric research. vol 164. 2023-06-28. PMID:37379611. |
however, it remains unclear how this treatment affects neural circuit changes in hippocampus and amygdala, which might contribute to the prevention of onset process of schizophrenia. |
2023-06-28 |
2023-08-14 |
rat |
| Kenta Deriha, Eri Hashimoto, Wataru Ukai, Francesca Marchisella, Emi Nishimura, Hanako Hashiguchi, Masaya Tayama, Takao Ishii, Marco A Riva, Chiaki Kawanish. Reduced sociability in a prenatal immune activation model: Modulation by a chronic blonanserin treatment through the amygdala-hippocampal axis. Journal of psychiatric research. vol 164. 2023-06-28. PMID:37379611. |
these results strongly implicate changes in pv expression, pv(+) gabaergic interneuron density, and bdnf long 3'utr expression levels, particularly in the dorsal hippocampus, in the pathophysiology and treatment responses of mia-induced schizophrenia and highlight the therapeutic potential of blonanserin for developmental stress-related schizophrenia. |
2023-06-28 |
2023-08-14 |
rat |
| Claudia Barth, Stener Nerland, Kjetil N Jørgensen, Beathe Haatveit, Laura A Wortinger, Ingrid Melle, Unn K Haukvik, Torill Ueland, Ole A Andreassen, Ingrid Agart. Altered Sex Differences in Hippocampal Subfield Volumes in Schizophrenia. Schizophrenia bulletin. 2023-06-24. PMID:37354490. |
altered sex differences in hippocampal subfield volumes in schizophrenia. |
2023-06-24 |
2023-08-14 |
Not clear |
| Lili Sahakyan, Christopher N Wahlheim, Thomas R Kwapi. Mnemonic discrimination deficits in multidimensional schizotypy. Hippocampus. 2023-06-22. PMID:37345675. |
schizophrenia is associated with disruptions in detecting subtle differences between objects, which is linked to hippocampal dysfunction. |
2023-06-22 |
2023-08-14 |
human |
| Lene C Olsen, Meital Galler, Menno P Witter, Pål Saetrom, Kally C O'Reill. Transcriptional development of the hippocampus and the dorsal-intermediate-ventral axis in rats. Hippocampus. 2023-06-06. PMID:37280038. |
our data indicate that neurodevelopmental disorders like epilepsy, schizophrenia and affective disorders are enriched with developmental degs in the hippocampus, regardless of dorsoventral location, with the greatest enrichment of these clinical disorders seen in genes whose expression changes from p0-9. |
2023-06-06 |
2023-08-14 |
rat |