| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W R Crum, F Danckaers, T Huysmans, M-C Cotel, S Natesan, M M Modo, J Sijbers, S C R Williams, S Kapur, A C Verno. Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss. Psychological medicine. vol 46. issue 15. 2017-11-16. PMID:27516217. |
one of the most consistently reported brain abnormalities in schizophrenia (scz) is decreased volume and shape deformation of the hippocampus. |
2017-11-16 |
2023-08-13 |
rat |
| Miho Ota, Noriko Sato, Shinsuke Hidese, Toshiya Teraishi, Norihide Maikusa, Hiroshi Matsuda, Kotaro Hattori, Hiroshi Kunug. Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects. Psychiatry research. Neuroimaging. vol 259. 2017-11-16. PMID:27987389. |
structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects. |
2017-11-16 |
2023-08-13 |
human |
| Miho Ota, Noriko Sato, Shinsuke Hidese, Toshiya Teraishi, Norihide Maikusa, Hiroshi Matsuda, Kotaro Hattori, Hiroshi Kunug. Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects. Psychiatry research. Neuroimaging. vol 259. 2017-11-16. PMID:27987389. |
schizophrenia patients exhibited significant volume reductions in the cornu ammonis (ca)1 compared to the controls, and in the dentate gyrus compared to the controls and mdd patients without medication, whereas there was no significant difference between the mdd patients and controls. |
2017-11-16 |
2023-08-13 |
human |
| Miho Ota, Noriko Sato, Shinsuke Hidese, Toshiya Teraishi, Norihide Maikusa, Hiroshi Matsuda, Kotaro Hattori, Hiroshi Kunug. Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects. Psychiatry research. Neuroimaging. vol 259. 2017-11-16. PMID:27987389. |
we identified differing volume reductions in hippocampal subfields and varying correlations between disease severity and subfield volumes depending on diagnosis, suggesting that volume differences in hippocampus subfields may provide important information regarding the pathophysiology of schizophrenia and mdd. |
2017-11-16 |
2023-08-13 |
human |
| Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T L. Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195569. |
rare damaging variants in dna repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T L. Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195569. |
schizophrenia is a complex neurodevelopmental disorder where changes in both hippocampus and memory-related cognitive functions are central. |
2017-11-16 |
2023-08-13 |
Not clear |
| Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T L. Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195569. |
the general aim of our study is to link the occurrence of rare damaging mutations involved in susceptibility gene pathways to the structure and function of hippocampus in order to define genetically and phenotypically based subgroups in schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T L. Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195569. |
taken together, our data demonstrate for the first time, to our knowledge, that damaging rare variants of genes in dna repair and cell cycle pathways are associated with aberrant hippocampal rsfc, which was further relative to cognitive deficits in first-episode treatment-naive schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T L. Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195569. |
therefore, our data provide some evidence for the occurrence of phenotypic alterations in hippocampal and swm function in a genetically defined subgroup of schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| F Harrisberger, R Smieskova, C Vogler, T Egli, A Schmidt, C Lenz, A E Simon, A Riecher-Rössler, A Papassotiropoulos, S Borgward. Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis. Translational psychiatry. vol 6. issue 8. 2017-11-13. PMID:27505231. |
these findings provide evidence that a subset of schizophrenia risk variants is negatively associated with hippocampal volumes, and higher values of this psrs are significantly associated with fep compared with the arms. |
2017-11-13 |
2023-08-13 |
Not clear |
| M M Darby, R H Yolken, S Sabunciya. Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders. Translational psychiatry. vol 6. issue 9. 2017-11-07. PMID:27622934. |
we then identified genes and canonical pathway gene sets with significantly altered expression in schizophrenia and bipolar disorder in the hippocampus and in schizophrenia, bipolar disorder and major depression in the orbitofrontal cortex. |
2017-11-07 |
2023-08-13 |
Not clear |
| Cecília Cerqueira Café-Mendes, Humberto Miguel Garay-Malpartida, Marília Brinati Malta, Larrissa de Sá Lima, Cristóforo Scavone, Zulma S Ferreira, Regina P Markus, Tania Marcouraki. Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus. Neuroscience letters. vol 636. 2017-10-24. PMID:27984197. |
the hippocampus is severely affected in disorders that have a neuroinflammatory component, such as alzheimer's disease, parkinson's disease, and schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Nasir Mirza, Richard Appleton, Sasha Burn, Daniel du Plessis, Roderick Duncan, Jibril Osman Farah, Bjarke Feenstra, Anders Hviid, Vivek Josan, Rajiv Mohanraj, Arif Shukralla, Graeme J Sills, Anthony G Marson, Munir Pirmohame. Genetic regulation of gene expression in the epileptic human hippocampus. Human molecular genetics. vol 26. issue 9. 2017-10-17. PMID:28334860. |
in contrast, gwas meta-analyses of two other brain diseases associated with hippocampal pathology (alzheimer's disease and schizophrenia) are more enriched with normal hippocampal eqtls than with epilepsy-eqtls. |
2017-10-17 |
2023-08-13 |
human |
| Maria Donata Orfei, Fabrizio Piras, Nerisa Banaj, Giorgio Di Lorenzo, Alberto Siracusano, Carlo Caltagirone, Pier Luca Bandinelli, Giuseppe Ducci, Gianfranco Spallett. Unrealistic self-overconfidence in schizophrenia is associated with left presubiculum atrophy and impaired episodic memory. Cortex; a journal devoted to the study of the nervous system and behavior. vol 86. 2017-10-09. PMID:27951456. |
our data support the hypothesis that unrealistic self-overconfidence in schizophrenia is related to the hippocampal presubiculum atrophy, which is involved in episodic memory and cognitive control and is supposed to be underpinned by difficulty in integrating new memories and thus in generating new hypotheses about the self. |
2017-10-09 |
2023-08-13 |
human |
| Johanna Hass, Esther Walton, Holger Kirsten, Jingyu Liu, Lutz Priebe, Christiane Wolf, Nazanin Karbalai, Randy Gollub, Tonya White, Veit Roessner, Kathrin U Müller, Tomas Paus, Michael N Smolka, Gunter Schumann, Markus Scholz, Sven Cichon, Vince Calhoun, Stefan Ehrlic. A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype. PloS one. vol 8. issue 6. 2017-10-05. PMID:23805179. |
patients with schizophrenia and their siblings typically show subtle changes of brain structures, such as a reduction of hippocampal volume. |
2017-10-05 |
2023-08-12 |
human |
| Johanna Hass, Esther Walton, Holger Kirsten, Jingyu Liu, Lutz Priebe, Christiane Wolf, Nazanin Karbalai, Randy Gollub, Tonya White, Veit Roessner, Kathrin U Müller, Tomas Paus, Michael N Smolka, Gunter Schumann, Markus Scholz, Sven Cichon, Vince Calhoun, Stefan Ehrlic. A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype. PloS one. vol 8. issue 6. 2017-10-05. PMID:23805179. |
hippocampal volume is heritable, may explain a variety of cognitive symptoms of schizophrenia and is thus considered an intermediate phenotype for this mental illness. |
2017-10-05 |
2023-08-12 |
human |
| N F Ho, J E Iglesias, M Y Sum, C N Kuswanto, Y Y Sitoh, J De Souza, Z Hong, B Fischl, J L Roffman, J Zhou, K Sim, D J Hol. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:26903271. |
progression from selective to general involvement of hippocampal subfields in schizophrenia. |
2017-09-29 |
2023-08-13 |
Not clear |
| N F Ho, J E Iglesias, M Y Sum, C N Kuswanto, Y Y Sitoh, J De Souza, Z Hong, B Fischl, J L Roffman, J Zhou, K Sim, D J Hol. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:26903271. |
volume deficits of the hippocampus in schizophrenia have been consistently reported. |
2017-09-29 |
2023-08-13 |
Not clear |
| N F Ho, J E Iglesias, M Y Sum, C N Kuswanto, Y Y Sitoh, J De Souza, Z Hong, B Fischl, J L Roffman, J Zhou, K Sim, D J Hol. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:26903271. |
however, the hippocampus is anatomically heterogeneous; it remains unclear whether certain portions of the hippocampus are affected more than others in schizophrenia. |
2017-09-29 |
2023-08-13 |
Not clear |
| N F Ho, J E Iglesias, M Y Sum, C N Kuswanto, Y Y Sitoh, J De Souza, Z Hong, B Fischl, J L Roffman, J Zhou, K Sim, D J Hol. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:26903271. |
in this study, we aimed to determine whether volume deficits in schizophrenia are confined to specific subfields of the hippocampus and to measure the subfield volume trajectories over the course of the illness. |
2017-09-29 |
2023-08-13 |
Not clear |