| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung M Yang, Ayan Ghoshal, Jeffrey M Hubbard, Florian Gackière, Romain Teyssié, Stuart A Neale, Seth C Hopkins, Kenneth S Koblan, Linda J Bristow, Nina Dedi. TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-12-19. PMID:38110609. |
aberrant dopaminergic and glutamatergic function, particularly within the striatum and hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia. |
2023-12-19 |
2023-12-21 |
mouse |
| Iris Jonker, Janine Doorduin, Henderikus Knegtering, Erna Van't Hag, Rudi A Dierckx, Erik F J de Vries, Robert A Schoevers, Hans C Klei. Antiviral treatment in schizophrenia: a randomized pilot PET study on the effects of valaciclovir on neuroinflammation. Psychological medicine. vol 53. issue 15. 2023-12-15. PMID:37016791. |
patients with schizophrenia experience cognitive impairment, which could be related to neuroinflammation in the hippocampus. |
2023-12-15 |
2023-12-17 |
Not clear |
| Anna M Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Re. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-12-13. PMID:38092734. |
we report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). |
2023-12-13 |
2023-12-17 |
human |
| Xun Yang, Yuan Song, Yuhan Zou, Yilin Li, Jianguang Zen. Neural correlates of prediction error in patients with schizophrenia: evidence from an fMRI meta-analysis. Cerebral cortex (New York, N.Y. : 1991). 2023-12-07. PMID:38061699. |
our meta-analysis showed that, relative to healthy controls, schizophrenia patients showed increased activity in the precentral gyrus and middle frontal gyrus and reduced activity in the mesolimbic circuit, including the striatum, thalamus, amygdala, hippocampus, anterior cingulate cortex, insula, superior temporal gyrus, and cerebellum, when processing prediction errors. |
2023-12-07 |
2023-12-17 |
Not clear |
| Yaşar Türk, İsmail Devecioğlu, Atakan Küskün, Cem Öge, Elmas Beyazyüz, Yakup Albayra. ROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophrenia. Psychiatry research. Neuroimaging. vol 336. 2023-11-05. PMID:37925764. |
notably, specific rois with reduced fa in schizophrenia patients included bilateral nucleus accumbens, left fusiform area, brain stem, anterior corpus callosum, left rostral and caudal anterior cingulate, right posterior cingulate, left thalamus, left hippocampus, left inferior temporal cortex, right superior temporal cortex, left pars triangularis and right lingual gyrus. |
2023-11-05 |
2023-11-08 |
human |
| Suzanne N Avery, Baxter P Rogers, Maureen McHugo, Kristan Armstrong, Jennifer Urbano Blackford, Simon N Vandekar, Neil D Woodward, Stephan Hecker. Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study. Biological psychiatry global open science. vol 3. issue 4. 2023-10-26. PMID:37881573. |
hippocampal abnormalities are among the most consistent findings in schizophrenia. |
2023-10-26 |
2023-11-08 |
Not clear |
| Daniel J Lodge, Hannah B Elam, Angela M Boley, Jennifer J Donega. Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons. Nature communications. vol 14. issue 1. 2023-10-20. PMID:37863893. |
people with schizophrenia show hyperactivity in the ventral hippocampus (vhipp) and we have previously demonstrated distinct behavioral roles for vhipp cell populations. |
2023-10-20 |
2023-11-08 |
Not clear |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. |
2023-10-13 |
2023-10-15 |
human |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
hippocampal hyperactivity is a novel pharmacological target in the treatment of schizophrenia. |
2023-10-13 |
2023-10-15 |
human |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
we hypothesized that levetiracetam (lev), a drug binding to the synaptic vesicle glycoprotein 2 a, normalizes hippocampal activity in persons with schizophrenia and can be measured using neuroimaging methods. |
2023-10-13 |
2023-10-15 |
human |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
additionally, hippocampal falff in patients with schizophrenia after lev treatment did not significantly differ from healthy control participants receiving placebo, suggesting that lev may normalize hippocampal hyperactivity. |
2023-10-13 |
2023-10-15 |
human |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
in the context of no significant group difference in bold signal, we found that hippocampal recruitment during scene processing is enhanced by lev more significantly in schizophrenia. |
2023-10-13 |
2023-10-15 |
human |
| Maxwell J Roeske, Maureen McHugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Hecker. Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-13. PMID:37833590. |
we conclude that pharmacological modulation of hippocampal hyperactivity in schizophrenia can be studied with some neuroimaging methods, but not others. |
2023-10-13 |
2023-10-15 |
human |
| Matthew M Nour, Daniel C McNamee, Yunzhe Liu, Raymond J Dola. Trajectories through semantic spaces in schizophrenia and the relationship to ripple bursts. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 42. 2023-10-10. PMID:37816054. |
schizophrenia is also linked to abnormalities in neural processes that support cognitive map representations, including hippocampal replay and high-frequency ripple oscillations. |
2023-10-10 |
2023-10-15 |
human |
| Matthew M Nour, Daniel C McNamee, Yunzhe Liu, Raymond J Dola. Trajectories through semantic spaces in schizophrenia and the relationship to ripple bursts. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 42. 2023-10-10. PMID:37816054. |
here, we report a computational assay of semantically guided conceptual sampling and exploit this to test a hypothesis that people with schizophrenia (pscz) exhibit abnormalities in semantically guided cognition that relate to hippocampal replay and ripples. |
2023-10-10 |
2023-10-15 |
human |
| Matthew M Nour, Daniel C McNamee, Yunzhe Liu, Raymond J Dola. Trajectories through semantic spaces in schizophrenia and the relationship to ripple bursts. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 42. 2023-10-10. PMID:37816054. |
in line with our hypothesis, the influence of semantic similarity on behavior was reduced in schizophrenia relative to controls, predicted negative psychotic symptoms, and correlated with an meg signature of hippocampal ripple power (but not replay). |
2023-10-10 |
2023-10-15 |
human |
| Susana Bulnes, Marina Picó-Gallardo, Harkaitz Bengoetxea, José Vicente Lafuent. Effects of curcumin nanodelivery on schizophrenia and glioblastoma. International review of neurobiology. vol 171. 2023-10-02. PMID:37783555. |
schizophrenia is a disabling psychiatric disorder related with an aberrant functional coupling between hippocampus and prefrontal cortex that might be crucial for cognitive dysfunction. |
2023-10-02 |
2023-10-07 |
Not clear |
| Paul J Harrison, David M Bannerma. GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia. Molecular psychiatry. 2023-09-22. PMID:37736757. |
we suggest that one consequence of nr2a dysfunction is impairment in a form of hippocampal synaptic plasticity, producing deficits in short-term habituation and thence elevated and dysregulated levels of attention, a phenotype of relevance to schizophrenia and its cognitive aspects. |
2023-09-22 |
2023-10-07 |
mouse |
| Meihong Xiu, Yong Fan, Qinqin Liu, Song Chen, Fengchun Wu, Xiangyang Zhan. Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia. International journal of clinical and health psychology : IJCHP. vol 23. issue 4. 2023-09-04. PMID:37663043. |
glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia. |
2023-09-04 |
2023-09-07 |
Not clear |
| Meihong Xiu, Yong Fan, Qinqin Liu, Song Chen, Fengchun Wu, Xiangyang Zhan. Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia. International journal of clinical and health psychology : IJCHP. vol 23. issue 4. 2023-09-04. PMID:37663043. |
previous studies have indicated that glucose metabolism and altered hippocampal structure and function play a pivotal role in cognitive deficits in schizophrenia (sz). |
2023-09-04 |
2023-09-07 |
Not clear |