| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Bast, W N Zhang, C Heidbreder, J Feldo. Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine. Neuroscience. vol 103. issue 2. 2001-06-14. PMID:11246148. |
the present finding that both clozapine and haloperidol failed to antagonize the disruption of prepulse inhibition induced by n-methyl-d-aspartate stimulation of the ventral hippocampus is discussed with respect to our previous contrary finding concerning the ameliorative effect of clozapine and with respect to the disruption of prepulse inhibition in rats being considered as a model of sensorimotor gating deficits in schizophrenia. |
2001-06-14 |
2023-08-12 |
rat |
| S A Alle. Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia. Journal of clinical pharmacology. vol 40. issue 11. 2001-05-31. PMID:11075316. |
effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia. |
2001-05-31 |
2023-08-12 |
Not clear |
| S A Alle. Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia. Journal of clinical pharmacology. vol 40. issue 11. 2001-05-31. PMID:11075316. |
a 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (hal) in combination with chlorpromazine (cpz) and during overlap treatment with clozapine. |
2001-05-31 |
2023-08-12 |
Not clear |
| S E Purdon, A Labelle, L Boula. Neuropsychological change in schizophrenia after 6 weeks of clozapine. Schizophrenia research. vol 48. issue 1. 2001-05-31. PMID:11278154. |
neuropsychological change in schizophrenia after 6 weeks of clozapine. |
2001-05-31 |
2023-08-12 |
Not clear |
| B Mullen, J S Brar, A H Vagnucci, R Gangul. Frequency of sexual dysfunctions in patients with schizophrenia on haloperidol, clozapine or risperidone. Schizophrenia research. vol 48. issue 1. 2001-05-31. PMID:11345946. |
frequency of sexual dysfunctions in patients with schizophrenia on haloperidol, clozapine or risperidone. |
2001-05-31 |
2023-08-12 |
Not clear |
| W K Tang, G S Ungvar. Electroconvulsive therapy in rehabilitation: the Hong Kong experience. Psychiatric services (Washington, D.C.). vol 52. issue 3. 2001-05-17. PMID:11239096. |
the introduction of clozapine has enlarged the proportion of individuals with schizophrenia whose psychotic symptoms can be controlled (2), but symptoms remain refractory in a large number of patients. |
2001-05-17 |
2023-08-12 |
Not clear |
| M Masellis, V S Basile, H Y Meltzer, J A Lieberman, S Sevy, D A Goldman, M W Hamblin, F M Macciardi, J L Kenned. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophrenia research. vol 47. issue 1. 2001-04-26. PMID:11163544. |
lack of association between the t-->c 267 serotonin 5-ht6 receptor gene (htr6) polymorphism and prediction of response to clozapine in schizophrenia. |
2001-04-26 |
2023-08-12 |
Not clear |
| M Masellis, V S Basile, H Y Meltzer, J A Lieberman, S Sevy, D A Goldman, M W Hamblin, F M Macciardi, J L Kenned. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophrenia research. vol 47. issue 1. 2001-04-26. PMID:11163544. |
we employed a pharmacogenetic approach in a group (n=185) of schizophrenia patients that have been clinically well characterized for clozapine response. |
2001-04-26 |
2023-08-12 |
Not clear |
| F E Scheepers, C C Gispen de Wied, H E Hulshoff Pol, R S Kah. Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia. The American journal of psychiatry. vol 158. issue 4. 2001-04-26. PMID:11282704. |
effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia. |
2001-04-26 |
2023-08-12 |
Not clear |
| F E Scheepers, C C Gispen de Wied, H E Hulshoff Pol, R S Kah. Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia. The American journal of psychiatry. vol 158. issue 4. 2001-04-26. PMID:11282704. |
studies have found that caudate volume increased after treatment with typical antipsychotics in patients with schizophrenia but decreased after treatment was changed to clozapine. |
2001-04-26 |
2023-08-12 |
Not clear |
| Y W Lam, L Ereshefsky, G B Toney, C Gonzale. Branded versus generic clozapine: bioavailability comparison and interchangeability issues. The Journal of clinical psychiatry. vol 62 Suppl 5. 2001-04-26. PMID:11305844. |
clozapine has been the treatment of choice for patients with refractory schizophrenia. |
2001-04-26 |
2023-08-12 |
Not clear |
| R F Squires, E Saederu. Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. Neurochemical research. vol 25. issue 12. 2001-04-19. PMID:11152388. |
additivities of compounds that increase the numbers of high affinity [3h]muscimol binding sites by different amounts define more than 9 gaba(a) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. |
2001-04-19 |
2023-08-12 |
rat |
| R L Findling, N K McNamara, B L Graciou. Paediatric uses of atypical antipsychotics. Expert opinion on pharmacotherapy. vol 1. issue 5. 2001-04-05. PMID:11249501. |
based on the available information, it appears that clozapine has a role in juvenile treatment resistant schizophrenia. |
2001-04-05 |
2023-08-12 |
Not clear |
| D A Revick. The new atypical antipsychotics: a review of pharmacoeconomic studies. Expert opinion on pharmacotherapy. vol 1. issue 2. 2001-04-05. PMID:11249546. |
the evidence, from a variety of studies, indicates that clozapine is a cost-effective treatment for neuroleptic refractory schizophrenia. |
2001-04-05 |
2023-08-12 |
Not clear |
| S K Kulkarni, I Nina. Dopamine D4 receptors and development of newer antipsychotic drugs. Fundamental & clinical pharmacology. vol 14. issue 6. 2001-03-29. PMID:11206702. |
the discovery of d4 receptors and the putative affinity of clozapine for d4 receptors have kindled development of selective d4 receptor antagonists for the treatment of schizophrenia. |
2001-03-29 |
2023-08-12 |
Not clear |
| E Spina, A Avenoso, M Salemi, G Facciolá, M G Scordo, M Ancione, A Madi. Plasma concentrations of clozapine and its major metabolites during combined treatment with paroxetine or sertraline. Pharmacopsychiatry. vol 33. issue 6. 2001-03-08. PMID:11147928. |
the effect of paroxetine or sertraline on steady-state plasma concentrations of clozapine and its major metabolites was studied in 17 patients with schizophrenia or schizoaffective disorder stabilized on clozapine therapy (200-400 mg/day). |
2001-03-08 |
2023-08-12 |
Not clear |
| I Reznik, L Volchek, R Mester, M Kotler, I Sarova-Pinhas, B Spivak, A Weizma. Myotoxicity and neurotoxicity during clozapine treatment. Clinical neuropharmacology. vol 23. issue 5. 2001-03-08. PMID:11154096. |
in 2.1% of medically healthy patients with schizophrenia treated with clozapine on a long-term basis, signs of myotoxicity were found. |
2001-03-08 |
2023-08-12 |
Not clear |
| S Kapur, P Roy, J Daskalakis, G Remington, R Zipursk. Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine. The American journal of psychiatry. vol 158. issue 2. 2001-03-08. PMID:11156818. |
the authors added haloperidol, a potent d(2) blocker, to ongoing treatment with clozapine in patients with schizophrenia to determine the effects of this combination on dopamine d(2) receptor blockade, prolactin level, and extrapyramidal side effects. |
2001-03-08 |
2023-08-12 |
Not clear |
| C A Galletly, C R Clark, A C McFarlane, D L Webe. The effect of clozapine on the speed and accuracy of information processing in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 8. 2001-03-01. PMID:11125857. |
the effect of clozapine on the speed and accuracy of information processing in schizophrenia. |
2001-03-01 |
2023-08-12 |
human |
| C A Galletly, C R Clark, A C McFarlane, D L Webe. The effect of clozapine on the speed and accuracy of information processing in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 8. 2001-03-01. PMID:11125857. |
the study aimed to investigate the effects of clozapine on the speed and accuracy of information processing in patients with schizophrenia. |
2001-03-01 |
2023-08-12 |
human |