| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Hwang, J Kim, J Y Shin, J Ii Kim, J S Seo, M J Webster, D Lee, S Ki. Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Translational psychiatry. vol 3. 2014-06-05. PMID:24169640. |
now using rna-seq data from the hippocampus, we have identified 144 differentially expressed genes in schizophrenia cases as compared with unaffected controls. |
2014-06-05 |
2023-08-12 |
human |
| Y Hwang, J Kim, J Y Shin, J Ii Kim, J S Seo, M J Webster, D Lee, S Ki. Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Translational psychiatry. vol 3. 2014-06-05. PMID:24169640. |
we identified a co-expression module associated with schizophrenia that includes the majority of differentially expressed genes related to immune/inflammation response as well as with the density of parvalbumin-containing neurons in the hippocampus. |
2014-06-05 |
2023-08-12 |
human |
| Y Hwang, J Kim, J Y Shin, J Ii Kim, J S Seo, M J Webster, D Lee, S Ki. Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Translational psychiatry. vol 3. 2014-06-05. PMID:24169640. |
the results indicate that abnormal immune/inflammation response in the hippocampus may underlie the pathophysiology of schizophrenia and may be associated with abnormalities in the parvalbumin-containing neurons that lead to the cognitive deficits of the disease. |
2014-06-05 |
2023-08-12 |
human |
| Kei Hamazaki, Tomohito Hamazaki, Hidekuni Inader. Abnormalities in the fatty acid composition of the postmortem entorhinal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23731984. |
we have previously measured pufa levels in the postmortem hippocampus from patients with schizophrenia or bipolar disorder and control subjects; however, we found no significant differences between the groups except for small changes in n-6 pufas. |
2014-05-30 |
2023-08-12 |
human |
| Dai Han, Li Xu, Honglei Xiao, Georgia C Prado Schmidt, Shenxun Sh. Dizocilpine reduces head diameter of dendritic spines in the hippocampus of adolescent rats. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23747234. |
spine deficits have been found in hippocampus of schizophrenia patients, and were associated with cognitive impairments. |
2014-05-30 |
2023-08-12 |
rat |
| Dai Han, Li Xu, Honglei Xiao, Georgia C Prado Schmidt, Shenxun Sh. Dizocilpine reduces head diameter of dendritic spines in the hippocampus of adolescent rats. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23747234. |
these results imply that subchronic mk-801 administration during adolescence might disturb the expression of rhoa, rac1 and cdc42 mrna, and then lead to the decay of the spines in hippocampus, which could be involved in cognitive impairments in schizophrenia. |
2014-05-30 |
2023-08-12 |
rat |
| Berend Malchow, Alkomiet Hasan, Thomas Schneider-Axmann, Alexander Jatzko, Oliver Gruber, Andrea Schmitt, Peter Falkai, Thomas Wobroc. Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia. European archives of psychiatry and clinical neuroscience. vol 263 Suppl 2. 2014-05-29. PMID:24085610. |
in this magnetic resonance imaging (mri) study in 47 first-episode schizophrenia patients and 30 healthy control subjects, we investigated effects of previous cannabis abuse and increased familial risk on subcortical brain regions such as hippocampus, amygdala, caudate nucleus, putamen, thalamus and subsegments of the corpus callosum (cc). |
2014-05-29 |
2023-08-12 |
human |
| Berend Malchow, Alkomiet Hasan, Thomas Schneider-Axmann, Alexander Jatzko, Oliver Gruber, Andrea Schmitt, Peter Falkai, Thomas Wobroc. Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia. European archives of psychiatry and clinical neuroscience. vol 263 Suppl 2. 2014-05-29. PMID:24085610. |
compared to healthy controls, schizophrenia patients displayed decreased volumes of the left hippocampus, bilateral amygdala and caudate nucleus as well as an increased area of the midsagittal cc1 segment of the corpus callosum. |
2014-05-29 |
2023-08-12 |
human |
| Mohammad Hosseini-Sharifabad, Abdoreza Sabah. Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia. Iranian journal of basic medical sciences. vol 17. issue 3. 2014-05-21. PMID:24847421. |
stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia. |
2014-05-21 |
2023-08-13 |
rat |
| Mohammad Hosseini-Sharifabad, Abdoreza Sabah. Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia. Iranian journal of basic medical sciences. vol 17. issue 3. 2014-05-21. PMID:24847421. |
the hippocampus has been implicated in pathophysiology of schizophrenia. |
2014-05-21 |
2023-08-13 |
rat |
| Mohammad Hosseini-Sharifabad, Abdoreza Sabah. Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia. Iranian journal of basic medical sciences. vol 17. issue 3. 2014-05-21. PMID:24847421. |
this study examined long-term effects of prenatal restraint stress on the stereological parameters in the cornu ammonis (ca) of adult male rats as an animal model of schizophrenia. |
2014-05-21 |
2023-08-13 |
rat |
| Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. |
atypical antipsychotic drugs (aapds) have been suggested to be more effective in improving cognitive impairment in schizophrenia than typical apds, a conclusion supported by differences in receptor affinities and neurotransmitter efflux in the cortex and the hippocampus. |
2014-05-14 |
2023-08-12 |
rat |
| Alma D Genis-Mendoza, R Ileana Gallegos-Silva, Mavil López-Casamichana, Carolina López-Rubalcava, Humberto Nicolin. Gene expression profiles of nucleus accumbens, prefrontal cortex and hippocampus in an animal model of schizophrenia: proposed candidate genes. Actas espanolas de psiquiatria. vol 41. issue 3. 2014-05-05. PMID:23803799. |
gene expression profiles of nucleus accumbens, prefrontal cortex and hippocampus in an animal model of schizophrenia: proposed candidate genes. |
2014-05-05 |
2023-08-12 |
rat |
| Alma D Genis-Mendoza, R Ileana Gallegos-Silva, Mavil López-Casamichana, Carolina López-Rubalcava, Humberto Nicolin. Gene expression profiles of nucleus accumbens, prefrontal cortex and hippocampus in an animal model of schizophrenia: proposed candidate genes. Actas espanolas de psiquiatria. vol 41. issue 3. 2014-05-05. PMID:23803799. |
in this study, we evaluated differences in the expression of brain genes using a recognized experimental prototype of schizophrenia: the animal model of ventral hippocampal lesion in neonate rats (vhln) compared to control animals. |
2014-05-05 |
2023-08-12 |
rat |
| Javier Gilabert-Juan, Maria Belles, Ana Rosa Saez, Hector Carceller, Sara Zamarbide-Fores, Maria Dolores Moltó, Juan Nache. A "double hit" murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus. Neurobiology of disease. vol 59. 2014-05-05. PMID:23891727. |
a "double hit" murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus. |
2014-05-05 |
2023-08-12 |
rat |
| Sarah L M Johnson, Lei Wang, Kathryn I Alpert, Deanna Greenstein, Liv Clasen, Francois Lalonde, Rachel Miller, Judith Rapoport, Nitin Gogta. Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. Journal of the American Academy of Child and Adolescent Psychiatry. vol 52. issue 5. 2014-05-02. PMID:23622854. |
hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. |
2014-05-02 |
2023-08-12 |
human |
| Sarah L M Johnson, Lei Wang, Kathryn I Alpert, Deanna Greenstein, Liv Clasen, Francois Lalonde, Rachel Miller, Judith Rapoport, Nitin Gogta. Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings. Journal of the American Academy of Child and Adolescent Psychiatry. vol 52. issue 5. 2014-05-02. PMID:23622854. |
the authors explored the nature and developmental trajectory of subregional shape abnormalities of the hippocampus in patients with childhood-onset schizophrenia (cos), their healthy siblings, and healthy volunteers. |
2014-05-02 |
2023-08-12 |
human |
| Andrew D Bolton, Marnie A Phillips, Martha Constantine-Pato. Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition. Journal of neurophysiology. vol 110. issue 7. 2014-04-11. PMID:23864370. |
here we show that the amino acid homocysteine (hcy), which is increased in the blood of schizophrenia patients, reduces desensitization of nmdars in cultured mouse neurons, human embryonic kidney cells transfected with glun1 + glun2a, glun2b, or glun2d subunits, and hippocampal slices. |
2014-04-11 |
2023-08-12 |
mouse |
| Yasushi Yabuki, Osamu Nakagawasai, Takeshi Tadano, Kohji Fukunag. [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 133. issue 5. 2014-04-09. PMID:23649390. |
neonatal ventral hippocampus (nvh)-lesioned rats had been known as neurodevelopmental animal model similar to schizophrenia. |
2014-04-09 |
2023-08-12 |
rat |
| A Melnik, S Tauber, C Dumrese, O Ullrich, S A Wol. Murine adult neural progenitor cells alter their proliferative behavior and gene expression after the activation of Toll-like-receptor 3. European journal of microbiology & immunology. vol 2. issue 3. 2014-04-01. PMID:24688771. |
one of the main morphological hallmarks of schizophrenia is a reduced size of the hippocampus. |
2014-04-01 |
2023-08-12 |
mouse |