| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William T O'Connor, Sean D O'She. Clozapine and GABA transmission in schizophrenia disease models: establishing principles to guide treatments. Pharmacology & therapeutics. vol 150. 2016-02-08. PMID:25585121. |
clozapine and gaba transmission in schizophrenia disease models: establishing principles to guide treatments. |
2016-02-08 |
2023-08-13 |
Not clear |
| William T O'Connor, Sean D O'She. Clozapine and GABA transmission in schizophrenia disease models: establishing principles to guide treatments. Pharmacology & therapeutics. vol 150. 2016-02-08. PMID:25585121. |
here we summarise the evidence for a gaba dysfunction in schizophrenia and review the functional neuroanatomy of five pathways implicated in schizophrenia, namely the mesocortical, mesolimbic, ventral striopallidal, dorsal striopallidal and perforant pathways including the role of local gaba transmission and we describe the effect of clozapine on local neurotransmitter release. |
2016-02-08 |
2023-08-13 |
Not clear |
| William T O'Connor, Sean D O'She. Clozapine and GABA transmission in schizophrenia disease models: establishing principles to guide treatments. Pharmacology & therapeutics. vol 150. 2016-02-08. PMID:25585121. |
the review concludes that while no single animal model is entirely successful in reproducing schizophreniform symptomatology, a disease model based on an ability to prevent and/or reverse the abrupt clozapine discontinuation-induced changes in gaba release in brain regions implicated in schizophrenia may be useful for hypothesis testing and for in vivo screening of novel ligands not limited to a single pharmacological class. |
2016-02-08 |
2023-08-13 |
Not clear |
| Natalie Hyde, Seetal Dodd, Kamalesh Venugopal, Christa Purdie, Michael Berk, Adrienne O'Nei. Prevalence of cardiovascular and metabolic events in patients prescribed clozapine: a retrospective observational, clinical cohort study. Current drug safety. vol 10. issue 2. 2016-02-08. PMID:25986036. |
the efficacy of clozapine for the treatment of schizophrenia has been demonstrated. |
2016-02-08 |
2023-08-13 |
Not clear |
| Valerie M Anderson, Meghan E Goldstein, Robert R Kydd, Bruce R Russel. Extensive gray matter volume reduction in treatment-resistant schizophrenia. The international journal of neuropsychopharmacology. vol 18. issue 7. 2016-02-05. PMID:25716781. |
approximately one-third of people with schizophrenia are treatment-resistant and some do not achieve remission with clozapine, the gold-standard antipsychotic medication for treatment-resistant schizophrenia. |
2016-02-05 |
2023-08-13 |
Not clear |
| S V Sathish Kumar, Vinod Kumar Sinh. Comparative study of sexual dysfunction and serum prolactin level associated with olanzapine, risperidone, and clozapine in patients with remitted schizophrenia. Indian journal of psychiatry. vol 57. issue 4. 2016-01-28. PMID:26816428. |
comparative study of sexual dysfunction and serum prolactin level associated with olanzapine, risperidone, and clozapine in patients with remitted schizophrenia. |
2016-01-28 |
2023-08-13 |
Not clear |
| Sourav Khanra, Rati Ranjan Sethy, Sanjay Kumar Munda, Christoday Raja Jayant Khes. An Unusual Case of Delirium after Restarting Clozapine. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 14. issue 1. 2016-01-21. PMID:26792049. |
clozapine is a gold standard medication and drug of choice in refractory schizophrenia. |
2016-01-21 |
2023-08-13 |
Not clear |
| Sourav Khanra, Rati Ranjan Sethy, Sanjay Kumar Munda, Christoday Raja Jayant Khes. An Unusual Case of Delirium after Restarting Clozapine. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 14. issue 1. 2016-01-21. PMID:26792049. |
we here present a case of delirium which emerged during retreatment with clozapine in a patient of paranoid schizophrenia. |
2016-01-21 |
2023-08-13 |
Not clear |
| Sandeep Grover, Swapnajeet Saho. Clozapine induced akathisia: a case report and review of the evidence. Indian journal of pharmacology. vol 47. issue 2. 2016-01-15. PMID:25878393. |
clozapine is a second-generation antipsychotic medication, which is mostly used in patients with treatment resistant schizophrenia. |
2016-01-15 |
2023-08-13 |
Not clear |
| Meghan Elizabeth Goldstein, Valerie Margaret Anderson, Avinesh Pillai, Robert R Kydd, Bruce R Russel. Glutamatergic neurometabolites in clozapine-responsive and -resistant schizophrenia. The international journal of neuropsychopharmacology. vol 18. issue 6. 2016-01-12. PMID:25603859. |
according to the current schizophrenia treatment guidelines, 3 levels of responsiveness to antipsychotic medication exist: those who respond to first-line antipsychotics, those with treatment-resistant schizophrenia who respond to clozapine, and those with clozapine-resistant or ultra-treatment resistant schizophrenia. |
2016-01-12 |
2023-08-13 |
Not clear |
| Florence Elizabeth Chamberlain, Nicholas Walsh, Jan Falkowsk. Chemotherapy for Hodgkin's lymphoma in a patient receiving clozapine for treatment-resistant schizophrenia: use of the Mental Capacity Act 2005. BJPsych bulletin. vol 39. issue 6. 2016-01-12. PMID:26755992. |
chemotherapy for hodgkin's lymphoma in a patient receiving clozapine for treatment-resistant schizophrenia: use of the mental capacity act 2005. |
2016-01-12 |
2023-08-13 |
Not clear |
| Florence Elizabeth Chamberlain, Nicholas Walsh, Jan Falkowsk. Chemotherapy for Hodgkin's lymphoma in a patient receiving clozapine for treatment-resistant schizophrenia: use of the Mental Capacity Act 2005. BJPsych bulletin. vol 39. issue 6. 2016-01-12. PMID:26755992. |
treatment resistance occurs in approximately 30% of individuals with schizophrenia and is commonly treated with clozapine. |
2016-01-12 |
2023-08-13 |
Not clear |
| Florence Elizabeth Chamberlain, Nicholas Walsh, Jan Falkowsk. Chemotherapy for Hodgkin's lymphoma in a patient receiving clozapine for treatment-resistant schizophrenia: use of the Mental Capacity Act 2005. BJPsych bulletin. vol 39. issue 6. 2016-01-12. PMID:26755992. |
in this case report, an individual with treatment-resistant schizophrenia developed nodular sclerosing hodgkin's lymphoma and is treated with concurrent clozapine and systemic chemotherapy. |
2016-01-12 |
2023-08-13 |
Not clear |
| Adam Wysokiński, Iwona Kłoszewsk. Uric acid levels in patients with schizophrenia on clozapine monotherapy. Nordic journal of psychiatry. vol 69. issue 6. 2016-01-06. PMID:25801748. |
uric acid levels in patients with schizophrenia on clozapine monotherapy. |
2016-01-06 |
2023-08-13 |
human |
| Adam Wysokiński, Iwona Kłoszewsk. Uric acid levels in patients with schizophrenia on clozapine monotherapy. Nordic journal of psychiatry. vol 69. issue 6. 2016-01-06. PMID:25801748. |
we tested the hypothesis that uric acid levels are higher in subjects with schizophrenia treated with clozapine than in healthy control and they correlate with anthropometric measurements, laboratory tests and results of bioimpedance analysis of body composition. |
2016-01-06 |
2023-08-13 |
human |
| Mong-Liang Lu, Tsu-Nai Wang, Tsang-Yaw Lin, Wen-Chuan Shao, Sheng-Huang Chang, Jen-Yu Chou, Yi-Feng Ho, Yin-To Liao, Vincent Chin-Hung Che. Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25496829. |
three hundred and thirty-three patients with schizophrenia under clozapine or olanzapine monotherapy were recruited. |
2016-01-05 |
2023-08-13 |
human |
| Shinichiro Nakajima, Hiroyoshi Takeuchi, Gagan Fervaha, Eric Plitman, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Yukiko Mihashi, Philip Gerretsen, Gary Remington, Benoit Mulsant, Ariel Graff-Guerrer. Comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the CATIE phase 2E data. Schizophrenia research. vol 161. issue 2-3. 2015-12-31. PMID:25556080. |
comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the catie phase 2e data. |
2015-12-31 |
2023-08-13 |
Not clear |
| Shinichiro Nakajima, Hiroyoshi Takeuchi, Gagan Fervaha, Eric Plitman, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Yukiko Mihashi, Philip Gerretsen, Gary Remington, Benoit Mulsant, Ariel Graff-Guerrer. Comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the CATIE phase 2E data. Schizophrenia research. vol 161. issue 2-3. 2015-12-31. PMID:25556080. |
the comparative antidepressant effects of clozapine and other atypical antipsychotics for schizophrenia remain elusive, leading us to examine this question using the data from the clinical antipsychotic trials of intervention effectiveness phase 2e. |
2015-12-31 |
2023-08-13 |
Not clear |
| Mathias Zink, Christoph U Correl. Glutamatergic agents for schizophrenia: current evidence and perspectives. Expert review of clinical pharmacology. vol 8. issue 3. 2015-12-30. PMID:25916667. |
suboptimal outcomes in schizophrenia are a consequence of lacking insight into the etiology, biomarkers and treatment-relevant subgroups, the therapeutic restriction to dopaminergic-modulating antipsychotics that fail to significantly improve negative and cognitive symptoms, non-adherence, and, in the case of treatment-resistance, the underutilization of clozapine. |
2015-12-30 |
2023-08-13 |
Not clear |
| Yunlong Zhu, Zhongliang Wang, Jianliang Ni, Yi Zhang, Meijuan Chen, Jun Cai, Xiao Li, Wen Zhang, Chen Zhan. Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese. Journal of human genetics. vol 60. issue 1. 2015-12-28. PMID:25354934. |
to explore whether the encoding ndufs1 gene confers susceptibility to schizophrenia or is associated with the severity of typical symptoms of schizophrenia, we recruited 519 stable schizophrenia patients receiving clozapine treatment and 594 healthy controls for genotyping to investigate the association of four selected tagging single-nucleotide polymorphisms (snps) of ndufs1 and both schizophrenia risk and symptom severity. |
2015-12-28 |
2023-08-13 |
human |