| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Teng Koh, Yi Shao, Andrew Sherwood, Dani R Smit. Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. Schizophrenia research. vol 171. issue 1-3. 2016-12-13. PMID:26811256. |
to better understand whether cognitive function is similarly affected in these models of hippocampal overactivity, we tested a ketamine mouse model of schizophrenia for cognitive performance in hippocampal- and medial prefrontal cortex (mpfc)-dependent tasks. |
2016-12-13 |
2023-08-13 |
mouse |
| Ming Teng Koh, Yi Shao, Andrew Sherwood, Dani R Smit. Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. Schizophrenia research. vol 171. issue 1-3. 2016-12-13. PMID:26811256. |
these results strengthened the utility of the ketamine model for preclinical investigations of hippocampal overactivity in schizophrenia. |
2016-12-13 |
2023-08-13 |
mouse |
| Sarah C McEwen, Anthony Hardy, Benjamin M Ellingson, Behnaz Jarrahi, Navjot Sandhu, Kenneth L Subotnik, Joseph Ventura, Keith H Nuechterlei. Prefrontal and Hippocampal Brain Volume Deficits: Role of Low Physical Activity on Brain Plasticity in First-Episode Schizophrenia Patients. Journal of the International Neuropsychological Society : JINS. vol 21. issue 10. 2016-11-14. PMID:26581798. |
prefrontal and hippocampal brain volume deficits: role of low physical activity on brain plasticity in first-episode schizophrenia patients. |
2016-11-14 |
2023-08-13 |
Not clear |
| Y Tian, J Yang, Y Lei, Z Zhang, Z Dai, X Chen, F Lui, J Zhang, S Lin. Neonatal ventral hippocampus lesion changes nuclear restricted protein/brain (NRP/B) expression in hippocampus, cortex and striatum in developmental periods of rats. Neuroscience. vol 319. 2016-11-14. PMID:26812035. |
rats with neonatal ventral hippocampal lesions (nvhl) can exhibit schizophrenia-like behaviors, and these rats have been widely used to study the developmental mechanisms of schizophrenia. |
2016-11-14 |
2023-08-13 |
rat |
| David D Aguilar, Andrea Giuffrida, Daniel J Lodg. THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia. Journal of psychopharmacology (Oxford, England). vol 30. issue 2. 2016-10-31. PMID:26510449. |
thc and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic pcp model of schizophrenia. |
2016-10-31 |
2023-08-13 |
rat |
| Klaus Oliver Schubert, Melanie Föcking, Kieran Wynne, David R Cotte. Proteome and pathway effects of chronic haloperidol treatment in mouse hippocampus. Proteomics. vol 16. issue 3. 2016-10-26. PMID:26607048. |
haloperidol, a widely used first-generation antipsychotic, has been shown to produce structural and functional changes of the hippocampus, a brain region also implicated in the neuropathology of disorders such as schizophrenia and bipolar disorder. |
2016-10-26 |
2023-08-13 |
mouse |
| S Subburaju, A J Coleman, W B Ruzicka, F M Bene. Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. Translational psychiatry. vol 6. 2016-10-17. PMID:26812044. |
toward dissecting the etiology of schizophrenia: hdac1 and daxx regulate gad67 expression in an in vitro hippocampal gaba neuron model. |
2016-10-17 |
2023-08-13 |
human |
| S Subburaju, A J Coleman, W B Ruzicka, F M Bene. Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. Translational psychiatry. vol 6. 2016-10-17. PMID:26812044. |
schizophrenia (sz) is associated with gaba neuron dysfunction in the hippocampus, particularly the stratum oriens of sector ca3/2. |
2016-10-17 |
2023-08-13 |
human |
| Jason Smucny, Ann Olincy, Donald C Rojas, Jason R Tregella. Neuronal effects of nicotine during auditory selective attention in schizophrenia. Human brain mapping. vol 37. issue 1. 2016-10-11. PMID:26518728. |
we hypothesized that nicotine would modulate attention-associated neuronal response in schizophrenia patients in the ventral parietal cortex (vpc), hippocampus, and anterior cingulate based on previous findings in control subjects. |
2016-10-11 |
2023-08-13 |
human |
| Hans C van Mierlo, Marleen H van Coevorden-Hameete, Leon P Munting, Esther de Graaff, Lot de Witt. No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26482911. |
we examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected hela cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Jason R Tregellas, Jason Smucny, Kristina T Legget, Karen E Steven. Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study. Schizophrenia research. vol 169. issue 1-3. 2016-09-27. PMID:26453015. |
this study examined effects of treatment with the ketogenic diet on hippocampal p20/n40 gating in dba/2 mice, a translational endophenotype that mirrors inhibitory deficits in p50 sensory gating in schizophrenia patients. |
2016-09-27 |
2023-08-13 |
mouse |
| Eva Janousova, Giovanni Montana, Tomas Kasparek, Daniel Schwar. Supervised, Multivariate, Whole-Brain Reduction Did Not Help to Achieve High Classification Performance in Schizophrenia Research. Frontiers in neuroscience. vol 10. 2016-09-09. PMID:27610072. |
in an experiment with magnetic resonance brain images of 52 first-episode schizophrenia patients and 52 healthy controls, this method allowed us to select brain areas relevant to schizophrenia, such as the left prefrontal cortex, the anterior cingulum, the right anterior insula, the thalamus, and the hippocampus. |
2016-09-09 |
2023-08-13 |
Not clear |
| Giovanni Provenzano, Zelia Corradi, Katia Monsorno, Tarcisio Fedrizzi, Laura Ricceri, Maria L Scattoni, Yuri Bozz. Comparative Gene Expression Analysis of Two Mouse Models of Autism: Transcriptome Profiling of the BTBR and En2 (-/-) Hippocampus. Frontiers in neuroscience. vol 10. 2016-09-09. PMID:27610074. |
interestingly, both btbr and en2 (-/-) hippocampal degs showed a significant enrichment of asd and schizophrenia (scz)-associated genes. |
2016-09-09 |
2023-08-13 |
mouse |
| Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
collectively, our results suggest that hippocampal astrocytes may contribute to the pathophysiology of schizophrenia symptoms associated with nmda receptor hypofunction by reactive transformation and altered bdnf signaling. |
2016-08-17 |
2023-08-13 |
rat |
| C A Tamminga, R S Zuki. Schizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology. Neuroscience. vol 309. 2016-08-09. PMID:26211447. |
schizophrenia: evidence implicating hippocampal glun2b protein and rest epigenetics in psychosis pathophysiology. |
2016-08-09 |
2023-08-13 |
human |
| C A Tamminga, R S Zuki. Schizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology. Neuroscience. vol 309. 2016-08-09. PMID:26211447. |
the hippocampus is strongly implicated in the psychotic symptoms of schizophrenia. |
2016-08-09 |
2023-08-13 |
human |
| Mei Huang, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Masanori Miyauchi, Herbert Y Meltze. Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement. Pharmacology, biochemistry, and behavior. vol 138. 2016-07-28. PMID:26383990. |
the effects of atypical apds to enhance rodent cortical, hippocampal, limbic, and dorsal striatal (dstr) da and acetylcholine (ach) release, contribute to their ability to improve novel object recognition (nor) in rodents treated with sub-chronic (sc) phencyclidine (pcp) and cognitive impairment associated with schizophrenia (cias). |
2016-07-28 |
2023-08-13 |
mouse |
| Xiong-Jian Luo, Manuel Mattheisen, Ming Li, Liang Huang, Marcella Rietschel, Anders D Børglum, Thomas D Als, Edwin J van den Oord, Karolina A Aberg, Ole Mors, Preben Bo Mortensen, Zhenwu Luo, Franziska Degenhardt, Sven Cichon, Thomas G Schulze, Markus M Nöthen, Bing Su, Zhongming Zhao, Lin Gan, Yong-Gang Ya. Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function. Schizophrenia bulletin. vol 41. issue 6. 2016-07-20. PMID:25759474. |
we found that the znf323 was significantly downregulated in hippocampus and frontal cortex of schizophrenia patients (p = .0038 and p = .0233, respectively). |
2016-07-20 |
2023-08-13 |
human |
| J-T Li, Y-Y Zhao, H-L Wang, X-D Wang, Y-A Su, T-M S. Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. Neuroscience. vol 308. 2016-07-19. PMID:26349007. |
these results parallel findings of hippocampal abnormalities in schizophrenia and lend support to the usefulness of neonatal nmdar blockade as a potential neurodevelopmental model for the disease. |
2016-07-19 |
2023-08-13 |
rat |
| Natalie Matosin, Francesca Fernandez-Enright, Jeremy S Lum, Martin Engel, Jessica L Andrews, Nils C Gassen, Klaus V Wagner, Mathias V Schmidt, Kelly A Newel. Molecular evidence of synaptic pathology in the CA1 region in schizophrenia. NPJ schizophrenia. vol 2. 2016-07-19. PMID:27430010. |
these findings support the presence of extensive molecular abnormalities to psd95 and several of its associated proteins in the ca1 region in schizophrenia, offering a small but significant step toward understanding how proteins in the psd are altered in the schizophrenia brain, and their relevance to overall hippocampal and cognitive dysfunction in the illness. |
2016-07-19 |
2023-08-13 |
human |